HIV molecular immunology database
Found 1 matching record:
| HXB2 Location | Gag(294-304) | Gag Epitope Map
View variants at this location |
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| Epitope |
RDYVDRFFKTL
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Epitope Alignment | ||||
| Variants |
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| Species (MHC/HLA) | human(A*24:02) | |||||
Showing all: 1 variant(s).
| Variant ID. | 2209 |
|---|---|
| Epitope Seq. | RDYVDRFFKTL |
| Variant Seq. | RDYVDRyFKTL |
| Mutations | F/Y |
| Epitope Location | F7Y |
| HXB2 Location | F300Y |
| Mutation Type | DR: diminished response SSF: subtype-specific susceptible form |
| Epitope Subtype | A |
| Variant Subtype | B |
| Note | CTL responses in three individuals with non-clade B infections were studied, 2 with subtype A infections, 1 with subtype C -- their infections all originated in East Africa. This epitope is similar to the A24 DYVDRYFKT epitope found for B subtype, but CTL from this A subtype infection required the additional Arg -- the B clade sequence change from F to Y diminished CTL reactivity. |
Dorrell1999 L. Dorrell, T. Dong, G. S. Ogg, S. Lister, S. McAdam, T. Rostron, C. Conlon, A. J. McMichael, and S. L. Rowland-Jones. Distinct Recognition of Non-Clade B Human Immunodeficiency Virus Type 1 Epitopes by Cytotoxic T Lymphocytes Generated from Donors Infected in Africa. J. Virol., 73:1708-1714, 1999. PubMed ID: 9882385. Show all entries for this paper.