HIV molecular immunology database
Found 1 matching record:
| HXB2 Location | Gag(296-304) | Gag Epitope Map
View variants at this location |
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| Epitope |
YVDRFYKTL
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Epitope Alignment | ||||
| Variants |
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| Species (MHC/HLA) | human(A*02:07) | |||||
Showing all: 1 variant(s).
| Variant ID. | 135 |
|---|---|
| Epitope Seq. | YVDRFYKTL |
| Variant Seq. | YVDRFfKTL |
| Mutations | Y/F |
| Epitope Location | Y6F |
| HXB2 Location | Y301F |
| Mutation Type | SSF: subtype-specific susceptible form |
| Epitope Subtype | B, D |
| Variant Subtype | A, C, CRF01_AE, F, G, H |
| Method | CD8 T-cell Elispot - IFNy |
| Note | The Thai subject VAIP-4 demonstrated broad CTL cross-reactivity towards gag constructs derived from subtypes A, B, C, D, F, G, H, and CRF-01_AE. Sequence alignments of this epitope showed conservation for clades B and D, and Y->F substitutions at position 6 for subtypes A, C, CDR01-AE, F, G, and H. YVDRFYKTL and the variant epitope YVDRFFKTL are recognized equally well. |
Currier2002b Jeffrey R Currier, Mark deSouza, Penprapa Chanbancherd, Wendy Bernstein, Deborah L Birx, and Josephine H Cox. Comprehensive Screening for Human Immunodeficiency Virus Type 1 Subtype-Specific CD8 Cytotoxic T Lymphocytes and Definition of Degenerate Epitopes Restricted by HLA-A0207 and -Cw0304 Alleles. J. Virol., 76(10):4971-4986, May 2002. PubMed ID: 11967314. Show all entries for this paper.