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Found 3 matching records:

Displaying record number 52791

HXB2 Location  Gag(77-85)   Gag Epitope Map
View variants at this location
Epitope SLYNTVATL   Epitope Alignment
Variants
SLfNTVATL   escape documented in this paper; susceptible form; TCR related mutation
SLYNTiATL   escape documented in this paper
SLYNTiAvL   escape documented in this paper; non-susceptible form; susceptible form; TCR related mutation
SLfNTiATL   escape documented in this paper; non-susceptible form; susceptible form; TCR related mutation
SLYNlVAvL   escape documented in this paper; non-susceptible form; TCR related mutation
SLYNTVAaL   observed variant
Epitope Name SL9
Species (MHC/HLA human(A2)

Variant Details

Showing all: 6 variant(s).


Variant ID.  1856
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfNTVATL
Mutations Y/F
Epitope Location Y3F
HXB2 Location Y79F
Mutation Type E: escape documented in this paper
SF: susceptible form
TCR: TCR related mutation
Method Chromium-release assay, Relative replication capacity assay, Sequence
Note CTL Clone 161JxA14 recognizes this variant but Clone 18030D23 from a different subject does not. Both clones recognize SL9 index sequence similarly.


Variant ID.  1857
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNTiATL
Mutations V/I
Epitope Location V6I
HXB2 Location V82I
Mutation Type E: escape documented in this paper
Method Chromium-release assay, Sequence
Note After 2 weeks of selective pressure by culturing with 1 of 4 SL9-specific clones i.e. 161JxA14, this variant arose and was not recognized.


Variant ID.  1858
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNTiAvL
Mutations V/I T/V
Epitope Location V6I T8V
HXB2 Location V82I T84V
Mutation Type E: escape documented in this paper
NSF: non-susceptible form
SF: susceptible form
TCR: TCR related mutation
Method Chromium-release assay, Relative replication capacity assay, Sequence
Note CTL Clone 18030D23 recognizes this variant but Clone 161JxA14 from a different subject does not. Both clones recognize SL9 Clade B index sequence similarly. Since the clones are from different HIV-1 infected subjects, with different TCR sequences, TCR is seen to contribute to escape differentially in this instance.


Variant ID.  1859
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfNTiATL
Mutations Y/F V/I
Epitope Location Y3F V6I
HXB2 Location Y79F V82I
Mutation Type E: escape documented in this paper
NSF: non-susceptible form
SF: susceptible form
TCR: TCR related mutation
Method Chromium-release assay, Relative replication capacity assay, Sequence
Note CTL Clone 18030D23 recognizes this variant but Clone 161JxA14 from a different subject does not. Both clones recognize SL9 index sequence similarly. Since the clones are from different HIV-1 infected subjects, with different TCR sequences, TCR is seen to contribute to escape differentially in this instance.


Variant ID.  1860
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNlVAvL
Mutations T/L T/V
Epitope Location T5L T8V
HXB2 Location T81L T84V
Mutation Type E: escape documented in this paper
NSF: non-susceptible form
TCR: TCR related mutation
Method Chromium-release assay, Relative replication capacity assay, Sequence
Note CTL Clones 18030D23 and 161JxA14 from different subjects do not recognize this variant. Both clones recognize SL9 index sequence similarly. Since the clones are from different HIV-1 infected subjects, with different TCR sequences, TCR is seen to contribute to escape differentially in this instance.


Variant ID.  1861
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNTVAaL
Mutations T/A
Epitope Location T8A
HXB2 Location T84A
Mutation Type OV: observed variant
Method Chromium-release assay, Sequence
Note This minority epitope variant was seen after 2 weeks of selection by SL9-specific clone 18030D23.

References

Yang2003 Otto O Yang, Phuong Thi Nguyen Sarkis, Ayub Ali, Jason D Harlow, Christian Brander, Spyros A Kalams, and Bruce D Walker. Determinant of HIV-1 Mutational Escape from Cytotoxic T Lymphocytes. J. Exp. Med., 197(10):1365-1375, May 2003. PubMed ID: 12743169. Show all entries for this paper.


Displaying record number 52787

HXB2 Location  Pol(464-472)   Pol Epitope Map
View variants at this location
Epitope ILKEPVHGV   Epitope Alignment
Variants
ILKElVHGV   escape documented in this paper
Epitope Name IV9
Species (MHC/HLA human(A2)

Variant Details

Showing all: 1 variant(s).


