HIV molecular immunology database


Search the Epitope Variant and Escape Mutation Database


Found 1 matching record:

Displaying record number 52330

HXB2 Location  Gag(296-304)   Gag Epitope Map
View variants at this location
Epitope YVDRFYKTL   Epitope Alignment
YVDRFfKTL   subtype-specific susceptible form
Species (MHC/HLA human(A*02:07)

Variant Details

Showing all: 1 variant(s).

Variant ID.  135
Epitope Seq.  YVDRFYKTL
Variant Seq.  YVDRFfKTL
Mutations Y/F
Epitope Location Y6F
HXB2 Location Y301F
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype B, D
Variant Subtype A, C, CRF01_AE, F, G, H
Method CD8 T-cell Elispot - IFNy
Note The Thai subject VAIP-4 demonstrated broad CTL cross-reactivity towards gag constructs derived from subtypes A, B, C, D, F, G, H, and CRF-01_AE. Sequence alignments of this epitope showed conservation for clades B and D, and Y->F substitutions at position 6 for subtypes A, C, CDR01-AE, F, G, and H. YVDRFYKTL and the variant epitope YVDRFFKTL are recognized equally well.


Currier2002b Jeffrey R Currier, Mark deSouza, Penprapa Chanbancherd, Wendy Bernstein, Deborah L Birx, and Josephine H Cox. Comprehensive Screening for Human Immunodeficiency Virus Type 1 Subtype-Specific CD8 Cytotoxic T Lymphocytes and Definition of Degenerate Epitopes Restricted by HLA-A0207 and -Cw0304 Alleles. J. Virol., 76(10):4971-4986, May 2002. PubMed ID: 11967314. Show all entries for this paper.

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