HIV molecular immunology database

 

Search the Epitope Variant and Escape Mutation Database

Help


Found 10 matching records:

Displaying record number 58382

HXB2 Location  Gag(26-40)   Gag Epitope Map
View variants at this location
Epitope KKHYMLKHIVWASRE   Epitope Alignment
Variants
KKHYMLKHlVWASRE   subtype-specific susceptible form
{g}KKkYkLKHlVWASR   subtype-specific non-susceptible form
KKkYrLKHlVWASRE   subtype-specific non-susceptible form
KKkYrLKHlVWASRE   subtype-specific non-susceptible form
Epitope Name Peptide 7
Species (MHC/HLA human

Variant Details

Showing all: 4 variant(s).


Variant ID.  2899
Epitope Seq.  KKHYMLKHIVWASRE
Variant Seq.  KKHYMLKHlVWASRE
Mutations I/L
Epitope Location I9L
HXB2 Location I34L
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Sequence
Note Chinese Clade-C peptide 7, KKHYMLKHlVWASRE, cross reacted to elicit a response from South African subjects carrying clade-C virus.


Variant ID.  2900
Epitope Seq.  {x}KKHYMLKHIVWASRE
Variant Seq.  {g}KKkYkLKHlVWASR
Mutations x/G I/L H/K M/K
Epitope Location x1G I10L H4K M6K
HXB2 Location x26G I35L H29K M31K
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype C
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note Consensus Clade-B peptide 7, {g}KKkYkLKHlVWASR, did not cross react to elicit a response from South African subjects carrying clade-C virus.


Variant ID.  2903
Epitope Seq.  KKHYMLKHIVWASRE
Variant Seq.  KKkYrLKHlVWASRE
Mutations H/K M/R I/L
Epitope Location H3K M5R I9L
HXB2 Location H28K M30R I34L
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype C
Variant Subtype A
Method CD8 T-cell Elispot - IFNy, Sequence
Note Consensus Clade-A peptide 7, KKkYrLKHlVWASRE, did not cross react to elicit a response from South African subjects carrying clade-C virus.


Variant ID.  2904
Epitope Seq.  KKHYMLKHIVWASRE
Variant Seq.  KKkYrLKHlVWASRE
Mutations H/K M/R I/L
Epitope Location H3K M5R I9L
HXB2 Location H28K M30R I34L
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype C
Variant Subtype D
Method CD8 T-cell Elispot - IFNy, Sequence
Note Consensus Clade-D peptide 7, KKkYrLKHlVWASRE, did not cross react to elicit a response from South African subjects carrying clade-C virus.

References

Zembe2011 Lycias Zembe, Wendy A. Burgers, Heather B. Jaspan, Linda-Gail Bekker, Helba Bredell, Gwynneth Stevens, Jill Gilmour, Josephine H. Cox, Patricia Fast, Peter Hayes, Eftyhia Vardas, Carolyn Williamson, and Clive M. Gray. Intra- and Inter-Clade Cross-Reactivity by HIV-1 Gag Specific T-Cells Reveals Exclusive and Commonly Targeted Regions: Implications for Current Vaccine Trials. PLoS One, 6(10):e26096, 2011. PubMed ID: 22022524. Show all entries for this paper.


Displaying record number 58383

HXB2 Location  Gag(42-56)   Gag Epitope Map
View variants at this location
Epitope ERFALNPGLLETSEG   Epitope Alignment
Variants
lERFAvNPGLLETSE   subtype-specific non-susceptible form
ERFALNPsLLETaEG   subtype-specific non-susceptible form
Epitope Name Peptide 11
Species (MHC/HLA human

Variant Details

Showing all: 2 variant(s).


Variant ID.  2905
Epitope Seq.  xERFALNPGLLETSE
Variant Seq.  lERFAvNPGLLETSE
Mutations x/L L/V
Epitope Location x1L L6V
HXB2 Location x42L L47V
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype C
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note Consensus Clade-B peptide 11, lERFAvNPGLLETSE, did not cross react to elicit a response from South African subjects carrying clade-C virus.


Variant ID.  2906
Epitope Seq.  ERFALNPGLLETSEG
Variant Seq.  ERFALNPsLLETaEG
Mutations S/A G/S
Epitope Location S13A G8S
HXB2 Location S54A G49S
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype C
Variant Subtype A
Method CD8 T-cell Elispot - IFNy, Sequence
Note Consensus Clade-A peptide 11, ERFALNPsLLETaEG, did not cross react to elicit a response from South African subjects carrying clade-C virus.

