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Displaying record number 52995

HXB2 Location Pol(283-290) Pol Epitope Map
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Epitope

TAFTIPSI

Epitope Alignment

Variants

TAFTIPSt escape documented in this paper

Species (MHC/HLA) human(B51)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`306`
Epitope Seq.	`TAFTIPSI`
Variant Seq.	`TAFTIPSt`
Mutations	I/T
Epitope Location	I8T
HXB2 Location	I290T
Mutation Type	E: escape documented in this paper
Note	A dramatic decrease in CTL activity against the epitope occurred as the mutation became fixed. The variant was found at 47 months post-seroconversion.

References

Geels2003 Mark J. Geels, Marion Cornelissen, Hanneke Schuitemaker, Kiersten Anderson, David Kwa, Jolanda Maas, John T. Dekker, Elly Baan, Fokla Zorgdrager, Remco van den Burg, Martijn van Beelen, Vladimir V. Lukashov, Tong-Ming Fu, William A. Paxton, Lia van der Hoek, Sheri A. Dubey, John W. Shiver, and Jaap Goudsmit. Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual. J. Virol., 77(23):12430-12440, Dec 2003. PubMed ID: 14610167. Show all entries for this paper.