HIV molecular immunology database

 

Search the Epitope Variant and Escape Mutation Database

Help


Found 9 matching records:

Displaying record number 5

HXB2 Location  Gag(18-26)   Gag Epitope Map
View variants at this location
Epitope KIRLRPGGK   Epitope Alignment
Variants
KIRLRPGGr   escape documented in this paper
rIRLRPGGr   escape documented in this paper
Species (MHC/HLA human(A3)

Variant Details

Showing all: 2 variant(s).


Variant ID.  1838
Epitope Seq.  KIRLRPGGK
Variant Seq.  KIRLRPGGr
Mutations K/R
Epitope Location K9R
HXB2 Location K26R
Mutation Type E: escape documented in this paper
Method Chromium-release assay
Note This escape was not recognized by HIV-transmitting mothers


Variant ID.  1839
Epitope Seq.  KIRLRPGGK
Variant Seq.  rIRLRPGGr
Mutations K/R K/R
Epitope Location K1R K9R
HXB2 Location K18R K26R
Mutation Type E: escape documented in this paper
Method Chromium-release assay
Note This escape was not recognized by HIV-transmitting mothers

References

Wilson1999a C. C. Wilson, R. C. Brown, B. T. Korber, B. M. Wilkes, D. J. Ruhl, D. Sakamoto, K. Kunstman, K. Luzuriaga, I. C. Hanson, S. M. Widmayer, A. Wiznia, S. Clapp, A. J. Ammann, R. A. Koup, S. M. Wolinsky, and B. D. Walker. Frequent Detection of Escape from Cytotoxic T-Lymphocyte Recognition in Perinatal Human Immunodeficiency Virus (HIV) Type 1 Transmission: The Ariel Project for the Prevention of Transmission of HIV from Mother to Infant. J. Virol., 73:3975-3985, 1999. PubMed ID: 10196293. Show all entries for this paper.


Displaying record number 330

HXB2 Location  Gag(298-306)   Gag Epitope Map
View variants at this location
Epitope DRFYKTLRA   Epitope Alignment
Variants
DRFYKiLRA   escape documented in this paper
Species (MHC/HLA human(B14)

Variant Details

Showing all: 1 variant(s).


Variant ID.  1840
Epitope Seq.  DRFYKTLRA
Variant Seq.  DRFYKiLRA
Mutations T/I
Epitope Location T6I
HXB2 Location T303I
Mutation Type E: escape documented in this paper
Method Chromium-release assay
Note This escape was not recognized by an HIV-transmitting mother.

References

Wilson1999a C. C. Wilson, R. C. Brown, B. T. Korber, B. M. Wilkes, D. J. Ruhl, D. Sakamoto, K. Kunstman, K. Luzuriaga, I. C. Hanson, S. M. Widmayer, A. Wiznia, S. Clapp, A. J. Ammann, R. A. Koup, S. M. Wolinsky, and B. D. Walker. Frequent Detection of Escape from Cytotoxic T-Lymphocyte Recognition in Perinatal Human Immunodeficiency Virus (HIV) Type 1 Transmission: The Ariel Project for the Prevention of Transmission of HIV from Mother to Infant. J. Virol., 73:3975-3985, 1999. PubMed ID: 10196293. Show all entries for this paper.


Displaying record number 421

HXB2 Location  Pol(262-270)   Pol Epitope Map
View variants at this location
Epitope TVLDVGDAY   Epitope Alignment
Variants
TVLDmGDAc   susceptible form
Species (MHC/HLA human(B35)

Variant Details

Showing all: 1 variant(s).


Variant ID.  1841
Epitope Seq.  TVLDVGDAY
Variant Seq.  TVLDmGDAc
Mutations V/M Y/C
Epitope Location V5M Y9C
HXB2 Location V266M Y270C
Mutation Type SF: susceptible form
Method Chromium-release assay
Note This variant was recognized by a non-transmitting mother.