Variant ID.  1862
Epitope Seq.  ILKEPVHGV
Variant Seq.  ILKElVHGV
Mutations P/L
Epitope Location P5L
HXB2 Location P468L
Mutation Type E: escape documented in this paper
Method Chromium-release assay, Sequence
Note After 2 weeks of passaging under selection by IV9-specific clone 68A62, this escape variant that was not recognized emerged.

References

Yang2003 Otto O Yang, Phuong Thi Nguyen Sarkis, Ayub Ali, Jason D Harlow, Christian Brander, Spyros A Kalams, and Bruce D Walker. Determinant of HIV-1 Mutational Escape from Cytotoxic T Lymphocytes. J. Exp. Med., 197(10):1365-1375, May 2003. PubMed ID: 12743169. Show all entries for this paper.


Displaying record number 52790

HXB2 Location  Nef(92-100)   Nef Epitope Map
View variants at this location
Epitope KEKGGLEGL   Epitope Alignment
Variants
KEKGGLEGi   escape documented in this paper
KkKGGLEGL   escape documented in this paper
KEKGGLEGp   escape documented in this paper
KEKGGLEeL   escape documented in this paper
KEKGGLErL   escape documented in this paper
KEKrGLErL   escape documented in this paper
KEnGGLEGL   escape documented in this paper
Epitope Name KL9
Species (MHC/HLA human(B60)

Variant Details

Showing all: 7 variant(s).


Variant ID.  1863
Epitope Seq.  KEKGGLEGL
Variant Seq.  KEKGGLEGi
Mutations L/I
Epitope Location L9I
HXB2 Location L100I
Mutation Type E: escape documented in this paper
Method Chromium-release assay, Sequence
Note After one round of week-long passaging under selection by KL9-specific CTL clone, STD11, this mutation was seen. It was not recognized.


Variant ID.  1864
Epitope Seq.  KEKGGLEGL
Variant Seq.  KkKGGLEGL
Mutations E/K
Epitope Location E2K
HXB2 Location E93K
Mutation Type E: escape documented in this paper
Method Chromium-release assay, Sequence
Note After one round of week-long passaging under selection by KL9-specific CTL clone, STD11, this mutation was seen. It was not recognized.


Variant ID.  1865
Epitope Seq.  KEKGGLEGL
Variant Seq.  KEKGGLEGp
Mutations L/P
Epitope Location L9P
HXB2 Location L100P
Mutation Type E: escape documented in this paper
Method Chromium-release assay, Sequence
Note After 2 weeks of passaging under selection by KL9-specific clone STD11, this escape variant that was not recognized emerged.


Variant ID.  1866
Epitope Seq.  KEKGGLEGL
Variant Seq.  KEKGGLEeL
Mutations G/E
Epitope Location G8E
HXB2 Location G99E
Mutation Type E: escape documented in this paper
Method Chromium-release assay, Sequence
Note After 2 weeks of passaging under selection by KL9-specific clone STD11, this escape variant that was not recognized emerged.


Variant ID.  1867
Epitope Seq.  KEKGGLEGL
Variant Seq.  KEKGGLErL
Mutations G/R
Epitope Location G8R
HXB2 Location G99R
Mutation Type E: escape documented in this paper
Method Chromium-release assay, Sequence
Note After 2 weeks of passaging under selection by KL9-specific clone STD11, this escape variant that was not recognized emerged.


Variant ID.  1868
Epitope Seq.  KEKGGLEGL
Variant Seq.  KEKrGLErL
Mutations G/R G/R
Epitope Location G4R G8R
HXB2 Location G95R G99R
Mutation Type E: escape documented in this paper
Method Chromium-release assay, Sequence
Note After 2 weeks of passaging under selection by KL9-specific clone STD11, this escape variant that was not recognized emerged.


Variant ID.  1869
Epitope Seq.  KEKGGLEGL
Variant Seq.  KEnGGLEGL
Mutations K/N
Epitope Location K3N
HXB2 Location K94N
Mutation Type E: escape documented in this paper
Method Chromium-release assay, Sequence
Note After 2 weeks of passaging under selection by KL9-specific clone STD11, this escape variant that was not recognized emerged.

References

Yang2003 Otto O Yang, Phuong Thi Nguyen Sarkis, Ayub Ali, Jason D Harlow, Christian Brander, Spyros A Kalams, and Bruce D Walker. Determinant of HIV-1 Mutational Escape from Cytotoxic T Lymphocytes. J. Exp. Med., 197(10):1365-1375, May 2003. PubMed ID: 12743169. Show all entries for this paper.


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