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Found 10 matching records:

Displaying record number 58382

HXB2 Location Gag(26-40) Gag Epitope Map
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KKHYMLKHIVWASRE

`KKHYMLKHlVWASRE`		subtype-specific susceptible form
`{g}KKkYkLKHlVWASR`		subtype-specific non-susceptible form
`KKkYrLKHlVWASRE`		subtype-specific non-susceptible form
`KKkYrLKHlVWASRE`		subtype-specific non-susceptible form

Epitope Name Peptide 7

Species (MHC/HLA) human

Variant Details

Showing all: 4 variant(s).

Variant ID.	`2899`
Epitope Seq.	`KKHYMLKHIVWASRE`
Variant Seq.	`KKHYMLKHlVWASRE`
Mutations	I/L
Epitope Location	I9L
HXB2 Location	I34L
Mutation Type	SSF: subtype-specific susceptible form
Epitope Subtype	C
Variant Subtype	C
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Chinese Clade-C peptide 7, KKHYMLKHlVWASRE, cross reacted to elicit a response from South African subjects carrying clade-C virus.

Variant ID.	`2900`
Epitope Seq.	`{x}KKHYMLKHIVWASRE`
Variant Seq.	`{g}KKkYkLKHlVWASR`
Mutations	x/G I/L H/K M/K
Epitope Location	x1G I10L H4K M6K
HXB2 Location	x26G I35L H29K M31K
Mutation Type	SNSF: subtype-specific non-susceptible form
Epitope Subtype	C
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Consensus Clade-B peptide 7, {g}KKkYkLKHlVWASR, did not cross react to elicit a response from South African subjects carrying clade-C virus.

Variant ID.	`2903`
Epitope Seq.	`KKHYMLKHIVWASRE`
Variant Seq.	`KKkYrLKHlVWASRE`
Mutations	H/K M/R I/L
Epitope Location	H3K M5R I9L
HXB2 Location	H28K M30R I34L
Mutation Type	SNSF: subtype-specific non-susceptible form
Epitope Subtype	C
Variant Subtype	A
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Consensus Clade-A peptide 7, KKkYrLKHlVWASRE, did not cross react to elicit a response from South African subjects carrying clade-C virus.

Variant ID.	`2904`
Epitope Seq.	`KKHYMLKHIVWASRE`
Variant Seq.	`KKkYrLKHlVWASRE`
Mutations	H/K M/R I/L
Epitope Location	H3K M5R I9L
HXB2 Location	H28K M30R I34L
Mutation Type	SNSF: subtype-specific non-susceptible form
Epitope Subtype	C
Variant Subtype	D
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Consensus Clade-D peptide 7, KKkYrLKHlVWASRE, did not cross react to elicit a response from South African subjects carrying clade-C virus.

References

Zembe2011 Lycias Zembe, Wendy A. Burgers, Heather B. Jaspan, Linda-Gail Bekker, Helba Bredell, Gwynneth Stevens, Jill Gilmour, Josephine H. Cox, Patricia Fast, Peter Hayes, Eftyhia Vardas, Carolyn Williamson, and Clive M. Gray. Intra- and Inter-Clade Cross-Reactivity by HIV-1 Gag Specific T-Cells Reveals Exclusive and Commonly Targeted Regions: Implications for Current Vaccine Trials. PLoS One, 6(10):e26096, 2011. PubMed ID: 22022524. Show all entries for this paper.

Displaying record number 58383

HXB2 Location Gag(42-56) Gag Epitope Map
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Epitope

ERFALNPGLLETSEG

Epitope Alignment

Variants

`lERFAvNPGLLETSE`		subtype-specific non-susceptible form
`ERFALNPsLLETaEG`		subtype-specific non-susceptible form

Epitope Name Peptide 11

Species (MHC/HLA) human

Variant Details

Showing all: 2 variant(s).

Variant ID.	`2905`
Epitope Seq.	`xERFALNPGLLETSE`
Variant Seq.	`lERFAvNPGLLETSE`
Mutations	x/L L/V
Epitope Location	x1L L6V
HXB2 Location	x42L L47V
Mutation Type	SNSF: subtype-specific non-susceptible form
Epitope Subtype	C
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Consensus Clade-B peptide 11, lERFAvNPGLLETSE, did not cross react to elicit a response from South African subjects carrying clade-C virus.

