Found 1 matching record:
HXB2 Location | Gag(240-249) | Gag Epitope Map
View variants at this location |
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Epitope |
TSTLQEQIGW
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Epitope Alignment | |||||||
Variants |
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Epitope Name | gag 240-9 | ||||||||
Species (MHC/HLA) | human(B57, B58) |
Showing all: 2 variant(s).
Variant ID. | 1012 |
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Epitope Seq. | TSTLQEQIGW |
Variant Seq. | TSTveEQIqW |
Mutations | L/V Q/E G/Q |
Epitope Location | L4V Q5E G9Q |
HXB2 Location | L243V Q244E G248Q |
Mutation Type | SNSF: subtype-specific non-susceptible form SSF: subtype-specific susceptible form |
Epitope Subtype | B |
Variant Subtype | HIV-2 |
Method | CD8 T-cell Elispot - IFNy |
Note | The HIV-2 variant of this epitope. 5/6 HIV-2 infected individuals could recognize both the HIV-1 and HIV-2 peptides, while 0/5 HIV-1 infected patients that could react with the HIV-1 peptide could also react with the HIV-2 peptide. |
Variant ID. | 1013 |
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Epitope Seq. | TSTLQEQIGW |
Variant Seq. | TSTLQEQIaW |
Mutations | G/A |
Epitope Location | G9A |
HXB2 Location | G248A |
Mutation Type | DR: diminished response SNSF: subtype-specific non-susceptible form SSF: subtype-specific susceptible form |
Epitope Subtype | B |
Variant Subtype | A |
Method | CD8 T-cell Elispot - IFNy |
Note | The clade A variant of this epitope. The variant resulted in significant reduction of CTL recognition in HIV-1 individuals, but was recognized by CTLs from HIV-2 infected patients. |
Lopes2003 A. Ross Lopes, Assan Jaye, Lucy Dorrell, Sehu Sabally, Abraham Alabi, Nicola A. Jones, Darren R. Flower, Anne De Groot, Phillipa Newton, R. Monica Lascar, Ian Williams, Hilton Whittle, Antonio Bertoletti, Persephone Borrow, and Mala K. Maini. Greater CD8+ TCR Heterogeneity and Functional Flexibility in HIV-2 Compared to HIV-1 Infection. J. Immunol., 171(1):307-316, 1 Jul 2003. PubMed ID: 12817012. Show all entries for this paper.
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