HIV molecular immunology database


Search the Epitope Variant and Escape Mutation Database


Found 1 matching record:

Displaying record number 1669

HXB2 Location  Nef(128-137)   Nef Epitope Map
View variants at this location
Epitope TPGPGVRYPL   Epitope Alignment
TPGPGiRYPL   susceptible form
Species (MHC/HLA human(B7)

Variant Details

Showing all: 1 variant(s).

Variant ID.  674
Epitope Seq.  TPGPGVRYPL
Variant Seq.  TPGPGiRYPL
Mutations V/I
Epitope Location V6I
HXB2 Location V133I
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note This epitope and the variant were recognized by 5/6 HIV infected women and by 4/5 HIV-exposed, persistently seronegative women. Responses to the epitope and the variant were much higher after HIV-1 seroconversion of previous HEPS.


Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: PubMed ID: 11375420. Show all entries for this paper.

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