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Found 1 matching record:

Displaying record number 1818

HXB2 Location  Gag(263-272)   Gag Epitope Map
View variants at this location
Epitope KRWIILGLNK   Epitope Alignment
Variants
KRWIImGLNK   compensatory mutation
KkWIILGLNK   diminished HLA binding or increased off-rate
KkWIImGLNK   diminished HLA binding or increased off-rate
KtWIILGLNK   diminished HLA binding or increased off-rate
KtWIImGLNK   compensatory mutation; diminished HLA binding or increased off-rate
Epitope Name KK10
Species (MHC/HLA human(B27)

Variant Details

Showing all: 5 variant(s).


Variant ID.  390
Epitope Seq.  KRWIILGLNK
Variant Seq.  KRWIImGLNK
Mutations L/M
Epitope Location L6M
HXB2 Location L268M
Mutation Type CM: compensatory mutation
Method HLA binding
Note Assumed compensatory mutation. Variant found in one B27 positive child but not in its B27 negative mother. Variant bound to B27 as well as the wt.


Variant ID.  391
Epitope Seq.  KRWIILGLNK
Variant Seq.  KkWIILGLNK
Mutations R/K
Epitope Location R2K
HXB2 Location R264K
Mutation Type DHB: diminished HLA binding or increased off-rate
Method HLA binding
Note Variant bound to B27 poorly compared to the wt.


Variant ID.  392
Epitope Seq.  KRWIILGLNK
Variant Seq.  KkWIImGLNK
Mutations R/K L/M
Epitope Location R2K L6M
HXB2 Location R264K L268M
Mutation Type DHB: diminished HLA binding or increased off-rate
Method HLA binding
Note Variant bound to B27 poorly compared to the wt.


Variant ID.  393
Epitope Seq.  KRWIILGLNK
Variant Seq.  KtWIILGLNK
Mutations R/T
Epitope Location R2T
HXB2 Location R264T
Mutation Type DHB: diminished HLA binding or increased off-rate
Method CD8 T-cell Elispot - IFNy
Note The variant was found in mothers and their infected children. There was no CTL response to the wt or the variant in mothers or in children. The variant failed to bind B27. Variant was replication competent.


Variant ID.  394
Epitope Seq.  KRWIILGLNK
Variant Seq.  KtWIImGLNK
Mutations R/T L/M
Epitope Location R2T L6M
HXB2 Location R264T L268M
Mutation Type CM: compensatory mutation
DHB: diminished HLA binding or increased off-rate
Method CD8 T-cell Elispot - IFNy
Note The variant was found in mothers and their infected children. There was no CTL response to the wt or the variant in mothers or in children. The variant failed to bind B27. The variant had presumed compensatory L/M mutation

References

Goulder2001c P. J. Goulder, C. Brander, Y. Tang, C. Tremblay, R. A. Colbert, M. M. Addo, E. S. Rosenberg, T. Nguyen, R. Allen, A. Trocha, M. Altfeld, S. He, M. Bunce, R. Funkhouser, S. I. Pelton, S. K. Burchett, K. McIntosh, B. T. Korber, and B. D. Walker. Evolution and transmission of stable CTL escape mutations in HIV infection. Nature, 412(6844):334-8, 19 Jul 2001. PubMed ID: 11460164. Show all entries for this paper.


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