Variant ID.	`2906`
Epitope Seq.	`ERFALNPGLLETSEG`
Variant Seq.	`ERFALNPsLLETaEG`
Mutations	S/A G/S
Epitope Location	S13A G8S
HXB2 Location	S54A G49S
Mutation Type	SNSF: subtype-specific non-susceptible form
Epitope Subtype	C
Variant Subtype	A
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Consensus Clade-A peptide 11, ERFALNPsLLETaEG, did not cross react to elicit a response from South African subjects carrying clade-C virus.

References

Displaying record number 58384

HXB2 Location Gag(58-72) Gag Epitope Map
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Epitope

KQIMKQLQPALQTGT

Epitope Alignment

Variants

`KQIiKQLQPALQTGT`		subtype-specific non-susceptible form
`crQIlgQLQPALQTGT`		subtype-specific susceptible form
`KQIigQLQPAiQTGs`		subtype-specific non-susceptible form
`cqQImeQLQsALkTse`		subtype-specific non-susceptible form

Epitope Name Peptide 15

Species (MHC/HLA) human

Variant Details

Showing all: 4 variant(s).

Variant ID.	`2907`
Epitope Seq.	`KQIMKQLQPALQTGT`
Variant Seq.	`KQIiKQLQPALQTGT`
Mutations	M/I
Epitope Location	M4I
HXB2 Location	M61I
Mutation Type	SNSF: subtype-specific non-susceptible form
Epitope Subtype	C
Variant Subtype	C
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Chinese Clade-C peptide 15, KQIiKQLQPALQTGT, did not cross react to elicit a response from South African subjects carrying clade-C virus.

Variant ID.	`2908`
Epitope Seq.	`xKQIMKQLQPALQTGT`
Variant Seq.	`crQIlgQLQPALQTGT`
Mutations	x/C K/R M/L K/G
Epitope Location	x1C K2R M5L K6G
HXB2 Location	x58C K59R M62L K63G
Mutation Type	SSF: subtype-specific susceptible form
Epitope Subtype	C
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Consensus Clade-B peptide 15, crQIlgQLQPALQTGT, cross reacted to elicit a response from South African subjects carrying clade-C virus.

Variant ID.	`2909`
Epitope Seq.	`KQIMKQLQPALQTGT`
Variant Seq.	`KQIigQLQPAiQTGs`
Mutations	L/I T/S M/I K/G
Epitope Location	L11I T15S M4I K5G
HXB2 Location	L68I T72S M61I K62G
Mutation Type	SNSF: subtype-specific non-susceptible form
Epitope Subtype	C
Variant Subtype	D
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Consensus Clade-D peptide 15, KQIigQLQPAiQTGs, did not cross react to elicit a response from South African subjects carrying clade-C virus.

Variant ID.	`2910`
Epitope Seq.	`xKQIMKQLQPALQTGT`
Variant Seq.	`cqQImeQLQsALkTse`
Mutations	x/C P/S Q/K G/S T/E K/Q K/E
Epitope Location	x1C P10S Q13K G15S T16E K2Q K6E
HXB2 Location	x58C P67S Q70K G72S T73E K59Q K63E
Mutation Type	SNSF: subtype-specific non-susceptible form
Epitope Subtype	C
Variant Subtype	A
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Consensus Clade-A peptide 15, cqQImeQLQsALkTse, did not cross react to elicit a response from South African subjects carrying clade-C virus.

References

Displaying record number 58385

HXB2 Location Gag(74-88) Gag Epitope Map
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Epitope

ELKSLYNTVATLYCV

Epitope Alignment

Variants

`ELrSLfNTVATLYCV`		subtype-specific susceptible form
`eELrSLYNTVATLYCV`		subtype-specific susceptible form
`ELrSLYNTVATLYCV`		subtype-specific susceptible form
`LKSLfNTVATLYCVH`		subtype-specific susceptible form

Epitope Name Peptide 19

Species (MHC/HLA) human

Variant Details

Showing all: 4 variant(s).

Variant ID.	`2911`
Epitope Seq.	`ELKSLYNTVATLYCV`
Variant Seq.	`ELrSLfNTVATLYCV`
Mutations	K/R Y/F
Epitope Location	K3R Y6F
HXB2 Location	K76R Y79F
Mutation Type	SSF: subtype-specific susceptible form
Epitope Subtype	C
Variant Subtype	C
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Chinese Clade-C peptide 19, ELrSLfNTVATLYCV, cross reacted to elicit a response from South African subjects carrying clade-C virus.