References

Zembe2011 Lycias Zembe, Wendy A. Burgers, Heather B. Jaspan, Linda-Gail Bekker, Helba Bredell, Gwynneth Stevens, Jill Gilmour, Josephine H. Cox, Patricia Fast, Peter Hayes, Eftyhia Vardas, Carolyn Williamson, and Clive M. Gray. Intra- and Inter-Clade Cross-Reactivity by HIV-1 Gag Specific T-Cells Reveals Exclusive and Commonly Targeted Regions: Implications for Current Vaccine Trials. PLoS One, 6(10):e26096, 2011. PubMed ID: 22022524. Show all entries for this paper.


Displaying record number 58384

HXB2 Location  Gag(58-72)   Gag Epitope Map
View variants at this location
Epitope KQIMKQLQPALQTGT   Epitope Alignment
Variants
KQIiKQLQPALQTGT   subtype-specific non-susceptible form
crQIlgQLQPALQTGT   subtype-specific susceptible form
KQIigQLQPAiQTGs   subtype-specific non-susceptible form
cqQImeQLQsALkTse   subtype-specific non-susceptible form
Epitope Name Peptide 15
Species (MHC/HLA human

Variant Details

Showing all: 4 variant(s).


Variant ID.  2907
Epitope Seq.  KQIMKQLQPALQTGT
Variant Seq.  KQIiKQLQPALQTGT
Mutations M/I
Epitope Location M4I
HXB2 Location M61I
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Sequence
Note Chinese Clade-C peptide 15, KQIiKQLQPALQTGT, did not cross react to elicit a response from South African subjects carrying clade-C virus.


Variant ID.  2908
Epitope Seq.  xKQIMKQLQPALQTGT
Variant Seq.  crQIlgQLQPALQTGT
Mutations x/C K/R M/L K/G
Epitope Location x1C K2R M5L K6G
HXB2 Location x58C K59R M62L K63G
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype C
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note Consensus Clade-B peptide 15, crQIlgQLQPALQTGT, cross reacted to elicit a response from South African subjects carrying clade-C virus.


Variant ID.  2909
Epitope Seq.  KQIMKQLQPALQTGT
Variant Seq.  KQIigQLQPAiQTGs
Mutations L/I T/S M/I K/G
Epitope Location L11I T15S M4I K5G
HXB2 Location L68I T72S M61I K62G
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype C
Variant Subtype D
Method CD8 T-cell Elispot - IFNy, Sequence
Note Consensus Clade-D peptide 15, KQIigQLQPAiQTGs, did not cross react to elicit a response from South African subjects carrying clade-C virus.


Variant ID.  2910
Epitope Seq.  xKQIMKQLQPALQTGT
Variant Seq.  cqQImeQLQsALkTse
Mutations x/C P/S Q/K G/S T/E K/Q K/E
Epitope Location x1C P10S Q13K G15S T16E K2Q K6E
HXB2 Location x58C P67S Q70K G72S T73E K59Q K63E
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype C
Variant Subtype A
Method CD8 T-cell Elispot - IFNy, Sequence
Note Consensus Clade-A peptide 15, cqQImeQLQsALkTse, did not cross react to elicit a response from South African subjects carrying clade-C virus.

References

Zembe2011 Lycias Zembe, Wendy A. Burgers, Heather B. Jaspan, Linda-Gail Bekker, Helba Bredell, Gwynneth Stevens, Jill Gilmour, Josephine H. Cox, Patricia Fast, Peter Hayes, Eftyhia Vardas, Carolyn Williamson, and Clive M. Gray. Intra- and Inter-Clade Cross-Reactivity by HIV-1 Gag Specific T-Cells Reveals Exclusive and Commonly Targeted Regions: Implications for Current Vaccine Trials. PLoS One, 6(10):e26096, 2011. PubMed ID: 22022524. Show all entries for this paper.


