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Found 2 matching records:

Displaying record number 59429

HXB2 Location Gag(166-175) Gag Epitope Map
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PEVIPMFSAL

`PEVIPMFaAL`		observed variant
`PEVIPMFmAL`		observed variant
`PEVIPMFtAL`		observed variant

Epitope Name Gag166-175

Species (MHC/HLA) human(C*03:04)

Variant Details

Showing all: 3 variant(s).

Variant ID.	`4040`
Epitope Seq.	`PEVIPMFSAL`
Variant Seq.	`PEVIPMFaAL`
Mutations	S/A
Epitope Location	S8A
HXB2 Location	S173A
Mutation Type	OV: observed variant
Method	Sequence
Note	The S173A variant at position 8, PEVIPMFaAL (34-8A), was present at a frequency of 2.4%

Variant ID.	`4041`
Epitope Seq.	`PEVIPMFSAL`
Variant Seq.	`PEVIPMFmAL`
Mutations	S/M
Epitope Location	S8M
HXB2 Location	S173M
Mutation Type	OV: observed variant
Method	Sequence
Note	The S173M variant at position 8, PEVIPMFmAL (34-8M), was present at a frequency of 1.3%.

Variant ID.	`4042`
Epitope Seq.	`PEVIPMFSAL`
Variant Seq.	`PEVIPMFtAL`
Mutations	S/T
Epitope Location	S8T
HXB2 Location	S173T
Mutation Type	OV: observed variant
Method	Sequence
Note	The S173T variant at position 8, PEVIPMFtAL (34-8T), was present at a frequency of 39.1%.

References

vanTeijlingen2014 Nienke H. van Teijlingen, Angelique Hölzemer, Christian Körner, Wilfredo F. García-Beltrán, Jamie L. Schafer, Lena Fadda, Todd J. Suscovich, Christian Brander, Mary Carrington, David T Evans, Debbie van Baarle, and Marcus Altfeld. Sequence Variations in HIV-1 p24 Gag-Derived Epitopes Can Alter Binding of KIR2DL2 to HLA-C*03:04 and Modulate Primary Natural Killer Cell Function. AIDS, 28(10):1399-1408, 19 Jun 2014. PubMed ID: 24785948. Show all entries for this paper.

Displaying record number 59431

HXB2 Location Gag(295-304) Gag Epitope Map
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Epitope

DYVDRFFKTL

Epitope Alignment

Variants

`DYVDRFFKvL`		escape documented in this paper
`DYVDRFFKaL`		escape documented in this paper
`DYVDRFFKcL`		escape documented in this paper
`DYVDRFFKiL`		escape documented in this paper

Epitope Name Gag295-304

Species (MHC/HLA) human(C*03:04)

Variant Details

Showing all: 4 variant(s).

Variant ID.	`4036`
Epitope Seq.	`DYVDRFFKTL`
Variant Seq.	`DYVDRFFKvL`
Mutations	T/V
Epitope Location	T9V
HXB2 Location	T303V
Mutation Type	E: escape documented in this paper
Method	Other
Note	The T303V variant at position 9, DYVDRFFKvL (163-9V), was present at a frequency of 5% and also strongly binds the inhibitory NK cell receptor, KIR2DL2, evading NK-cell mediated killing.

Variant ID.	`4037`
Epitope Seq.	`DYVDRFFKTL`
Variant Seq.	`DYVDRFFKaL`
Mutations	T/A
Epitope Location	T9A
HXB2 Location	T303A
Mutation Type	E: escape documented in this paper
Method	Other
Note	The T303A variant at position 9, DYVDRFFKaL (163-9A), was present at a frequency of 2.4% and also binds the inhibitory NK cell receptor, KIR2DL2.

Variant ID.	`4038`
Epitope Seq.	`DYVDRFFKTL`
Variant Seq.	`DYVDRFFKcL`
Mutations	T/C
Epitope Location	T9C
HXB2 Location	T303C
Mutation Type	E: escape documented in this paper
Method	Other
Note	The T303C variant at position 9, DYVDRFFKcL (163-9C), was present at a frequency of 1.5% and also binds the inhibitory NK cell receptor, KIR2DL2.

Variant ID.	`4039`
Epitope Seq.	`DYVDRFFKTL`
Variant Seq.	`DYVDRFFKiL`
Mutations	T/I
Epitope Location	T9I
HXB2 Location	T303I
Mutation Type	E: escape documented in this paper
Method	Other
Note	The T303I variant at position 9, DYVDRFFKiL (163-9I), was present at a frequency of 1% and also binds the inhibitory NK cell receptor, KIR2DL2.