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Found 1 matching record:

Displaying record number 52677

HXB2 Location  gp160(67-75)   gp160 Epitope Map
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Epitope NIWATHACV   Epitope Alignment
Variants
NvWATHACV   non-susceptible form; susceptible form
Epitope Name Env67(2I)
Species (MHC/HLA human(A2)

Variant Details

Showing all: 1 variant(s).


Variant ID.  127
Epitope Seq.  NIWATHACV
Variant Seq.  NvWATHACV
Mutations I/V
Epitope Location I2V
HXB2 Location I68V
Mutation Type NSF: non-susceptible form
SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Chromium-release assay, Flow cytometric T-cell cytokine assay
Note This peptide was a good A2 binder, and induced CTL and CD8+ T-cell IFN gamma responses in mice. Responses were detected in 1/17 HIV+ HLA-A2 subjects. The variant nVwathacv was also immunogenic in transgenic mice, but was not recognized in the 17 people tested.

References

Corbet2003 Sylvie Corbet, Henrik Vedel Nielsen, Lasse Vinner, Sanne Lauemoller, Dominic Therrien, Sheila Tang, Gitte Kronborg, Lars Mathiesen, Paul Chaplin, Søren Brunak, Søren Buus, and Anders Fomsgaard. Optimization and Immune Recognition of Multiple Novel Conserved HLA-A2, Human Immunodeficiency Virus Type 1-Specific CTL Epitopes. J. Gen. Virol., 84(Pt 9):2409-2421, Sep 2003. PubMed ID: 12917462. Show all entries for this paper.


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