Variant ID.	`2912`
Epitope Seq.	`xELKSLYNTVATLYCV`
Variant Seq.	`eELrSLYNTVATLYCV`
Mutations	x/E K/R
Epitope Location	x1E K4R
HXB2 Location	x74E K77R
Mutation Type	SSF: subtype-specific susceptible form
Epitope Subtype	C
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Consensus Clade-B peptide 19, eELrSLYNTVATLYCV, cross reacted to elicit a response from South African subjects carrying clade-C virus.

Variant ID.	`2913`
Epitope Seq.	`ELKSLYNTVATLYCV`
Variant Seq.	`ELrSLYNTVATLYCV`
Mutations	K/R
Epitope Location	K3R
HXB2 Location	K76R
Mutation Type	SSF: subtype-specific susceptible form
Epitope Subtype	C
Variant Subtype	D
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Consensus Clade-D peptide 19, ELrSLYNTVATLYCV, cross reacted to elicit a response from South African subjects carrying clade-C virus.

Variant ID.	`2914`
Epitope Seq.	`LKSLYNTVATLYCVx`
Variant Seq.	`LKSLfNTVATLYCVH`
Mutations	x/H Y/F
Epitope Location	x15H Y5F
HXB2 Location	x88H Y78F
Mutation Type	SSF: subtype-specific susceptible form
Epitope Subtype	C
Variant Subtype	A
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Consensus Clade-A peptide 19, LKSLfNTVATLYCVH, cross reacted to elicit a response from South African subjects carrying clade-C virus.

References

Displaying record number 58386

HXB2 Location Gag(129-143) Gag Epitope Map
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Epitope

SQNYPIVQNLQGQMV

Epitope Alignment

Variants

`sqvSQNYPIVQNLQG`		subtype-specific susceptible form
`kvSQNYalkhrayel`		subtype-specific non-susceptible form

Epitope Name Peptide 32

Species (MHC/HLA) human

Variant Details

Showing all: 2 variant(s).

Variant ID.	`2915`
Epitope Seq.	`xxxSQNYPIVQNLQG`
Variant Seq.	`sqvSQNYPIVQNLQG`
Mutations	x/S x/Q x/V
Epitope Location	x1S x2Q x3V
HXB2 Location	x129S x130Q x131V
Mutation Type	SSF: subtype-specific susceptible form
Epitope Subtype	C
Variant Subtype	D
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Consensus Clade-D peptide 32, sqvSQNYPIVQNLQG, cross reacted to elicit a response from South African subjects carrying clade-C virus.

Variant ID.	`2916`
Epitope Seq.	`xxSQNYPIVQNLQGM`
Variant Seq.	`kvSQNYalkhrayel`
Mutations	x/K Q/H N/R L/A Q/Y G/E M/L x/V P/A I/L V/K
Epitope Location	x1K Q10H N11R L12A Q13Y G14E M15L x2V P7A I8L V9K
HXB2 Location	x129K Q138H N139R L140A Q141Y G142E M143L x130V P135A I136L V137K
Mutation Type	SNSF: subtype-specific non-susceptible form
Epitope Subtype	C
Variant Subtype	A
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Consensus Clade-A peptide 32, kvSQNYalkhrayel, did not elicit a response from South African subjects carrying clade-C virus.

References

Displaying record number 58387

HXB2 Location Gag(154-168) Gag Epitope Map
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Epitope

AWVKVIEEKAFSPEV

Epitope Alignment

Variants

nAWVKVvEEKAFSPE subtype-specific non-susceptible form

Epitope Name Peptide 38

Species (MHC/HLA) human

Variant Details

Showing all: 1 variant(s).

Variant ID.	`2917`
Epitope Seq.	`xAWVKVIEEKAFSPE`
Variant Seq.	`nAWVKVvEEKAFSPE`
Mutations	x/N I/V
Epitope Location	x1N I7V
HXB2 Location	x154N I160V
Mutation Type	SNSF: subtype-specific non-susceptible form
Epitope Subtype	C
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Consensus Clade-B peptide 38, xAWVKVIEEKAFSPE, did not elicit a response from South African subjects carrying clade-C virus.

