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Displaying record number 53067

HXB2 Location gp160(121-129) gp160 Epitope Map
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KLTPLCVTL

`KiTPLCVTL`		susceptible form
`KmTPLCVTL`		susceptible form
`KLTPLCVTm`		non-susceptible form
`rLTPLCVTL`		susceptible form
`qLTPLCVTL`		susceptible form
`eLTPLCVTL`		non-susceptible form
`KLTsLCVTL`		susceptible form
`KLTqLCVTL`		non-susceptible form
`KLTPfCVTL`		non-susceptible form
`KLTPrCVTL`		diminished HLA binding or increased off-rate; non-susceptible form
`KLTPLCiTL`		susceptible form
`KLTPLCVpL`		non-susceptible form
`KLTPLCVsL`		susceptible form
`KLTPLCVaL`		susceptible form
`KLTPLCViL`		susceptible form
`qiTPLCVTL`		diminished HLA binding or increased off-rate; non-susceptible form
`qmTfLCVqm`		diminished HLA binding or increased off-rate; non-susceptible form
`KmTfLCVqm`		diminished HLA binding or increased off-rate; non-susceptible form

Epitope Name Env 134

Species (MHC/HLA) human, humanized mouse(A*02:01)

Variant Details

Showing all: 18 variant(s).

Variant ID.	`1149`
Epitope Seq.	`KLTPLCVTL`
Variant Seq.	`KiTPLCVTL`
Mutations	L/I
Epitope Location	L2I
HXB2 Location	L122I
Mutation Type	SF: susceptible form
Epitope Subtype	B, C
Method	CD8 T-cell Elispot - IFNy, HLA binding
Note	This anchor position variant elicited a CTL response with cells from mice immunized with the index form. It was weakly recognized by CTL lines derived from HIV-1 uninfected donors.

Variant ID.	`1150`
Epitope Seq.	`KLTPLCVTL`
Variant Seq.	`KmTPLCVTL`
Mutations	L/M
Epitope Location	L2M
HXB2 Location	L122M
Mutation Type	SF: susceptible form
Epitope Subtype	B, C
Variant Subtype	C
Method	CD8 T-cell Elispot - IFNy, HLA binding
Note	This anchor position variant elicited a CTL response with cells from mice immunized with the index form.

Variant ID.	`1151`
Epitope Seq.	`KLTPLCVTL`
Variant Seq.	`KLTPLCVTm`
Mutations	L/M
Epitope Location	L9M
HXB2 Location	L129M
Mutation Type	NSF: non-susceptible form
Epitope Subtype	B, C
Method	CD8 T-cell Elispot - IFNy, HLA binding
Note	This anchor position variant elicited a CTL response with cells from mice immunized with the index form. It was not recognized by CTL lines derived from HIV-1 uninfected donors.

Variant ID.	`1152`
Epitope Seq.	`KLTPLCVTL`
Variant Seq.	`rLTPLCVTL`
Mutations	K/R
Epitope Location	K1R
HXB2 Location	K121R
Mutation Type	SF: susceptible form
Epitope Subtype	B, C
Variant Subtype	C
Method	CD8 T-cell Elispot - IFNy, HLA binding
Note	This nonanchor position variant elicited a CTL response with cells from mice immunized with the index form.

Variant ID.	`1154`
Epitope Seq.	`KLTPLCVTL`
Variant Seq.	`qLTPLCVTL`
Mutations	K/Q
Epitope Location	K1Q
HXB2 Location	K121Q
Mutation Type	SF: susceptible form
Epitope Subtype	B, C
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, HLA binding
Note	This nonanchor position variant elicited a CTL response with cells from mice immunized with the index form. It was weakly recognized by CTL lines derived from HIV-1 uninfected donors.

Variant ID.	`1155`
Epitope Seq.	`KLTPLCVTL`
Variant Seq.	`eLTPLCVTL`
Mutations	K/E
Epitope Location	K1E
HXB2 Location	K121E
Mutation Type	NSF: non-susceptible form
Epitope Subtype	B, C
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, HLA binding
Note	This nonanchor position variant elicited a CTL response with cells from mice immunized with the index form. It was not recognized by CTL lines derived from HIV-1 uninfected donors. Binding to HLA is at a very low level.

Variant ID.	`1156`
Epitope Seq.	`KLTPLCVTL`
Variant Seq.	`KLTsLCVTL`
Mutations	P/S
Epitope Location	P4S
HXB2 Location	P124S
Mutation Type	SF: susceptible form
Epitope Subtype	B, C
Variant Subtype	C
Method	CD8 T-cell Elispot - IFNy, HLA binding
Note	This nonanchor position variant elicited a CTL response with cells from mice immunized with the index form.

Variant ID.	`1157`
Epitope Seq.	`KLTPLCVTL`
Variant Seq.	`KLTqLCVTL`
Mutations	P/Q
Epitope Location	P4Q
HXB2 Location	P124Q
Mutation Type	NSF: non-susceptible form
Epitope Subtype	B, C
Variant Subtype	C
Method	CD8 T-cell Elispot - IFNy, HLA binding
Note	This nonanchor position variant did not elicit a CTL response with cells from mice immunized with the index form.