References

Wilson1999a C. C. Wilson, R. C. Brown, B. T. Korber, B. M. Wilkes, D. J. Ruhl, D. Sakamoto, K. Kunstman, K. Luzuriaga, I. C. Hanson, S. M. Widmayer, A. Wiznia, S. Clapp, A. J. Ammann, R. A. Koup, S. M. Wolinsky, and B. D. Walker. Frequent Detection of Escape from Cytotoxic T-Lymphocyte Recognition in Perinatal Human Immunodeficiency Virus (HIV) Type 1 Transmission: The Ariel Project for the Prevention of Transmission of HIV from Mother to Infant. J. Virol., 73:3975-3985, 1999. PubMed ID: 10196293. Show all entries for this paper.


Displaying record number 452

HXB2 Location  Pol(313-321)   Pol Epitope Map
View variants at this location
Epitope AIFQSSMTK   Epitope Alignment
Variants
AIFQSSMTr   susceptible form
AIFlSSMTK   escape documented in this paper
tIsQSSMTK   escape documented in this paper
AIlQSSMTK   observed variant
Species (MHC/HLA human(A3)

Variant Details

Showing all: 4 variant(s).


Variant ID.  1842
Epitope Seq.  AIFQSSMTK
Variant Seq.  AIFQSSMTr
Mutations K/R
Epitope Location K9R
HXB2 Location K321R
Mutation Type SF: susceptible form
Method Chromium-release assay
Note This variant was recognized by an infected infant.


Variant ID.  1844
Epitope Seq.  AIFQSSMTK
Variant Seq.  AIFlSSMTK
Mutations Q/L
Epitope Location Q4L
HXB2 Location Q316L
Mutation Type E: escape documented in this paper
Method Chromium-release assay
Note This variant was not recognized by an infected infant.


Variant ID.  1845
Epitope Seq.  AIFQSSMTK
Variant Seq.  tIsQSSMTK
Mutations A/T F/S
Epitope Location A1T F3S
HXB2 Location A313T F315S
Mutation Type E: escape documented in this paper
Method Chromium-release assay
Note This variant was not recognized by an infected infant.


Variant ID.  2266
Epitope Seq.  AIFQSSMTK
Variant Seq.  AIlQSSMTK
Mutations F/L
Epitope Location F3L
HXB2 Location F315L
Mutation Type OV: observed variant
Method Chromium-release assay, Sequence
Note This variant was not tested for CTL recognition by infant carrying it.

References

Wilson1999a C. C. Wilson, R. C. Brown, B. T. Korber, B. M. Wilkes, D. J. Ruhl, D. Sakamoto, K. Kunstman, K. Luzuriaga, I. C. Hanson, S. M. Widmayer, A. Wiznia, S. Clapp, A. J. Ammann, R. A. Koup, S. M. Wolinsky, and B. D. Walker. Frequent Detection of Escape from Cytotoxic T-Lymphocyte Recognition in Perinatal Human Immunodeficiency Virus (HIV) Type 1 Transmission: The Ariel Project for the Prevention of Transmission of HIV from Mother to Infant. J. Virol., 73:3975-3985, 1999. PubMed ID: 10196293. Show all entries for this paper.


Displaying record number 493

HXB2 Location  Pol(426-434)   Pol Epitope Map
View variants at this location
Epitope YPGIKVRQL   Epitope Alignment
Variants
YPGIKVkQL   susceptible form
YaGIKVRQL   susceptible form
YhGIKVRQL   escape documented in this paper
YhkIKVRQL   observed variant
Species (MHC/HLA human(B42)

Variant Details

Showing all: 4 variant(s).


Variant ID.  1846
Epitope Seq.  YPGIKVRQL
Variant Seq.  YPGIKVkQL
Mutations R/K
Epitope Location R7K
HXB2 Location R432K
Mutation Type SF: susceptible form
Method Chromium-release assay
Note This variant was recognized by an HIV-transmitting mother.


