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Displaying record number 53067

HXB2 Location  gp160(121-129)   gp160 Epitope Map
View variants at this location
Epitope KLTPLCVTL   Epitope Alignment
Variants
KiTPLCVTL   susceptible form
KmTPLCVTL   susceptible form
KLTPLCVTm   non-susceptible form
rLTPLCVTL   susceptible form
qLTPLCVTL   susceptible form
eLTPLCVTL   non-susceptible form
KLTsLCVTL   susceptible form
KLTqLCVTL   non-susceptible form
KLTPfCVTL   non-susceptible form
KLTPrCVTL   diminished HLA binding or increased off-rate; non-susceptible form
KLTPLCiTL   susceptible form
KLTPLCVpL   non-susceptible form
KLTPLCVsL   susceptible form
KLTPLCVaL   susceptible form
KLTPLCViL   susceptible form
qiTPLCVTL   diminished HLA binding or increased off-rate; non-susceptible form
qmTfLCVqm   diminished HLA binding or increased off-rate; non-susceptible form
KmTfLCVqm   diminished HLA binding or increased off-rate; non-susceptible form
Epitope Name Env 134
Species (MHC/HLA human, humanized mouse(A*02:01)

Variant Details

Showing all: 18 variant(s).


Variant ID.  1149
Epitope Seq.  KLTPLCVTL
Variant Seq.  KiTPLCVTL
Mutations L/I
Epitope Location L2I
HXB2 Location L122I
Mutation Type SF: susceptible form
Epitope Subtype B, C
Method CD8 T-cell Elispot - IFNy, HLA binding
Note This anchor position variant elicited a CTL response with cells from mice immunized with the index form. It was weakly recognized by CTL lines derived from HIV-1 uninfected donors.


Variant ID.  1150
Epitope Seq.  KLTPLCVTL
Variant Seq.  KmTPLCVTL
Mutations L/M
Epitope Location L2M
HXB2 Location L122M
Mutation Type SF: susceptible form
Epitope Subtype B, C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, HLA binding
Note This anchor position variant elicited a CTL response with cells from mice immunized with the index form.


Variant ID.  1151
Epitope Seq.  KLTPLCVTL
Variant Seq.  KLTPLCVTm
Mutations L/M
Epitope Location L9M
HXB2 Location L129M
Mutation Type NSF: non-susceptible form
Epitope Subtype B, C
Method CD8 T-cell Elispot - IFNy, HLA binding
Note This anchor position variant elicited a CTL response with cells from mice immunized with the index form. It was not recognized by CTL lines derived from HIV-1 uninfected donors.


Variant ID.  1152
Epitope Seq.  KLTPLCVTL
Variant Seq.  rLTPLCVTL
Mutations K/R
Epitope Location K1R
HXB2 Location K121R
Mutation Type SF: susceptible form
Epitope Subtype B, C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, HLA binding
Note This nonanchor position variant elicited a CTL response with cells from mice immunized with the index form.


Variant ID.  1154
Epitope Seq.  KLTPLCVTL
Variant Seq.  qLTPLCVTL
Mutations K/Q
Epitope Location K1Q
HXB2 Location K121Q
Mutation Type SF: susceptible form
Epitope Subtype B, C
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, HLA binding
Note This nonanchor position variant elicited a CTL response with cells from mice immunized with the index form. It was weakly recognized by CTL lines derived from HIV-1 uninfected donors.


Variant ID.  1155
Epitope Seq.  KLTPLCVTL
Variant Seq.  eLTPLCVTL
Mutations K/E
Epitope Location K1E
HXB2 Location K121E
Mutation Type NSF: non-susceptible form
Epitope Subtype B, C
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, HLA binding
Note This nonanchor position variant elicited a CTL response with cells from mice immunized with the index form. It was not recognized by CTL lines derived from HIV-1 uninfected donors. Binding to HLA is at a very low level.


Variant ID.  1156
Epitope Seq.  KLTPLCVTL
Variant Seq.  KLTsLCVTL
Mutations P/S
Epitope Location P4S
HXB2 Location P124S
Mutation Type SF: susceptible form
Epitope Subtype B, C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, HLA binding
Note This nonanchor position variant elicited a CTL response with cells from mice immunized with the index form.


Variant ID.  1157
Epitope Seq.  KLTPLCVTL
Variant Seq.  KLTqLCVTL
Mutations P/Q
Epitope Location P4Q
HXB2 Location P124Q
Mutation Type NSF: non-susceptible form
Epitope Subtype B, C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, HLA binding
Note This nonanchor position variant did not elicit a CTL response with cells from mice immunized with the index form.


Variant ID.  1158
Epitope Seq.  KLTPLCVTL
Variant Seq.  KLTPfCVTL
Mutations L/F
Epitope Location L5F
HXB2 Location L125F
Mutation Type NSF: non-susceptible form
Epitope Subtype B, C
Method CD8 T-cell Elispot - IFNy, HLA binding
Note This nonanchor position variant did not elicit a CTL response with cells from mice immunized with the index form. It was not recognized by CTL lines derived from HIV-1


Variant ID.  1159
Epitope Seq.  KLTPLCVTL
Variant Seq.  KLTPrCVTL
Mutations L/R
Epitope Location L5R
HXB2 Location L125R
Mutation Type DHB: diminished HLA binding or increased off-rate
NSF: non-susceptible form
Epitope Subtype B, C
Method CD8 T-cell Elispot - IFNy, HLA binding
Note This nonanchor position variant did not elicit a CTL response with cells from mice immunized with the index form. It was not recognized by CTL lines derived from HIV-1. Binding to HLA is at a very low level.


