Found 1 matching record:
HXB2 Location | Gag(263-272) | Gag Epitope Map
View variants at this location |
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Epitope |
KRWIILGLNK
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Epitope Alignment | ||||||||||||||||
Variants |
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Species (MHC/HLA) | human(B*27:05) |
Showing all: 5 variant(s).
Variant ID. | 729 |
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Epitope Seq. | KRWIILGLNK |
Variant Seq. | KkWIILGLNK |
Mutations | R/K |
Epitope Location | R2K |
HXB2 Location | R264K |
Mutation Type | OV: observed variant |
Method | Tetramer binding |
Note | This variant was found in only 2/329 sequences, as R/K mutation was strongly associated with L/M mutation. This mutation occurs rarely in clade B viruses. Position under positive selection pressure. |
Variant ID. | 730 |
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Epitope Seq. | KRWIILGLNK |
Variant Seq. | KRWIImGLNK |
Mutations | L/M |
Epitope Location | L6M |
HXB2 Location | L268M |
Mutation Type | CM: compensatory mutation |
Method | Tetramer binding |
Note | Variant was present in 1/25 of the viral sequences 52 weeks after infection in one of the patients. Mutation occurs relatively early in the infection. L/M may be a compensatory mutation. |
Variant ID. | 731 |
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Epitope Seq. | KRWIILGLNK |
Variant Seq. | KiWIImGLNK |
Mutations | R/I L/M |
Epitope Location | R2I L6M |
HXB2 Location | R264I L268M |
Mutation Type | OV: observed variant |
Note | This variant was found in one of the patients in 4% of the sequences 1 year after initial infection. |
Variant ID. | 732 |
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Epitope Seq. | KRWIILGLNK |
Variant Seq. | KkWIImGLNK |
Mutations | R/K L/M |
Epitope Location | R2K L6M |
HXB2 Location | R264K L268M |
Mutation Type | DHB: diminished HLA binding or increased off-rate IE: inferred escape |
Method | Tetramer binding |
Note | Variant was present in 96% of the viral sequences 52 weeks after infection in one of the patients, and after 12 weeks in another, following L/M variant. The two mutations are strongly linked. Substitution reduced binding to B27 and occurred in conjunction with high viral loads. |
Variant ID. | 2292 |
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Epitope Seq. | {E**}KRWIILGLNK |
Variant Seq. | {d**}KgWIILGLNK |
Mutations | R/G E/D |
Epitope Location | R2G E-3D |
HXB2 Location | R264G E260D |
Mutation Type | DHB: diminished HLA binding or increased off-rate IE: inferred escape |
Method | Tetramer binding |
Note | Substitution reduced binding to B27 and occurred in conjunction with high viral loads. The two mutations are strongly linked. E/D may be compensatory mutation. No CTL responses. |
Kelleher2001 A. D. Kelleher, C. Long, E. C. Holmes, R. L. Allen, J. Wilson, C. Conlon, C. Workman, S. Shaunak, K. Olson, P. Goulder, C. Brander, G. Ogg, J. S. Sullivan, W. Dyer, I. Jones, A. J. McMichael, S. Rowland-Jones, and R. E. Phillips. Clustered mutations in HIV-1 gag are consistently required for escape from HLA-B27-restricted cytotoxic T lymphocyte responses. J. Exp. Med., 193(3):375-86, 5 Feb 2001. URL: http://www.jem.org/cgi/content/full/193/3/375. PubMed ID: 11157057. Show all entries for this paper.
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