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HIV Molecular Immunology Database

Search the Epitope Variant and Escape Mutation Database

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Found 1 matching record:

Displaying record number 1352

HXB2 Location  Gag(263-272)   Gag Epitope Map
View variants at this location
Epitope KRWIILGLNK   Epitope Alignment
Variants
KkWIILGLNK   observed variant
KRWIImGLNK   compensatory mutation
KiWIImGLNK   observed variant
KkWIImGLNK   diminished HLA binding or increased off-rate; inferred escape
{d**}KgWIILGLNK   diminished HLA binding or increased off-rate; inferred escape
Species (MHC/HLA human(B*27:05)

Variant Details

Showing all: 5 variant(s).


Variant ID.  729
Epitope Seq.  KRWIILGLNK
Variant Seq.  KkWIILGLNK
Mutations R/K
Epitope Location R2K
HXB2 Location R264K
Mutation Type OV: observed variant
Method Tetramer binding
Note This variant was found in only 2/329 sequences, as R/K mutation was strongly associated with L/M mutation. This mutation occurs rarely in clade B viruses. Position under positive selection pressure.


Variant ID.  730
Epitope Seq.  KRWIILGLNK
Variant Seq.  KRWIImGLNK
Mutations L/M
Epitope Location L6M
HXB2 Location L268M
Mutation Type CM: compensatory mutation
Method Tetramer binding
Note Variant was present in 1/25 of the viral sequences 52 weeks after infection in one of the patients. Mutation occurs relatively early in the infection. L/M may be a compensatory mutation.


Variant ID.  731
Epitope Seq.  KRWIILGLNK
Variant Seq.  KiWIImGLNK
Mutations R/I L/M
Epitope Location R2I L6M
HXB2 Location R264I L268M
Mutation Type OV: observed variant
Note This variant was found in one of the patients in 4% of the sequences 1 year after initial infection.


Variant ID.  732
Epitope Seq.  KRWIILGLNK
Variant Seq.  KkWIImGLNK
Mutations R/K L/M
Epitope Location R2K L6M
HXB2 Location R264K L268M
Mutation Type DHB: diminished HLA binding or increased off-rate
IE: inferred escape
Method Tetramer binding
Note Variant was present in 96% of the viral sequences 52 weeks after infection in one of the patients, and after 12 weeks in another, following L/M variant. The two mutations are strongly linked. Substitution reduced binding to B27 and occurred in conjunction with high viral loads.


Variant ID.  2292
Epitope Seq.  {E**}KRWIILGLNK
Variant Seq.  {d**}KgWIILGLNK
Mutations R/G E/D
Epitope Location R2G E-3D
HXB2 Location R264G E260D
Mutation Type DHB: diminished HLA binding or increased off-rate
IE: inferred escape
Method Tetramer binding
Note Substitution reduced binding to B27 and occurred in conjunction with high viral loads. The two mutations are strongly linked. E/D may be compensatory mutation. No CTL responses.

References

Kelleher2001 A. D. Kelleher, C. Long, E. C. Holmes, R. L. Allen, J. Wilson, C. Conlon, C. Workman, S. Shaunak, K. Olson, P. Goulder, C. Brander, G. Ogg, J. S. Sullivan, W. Dyer, I. Jones, A. J. McMichael, S. Rowland-Jones, and R. E. Phillips. Clustered mutations in HIV-1 gag are consistently required for escape from HLA-B27-restricted cytotoxic T lymphocyte responses. J. Exp. Med., 193(3):375-86, 5 Feb 2001. URL: http://www.jem.org/cgi/content/full/193/3/375. PubMed ID: 11157057. Show all entries for this paper.


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