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Found 1 matching record:

Displaying record number 1757

HXB2 Location  gp160(586-593)   gp160 Epitope Map
View variants at this location
Epitope YLKDQQLL   Epitope Alignment
Variants
rYLKDQkLL   subtype-specific non-susceptible form
Species (MHC/HLA human(A*24)

Variant Details

Showing all: 1 variant(s).


Variant ID.  88
Epitope Seq.  YLKDQQLL
Variant Seq.  rYLKDQkLL
Mutations Y/R L/Y K/L D/K Q/D L/K
Epitope Location Y1R L2Y K3L D4K Q5D L7K
HXB2 Location Y586R L587Y K588L D589K Q590D L592K
Mutation Type SNSF: subtype-specific non-susceptible form
Method Chromium-release assay, HLA binding
Note The HLA-A24 subjects tested did not recognize the E clade version rYLKDQkLL, which differs from the previously defined B clade version YLKDQQLL by one amino acid, with an additional amino acid added on.

References

Bond2001 K. B. Bond, B. Sriwanthana, T. W. Hodge, A. S. De Groot, T. D. Mastro, N. L. Young, N. Promadej, J. D. Altman, K. Limpakarnjanarat, and J. M. McNicholl. An HLA-directed molecular and bioinformatics approach identifies new HLA-A11 HIV-1 subtype E cytotoxic T lymphocyte epitopes in HIV-1-infected Thais. AIDS Res. Hum. Retroviruses, 17(8):703-17, 20 May 2001. PubMed ID: 11429111. Show all entries for this paper.


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