Displaying record number 58385

HXB2 Location  Gag(74-88)   Gag Epitope Map
View variants at this location
Epitope ELKSLYNTVATLYCV   Epitope Alignment
Variants
ELrSLfNTVATLYCV   subtype-specific susceptible form
eELrSLYNTVATLYCV   subtype-specific susceptible form
ELrSLYNTVATLYCV   subtype-specific susceptible form
LKSLfNTVATLYCVH   subtype-specific susceptible form
Epitope Name Peptide 19
Species (MHC/HLA human

Variant Details

Showing all: 4 variant(s).


Variant ID.  2911
Epitope Seq.  ELKSLYNTVATLYCV
Variant Seq.  ELrSLfNTVATLYCV
Mutations K/R Y/F
Epitope Location K3R Y6F
HXB2 Location K76R Y79F
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Sequence
Note Chinese Clade-C peptide 19, ELrSLfNTVATLYCV, cross reacted to elicit a response from South African subjects carrying clade-C virus.


Variant ID.  2912
Epitope Seq.  xELKSLYNTVATLYCV
Variant Seq.  eELrSLYNTVATLYCV
Mutations x/E K/R
Epitope Location x1E K4R
HXB2 Location x74E K77R
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype C
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note Consensus Clade-B peptide 19, eELrSLYNTVATLYCV, cross reacted to elicit a response from South African subjects carrying clade-C virus.


Variant ID.  2913
Epitope Seq.  ELKSLYNTVATLYCV
Variant Seq.  ELrSLYNTVATLYCV
Mutations K/R
Epitope Location K3R
HXB2 Location K76R
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype C
Variant Subtype D
Method CD8 T-cell Elispot - IFNy, Sequence
Note Consensus Clade-D peptide 19, ELrSLYNTVATLYCV, cross reacted to elicit a response from South African subjects carrying clade-C virus.


Variant ID.  2914
Epitope Seq.  LKSLYNTVATLYCVx
Variant Seq.  LKSLfNTVATLYCVH
Mutations x/H Y/F
Epitope Location x15H Y5F
HXB2 Location x88H Y78F
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype C
Variant Subtype A
Method CD8 T-cell Elispot - IFNy, Sequence
Note Consensus Clade-A peptide 19, LKSLfNTVATLYCVH, cross reacted to elicit a response from South African subjects carrying clade-C virus.

References

Zembe2011 Lycias Zembe, Wendy A. Burgers, Heather B. Jaspan, Linda-Gail Bekker, Helba Bredell, Gwynneth Stevens, Jill Gilmour, Josephine H. Cox, Patricia Fast, Peter Hayes, Eftyhia Vardas, Carolyn Williamson, and Clive M. Gray. Intra- and Inter-Clade Cross-Reactivity by HIV-1 Gag Specific T-Cells Reveals Exclusive and Commonly Targeted Regions: Implications for Current Vaccine Trials. PLoS One, 6(10):e26096, 2011. PubMed ID: 22022524. Show all entries for this paper.


Displaying record number 58386

HXB2 Location  Gag(129-143)   Gag Epitope Map
View variants at this location
Epitope SQNYPIVQNLQGQMV   Epitope Alignment
Variants
sqvSQNYPIVQNLQG   subtype-specific susceptible form
kvSQNYalkhrayel   subtype-specific non-susceptible form
Epitope Name Peptide 32
Species (MHC/HLA human

Variant Details

Showing all: 2 variant(s).


Variant ID.  2915
Epitope Seq.  xxxSQNYPIVQNLQG
Variant Seq.  sqvSQNYPIVQNLQG
Mutations x/S x/Q x/V
Epitope Location x1S x2Q x3V
HXB2 Location x129S x130Q x131V
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype C
Variant Subtype D
Method CD8 T-cell Elispot - IFNy, Sequence
Note Consensus Clade-D peptide 32, sqvSQNYPIVQNLQG, cross reacted to elicit a response from South African subjects carrying clade-C virus.


Variant ID.  2916
Epitope Seq.  xxSQNYPIVQNLQGM
Variant Seq.  kvSQNYalkhrayel
Mutations x/K Q/H N/R L/A Q/Y G/E M/L x/V P/A I/L V/K
Epitope Location x1K Q10H N11R L12A Q13Y G14E M15L x2V P7A I8L V9K
HXB2 Location x129K Q138H N139R L140A Q141Y G142E M143L x130V P135A I136L V137K
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype C
Variant Subtype A
Method CD8 T-cell Elispot - IFNy, Sequence
Note Consensus Clade-A peptide 32, kvSQNYalkhrayel, did not elicit a response from South African subjects carrying clade-C virus.

