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Found 1 matching record:

Displaying record number 52761

HXB2 Location  Gag(308-316)   Gag Epitope Map
View variants at this location
Epitope QASQEVKNW   Epitope Alignment
Variants
QASQdVKNW   non-susceptible form; susceptible form
QAtQEVKNW   observed variant
QAtQdVKNW   observed variant
QASQdVKNx   observed variant
Epitope Name QW9
Species (MHC/HLA human(B*5701)

Variant Details

Showing all: 4 variant(s).


Variant ID.  1296
Epitope Seq.  QASQEVKNW
Variant Seq.  QASQdVKNW
Mutations E/D
Epitope Location E5D
HXB2 Location E312D
Mutation Type NSF: non-susceptible form
SF: susceptible form
Method HLA binding, Intracellular cytokine staining, Sequence
Note The E312D variant is more common in progressors (8/17) than controllers (1/10) of infection. This variant does not reliably confer loss of binding to HLA. 2/4 carriers of this variant and not the consensus, recognized it, but 2/4 did not.


Variant ID.  1297
Epitope Seq.  QASQEVKNW
Variant Seq.  QAtQEVKNW
Mutations S/T
Epitope Location S3T
HXB2 Location S310T
Mutation Type OV: observed variant
Method Sequence
Note This variant is found in 1/10 nonprogressors and 1/12 untreated progressors.


Variant ID.  1298
Epitope Seq.  QASQEVKNW
Variant Seq.  QAtQdVKNW
Mutations S/T E/D
Epitope Location S3T E5D
HXB2 Location S310T E312D
Mutation Type OV: observed variant
Method Sequence
Note This variant is found in 1/10 nonprogressors.


Variant ID.  1299
Epitope Seq.  QASQEVKNW
Variant Seq.  QASQdVKNx
Mutations E/D W/X
Epitope Location E5D W9X
HXB2 Location E312D W316X
Mutation Type OV: observed variant
Method Sequence
Note This variant is found in 1/10 nonprogressors.

References

Migueles2003 Stephen A. Migueles, Alisha C. Laborico, Hiromi Imamichi, W. Lesley Shupert, Cassandra Royce, Mary McLaughlin, Linda Ehler, Julia Metcalf, Shuying Liu, Claire W. Hallahan, and Mark Connors. The Differential Ability of HLA B*5701+ Long-Term Nonprogressors and Progressors to Restrict Human Immunodeficiency Virus Replication Is Not Caused by Loss of Recognition of Autologous Viral gag Sequences. J. Virol., 77(12):6889-6898, Jun 2003. PubMed ID: 12768008. Show all entries for this paper.


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