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Found 1 matching record:

Displaying record number 52828

HXB2 Location  Pol(894-903)   Pol Epitope Map
View variants at this location
Epitope AVFIHNFKRK   Epitope Alignment
Variants
AVFvHNFKRK   non-susceptible form
Epitope Name A3-AK10 Pol
Species (MHC/HLA human(A3)

Variant Details

Showing all: 1 variant(s).


Variant ID.  47
Epitope Seq.  AVFIHNFKRK
Variant Seq.  AVFvHNFKRK
Mutations I/V
Epitope Location I4V
HXB2 Location I897V
Mutation Type NSF: non-susceptible form
Method CD8 T-cell Elispot - IFNy
Note Superinfection. The second infecting strain had the variant avfVhnfkrk. The CTL response to the second variant was zero at all timepoints. The CTL response to the first variant was low and declined over time.

References

Altfeld2002a Marcus Altfeld, Todd M. Allen, Xu G. Yu, Mary N. Johnston, Deepak Agrawal, Bette T. Korber, David C. Montefiori, David H. O'Connor, Ben T. Davis, Paul K. Lee, Erica L. Maier, Jason Harlow, Philip J. R. Goulder, Christian Brander, Eric S. Rosenberg, and Bruce D. Walker. HIV-1 Superinfection Despite Broad CD8+ T-Cell Responses Containing Replication of the Primary Virus. Nature, 420(6914):434-439, 28 Nov 2002. PubMed ID: 12459786. Show all entries for this paper.


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