References

Zembe2011 Lycias Zembe, Wendy A. Burgers, Heather B. Jaspan, Linda-Gail Bekker, Helba Bredell, Gwynneth Stevens, Jill Gilmour, Josephine H. Cox, Patricia Fast, Peter Hayes, Eftyhia Vardas, Carolyn Williamson, and Clive M. Gray. Intra- and Inter-Clade Cross-Reactivity by HIV-1 Gag Specific T-Cells Reveals Exclusive and Commonly Targeted Regions: Implications for Current Vaccine Trials. PLoS One, 6(10):e26096, 2011. PubMed ID: 22022524. Show all entries for this paper.


Displaying record number 58387

HXB2 Location  Gag(154-168)   Gag Epitope Map
View variants at this location
Epitope AWVKVIEEKAFSPEV   Epitope Alignment
Variants
nAWVKVvEEKAFSPE   subtype-specific non-susceptible form
Epitope Name Peptide 38
Species (MHC/HLA human

Variant Details

Showing all: 1 variant(s).


Variant ID.  2917
Epitope Seq.  xAWVKVIEEKAFSPE
Variant Seq.  nAWVKVvEEKAFSPE
Mutations x/N I/V
Epitope Location x1N I7V
HXB2 Location x154N I160V
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype C
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note Consensus Clade-B peptide 38, xAWVKVIEEKAFSPE, did not elicit a response from South African subjects carrying clade-C virus.

References

Zembe2011 Lycias Zembe, Wendy A. Burgers, Heather B. Jaspan, Linda-Gail Bekker, Helba Bredell, Gwynneth Stevens, Jill Gilmour, Josephine H. Cox, Patricia Fast, Peter Hayes, Eftyhia Vardas, Carolyn Williamson, and Clive M. Gray. Intra- and Inter-Clade Cross-Reactivity by HIV-1 Gag Specific T-Cells Reveals Exclusive and Commonly Targeted Regions: Implications for Current Vaccine Trials. PLoS One, 6(10):e26096, 2011. PubMed ID: 22022524. Show all entries for this paper.


Displaying record number 58388

HXB2 Location  Gag(238-252)   Gag Epitope Map
View variants at this location
Epitope GTTSTLQEQIAWMTS   Epitope Alignment
Variants
GTTSTLQgQIAWMTS   subtype-specific non-susceptible form
aGTTSTLQEQIgWMT   subtype-specific non-susceptible form
GTTSTLQEQIgWMTS   subtype-specific non-susceptible form
Epitope Name Peptide 59
Species (MHC/HLA human

Variant Details

Showing all: 3 variant(s).


Variant ID.  2919
Epitope Seq.  GTTSTLQEQIAWMTS
Variant Seq.  GTTSTLQgQIAWMTS
Mutations E/G
Epitope Location E8G
HXB2 Location E245G
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Sequence
Note Chinese Clade-C peptide 59, GTTSTLQgQIAWMTS, did not elicit a response from South African subjects carrying clade-C virus.


Variant ID.  2920
Epitope Seq.  xGTTSTLQEQIAWMT
Variant Seq.  aGTTSTLQEQIgWMT
Mutations x/A A/G
Epitope Location x1A A12G
HXB2 Location x238A A249G
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype C
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note Consensus Clade-B peptide 59, aGTTSTLQEQIgWMT, did not elicit a response from South African subjects carrying clade-C virus.


Variant ID.  2921
Epitope Seq.  GTTSTLQEQIAWMTS
Variant Seq.  GTTSTLQEQIgWMTS
Mutations A/G
Epitope Location A11G
HXB2 Location A248G
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype C
Variant Subtype A
Method CD8 T-cell Elispot - IFNy, Sequence
Note Consensus Clade-A peptide 59, GTTSTLQEQIgWMTS, did not elicit a response from South African subjects carrying clade-C virus.