References

Displaying record number 58388

HXB2 Location Gag(238-252) Gag Epitope Map
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Epitope

GTTSTLQEQIAWMTS

Epitope Alignment

Variants

`GTTSTLQgQIAWMTS`		subtype-specific non-susceptible form
`aGTTSTLQEQIgWMT`		subtype-specific non-susceptible form
`GTTSTLQEQIgWMTS`		subtype-specific non-susceptible form

Epitope Name Peptide 59

Species (MHC/HLA) human

Variant Details

Showing all: 3 variant(s).

Variant ID.	`2919`
Epitope Seq.	`GTTSTLQEQIAWMTS`
Variant Seq.	`GTTSTLQgQIAWMTS`
Mutations	E/G
Epitope Location	E8G
HXB2 Location	E245G
Mutation Type	SNSF: subtype-specific non-susceptible form
Epitope Subtype	C
Variant Subtype	C
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Chinese Clade-C peptide 59, GTTSTLQgQIAWMTS, did not elicit a response from South African subjects carrying clade-C virus.

Variant ID.	`2920`
Epitope Seq.	`xGTTSTLQEQIAWMT`
Variant Seq.	`aGTTSTLQEQIgWMT`
Mutations	x/A A/G
Epitope Location	x1A A12G
HXB2 Location	x238A A249G
Mutation Type	SNSF: subtype-specific non-susceptible form
Epitope Subtype	C
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Consensus Clade-B peptide 59, aGTTSTLQEQIgWMT, did not elicit a response from South African subjects carrying clade-C virus.

Variant ID.	`2921`
Epitope Seq.	`GTTSTLQEQIAWMTS`
Variant Seq.	`GTTSTLQEQIgWMTS`
Mutations	A/G
Epitope Location	A11G
HXB2 Location	A248G
Mutation Type	SNSF: subtype-specific non-susceptible form
Epitope Subtype	C
Variant Subtype	A
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Consensus Clade-A peptide 59, GTTSTLQEQIgWMTS, did not elicit a response from South African subjects carrying clade-C virus.

References

Displaying record number 58389

HXB2 Location Gag(254-268) Gag Epitope Map
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Epitope

PPIPVGDIYKRWIIL

Epitope Alignment

Variants

`PPvPVGeIYKRWIIL`		subtype-specific susceptible form
`nPPIPVGeIYKRWII`		subtype-specific susceptible form
`PPIPVGeIYKRWIIL`		subtype-specific susceptible form

Epitope Name Peptide 63

Species (MHC/HLA) human

Variant Details

Showing all: 3 variant(s).

Variant ID.	`2922`
Epitope Seq.	`PPIPVGDIYKRWIIL`
Variant Seq.	`PPvPVGeIYKRWIIL`
Mutations	I/V D/E
Epitope Location	I3V D7E
HXB2 Location	I256V D260E
Mutation Type	SSF: subtype-specific susceptible form
Epitope Subtype	C
Variant Subtype	C
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Chinese Clade-C peptide 63, PPvPVGeIYKRWIIL, cross reacted to elicit a response from South African subjects carrying clade-C virus.

Variant ID.	`2923`
Epitope Seq.	`xPPIPVGDIYKRWII`
Variant Seq.	`nPPIPVGeIYKRWII`
Mutations	x/N D/E
Epitope Location	x1N D8E
HXB2 Location	x254N D261E
Mutation Type	SSF: subtype-specific susceptible form
Epitope Subtype	C
Variant Subtype	C
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Consensus Clade-B peptide 63, nPPIPVGeIYKRWII, cross reacted to elicit a response from South African subjects carrying clade-C virus.

Variant ID.	`2924`
Epitope Seq.	`PPIPVGDIYKRWIIL`
Variant Seq.	`PPIPVGeIYKRWIIL`
Mutations	D/E
Epitope Location	D7E
HXB2 Location	D260E
Mutation Type	SSF: subtype-specific susceptible form
Epitope Subtype	C
Variant Subtype	D
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Chinese Clade-D peptide 63, PPIPVGeIYKRWIIL, cross reacted to elicit a response from South African subjects carrying clade-C virus.

References

Displaying record number 58390

HXB2 Location Gag(322-336) Gag Epitope Map
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Epitope

LVQNANPDCKTILRA

Epitope Alignment

Variants

`lLVQNANPDCKTILRk`		subtype-specific susceptible form
`LVQNANPDCKsILRA`		subtype-specific susceptible form
`LVQNANPDCKTILkA`		subtype-specific susceptible form

Epitope Name Peptide 80

Species (MHC/HLA) human

Variant Details

Showing all: 3 variant(s).

