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Found 1 matching record:

Displaying record number 52727

HXB2 Location  Pol(132-140)   Pol Epitope Map
View variants at this location
Epitope LVGPTPVNI   Epitope Alignment
Variants
LVGPTPaNI   diminished response; escape documented in this paper
LVGPTPVNv   observed variant
Epitope Name PR82V
Species (MHC/HLA human(A2)

Variant Details

Showing all: 2 variant(s).


Variant ID.  625
Epitope Seq.  LVGPTPVNI
Variant Seq.  LVGPTPaNI
Mutations V/A
Epitope Location V7A
HXB2 Location V138A
Mutation Type DR: diminished response
E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, Chromium-release assay
Note The variant was generally not recognized by wt CTL response, and when recognized, it was of low to moderate avidity. The emergence of the variant could not inhibit the wt CTL response, suggesting that the mutation did not affect recognition.


Variant ID.  626
Epitope Seq.  LVGPTPVNI
Variant Seq.  LVGPTPVNv
Mutations I/V
Epitope Location I9V
HXB2 Location I140V
Mutation Type OV: observed variant
Note The emergence of the variant could not inhibit the wt CTL response, suggesting that the mutation did not affect recognition.

References

Karlsson2003 Annika C Karlsson, Steven G Deeks, Jason D Barbour, Brandon D Heiken, Sophie R Younger, Rebecca Hoh, Meghan Lane, Matti Sällberg, Gabriel M Ortiz, James F Demarest, Teri Liegler, Robert M Grant, Jeffrey N Martin, and Douglas F Nixon. Dual Pressure from Antiretroviral Therapy and Cell-Mediated Immune Response on the Human Immunodeficiency Virus Type 1 Protease Gene. J. Virol., 77(12):6743-6752, Jun 2003. PubMed ID: 12767994. Show all entries for this paper.


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