References

Zembe2011 Lycias Zembe, Wendy A. Burgers, Heather B. Jaspan, Linda-Gail Bekker, Helba Bredell, Gwynneth Stevens, Jill Gilmour, Josephine H. Cox, Patricia Fast, Peter Hayes, Eftyhia Vardas, Carolyn Williamson, and Clive M. Gray. Intra- and Inter-Clade Cross-Reactivity by HIV-1 Gag Specific T-Cells Reveals Exclusive and Commonly Targeted Regions: Implications for Current Vaccine Trials. PLoS One, 6(10):e26096, 2011. PubMed ID: 22022524. Show all entries for this paper.


Displaying record number 58389

HXB2 Location  Gag(254-268)   Gag Epitope Map
View variants at this location
Epitope PPIPVGDIYKRWIIL   Epitope Alignment
Variants
PPvPVGeIYKRWIIL   subtype-specific susceptible form
nPPIPVGeIYKRWII   subtype-specific susceptible form
PPIPVGeIYKRWIIL   subtype-specific susceptible form
Epitope Name Peptide 63
Species (MHC/HLA human

Variant Details

Showing all: 3 variant(s).


Variant ID.  2922
Epitope Seq.  PPIPVGDIYKRWIIL
Variant Seq.  PPvPVGeIYKRWIIL
Mutations I/V D/E
Epitope Location I3V D7E
HXB2 Location I256V D260E
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Sequence
Note Chinese Clade-C peptide 63, PPvPVGeIYKRWIIL, cross reacted to elicit a response from South African subjects carrying clade-C virus.


Variant ID.  2923
Epitope Seq.  xPPIPVGDIYKRWII
Variant Seq.  nPPIPVGeIYKRWII
Mutations x/N D/E
Epitope Location x1N D8E
HXB2 Location x254N D261E
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Sequence
Note Consensus Clade-B peptide 63, nPPIPVGeIYKRWII, cross reacted to elicit a response from South African subjects carrying clade-C virus.


Variant ID.  2924
Epitope Seq.  PPIPVGDIYKRWIIL
Variant Seq.  PPIPVGeIYKRWIIL
Mutations D/E
Epitope Location D7E
HXB2 Location D260E
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype C
Variant Subtype D
Method CD8 T-cell Elispot - IFNy, Sequence
Note Chinese Clade-D peptide 63, PPIPVGeIYKRWIIL, cross reacted to elicit a response from South African subjects carrying clade-C virus.

References

Zembe2011 Lycias Zembe, Wendy A. Burgers, Heather B. Jaspan, Linda-Gail Bekker, Helba Bredell, Gwynneth Stevens, Jill Gilmour, Josephine H. Cox, Patricia Fast, Peter Hayes, Eftyhia Vardas, Carolyn Williamson, and Clive M. Gray. Intra- and Inter-Clade Cross-Reactivity by HIV-1 Gag Specific T-Cells Reveals Exclusive and Commonly Targeted Regions: Implications for Current Vaccine Trials. PLoS One, 6(10):e26096, 2011. PubMed ID: 22022524. Show all entries for this paper.


Displaying record number 58390

HXB2 Location  Gag(322-336)   Gag Epitope Map
View variants at this location
Epitope LVQNANPDCKTILRA   Epitope Alignment
Variants
lLVQNANPDCKTILRk   subtype-specific susceptible form
LVQNANPDCKsILRA   subtype-specific susceptible form
LVQNANPDCKTILkA   subtype-specific susceptible form
Epitope Name Peptide 80
Species (MHC/HLA human

Variant Details

Showing all: 3 variant(s).


Variant ID.  2925
Epitope Seq.  xLVQNANPDCKTILRA
Variant Seq.  lLVQNANPDCKTILRk
Mutations x/L A/K
Epitope Location x1L A16K
HXB2 Location x322L A337K
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype C
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note Consensus Clade-B peptide 80, lLVQNANPDCKTILRk, cross reacted to elicit a response from South African subjects carrying clade-C virus.


Variant ID.  2926
Epitope Seq.  LVQNANPDCKTILRA
Variant Seq.  LVQNANPDCKsILRA
Mutations T/S
Epitope Location T11S
HXB2 Location T332S
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype C
Variant Subtype A
Method CD8 T-cell Elispot - IFNy, Sequence
Note Consensus Clade-A peptide 80, LVQNANPDCKsILRA, cross reacted to elicit a response from South African subjects carrying clade-C virus.


