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Displaying record number 55092

HXB2 Location  Gag(162-172)   Gag Epitope Map
View variants at this location
Epitope KAFSPEVIPMF   Epitope Alignment
Variants
KgFSPEVIPMF   subtype-specific non-susceptible form; subtype-specific susceptible form
KnFSPEVIPMF   subtype-specific non-susceptible form; subtype-specific susceptible form
KsFSPEVIPMF   observed variant
KgFnPEVIPMF   diminished HLA binding or increased off-rate; subtype-specific non-susceptible form; subtype-specific susceptible form
KgFkPEVIPMF   diminished HLA binding or increased off-rate; subtype-specific non-susceptible form; subtype-specific susceptible form
KsFSPEtIPMF   observed variant
KAFSPEiIPMF   subtype-specific susceptible form
KsFSPEiIPMF   observed variant
KAFnPEVIPMF   observed variant
KAFnPEiIPMF   observed variant
rAFSPEVIPMF   observed variant
KAFSPkVIPMF   observed variant
KAlSPEVIPMF   susceptible form
KAFSPEVIPvF   susceptible form
KAFSqEVIPMF   non-susceptible form
KAFSPEaIPMF   observed variant
Epitope Name KF11
Species (MHC/HLA human(B*57:01, B*57:03)

Variant Details

Showing all: 16 variant(s).


Variant ID.  1885
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KgFSPEVIPMF
Mutations A/G
Epitope Location A2G
HXB2 Location A163G
Mutation Type SNSF: subtype-specific non-susceptible form
SSF: subtype-specific susceptible form
Epitope Subtype B, C
Variant Subtype B, C
Method CD8 T-cell Elispot - IFNy, Chromium-release assay, Intracellular cytokine staining, Sequence, Tetramer binding
Note This variant is seen in both Clades B and C and binds HLA-B*5703. A162G variant in Clade C is detected significantly more frequently than in Clade B and is preferentially selected in context of HLA-B*5703. This A2G variant was recognized by HLA-B*5701- and -B*5703-expressing subjects.


Variant ID.  1886
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KnFSPEVIPMF
Mutations A/N
Epitope Location A2N
HXB2 Location A163N
Mutation Type SNSF: subtype-specific non-susceptible form
SSF: subtype-specific susceptible form
Epitope Subtype B, C
Variant Subtype B, C
Method CD8 T-cell Elispot - IFNy, Chromium-release assay, Intracellular cytokine staining, Sequence, Tetramer binding
Note This variant is seen in both Clades B and C and binds HLA-B*5703 and -B*5701. A162N variant in Clade C is detected significantly more frequently than in Clade B and is preferentially selected in context of HLA-B*5703. This A2N variant was recognized by HLA-B*5701- and -B*5703-expressing subjects.


Variant ID.  1887
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KsFSPEVIPMF
Mutations A/S
Epitope Location A2S
HXB2 Location A163S
Mutation Type OV: observed variant
Epitope Subtype B, C
Variant Subtype B, C
Method Sequence
Note This variant is seen in both Clades B and C and binds HLA-B*5703. A162S variant in Clade C is detected significantly more frequently than in Clade B and is preferentially selected in context of HLA-B*5703.


Variant ID.  1889
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KgFnPEVIPMF
Mutations A/G S/N
Epitope Location A2G S4N
HXB2 Location A163G S165N
Mutation Type DHB: diminished HLA binding or increased off-rate
SNSF: subtype-specific non-susceptible form
SSF: subtype-specific susceptible form
Epitope Subtype B, C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Chromium-release assay, Intracellular cytokine staining, Sequence, Tetramer binding
Note This variant is seen only in Clade C and binds HLA-B*5703. S164N variant is seen most frequently and is preferentially selected in context of HLA-B*5703. This A2G-S4N variant was recognized by HLA-B*5701- but not by -B*5703-expressing subjects, though avidity of recognition was reduced.


Variant ID.  1890
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KgFkPEVIPMF
Mutations A/G S/K
Epitope Location A2G S4K
HXB2 Location A163G S165K
Mutation Type DHB: diminished HLA binding or increased off-rate
SNSF: subtype-specific non-susceptible form
SSF: subtype-specific susceptible form
Epitope Subtype B, C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Chromium-release assay, Intracellular cytokine staining, Sequence, Tetramer binding
Note This variant is seen only in Clade C and binds HLA-B*5703. S164K variant is seen most frequently and is preferentially selected in context of HLA-B*5703. This A2G-S4K variant was recognized by HLA-B*5701- but not by -B*5703-expressing subjects, though avidity of recognition was reduced.