Variant ID.	`1158`
Epitope Seq.	`KLTPLCVTL`
Variant Seq.	`KLTPfCVTL`
Mutations	L/F
Epitope Location	L5F
HXB2 Location	L125F
Mutation Type	NSF: non-susceptible form
Epitope Subtype	B, C
Method	CD8 T-cell Elispot - IFNy, HLA binding
Note	This nonanchor position variant did not elicit a CTL response with cells from mice immunized with the index form. It was not recognized by CTL lines derived from HIV-1

Variant ID.	`1159`
Epitope Seq.	`KLTPLCVTL`
Variant Seq.	`KLTPrCVTL`
Mutations	L/R
Epitope Location	L5R
HXB2 Location	L125R
Mutation Type	DHB: diminished HLA binding or increased off-rate NSF: non-susceptible form
Epitope Subtype	B, C
Method	CD8 T-cell Elispot - IFNy, HLA binding
Note	This nonanchor position variant did not elicit a CTL response with cells from mice immunized with the index form. It was not recognized by CTL lines derived from HIV-1. Binding to HLA is at a very low level.

Variant ID.	`1160`
Epitope Seq.	`KLTPLCVTL`
Variant Seq.	`KLTPLCiTL`
Mutations	V/I
Epitope Location	V7I
HXB2 Location	V127I
Mutation Type	SF: susceptible form
Epitope Subtype	B, C
Method	CD8 T-cell Elispot - IFNy, HLA binding
Note	This nonanchor position variant elicited a CTL response with cells from mice immunized with the index form. It was recognized by CTL lines derived from HIV-1.

Variant ID.	`1161`
Epitope Seq.	`KLTPLCVTL`
Variant Seq.	`KLTPLCVpL`
Mutations	T/P
Epitope Location	T8P
HXB2 Location	T128P
Mutation Type	NSF: non-susceptible form
Epitope Subtype	B, C
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, HLA binding
Note	This nonanchor position variant elicited a CTL response with cells from mice immunized with the index form. It was not recognized by CTL lines derived from HIV-1.

Variant ID.	`1162`
Epitope Seq.	`KLTPLCVTL`
Variant Seq.	`KLTPLCVsL`
Mutations	T/S
Epitope Location	T8S
HXB2 Location	T128S
Mutation Type	SF: susceptible form
Epitope Subtype	B, C
Method	CD8 T-cell Elispot - IFNy, HLA binding
Note	This nonanchor position variant elicited a CTL response with cells from mice immunized with the index form. It was weakly recognized by CTL lines derived from HIV-1.

Variant ID.	`1163`
Epitope Seq.	`KLTPLCVTL`
Variant Seq.	`KLTPLCVaL`
Mutations	T/A
Epitope Location	T8A
HXB2 Location	T128A
Mutation Type	SF: susceptible form
Epitope Subtype	B, C
Method	CD8 T-cell Elispot - IFNy, HLA binding
Note	This nonanchor position variant elicited a CTL response with cells from mice immunized with the index form. It was recognized by CTL lines derived from HIV-1.

Variant ID.	`1164`
Epitope Seq.	`KLTPLCVTL`
Variant Seq.	`KLTPLCViL`
Mutations	T/I
Epitope Location	T8I
HXB2 Location	T128I
Mutation Type	SF: susceptible form
Epitope Subtype	B, C
Method	CD8 T-cell Elispot - IFNy, HLA binding
Note	This nonanchor position variant elicited a CTL response with cells from mice immunized with the index form. It was weakly recognized by CTL lines derived from HIV-1.

Variant ID.	`1165`
Epitope Seq.	`KLTPLCVTL`
Variant Seq.	`qiTPLCVTL`
Mutations	K/Q L/I
Epitope Location	K1Q L2I
HXB2 Location	K121Q L122I
Mutation Type	DHB: diminished HLA binding or increased off-rate NSF: non-susceptible form
Epitope Subtype	B, C
Method	CD8 T-cell Elispot - IFNy, HLA binding
Note	This multiple substitution variant did not elicit a CTL response with cells from mice immunized with the index form. It was not recognized by CTL lines derived from HIV-1. Binding to HLA was at a very low level.

Variant ID.	`1166`
Epitope Seq.	`KLTPLCVTL`
Variant Seq.	`qmTfLCVqm`
Mutations	K/Q L/M P/F T/Q L/M
Epitope Location	K1Q L2M P4F T8Q L9M
HXB2 Location	K121Q L122M P124F T128Q L129M
Mutation Type	DHB: diminished HLA binding or increased off-rate NSF: non-susceptible form
Epitope Subtype	B, C
Method	CD8 T-cell Elispot - IFNy, HLA binding
Note	This multiple substitution variant did not elicit a CTL response with cells from mice immunized with the index form. It was not recognized by CTL lines derived from HIV-1. Binding to HLA was at a very low level.

Variant ID.	`1167`
Epitope Seq.	`KLTPLCVTL`
Variant Seq.	`KmTfLCVqm`
Mutations	L/M P/F T/Q L/M
Epitope Location	L2M P4F T8Q L9M
HXB2 Location	L122M P124F T128Q L129M
Mutation Type	DHB: diminished HLA binding or increased off-rate NSF: non-susceptible form
Epitope Subtype	B, C
Method	CD8 T-cell Elispot - IFNy, HLA binding
Note	This multiple substitution variant did not elicit a CTL response with cells from mice immunized with the index form. It was not recognized by CTL lines derived from HIV-1. Binding to HLA was at a very low level.

References

McKinney2004 Denise M. McKinney, Rhonda Skvoretz, Brian D. Livingston, Cara C. Wilson, Michelle Anders, Robert W. Chesnut, Alessandro Sette, Max Essex, Vladimir Novitsky, and Mark J. Newman. Recognition of Variant HIV-1 Epitopes from Diverse Viral Subtypes by Vaccine-Induced CTL. J. Immunol., 173(3):1941-1950, 1 Aug 2004. PubMed ID: 15265928. Show all entries for this paper.