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Displaying record number 1818

HXB2 Location Gag(263-272) Gag Epitope Map
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KRWIILGLNK

`KRWIImGLNK`		compensatory mutation
`KkWIILGLNK`		diminished HLA binding or increased off-rate
`KkWIImGLNK`		diminished HLA binding or increased off-rate
`KtWIILGLNK`		diminished HLA binding or increased off-rate
`KtWIImGLNK`		compensatory mutation; diminished HLA binding or increased off-rate

Epitope Name KK10

Species (MHC/HLA) human(B27)

Variant Details

Showing all: 5 variant(s).

Variant ID.	`390`
Epitope Seq.	`KRWIILGLNK`
Variant Seq.	`KRWIImGLNK`
Mutations	L/M
Epitope Location	L6M
HXB2 Location	L268M
Mutation Type	CM: compensatory mutation
Method	HLA binding
Note	Assumed compensatory mutation. Variant found in one B27 positive child but not in its B27 negative mother. Variant bound to B27 as well as the wt.

Variant ID.	`391`
Epitope Seq.	`KRWIILGLNK`
Variant Seq.	`KkWIILGLNK`
Mutations	R/K
Epitope Location	R2K
HXB2 Location	R264K
Mutation Type	DHB: diminished HLA binding or increased off-rate
Method	HLA binding
Note	Variant bound to B27 poorly compared to the wt.

Variant ID.	`392`
Epitope Seq.	`KRWIILGLNK`
Variant Seq.	`KkWIImGLNK`
Mutations	R/K L/M
Epitope Location	R2K L6M
HXB2 Location	R264K L268M
Mutation Type	DHB: diminished HLA binding or increased off-rate
Method	HLA binding
Note	Variant bound to B27 poorly compared to the wt.

Variant ID.	`393`
Epitope Seq.	`KRWIILGLNK`
Variant Seq.	`KtWIILGLNK`
Mutations	R/T
Epitope Location	R2T
HXB2 Location	R264T
Mutation Type	DHB: diminished HLA binding or increased off-rate
Method	CD8 T-cell Elispot - IFNy
Note	The variant was found in mothers and their infected children. There was no CTL response to the wt or the variant in mothers or in children. The variant failed to bind B27. Variant was replication competent.

Variant ID.	`394`
Epitope Seq.	`KRWIILGLNK`
Variant Seq.	`KtWIImGLNK`
Mutations	R/T L/M
Epitope Location	R2T L6M
HXB2 Location	R264T L268M
Mutation Type	CM: compensatory mutation DHB: diminished HLA binding or increased off-rate
Method	CD8 T-cell Elispot - IFNy
Note	The variant was found in mothers and their infected children. There was no CTL response to the wt or the variant in mothers or in children. The variant failed to bind B27. The variant had presumed compensatory L/M mutation

References

Goulder2001c P. J. Goulder, C. Brander, Y. Tang, C. Tremblay, R. A. Colbert, M. M. Addo, E. S. Rosenberg, T. Nguyen, R. Allen, A. Trocha, M. Altfeld, S. He, M. Bunce, R. Funkhouser, S. I. Pelton, S. K. Burchett, K. McIntosh, B. T. Korber, and B. D. Walker. Evolution and transmission of stable CTL escape mutations in HIV infection. Nature, 412(6844):334-8, 19 Jul 2001. PubMed ID: 11460164. Show all entries for this paper.