Variant ID.  1847
Epitope Seq.  YPGIKVRQL
Variant Seq.  YaGIKVRQL
Mutations P/A
Epitope Location P2A
HXB2 Location P427A
Mutation Type SF: susceptible form
Method Chromium-release assay
Note This variant was recognized by an HIV-transmitting mother as well as her infected infant.


Variant ID.  1848
Epitope Seq.  YPGIKVRQL
Variant Seq.  YhGIKVRQL
Mutations P/H
Epitope Location P2H
HXB2 Location P427H
Mutation Type E: escape documented in this paper
Method Chromium-release assay
Note This variant was not recognized by an HIV-transmitting mother.


Variant ID.  2267
Epitope Seq.  YPGIKVRQL
Variant Seq.  YhkIKVRQL
Mutations P/H G/K
Epitope Location P2H G3K
HXB2 Location P427H G428K
Mutation Type OV: observed variant
Method Chromium-release assay, Sequence
Note This variant was not tested for CTL recognition by an HIV-transmitting mother.

References

Wilson1999a C. C. Wilson, R. C. Brown, B. T. Korber, B. M. Wilkes, D. J. Ruhl, D. Sakamoto, K. Kunstman, K. Luzuriaga, I. C. Hanson, S. M. Widmayer, A. Wiznia, S. Clapp, A. J. Ammann, R. A. Koup, S. M. Wolinsky, and B. D. Walker. Frequent Detection of Escape from Cytotoxic T-Lymphocyte Recognition in Perinatal Human Immunodeficiency Virus (HIV) Type 1 Transmission: The Ariel Project for the Prevention of Transmission of HIV from Mother to Infant. J. Virol., 73:3975-3985, 1999. PubMed ID: 10196293. Show all entries for this paper.


Displaying record number 565

HXB2 Location  Pol(593-603)   Pol Epitope Map
View variants at this location
Epitope ETFYVDGAANR   Epitope Alignment
Variants
ETyYVnGAANR   diminished response
Species (MHC/HLA human(A26)

Variant Details

Showing all: 1 variant(s).


Variant ID.  1850
Epitope Seq.  ETFYVDGAANR
Variant Seq.  ETyYVnGAANR
Mutations F/Y D/N
Epitope Location F3Y D6N
HXB2 Location F595Y D598N
Mutation Type DR: diminished response
Method Chromium-release assay
Note This variant showed reduced CTL recognition by a non-transmitting mother.

References

Wilson1999a C. C. Wilson, R. C. Brown, B. T. Korber, B. M. Wilkes, D. J. Ruhl, D. Sakamoto, K. Kunstman, K. Luzuriaga, I. C. Hanson, S. M. Widmayer, A. Wiznia, S. Clapp, A. J. Ammann, R. A. Koup, S. M. Wolinsky, and B. D. Walker. Frequent Detection of Escape from Cytotoxic T-Lymphocyte Recognition in Perinatal Human Immunodeficiency Virus (HIV) Type 1 Transmission: The Ariel Project for the Prevention of Transmission of HIV from Mother to Infant. J. Virol., 73:3975-3985, 1999. PubMed ID: 10196293. Show all entries for this paper.


Displaying record number 780

HXB2 Location  gp160(375-383)   gp160 Epitope Map
View variants at this location
Epitope SFTCGGEFF   Epitope Alignment
Variants
SsTCGGEFF   diminished response
SFTCGGgvF   escape documented in this paper
SFTCGGgFF   diminished response
Species (MHC/HLA human(B15)

Variant Details

Showing all: 3 variant(s).


Variant ID.  1851
Epitope Seq.  SFTCGGEFF
Variant Seq.  SsTCGGEFF
Mutations F/S
Epitope Location F2S
HXB2 Location F376S
Mutation Type DR: diminished response
Method Chromium-release assay
Note This variant showed reduced CTL recognition by an HIV-transmitting mother.


Variant ID.  1852
Epitope Seq.  SFTCGGEFF
Variant Seq.  SFTCGGgvF
Mutations E/G F/V
Epitope Location E7G F8V
HXB2 Location E381G F382V
Mutation Type E: escape documented in this paper
Method Chromium-release assay
Note This escape was not recognized by an HIV-transmitting mother.


