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Displaying record number 52828

HXB2 Location Pol(894-903) Pol Epitope Map
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Epitope

AVFIHNFKRK

Epitope Alignment

Variants

AVFvHNFKRK non-susceptible form

Epitope Name A3-AK10 Pol

Species (MHC/HLA) human(A3)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`47`
Epitope Seq.	`AVFIHNFKRK`
Variant Seq.	`AVFvHNFKRK`
Mutations	I/V
Epitope Location	I4V
HXB2 Location	I897V
Mutation Type	NSF: non-susceptible form
Method	CD8 T-cell Elispot - IFNy
Note	Superinfection. The second infecting strain had the variant avfVhnfkrk. The CTL response to the second variant was zero at all timepoints. The CTL response to the first variant was low and declined over time.

References

Altfeld2002a Marcus Altfeld, Todd M. Allen, Xu G. Yu, Mary N. Johnston, Deepak Agrawal, Bette T. Korber, David C. Montefiori, David H. O'Connor, Ben T. Davis, Paul K. Lee, Erica L. Maier, Jason Harlow, Philip J. R. Goulder, Christian Brander, Eric S. Rosenberg, and Bruce D. Walker. HIV-1 Superinfection Despite Broad CD8+ T-Cell Responses Containing Replication of the Primary Virus. Nature, 420(6914):434-439, 28 Nov 2002. PubMed ID: 12459786. Show all entries for this paper.