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Found 1 matching record:

Displaying record number 485

HXB2 Location  Pol(399-407)   Pol Epitope Map
View variants at this location
Epitope IVLPEKDSW   Epitope Alignment
Variants
ImLPEKDSW   susceptible form
ItLPEKgSW   non-susceptible form
IeLPEKDSW   susceptible form
Species (MHC/HLA human(B*57:01)

Variant Details

Showing all: 3 variant(s).


Variant ID.  1268
Epitope Seq.  IVLPEKDSW
Variant Seq.  ImLPEKDSW
Mutations V/M
Epitope Location V2M
HXB2 Location V400M
Mutation Type SF: susceptible form
Note Cross-recognition of the variant by index epitope-specific CTL is seen even though binding of the variant to HLA-B*5701 is diminished.


Variant ID.  1269
Epitope Seq.  IVLPEKDSW
Variant Seq.  ItLPEKgSW
Mutations V/T D/G
Epitope Location V2T D7G
HXB2 Location V400T D405G
Mutation Type NSF: non-susceptible form
Note This variant binds HLA-B*5701 with similar affinity as the index peptide does, but it is not recognized by index peptide-specific CTL.


Variant ID.  1270
Epitope Seq.  IVLPEKDSW
Variant Seq.  IeLPEKDSW
Mutations V/E
Epitope Location V2E
HXB2 Location V400E
Mutation Type SF: susceptible form
Note This variant binds HLA-B*5701 with reduced affinity, but it is recognized by index peptide-specific CTL.

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

vanderBurg1997 S. H. van der Burg, M. R. Klein, O. Pontesilli, A. M. Holwerda, J. Drijfhout, W. M. Kast, F. Miedema, and C. J. M. Melief. HIV-1 Reverse Transcriptase-Specific CTL against Conserved Epitopes Do Not Protect against Progression to AIDS. J. Immunol., 159:3648-3654, 1997. PubMed ID: 9317165. Show all entries for this paper.


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