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Displaying record number 53233

HXB2 Location  Tat(24-32)   Tat Epitope Map
View variants at this location
Epitope NCYCKRCCF   Epitope Alignment
Variants
kCYCKRCCF   escape documented in this paper
NCYCKkCCF   observed variant
tCYCKRCCF   observed variant
kCYCKsCCF   observed variant
kCYCKkCCF   observed variant
NCYCKkCCy   susceptible form
Epitope Name Tat NF9
Species (MHC/HLA human(A*29:02)

Variant Details

Showing all: 6 variant(s).


Variant ID.  532
Epitope Seq.  NCYCKRCCF
Variant Seq.  kCYCKRCCF
Mutations N/K
Epitope Location N1K
HXB2 Location N24K
Mutation Type E: escape documented in this paper
Note The CTL response diminished in vivo as this variant appeared. The variant was evident by day 72.


Variant ID.  533
Epitope Seq.  NCYCKRCCF
Variant Seq.  NCYCKkCCF
Mutations R/K
Epitope Location R6K
HXB2 Location R29K
Mutation Type OV: observed variant
Note 1/7 clones, variant evident in samples taken at day 391.


Variant ID.  534
Epitope Seq.  NCYCKRCCF
Variant Seq.  tCYCKRCCF
Mutations N/T
Epitope Location N1T
HXB2 Location N24T
Mutation Type OV: observed variant
Note 5/7 clones, variant evident in samples taken at day 772.


Variant ID.  535
Epitope Seq.  NCYCKRCCF
Variant Seq.  kCYCKsCCF
Mutations N/K R/S
Epitope Location N1K R6S
HXB2 Location N24K R29S
Mutation Type OV: observed variant
Note 1/9 clones, variant evident in samples taken at day 772.


Variant ID.  536
Epitope Seq.  NCYCKRCCF
Variant Seq.  kCYCKkCCF
Mutations N/K R/K
Epitope Location N1K R6K
HXB2 Location N24K R29K
Mutation Type OV: observed variant
Note 1/9 clones, variant evident in samples taken at day 772.


Variant ID.  5095
Epitope Seq.  NCYCKRCCF
Variant Seq.  NCYCKkCCy
Mutations R/K F/Y
Epitope Location R6K F9Y
HXB2 Location R29K F32Y
Mutation Type SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy
Note Please see CTL record #53225 for mutations in corresponding autologous variant NCYCKkCCy observed in subtype B-infected patient BORI.

References

Jones2004 Nicola A. Jones, Xiping Wei, Darren R. Flower, MaiLee Wong, Franziska Michor, Michael S. Saag, Beatrice H. Hahn, Martin A. Nowak, George M. Shaw, and Persephone Borrow. Determinants of Human Immunodeficiency Virus Type 1 Escape from the Primary CD8+ Cytotoxic T Lymphocyte Response. J. Exp. Med., 200(10):1243-1256, 15 Nov 2004. PubMed ID: 15545352. Show all entries for this paper.

Yang2019 Yiding Yang, and Vitaly V. Ganusov. Defining Kinetic Properties of HIV-Specific CD8(+) T-Cell Responses in Acute Infection. Microorganisms, 7(3):microorganisms7030069 doi, Mar 2019. PubMed ID: 30836625 Show all entries for this paper.


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