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HIV Molecular Immunology Database

Search the Epitope Variant and Escape Mutation Database

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Found 1 matching record:

Displaying record number 53387

HXB2 Location  Gag(240-249)   Gag Epitope Map
View variants at this location
Epitope TSTLQEQIGW   Epitope Alignment
Variants
TSTveEQIqW   subtype-specific non-susceptible form; subtype-specific susceptible form
TSTLQEQIaW   diminished response; subtype-specific non-susceptible form; subtype-specific susceptible form
Epitope Name gag 240-9
Species (MHC/HLA human(B57, B58)

Variant Details

Showing all: 2 variant(s).


Variant ID.  1012
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSTveEQIqW
Mutations L/V Q/E G/Q
Epitope Location L4V Q5E G9Q
HXB2 Location L243V Q244E G248Q
Mutation Type SNSF: subtype-specific non-susceptible form
SSF: subtype-specific susceptible form
Epitope Subtype B
Variant Subtype HIV-2
Method CD8 T-cell Elispot - IFNy
Note The HIV-2 variant of this epitope. 5/6 HIV-2 infected individuals could recognize both the HIV-1 and HIV-2 peptides, while 0/5 HIV-1 infected patients that could react with the HIV-1 peptide could also react with the HIV-2 peptide.


Variant ID.  1013
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSTLQEQIaW
Mutations G/A
Epitope Location G9A
HXB2 Location G248A
Mutation Type DR: diminished response
SNSF: subtype-specific non-susceptible form
SSF: subtype-specific susceptible form
Epitope Subtype B
Variant Subtype A
Method CD8 T-cell Elispot - IFNy
Note The clade A variant of this epitope. The variant resulted in significant reduction of CTL recognition in HIV-1 individuals, but was recognized by CTLs from HIV-2 infected patients.

References

Lopes2003 A. Ross Lopes, Assan Jaye, Lucy Dorrell, Sehu Sabally, Abraham Alabi, Nicola A. Jones, Darren R. Flower, Anne De Groot, Phillipa Newton, R. Monica Lascar, Ian Williams, Hilton Whittle, Antonio Bertoletti, Persephone Borrow, and Mala K. Maini. Greater CD8+ TCR Heterogeneity and Functional Flexibility in HIV-2 Compared to HIV-1 Infection. J. Immunol., 171(1):307-316, 1 Jul 2003. PubMed ID: 12817012. Show all entries for this paper.


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