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Displaying record number 52516

HXB2 Location  Nef(92-100)   Nef Epitope Map
View variants at this location
Epitope KEKGGLEGL   Epitope Alignment
Variants
KgKGGLEGL   escape documented in this paper
KkKGGLEGL   escape documented in this paper
KEnGGLErL   inferred escape
KEKrGLErL   inferred escape
KEKGGLkGL   inferred escape
KEKGGLdGL   inferred escape
KEKGGLErL   inferred escape
KEKGGLEeL   inferred escape
KEKGGLEGp   inferred escape
KEKGGLEGi   inferred escape
Species (MHC/HLA human(B60)

Variant Details

Showing all: 10 variant(s).


Variant ID.  21
Epitope Seq.  KEKGGLEGL
Variant Seq.  KgKGGLEGL
Mutations E/G
Epitope Location E2G
HXB2 Location E93G
Mutation Type E: escape documented in this paper
Method Assay for Class I down-regulation by Nef
Note The molecular clone HIV-1 NL4-3.1 was passaged under selective pressure in the presence of 2 Nef KEKGGLEGL-specific CTL clones (KM3 and STD11) isolated from different individuals, giving rise to rapid selection of escape mutations. This mutation was observed in 3/72 sequences, selected by KM3 clone, and shown to impair the down regulation of class I MHC by Nef.


Variant ID.  22
Epitope Seq.  KEKGGLEGL
Variant Seq.  KkKGGLEGL
Mutations E/K
Epitope Location E2K
HXB2 Location E93K
Mutation Type E: escape documented in this paper
Method Assay for Class I down-regulation by Nef
Note The molecular clone HIV-1 NL4-3.1 was passaged under selective pressure in the presence of 2 Nef KEKGGLEGL-specific CTL clones (KM3 and STD11) isolated from different individuals, giving rise to rapid selection of escape mutations. This mutation was observed in 2/72 sequences, selected by STD11 clone, and shown to impair the down regulation of class I MHC by Nef


Variant ID.  23
Epitope Seq.  KEKGGLEGL
Variant Seq.  KEnGGLErL
Mutations K/N G/R
Epitope Location K3N G8R
HXB2 Location K94N G99R
Mutation Type IE: inferred escape
Method Sequence
Note The molecular clone HIV-1 NL4-3.1 was passaged under selective pressure in the presence of 2 Nef KEKGGLEGL-specific CTL clones (KM3 and STD11) isolated from different individuals, giving rise to rapid selection of escape mutations. This mutation was observed in 1/72 sequences and selected by STD11 clone. Viral escape from CTL in vitro was commonly associated with functional impairment of MHC-1 down modulation.


Variant ID.  24
Epitope Seq.  KEKGGLEGL
Variant Seq.  KEKrGLErL
Mutations G/R G/R
Epitope Location G4R G8R
HXB2 Location G95R G99R
Mutation Type IE: inferred escape
Method Sequence
Note The molecular clone HIV-1 NL4-3.1 was passaged under selective pressure in the presence of 2 Nef KEKGGLEGL-specific CTL clones (KM3 and STD11) isolated from different individuals, giving rise to rapid selection of escape mutations. This mutation was observed in 1/72 sequences and selected by STD11 clone. Viral escape from CTL in vitro was commonly associated with functional impairment of MHC-1 down modulation.


Variant ID.  25
Epitope Seq.  KEKGGLEGL
Variant Seq.  KEKGGLkGL
Mutations E/K
Epitope Location E7K
HXB2 Location E98K
Mutation Type IE: inferred escape
Method Sequence
Note The molecular clone HIV-1 NL4-3.1 was passaged under selective pressure in the presence of 2 Nef KEKGGLEGL-specific CTL clones (KM3 and STD11) isolated from different individuals, giving rise to rapid selection of escape mutations. This mutation was observed in 3/72 sequences and selected by KM3 clone.


Variant ID.  26
Epitope Seq.  KEKGGLEGL
Variant Seq.  KEKGGLdGL
Mutations E/D
Epitope Location E7D
HXB2 Location E98D
Mutation Type IE: inferred escape
Method Sequence
Note The molecular clone HIV-1 NL4-3.1 was passaged under selective pressure in the presence of 2 Nef KEKGGLEGL-specific CTL clones (KM3 and STD11) isolated from different individuals, giving rise to rapid selection of escape mutations. This mutation was observed in 1/72 sequences and selected by KM3 clone. Viral escape from CTL in vitro was commonly associated with functional impairment of MHC-1 down modulation.


Variant ID.  27
Epitope Seq.  KEKGGLEGL
Variant Seq.  KEKGGLErL
Mutations G/R
Epitope Location G8R
HXB2 Location G99R
Mutation Type IE: inferred escape
Method Sequence
Note The molecular clone HIV-1 NL4-3.1 was passaged under selective pressure in the presence of 2 Nef KEKGGLEGL-specific CTL clones (KM3 and STD11) isolated from different individuals, giving rise to rapid selection of escape mutations. This mutation was observed in 2/72 sequences and selected by both KM3 and STD11 clones. Viral escape from CTL in vitro was commonly associated with functional impairment of MHC-1 down modulation.


Variant ID.  28
Epitope Seq.  KEKGGLEGL
Variant Seq.  KEKGGLEeL
Mutations G/E
Epitope Location G8E
HXB2 Location G99E
Mutation Type IE: inferred escape
Method Sequence
Note The molecular clone HIV-1 NL4-3.1 was passaged under selective pressure in the presence of 2 Nef KEKGGLEGL-specific CTL clones (KM3 and STD11) isolated from different individuals, giving rise to rapid selection of escape mutations. This mutation was observed in 1/72 sequences and selected by STD11 clone. Viral escape from CTL in vitro was commonly associated with functional impairment of MHC-1 down modulation.


Variant ID.  29
Epitope Seq.  KEKGGLEGL
Variant Seq.  KEKGGLEGp
Mutations L/P
Epitope Location L9P
HXB2 Location L100P
Mutation Type IE: inferred escape
Method Sequence
Note The molecular clone HIV-1 NL4-3.1 was passaged under selective pressure in the presence of 2 Nef KEKGGLEGL-specific CTL clones (KM3 and STD11) isolated from different individuals, giving rise to rapid selection of escape mutations. This mutation was observed in 1/72 sequences and selected by STD11 clone. Viral escape from CTL in vitro was commonly associated with functional impairment of MHC-1 down modulation.


Variant ID.  30
Epitope Seq.  KEKGGLEGL
Variant Seq.  KEKGGLEGi
Mutations L/I
Epitope Location L9I
HXB2 Location L100I
Mutation Type IE: inferred escape
Method Sequence
Note The molecular clone HIV-1 NL4-3.1 was passaged under selective pressure in the presence of 2 Nef KEKGGLEGL-specific CTL clones (KM3 and STD11) isolated from different individuals, giving rise to rapid selection of escape mutations. This mutation was observed in 9/72 sequences and selected by STD11 clone. Viral escape from CTL in vitro was commonly associated with functional impairment of MHC-1 down modulation.

References

Ali2003 Ayub Ali, Satish Pillai, Hwee Ng, Rachel Lubong, Douglas D. Richman, Beth D. Jamieson, Yan Ding, M. Juliana McElrath, John C. Guatelli, and Otto O. Yang. Broadly Increased Sensitivity to Cytotoxic T Lymphocytes Resulting from Nef Epitope Escape Mutations. J. Immunol., 171(8):3999-4005, Oct 2003. PubMed ID: 14530319. Show all entries for this paper.


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