HIV molecular immunology database


Search the Epitope Variant and Escape Mutation Database


Found 1 matching record:

Displaying record number 1713

HXB2 Location  Gag(203-212)   Gag Epitope Map
View variants at this location
Epitope DTINEEAAEW   Epitope Alignment
eTINEEAAEW   diminished response; subtype-specific susceptible form
Species (MHC/HLA human(B53)

Variant Details

Showing all: 1 variant(s).

Variant ID.  2210
Epitope Seq.  DTINEEAAEW
Variant Seq.  eTINEEAAEW
Mutations D/E
Epitope Location D1E
HXB2 Location D203E
Mutation Type DR: diminished response
SSF: subtype-specific susceptible form
Epitope Subtype A
Variant Subtype B, C, D
Method CD8 T-cell Elispot - IFNy, Cytotoxicity assay, Tetramer binding
Note DTINEEAAEW was not subtype A-specific and there was cross-recognition, although diminished, of the subtype B, C, and D variant, ETINEEAAEW.


Dorrell2001 L. Dorrell, B. E. Willcox, E. Y. Jones, G. Gillespie, H. Njai, S. Sabally, A. Jaye, K. DeGleria, T. Rostron, E. Lepin, A. McMichael, H. Whittle, and S. Rowland-Jones. Cytotoxic T lymphocytes recognize structurally diverse, clade-specific and cross-reactive peptides in human immunodeficiency virus type-1 gag through HLA-B53. Eur. J. Immunol., 31(6):1747-56, Jun 2001. PubMed ID: 11385619. Show all entries for this paper.

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