Variant ID.  1853
Epitope Seq.  SFTCGGEFF
Variant Seq.  SFTCGGgFF
Mutations E/G
Epitope Location E7G
HXB2 Location E381G
Mutation Type DR: diminished response
Method Chromium-release assay
Note This variant showed reduced CTL recognition by an HIV-transmitting mother.

References

Wilson1999a C. C. Wilson, R. C. Brown, B. T. Korber, B. M. Wilkes, D. J. Ruhl, D. Sakamoto, K. Kunstman, K. Luzuriaga, I. C. Hanson, S. M. Widmayer, A. Wiznia, S. Clapp, A. J. Ammann, R. A. Koup, S. M. Wolinsky, and B. D. Walker. Frequent Detection of Escape from Cytotoxic T-Lymphocyte Recognition in Perinatal Human Immunodeficiency Virus (HIV) Type 1 Transmission: The Ariel Project for the Prevention of Transmission of HIV from Mother to Infant. J. Virol., 73:3975-3985, 1999. PubMed ID: 10196293. Show all entries for this paper.


Displaying record number 783

HXB2 Location  gp160(376-384)   gp160 Epitope Map
View variants at this location
Epitope PNCGGEFFY   Epitope Alignment
Variants
PNCrGEFFY   escape documented in this paper
Species (MHC/HLA human(A29)

Variant Details

Showing all: 1 variant(s).


Variant ID.  1854
Epitope Seq.  PNCGGEFFY
Variant Seq.  PNCrGEFFY
Mutations G/R
Epitope Location G4R
HXB2 Location G379R
Mutation Type E: escape documented in this paper
Method Chromium-release assay
Note This variant was not recognized by a non-transmitting mother.

References

Wilson1999a C. C. Wilson, R. C. Brown, B. T. Korber, B. M. Wilkes, D. J. Ruhl, D. Sakamoto, K. Kunstman, K. Luzuriaga, I. C. Hanson, S. M. Widmayer, A. Wiznia, S. Clapp, A. J. Ammann, R. A. Koup, S. M. Wolinsky, and B. D. Walker. Frequent Detection of Escape from Cytotoxic T-Lymphocyte Recognition in Perinatal Human Immunodeficiency Virus (HIV) Type 1 Transmission: The Ariel Project for the Prevention of Transmission of HIV from Mother to Infant. J. Virol., 73:3975-3985, 1999. PubMed ID: 10196293. Show all entries for this paper.


Displaying record number 1045

HXB2 Location  Nef(120-128)   Nef Epitope Map
View variants at this location
Epitope FFPDWKNYT   Epitope Alignment
Variants
lFPDWKNYT   escape documented in this paper
Species (MHC/HLA human(B15)

Variant Details

Showing all: 1 variant(s).


Variant ID.  1855
Epitope Seq.  FFPDWKNYT
Variant Seq.  lFPDWKNYT
Mutations F/L
Epitope Location F1L
HXB2 Location F120L
Mutation Type E: escape documented in this paper
Method Chromium-release assay
Note This escape was not recognized by an infected infant.

References

Wilson1999a C. C. Wilson, R. C. Brown, B. T. Korber, B. M. Wilkes, D. J. Ruhl, D. Sakamoto, K. Kunstman, K. Luzuriaga, I. C. Hanson, S. M. Widmayer, A. Wiznia, S. Clapp, A. J. Ammann, R. A. Koup, S. M. Wolinsky, and B. D. Walker. Frequent Detection of Escape from Cytotoxic T-Lymphocyte Recognition in Perinatal Human Immunodeficiency Virus (HIV) Type 1 Transmission: The Ariel Project for the Prevention of Transmission of HIV from Mother to Infant. J. Virol., 73:3975-3985, 1999. PubMed ID: 10196293. Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Managed by Triad National Security, LLC for the U.S. Department of Energy’s National Nuclear Security Administration
Copyright © 2022 Triad National Security, LLC | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health