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Found 9 matching records:

Displaying record number 5

HXB2 Location Gag(18-26) Gag Epitope Map
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KIRLRPGGK

`KIRLRPGGr`		escape documented in this paper
`rIRLRPGGr`		escape documented in this paper

Species (MHC/HLA) human(A3)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`1838`
Epitope Seq.	`KIRLRPGGK`
Variant Seq.	`KIRLRPGGr`
Mutations	K/R
Epitope Location	K9R
HXB2 Location	K26R
Mutation Type	E: escape documented in this paper
Method	Chromium-release assay
Note	This escape was not recognized by HIV-transmitting mothers

Variant ID.	`1839`
Epitope Seq.	`KIRLRPGGK`
Variant Seq.	`rIRLRPGGr`
Mutations	K/R K/R
Epitope Location	K1R K9R
HXB2 Location	K18R K26R
Mutation Type	E: escape documented in this paper
Method	Chromium-release assay
Note	This escape was not recognized by HIV-transmitting mothers

References

Wilson1999a C. C. Wilson, R. C. Brown, B. T. Korber, B. M. Wilkes, D. J. Ruhl, D. Sakamoto, K. Kunstman, K. Luzuriaga, I. C. Hanson, S. M. Widmayer, A. Wiznia, S. Clapp, A. J. Ammann, R. A. Koup, S. M. Wolinsky, and B. D. Walker. Frequent Detection of Escape from Cytotoxic T-Lymphocyte Recognition in Perinatal Human Immunodeficiency Virus (HIV) Type 1 Transmission: The Ariel Project for the Prevention of Transmission of HIV from Mother to Infant. J. Virol., 73:3975-3985, 1999. PubMed ID: 10196293. Show all entries for this paper.

Displaying record number 330

HXB2 Location Gag(298-306) Gag Epitope Map
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Epitope

DRFYKTLRA

Epitope Alignment

Variants

DRFYKiLRA escape documented in this paper

Species (MHC/HLA) human(B14)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`1840`
Epitope Seq.	`DRFYKTLRA`
Variant Seq.	`DRFYKiLRA`
Mutations	T/I
Epitope Location	T6I
HXB2 Location	T303I
Mutation Type	E: escape documented in this paper
Method	Chromium-release assay
Note	This escape was not recognized by an HIV-transmitting mother.

References

Displaying record number 421

HXB2 Location Pol(262-270) Pol Epitope Map
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Epitope

TVLDVGDAY

Epitope Alignment

Variants

TVLDmGDAc susceptible form

Species (MHC/HLA) human(B35)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`1841`
Epitope Seq.	`TVLDVGDAY`
Variant Seq.	`TVLDmGDAc`
Mutations	V/M Y/C
Epitope Location	V5M Y9C
HXB2 Location	V266M Y270C
Mutation Type	SF: susceptible form
Method	Chromium-release assay
Note	This variant was recognized by a non-transmitting mother.

References

Displaying record number 452

HXB2 Location Pol(313-321) Pol Epitope Map
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Epitope

AIFQSSMTK

Epitope Alignment

Variants

`AIFQSSMTr`		susceptible form
`AIFlSSMTK`		escape documented in this paper
`tIsQSSMTK`		escape documented in this paper
`AIlQSSMTK`		observed variant

Species (MHC/HLA) human(A3)

Variant Details

Showing all: 4 variant(s).

Variant ID.	`1842`
Epitope Seq.	`AIFQSSMTK`
Variant Seq.	`AIFQSSMTr`
Mutations	K/R
Epitope Location	K9R
HXB2 Location	K321R
Mutation Type	SF: susceptible form
Method	Chromium-release assay
Note	This variant was recognized by an infected infant.

Variant ID.	`1844`
Epitope Seq.	`AIFQSSMTK`
Variant Seq.	`AIFlSSMTK`
Mutations	Q/L
Epitope Location	Q4L
HXB2 Location	Q316L
Mutation Type	E: escape documented in this paper
Method	Chromium-release assay
Note	This variant was not recognized by an infected infant.

Variant ID.	`1845`
Epitope Seq.	`AIFQSSMTK`
Variant Seq.	`tIsQSSMTK`
Mutations	A/T F/S
Epitope Location	A1T F3S
HXB2 Location	A313T F315S
Mutation Type	E: escape documented in this paper
Method	Chromium-release assay
Note	This variant was not recognized by an infected infant.

Variant ID.	`2266`
Epitope Seq.	`AIFQSSMTK`
Variant Seq.	`AIlQSSMTK`
Mutations	F/L
Epitope Location	F3L
HXB2 Location	F315L
Mutation Type	OV: observed variant
Method	Chromium-release assay, Sequence
Note	This variant was not tested for CTL recognition by infant carrying it.