Variant ID.	`2925`
Epitope Seq.	`xLVQNANPDCKTILRA`
Variant Seq.	`lLVQNANPDCKTILRk`
Mutations	x/L A/K
Epitope Location	x1L A16K
HXB2 Location	x322L A337K
Mutation Type	SSF: subtype-specific susceptible form
Epitope Subtype	C
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Consensus Clade-B peptide 80, lLVQNANPDCKTILRk, cross reacted to elicit a response from South African subjects carrying clade-C virus.

Variant ID.	`2926`
Epitope Seq.	`LVQNANPDCKTILRA`
Variant Seq.	`LVQNANPDCKsILRA`
Mutations	T/S
Epitope Location	T11S
HXB2 Location	T332S
Mutation Type	SSF: subtype-specific susceptible form
Epitope Subtype	C
Variant Subtype	A
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Consensus Clade-A peptide 80, LVQNANPDCKsILRA, cross reacted to elicit a response from South African subjects carrying clade-C virus.

Variant ID.	`2927`
Epitope Seq.	`LVQNANPDCKTILRA`
Variant Seq.	`LVQNANPDCKTILkA`
Mutations	R/K
Epitope Location	R14K
HXB2 Location	R335K
Mutation Type	SSF: subtype-specific susceptible form
Epitope Subtype	C
Variant Subtype	D
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Consensus Clade-D peptide 80, LVQNANPDCKTILkA, cross reacted to elicit a response from South African subjects carrying clade-C virus.

References

Displaying record number 58391

HXB2 Location Gag(358-373) Gag Epitope Map
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Epitope

HKARVLAEAMSQTNS

Epitope Alignment

Variants

`HKARVLAEAMSQ(a)TN`		subtype-specific susceptible form
`HKARVLgtgarasvl`		subtype-specific non-susceptible form
`{g}HKARVLAEAMSQ(v)T`		subtype-specific non-susceptible form
`HKARVLAEAMSQaNg`		subtype-specific non-susceptible form

Epitope Name Peptide 89

Species (MHC/HLA) human

Variant Details

Showing all: 4 variant(s).

Variant ID.	`2928`
Epitope Seq.	`HKARVLAEAMSQTNS`
Variant Seq.	`HKARVLAEAMSQ(a)TN`
Mutations	-/A
Epitope Location	-(12.1)A
HXB2 Location	-(369.1)A
Mutation Type	SSF: subtype-specific susceptible form
Epitope Subtype	C
Variant Subtype	D
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Consensus Clade-D peptide 89, HKARVLAEAMSQ(a)TN, which carries an insertion, cross reacted to elicit a response from South African subjects carrying clade-C virus.

Variant ID.	`2929`
Epitope Seq.	`HKARVLAEAMSQTNS`
Variant Seq.	`HKARVLgtgarasvl`
Mutations	M/A S/R Q/A T/S N/V S/L A/G E/T A/G
Epitope Location	M10A S11R Q12A T13S N14V S15L A7G E8T A9G
HXB2 Location	M367A S368R Q369A T370S N371V S372L A364G E365T A366G
Mutation Type	SNSF: subtype-specific non-susceptible form
Epitope Subtype	C
Variant Subtype	A
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Consensus Clade-A peptide 89, HKARVLgtgarasvl, did not elicit a response from South African subjects carrying clade-C virus.

Variant ID.	`2930`
Epitope Seq.	`HKARVLAEAMSQTNS`
Variant Seq.	`{g}HKARVLAEAMSQ(v)T`
Mutations	-/V x/G
Epitope Location	-(15.1)V x2G
HXB2 Location	-(372.1)V x359G
Mutation Type	SNSF: subtype-specific non-susceptible form
Epitope Subtype	C
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Consensus Clade-B peptide 89, {g}HKARVLAEAMSQ(v)T, did not elicit a response from South African subjects carrying clade-C virus.

Variant ID.	`2931`
Epitope Seq.	`HKARVLAEAMSQTNS`
Variant Seq.	`HKARVLAEAMSQaNg`
Mutations	T/A S/G
Epitope Location	T13A S15G
HXB2 Location	T370A S372G
Mutation Type	SNSF: subtype-specific non-susceptible form
Epitope Subtype	C
Variant Subtype	C
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Chinese Clade-C peptide 89, HKARVLAEAMSQaNg, did not elicit a response from South African subjects carrying clade-C virus.