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Found 1 matching record:

Displaying record number 279

HXB2 Location  Gag(263-272)   Gag Epitope Map
View variants at this location
Epitope KRWIILGLNK   Epitope Alignment
Variants
KRWIImGLNK   susceptible form
Species (MHC/HLA human(B27)

Variant Details

Showing all: 1 variant(s).


Variant ID.  381
Epitope Seq.  KRWIILGLNK
Variant Seq.  KRWIImGLNK
Mutations L/M
Epitope Location L6M
HXB2 Location L268M
Mutation Type SF: susceptible form
Note This variant was recognized more efficiently than the wt epitope by patient CTLs.

References

Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.

Phillips1991 R. E. Phillips, S. Rowland-Jones, D. F. Nixon, F. M. Gotch, J. P. Edwards, A. O. Ogunlesi, J. G. Elvin, J. A. Rothbard, C. R. Bangham, C. R. Rizza, and A. J. McMichael. Human Immunodeficiency Virus Genetic Variation That Can Escape Cytotoxic T Cell Recognition. Nature, 354:453-459, 1991. Fluctuations in the specificity of cytotoxic T-cells for HIV were correlated with variability in proviral gag (DNA) epitope sequences. PubMed ID: 1721107. Show all entries for this paper.


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