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Found 1 matching record:

Displaying record number 52825

HXB2 Location  Vpr(34-42)   Vpr Epitope Map
View variants at this location
Epitope FPRTWLHGL   Epitope Alignment
Variants
FPwTWLHGL   diminished response
Epitope Name B7-FL9 Vpr
Species (MHC/HLA human(B7)

Variant Details

Showing all: 1 variant(s).


Variant ID.  51
Epitope Seq.  FPRTWLHGL
Variant Seq.  FPwTWLHGL
Mutations R/W
Epitope Location R3W
HXB2 Location R36W
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy
Note Superinfection. The second infecting strain had the variant fpWtwlhgl. The CTL response declined over time and the response to the second variant was lower than to the first one all the time points.

References

Altfeld2002a Marcus Altfeld, Todd M. Allen, Xu G. Yu, Mary N. Johnston, Deepak Agrawal, Bette T. Korber, David C. Montefiori, David H. O'Connor, Ben T. Davis, Paul K. Lee, Erica L. Maier, Jason Harlow, Philip J. R. Goulder, Christian Brander, Eric S. Rosenberg, and Bruce D. Walker. HIV-1 Superinfection Despite Broad CD8+ T-Cell Responses Containing Replication of the Primary Virus. Nature, 420(6914):434-439, 28 Nov 2002. PubMed ID: 12459786. Show all entries for this paper.


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