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Found 1 matching record:

Displaying record number 438

HXB2 Location  Pol(306-314)   Pol Epitope Map
View variants at this location
Epitope QGWKGSPAI   Epitope Alignment
Variants
QGWKGaPAI   observed variant
Species (MHC/HLA human(B*51:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  1768
Epitope Seq.  QGWKGSPAI
Variant Seq.  QGWKGaPAI
Mutations S/A
Epitope Location S6A
HXB2 Location S311A
Mutation Type OV: observed variant
Method Chromium-release assay, HLA binding
Note 2/38 Clade B strain sequences carried this 6A variant. Challenge epitope elicited CTL response in1 of 3 HLA-B51 seropositive individuals, and bound HLA-B*5101 with low strength. Variant not tested.

References

Tomiyama1999 H. Tomiyama, T. Sakaguchi, K. Miwa, S. Oka, A. Iwamoto, Y. Kaneko, and M. Takiguchi. Identification of multiple HIV-1 CTL epitopes presented by HLA-B*5101. Hum. Immunol., 60:177-86, 1999. PubMed ID: 10321954. Show all entries for this paper.


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