References

Displaying record number 493

HXB2 Location Pol(426-434) Pol Epitope Map
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Epitope

YPGIKVRQL

Epitope Alignment

Variants

`YPGIKVkQL`		susceptible form
`YaGIKVRQL`		susceptible form
`YhGIKVRQL`		escape documented in this paper
`YhkIKVRQL`		observed variant

Species (MHC/HLA) human(B42)

Variant Details

Showing all: 4 variant(s).

Variant ID.	`1846`
Epitope Seq.	`YPGIKVRQL`
Variant Seq.	`YPGIKVkQL`
Mutations	R/K
Epitope Location	R7K
HXB2 Location	R432K
Mutation Type	SF: susceptible form
Method	Chromium-release assay
Note	This variant was recognized by an HIV-transmitting mother.

Variant ID.	`1847`
Epitope Seq.	`YPGIKVRQL`
Variant Seq.	`YaGIKVRQL`
Mutations	P/A
Epitope Location	P2A
HXB2 Location	P427A
Mutation Type	SF: susceptible form
Method	Chromium-release assay
Note	This variant was recognized by an HIV-transmitting mother as well as her infected infant.

Variant ID.	`1848`
Epitope Seq.	`YPGIKVRQL`
Variant Seq.	`YhGIKVRQL`
Mutations	P/H
Epitope Location	P2H
HXB2 Location	P427H
Mutation Type	E: escape documented in this paper
Method	Chromium-release assay
Note	This variant was not recognized by an HIV-transmitting mother.

Variant ID.	`2267`
Epitope Seq.	`YPGIKVRQL`
Variant Seq.	`YhkIKVRQL`
Mutations	P/H G/K
Epitope Location	P2H G3K
HXB2 Location	P427H G428K
Mutation Type	OV: observed variant
Method	Chromium-release assay, Sequence
Note	This variant was not tested for CTL recognition by an HIV-transmitting mother.

References

Displaying record number 565

HXB2 Location Pol(593-603) Pol Epitope Map
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Epitope

ETFYVDGAANR

Epitope Alignment

Variants

ETyYVnGAANR diminished response

Species (MHC/HLA) human(A26)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`1850`
Epitope Seq.	`ETFYVDGAANR`
Variant Seq.	`ETyYVnGAANR`
Mutations	F/Y D/N
Epitope Location	F3Y D6N
HXB2 Location	F595Y D598N
Mutation Type	DR: diminished response
Method	Chromium-release assay
Note	This variant showed reduced CTL recognition by a non-transmitting mother.

References

Displaying record number 780

HXB2 Location gp160(375-383) gp160 Epitope Map
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Epitope

SFTCGGEFF

Epitope Alignment

Variants

`SsTCGGEFF`		diminished response
`SFTCGGgvF`		escape documented in this paper
`SFTCGGgFF`		diminished response

Species (MHC/HLA) human(B15)

Variant Details

Showing all: 3 variant(s).

Variant ID.	`1851`
Epitope Seq.	`SFTCGGEFF`
Variant Seq.	`SsTCGGEFF`
Mutations	F/S
Epitope Location	F2S
HXB2 Location	F376S
Mutation Type	DR: diminished response
Method	Chromium-release assay
Note	This variant showed reduced CTL recognition by an HIV-transmitting mother.

Variant ID.	`1852`
Epitope Seq.	`SFTCGGEFF`
Variant Seq.	`SFTCGGgvF`
Mutations	E/G F/V
Epitope Location	E7G F8V
HXB2 Location	E381G F382V
Mutation Type	E: escape documented in this paper
Method	Chromium-release assay
Note	This escape was not recognized by an HIV-transmitting mother.

Variant ID.	`1853`
Epitope Seq.	`SFTCGGEFF`
Variant Seq.	`SFTCGGgFF`
Mutations	E/G
Epitope Location	E7G
HXB2 Location	E381G
Mutation Type	DR: diminished response
Method	Chromium-release assay
Note	This variant showed reduced CTL recognition by an HIV-transmitting mother.

References

Displaying record number 783

HXB2 Location gp160(376-384) gp160 Epitope Map
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Epitope

PNCGGEFFY

Epitope Alignment

Variants

PNCrGEFFY escape documented in this paper

Species (MHC/HLA) human(A29)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`1854`
Epitope Seq.	`PNCGGEFFY`
Variant Seq.	`PNCrGEFFY`
Mutations	G/R
Epitope Location	G4R
HXB2 Location	G379R
Mutation Type	E: escape documented in this paper
Method	Chromium-release assay
Note	This variant was not recognized by a non-transmitting mother.

References

Displaying record number 1045

HXB2 Location Nef(120-128) Nef Epitope Map
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Epitope

FFPDWKNYT

Epitope Alignment

Variants

lFPDWKNYT escape documented in this paper

Species (MHC/HLA) human(B15)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`1855`
Epitope Seq.	`FFPDWKNYT`
Variant Seq.	`lFPDWKNYT`
Mutations	F/L
Epitope Location	F1L
HXB2 Location	F120L
Mutation Type	E: escape documented in this paper
Method	Chromium-release assay
Note	This escape was not recognized by an infected infant.