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Displaying record number 52065

HXB2 Location Pol(283-290) Pol Epitope Map
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TAFTIPSI

`TAFTIPSx`		escape documented in this paper
`TAFTIPSt`		calculated diminished HLA binding; observed variant

Species (MHC/HLA) human(B*51:01)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`1315`
Epitope Seq.	`TAFTIPSI`
Variant Seq.	`TAFTIPSx`
Mutations	I/X
Epitope Location	I8X
HXB2 Location	I290X
Mutation Type	E: escape documented in this paper
Method	HLA binding, Sequence
Note	98% of subjects in an HLA-B*5101 cohort carried this I135x escape. It is suggested that it is selected during the acute phase of infection rather than at transmission or at chronic infection.

Variant ID.	`2218`
Epitope Seq.	`TAFTIPSI`
Variant Seq.	`TAFTIPSt`
Mutations	I/T
Epitope Location	I8T
HXB2 Location	I290T
Mutation Type	CHB: calculated diminished HLA binding OV: observed variant
Method	Sequence
Note	The predominant substitution in this epitope is I135t. Binding of this mutant to HLA-B*5101 would be abrogated in vivo as per binding association studies.

References

Moore2002b Corey B. Moore, Mina John, Ian R. James, Frank T. Christiansen, Campbell S. Witt, and Simon A. Mallal. Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level. Science, 296(5572):1439-1443, 24 May 2002. PubMed ID: 12029127. Show all entries for this paper.