Variant ID.  1160
Epitope Seq.  KLTPLCVTL
Variant Seq.  KLTPLCiTL
Mutations V/I
Epitope Location V7I
HXB2 Location V127I
Mutation Type SF: susceptible form
Epitope Subtype B, C
Method CD8 T-cell Elispot - IFNy, HLA binding
Note This nonanchor position variant elicited a CTL response with cells from mice immunized with the index form. It was recognized by CTL lines derived from HIV-1.


Variant ID.  1161
Epitope Seq.  KLTPLCVTL
Variant Seq.  KLTPLCVpL
Mutations T/P
Epitope Location T8P
HXB2 Location T128P
Mutation Type NSF: non-susceptible form
Epitope Subtype B, C
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, HLA binding
Note This nonanchor position variant elicited a CTL response with cells from mice immunized with the index form. It was not recognized by CTL lines derived from HIV-1.


Variant ID.  1162
Epitope Seq.  KLTPLCVTL
Variant Seq.  KLTPLCVsL
Mutations T/S
Epitope Location T8S
HXB2 Location T128S
Mutation Type SF: susceptible form
Epitope Subtype B, C
Method CD8 T-cell Elispot - IFNy, HLA binding
Note This nonanchor position variant elicited a CTL response with cells from mice immunized with the index form. It was weakly recognized by CTL lines derived from HIV-1.


Variant ID.  1163
Epitope Seq.  KLTPLCVTL
Variant Seq.  KLTPLCVaL
Mutations T/A
Epitope Location T8A
HXB2 Location T128A
Mutation Type SF: susceptible form
Epitope Subtype B, C
Method CD8 T-cell Elispot - IFNy, HLA binding
Note This nonanchor position variant elicited a CTL response with cells from mice immunized with the index form. It was recognized by CTL lines derived from HIV-1.


Variant ID.  1164
Epitope Seq.  KLTPLCVTL
Variant Seq.  KLTPLCViL
Mutations T/I
Epitope Location T8I
HXB2 Location T128I
Mutation Type SF: susceptible form
Epitope Subtype B, C
Method CD8 T-cell Elispot - IFNy, HLA binding
Note This nonanchor position variant elicited a CTL response with cells from mice immunized with the index form. It was weakly recognized by CTL lines derived from HIV-1.


Variant ID.  1165
Epitope Seq.  KLTPLCVTL
Variant Seq.  qiTPLCVTL
Mutations K/Q L/I
Epitope Location K1Q L2I
HXB2 Location K121Q L122I
Mutation Type DHB: diminished HLA binding or increased off-rate
NSF: non-susceptible form
Epitope Subtype B, C
Method CD8 T-cell Elispot - IFNy, HLA binding
Note This multiple substitution variant did not elicit a CTL response with cells from mice immunized with the index form. It was not recognized by CTL lines derived from HIV-1. Binding to HLA was at a very low level.


Variant ID.  1166
Epitope Seq.  KLTPLCVTL
Variant Seq.  qmTfLCVqm
Mutations K/Q L/M P/F T/Q L/M
Epitope Location K1Q L2M P4F T8Q L9M
HXB2 Location K121Q L122M P124F T128Q L129M
Mutation Type DHB: diminished HLA binding or increased off-rate
NSF: non-susceptible form
Epitope Subtype B, C
Method CD8 T-cell Elispot - IFNy, HLA binding
Note This multiple substitution variant did not elicit a CTL response with cells from mice immunized with the index form. It was not recognized by CTL lines derived from HIV-1. Binding to HLA was at a very low level.


Variant ID.  1167
Epitope Seq.  KLTPLCVTL
Variant Seq.  KmTfLCVqm
Mutations L/M P/F T/Q L/M
Epitope Location L2M P4F T8Q L9M
HXB2 Location L122M P124F T128Q L129M
Mutation Type DHB: diminished HLA binding or increased off-rate
NSF: non-susceptible form
Epitope Subtype B, C
Method CD8 T-cell Elispot - IFNy, HLA binding
Note This multiple substitution variant did not elicit a CTL response with cells from mice immunized with the index form. It was not recognized by CTL lines derived from HIV-1. Binding to HLA was at a very low level.

References

McKinney2004 Denise M. McKinney, Rhonda Skvoretz, Brian D. Livingston, Cara C. Wilson, Michelle Anders, Robert W. Chesnut, Alessandro Sette, Max Essex, Vladimir Novitsky, and Mark J. Newman. Recognition of Variant HIV-1 Epitopes from Diverse Viral Subtypes by Vaccine-Induced CTL. J. Immunol., 173(3):1941-1950, 1 Aug 2004. PubMed ID: 15265928. Show all entries for this paper.


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