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Found 1 matching record:

Displaying record number 316

HXB2 Location  Gag(294-304)   Gag Epitope Map
View variants at this location
Epitope RDYVDRFFKTL   Epitope Alignment
Variants
RDYVDRyFKTL   diminished response; subtype-specific susceptible form
Species (MHC/HLA human(A*24:02)

Variant Details

Showing all: 1 variant(s).


Variant ID.  2209
Epitope Seq.  RDYVDRFFKTL
Variant Seq.  RDYVDRyFKTL
Mutations F/Y
Epitope Location F7Y
HXB2 Location F300Y
Mutation Type DR: diminished response
SSF: subtype-specific susceptible form
Epitope Subtype A
Variant Subtype B
Note CTL responses in three individuals with non-clade B infections were studied, 2 with subtype A infections, 1 with subtype C -- their infections all originated in East Africa. This epitope is similar to the A24 DYVDRYFKT epitope found for B subtype, but CTL from this A subtype infection required the additional Arg -- the B clade sequence change from F to Y diminished CTL reactivity.

References

Dorrell1999 L. Dorrell, T. Dong, G. S. Ogg, S. Lister, S. McAdam, T. Rostron, C. Conlon, A. J. McMichael, and S. L. Rowland-Jones. Distinct Recognition of Non-Clade B Human Immunodeficiency Virus Type 1 Epitopes by Cytotoxic T Lymphocytes Generated from Donors Infected in Africa. J. Virol., 73:1708-1714, 1999. PubMed ID: 9882385. Show all entries for this paper.


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