HIV molecular immunology database
Found 1 matching record:
|HXB2 Location||Pol(283-290)|| Pol Epitope Map
View variants at this location
Showing all: 2 variant(s).
|Mutation Type||E: escape documented in this paper|
|Method||HLA binding, Sequence|
|Note||98% of subjects in an HLA-B*5101 cohort carried this I135x escape. It is suggested that it is selected during the acute phase of infection rather than at transmission or at chronic infection.|
|Mutation Type||CHB: calculated diminished HLA binding
OV: observed variant
|Note||The predominant substitution in this epitope is I135t. Binding of this mutant to HLA-B*5101 would be abrogated in vivo as per binding association studies.|
Moore2002b Corey B. Moore, Mina John, Ian R. James, Frank T. Christiansen, Campbell S. Witt, and Simon A. Mallal. Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level. Science, 296(5572):1439-1443, 24 May 2002. PubMed ID: 12029127. Show all entries for this paper.