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Found 1 matching record:

Displaying record number 52065

HXB2 Location  Pol(283-290)   Pol Epitope Map
View variants at this location
Epitope TAFTIPSI   Epitope Alignment
Variants
TAFTIPSx   escape documented in this paper
TAFTIPSt   calculated diminished HLA binding; observed variant
Species (MHC/HLA human(B*51:01)

Variant Details

Showing all: 2 variant(s).


Variant ID.  1315
Epitope Seq.  TAFTIPSI
Variant Seq.  TAFTIPSx
Mutations I/X
Epitope Location I8X
HXB2 Location I290X
Mutation Type E: escape documented in this paper
Method HLA binding, Sequence
Note 98% of subjects in an HLA-B*5101 cohort carried this I135x escape. It is suggested that it is selected during the acute phase of infection rather than at transmission or at chronic infection.


Variant ID.  2218
Epitope Seq.  TAFTIPSI
Variant Seq.  TAFTIPSt
Mutations I/T
Epitope Location I8T
HXB2 Location I290T
Mutation Type CHB: calculated diminished HLA binding
OV: observed variant
Method Sequence
Note The predominant substitution in this epitope is I135t. Binding of this mutant to HLA-B*5101 would be abrogated in vivo as per binding association studies.

References

Moore2002b Corey B. Moore, Mina John, Ian R. James, Frank T. Christiansen, Campbell S. Witt, and Simon A. Mallal. Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level. Science, 296(5572):1439-1443, 24 May 2002. PubMed ID: 12029127. Show all entries for this paper.


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