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Displaying record number 52822

HXB2 Location Pol(511-521) Pol Epitope Map
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Epitope

RTRGAHTNDVK

Epitope Alignment

Variants

RTRGAHTNDVr diminished response

Epitope Name A3-RK11 Pol

Species (MHC/HLA) human(A3)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`46`
Epitope Seq.	`RTRGAHTNDVK`
Variant Seq.	`RTRGAHTNDVr`
Mutations	K/R
Epitope Location	K11R
HXB2 Location	K521R
Mutation Type	DR: diminished response
Method	CD8 T-cell Elispot - IFNy
Note	Superinfection. The second infecting strain had the variant rtrgahtndvR. The CTL response to both variants declined over time, and the response to the second variant was lower than to the first throughout.

References

Altfeld2002a Marcus Altfeld, Todd M. Allen, Xu G. Yu, Mary N. Johnston, Deepak Agrawal, Bette T. Korber, David C. Montefiori, David H. O'Connor, Ben T. Davis, Paul K. Lee, Erica L. Maier, Jason Harlow, Philip J. R. Goulder, Christian Brander, Eric S. Rosenberg, and Bruce D. Walker. HIV-1 Superinfection Despite Broad CD8+ T-Cell Responses Containing Replication of the Primary Virus. Nature, 420(6914):434-439, 28 Nov 2002. PubMed ID: 12459786. Show all entries for this paper.