Variant ID.  2927
Epitope Seq.  LVQNANPDCKTILRA
Variant Seq.  LVQNANPDCKTILkA
Mutations R/K
Epitope Location R14K
HXB2 Location R335K
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype C
Variant Subtype D
Method CD8 T-cell Elispot - IFNy, Sequence
Note Consensus Clade-D peptide 80, LVQNANPDCKTILkA, cross reacted to elicit a response from South African subjects carrying clade-C virus.

References

Zembe2011 Lycias Zembe, Wendy A. Burgers, Heather B. Jaspan, Linda-Gail Bekker, Helba Bredell, Gwynneth Stevens, Jill Gilmour, Josephine H. Cox, Patricia Fast, Peter Hayes, Eftyhia Vardas, Carolyn Williamson, and Clive M. Gray. Intra- and Inter-Clade Cross-Reactivity by HIV-1 Gag Specific T-Cells Reveals Exclusive and Commonly Targeted Regions: Implications for Current Vaccine Trials. PLoS One, 6(10):e26096, 2011. PubMed ID: 22022524. Show all entries for this paper.


Displaying record number 58391

HXB2 Location  Gag(358-373)   Gag Epitope Map
View variants at this location
Epitope HKARVLAEAMSQTNS   Epitope Alignment
Variants
HKARVLAEAMSQ(a)TN   subtype-specific susceptible form
HKARVLgtgarasvl   subtype-specific non-susceptible form
{g}HKARVLAEAMSQ(v)T   subtype-specific non-susceptible form
HKARVLAEAMSQaNg   subtype-specific non-susceptible form
Epitope Name Peptide 89
Species (MHC/HLA human

Variant Details

Showing all: 4 variant(s).


Variant ID.  2928
Epitope Seq.  HKARVLAEAMSQTNS
Variant Seq.  HKARVLAEAMSQ(a)TN
Mutations -/A
Epitope Location -(12.1)A
HXB2 Location -(369.1)A
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype C
Variant Subtype D
Method CD8 T-cell Elispot - IFNy, Sequence
Note Consensus Clade-D peptide 89, HKARVLAEAMSQ(a)TN, which carries an insertion, cross reacted to elicit a response from South African subjects carrying clade-C virus.


Variant ID.  2929
Epitope Seq.  HKARVLAEAMSQTNS
Variant Seq.  HKARVLgtgarasvl
Mutations M/A S/R Q/A T/S N/V S/L A/G E/T A/G
Epitope Location M10A S11R Q12A T13S N14V S15L A7G E8T A9G
HXB2 Location M367A S368R Q369A T370S N371V S372L A364G E365T A366G
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype C
Variant Subtype A
Method CD8 T-cell Elispot - IFNy, Sequence
Note Consensus Clade-A peptide 89, HKARVLgtgarasvl, did not elicit a response from South African subjects carrying clade-C virus.


Variant ID.  2930
Epitope Seq.  HKARVLAEAMSQTNS
Variant Seq.  {g}HKARVLAEAMSQ(v)T
Mutations -/V x/G
Epitope Location -(15.1)V x2G
HXB2 Location -(372.1)V x359G
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype C
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note Consensus Clade-B peptide 89, {g}HKARVLAEAMSQ(v)T, did not elicit a response from South African subjects carrying clade-C virus.


Variant ID.  2931
Epitope Seq.  HKARVLAEAMSQTNS
Variant Seq.  HKARVLAEAMSQaNg
Mutations T/A S/G
Epitope Location T13A S15G
HXB2 Location T370A S372G
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Sequence
Note Chinese Clade-C peptide 89, HKARVLAEAMSQaNg, did not elicit a response from South African subjects carrying clade-C virus.

References

Zembe2011 Lycias Zembe, Wendy A. Burgers, Heather B. Jaspan, Linda-Gail Bekker, Helba Bredell, Gwynneth Stevens, Jill Gilmour, Josephine H. Cox, Patricia Fast, Peter Hayes, Eftyhia Vardas, Carolyn Williamson, and Clive M. Gray. Intra- and Inter-Clade Cross-Reactivity by HIV-1 Gag Specific T-Cells Reveals Exclusive and Commonly Targeted Regions: Implications for Current Vaccine Trials. PLoS One, 6(10):e26096, 2011. PubMed ID: 22022524. Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Managed by Triad National Security, LLC for the U.S. Department of Energy’s National Nuclear Security Administration
Copyright © 2022 Triad National Security, LLC | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health