Variant ID.  1892
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KsFSPEtIPMF
Mutations A/S V/T
Epitope Location A2S V7T
HXB2 Location A163S V168T
Mutation Type OV: observed variant
Epitope Subtype B, C
Variant Subtype C
Method Sequence
Note This variant is seen only in Clade C and binds HLA-B*5703.


Variant ID.  1893
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KAFSPEiIPMF
Mutations V/I
Epitope Location V7I
HXB2 Location V168I
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype B, C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Chromium-release assay, Intracellular cytokine staining, Sequence, Tetramer binding
Note This variant is seen only in Clade C and binds HLA-B*5701. The V7I variant was recognized by HLA-B*5701- and -B*5703-expressing subjects.


Variant ID.  1894
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KsFSPEiIPMF
Mutations A/S V/I
Epitope Location A2S V7I
HXB2 Location A163S V168I
Mutation Type OV: observed variant
Epitope Subtype B, C
Variant Subtype B
Method Sequence
Note This variant is seen only in Clade B and binds HLA-B*5703.


Variant ID.  1895
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KAFnPEVIPMF
Mutations S/N
Epitope Location S4N
HXB2 Location S165N
Mutation Type OV: observed variant
Epitope Subtype B, C
Variant Subtype B, C
Method Sequence
Note This variant was seen only in non-HLA-B57 carriers, in both Clades B and C sequences.


Variant ID.  1896
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KAFnPEiIPMF
Mutations S/N V/I
Epitope Location S4N V7I
HXB2 Location S165N V168I
Mutation Type OV: observed variant
Epitope Subtype B, C
Variant Subtype C
Method Sequence
Note This variant was seen only in non-HLA-B57 carriers, and only in their Clade C sequences.


Variant ID.  1897
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  rAFSPEVIPMF
Mutations K/R
Epitope Location K1R
HXB2 Location K162R
Mutation Type OV: observed variant
Epitope Subtype B, C
Variant Subtype B, C
Method Sequence
Note This variant was seen only in non-HLA-B57 carriers, in both Clades B and C sequences.


Variant ID.  1898
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KAFSPkVIPMF
Mutations E/K
Epitope Location E6K
HXB2 Location E167K
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype C
Method Sequence
Note This variant was seen only in non-HLA-B57 carriers, and only in Clade C sequences.


Variant ID.  1900
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KAlSPEVIPMF
Mutations F/L
Epitope Location F3L
HXB2 Location F164L
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Sequence
Note The F3L variant was recognized by HLA-B*5701- and -B*5703-expressing subjects.


Variant ID.  1901
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KAFSPEVIPvF
Mutations M/V
Epitope Location M10V
HXB2 Location M171V
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Sequence
Note The M10V variant was recognized by HLA-B*5701- and -B*5703-expressing subjects.


Variant ID.  1902
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KAFSqEVIPMF
Mutations P/Q
Epitope Location P5Q
HXB2 Location P166Q
Mutation Type NSF: non-susceptible form
Method CD8 T-cell Elispot - IFNy, Sequence
Note The P5Q variant was not recognized by HLA-B*5701- and -B*5703-expressing subjects.


Variant ID.  2268
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KAFSPEaIPMF
Mutations V/A
Epitope Location V7A
HXB2 Location V168A
Mutation Type OV: observed variant
Epitope Subtype C
Variant Subtype B
Method Sequence
Note This variant was seen only in non-HLA-B57 carriers, and only in Clade B sequences.

References

Yu2007a Xu G Yu, Mathias Lichterfeld, Senica Chetty, Katie L. Williams, Stanley K. Mui, Toshiyuki Miura, Nicole Frahm, Margaret E. Feeney, Yanhua Tang, Florencia Pereyra, Montiago X. Labute, Katja Pfafferott, Alisdair Leslie, Hayley Crawford, Rachel Allgaier, William Hildebrand, Richard Kaslow, Christian Brander, Todd M. Allen, Eric S. Rosenberg, Photini Kiepiela, Madhu Vajpayee, Paul A. Goepfert, Marcus Altfeld, Philip J. R. Goulder, and Bruce D Walker. Mutually Exclusive T-Cell Receptor Induction and Differential Susceptibility to Human Immunodeficiency Virus Type 1 Mutational Escape Associated with a Two-Amino-Acid Difference between HLA Class I Subtypes. J. Virol., 81(4):1619-1631, Feb 2007. PubMed ID: 17121793. Show all entries for this paper.


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