HIV molecular immunology database


Search the Epitope Variant and Escape Mutation Database


Found 1 matching record:

Displaying record number 52822

HXB2 Location  Pol(511-521)   Pol Epitope Map
View variants at this location
Epitope RTRGAHTNDVK   Epitope Alignment
RTRGAHTNDVr   diminished response
Epitope Name A3-RK11 Pol
Species (MHC/HLA human(A3)

Variant Details

Showing all: 1 variant(s).

Variant ID.  46
Variant Seq.  RTRGAHTNDVr
Mutations K/R
Epitope Location K11R
HXB2 Location K521R
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy
Note Superinfection. The second infecting strain had the variant rtrgahtndvR. The CTL response to both variants declined over time, and the response to the second variant was lower than to the first throughout.


Altfeld2002a Marcus Altfeld, Todd M. Allen, Xu G. Yu, Mary N. Johnston, Deepak Agrawal, Bette T. Korber, David C. Montefiori, David H. O'Connor, Ben T. Davis, Paul K. Lee, Erica L. Maier, Jason Harlow, Philip J. R. Goulder, Christian Brander, Eric S. Rosenberg, and Bruce D. Walker. HIV-1 Superinfection Despite Broad CD8+ T-Cell Responses Containing Replication of the Primary Virus. Nature, 420(6914):434-439, 28 Nov 2002. PubMed ID: 12459786. Show all entries for this paper.

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