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Found 1 matching record:

Displaying record number 1356

HXB2 Location  gp160(207-216)   gp160 Epitope Map
View variants at this location
Epitope KMSFEPIPIH   Epitope Alignment
Variants
KvSFEPIPIH   diminished response; subtype-specific susceptible form
KvtFEPIPIH   subtype-specific non-susceptible form
Species (MHC/HLA human(A29)

Variant Details

Showing all: 2 variant(s).


Variant ID.  111
Epitope Seq.  KMSFEPIPIH
Variant Seq.  KvSFEPIPIH
Mutations M/V
Epitope Location M2V
HXB2 Location M208V
Mutation Type DR: diminished response
SSF: subtype-specific susceptible form
Epitope Subtype A
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Chromium-release assay
Note CTL derived from subtype A clade infection (patient SP 528), recognized the subtype A version of the peptide (KMSFEPIPIH), had a slightly reduced specific lysis using the B clade version of the peptide (KVSFEPIPIH), and no lysis using the D clade version of the epitope (KVTFEPIPIH)


Variant ID.  112
Epitope Seq.  KMSFEPIPIH
Variant Seq.  KvtFEPIPIH
Mutations M/V S/T
Epitope Location M2V S3T
HXB2 Location M208V S209T
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype A
Variant Subtype D
Method CD8 T-cell Elispot - IFNy, Chromium-release assay
Note CTL derived from subtype A clade infection (patient SP 528), recognized the subtype A version of the peptide (KMSFEPIPIH), had a slightly reduced specific lysis using the B clade version of the peptide (KVSFEPIPIH), and no lysis using the D clade version of the epitope (KVTFEPIPIH)

References

Cao2000 H. Cao, I. Mani, R. Vincent, R. Mugerwa, P. Mugyenyi, P. Kanki, J. Ellner, and B. D. Walker. Cellular immunity to human immunodeficiency virus type 1 (HIV-1) clades: relevance to HIV-1 vaccine trials in Uganda. J. Infect. Dis., 182(5):1350-6, Nov 2000. PubMed ID: 11023458. Show all entries for this paper.


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