Search the Epitope Variant and Escape Mutation Database

Help

Codes and Symbols in Variants
Variant and Mutation Types
Variants Database Help

Found 1 matching record:

Displaying record number 438

HXB2 Location Pol(306-314) Pol Epitope Map
View variants at this location

Epitope

QGWKGSPAI

Epitope Alignment

Variants

QGWKGaPAI observed variant

Species (MHC/HLA) human(B*51:01)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`1768`
Epitope Seq.	`QGWKGSPAI`
Variant Seq.	`QGWKGaPAI`
Mutations	S/A
Epitope Location	S6A
HXB2 Location	S311A
Mutation Type	OV: observed variant
Method	Chromium-release assay, HLA binding
Note	2/38 Clade B strain sequences carried this 6A variant. Challenge epitope elicited CTL response in1 of 3 HLA-B51 seropositive individuals, and bound HLA-B*5101 with low strength. Variant not tested.

References

Tomiyama1999 H. Tomiyama, T. Sakaguchi, K. Miwa, S. Oka, A. Iwamoto, Y. Kaneko, and M. Takiguchi. Identification of multiple HIV-1 CTL epitopes presented by HLA-B*5101. Hum. Immunol., 60:177-86, 1999. PubMed ID: 10321954. Show all entries for this paper.