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Found 1 matching record:

Displaying record number 354

HXB2 Location  Gag(329-337)   Gag Epitope Map
View variants at this location
Epitope DCKTILKAL   Epitope Alignment
Variants
DCrTILKAL   escape documented in this paper
Species (MHC/HLA human(B8)

Variant Details

Showing all: 1 variant(s).


Variant ID.  1347
Epitope Seq.  DCKTILKAL
Variant Seq.  DCrTILKAL
Mutations K/R
Epitope Location K3R
HXB2 Location K331R
Mutation Type E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, Chromium-release assay, HLA binding, Longitudinal study
Note Both K and R variants bind HLA-B8. Initial recognition of the K variant is soon lost. The predominant R variant is never recognized by patient CTL.

References

Nowak1995 M. A. Nowak, R. M. May, R. E. Phillips, S. Rowland-Jones, D. G. Lalloo, S. McAdam, P. Klenerman, B. Koppe, K. Sigmund, C. R. M. Bangham, and A. J. McMichael. Antigenic Oscillations and Shifting Immunodominance in HIV-1 Infections. Nature, 375:606-611, 1995. This paper presents longitudinal studies of epitope variation and corresponding CTL responses in two patients. A mathematical model was created to provide a framework to explain the observed shifts in epitope and CTLp frequencies. For discussion, see also: J. M. Coffin, Nature 375:534-535 (1995). PubMed ID: 7791879. Show all entries for this paper.


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