HIV molecular immunology database
Found 22 matching records:
HXB2 Location | Gag(31-41) | Gag Epitope Map
View variants at this location |
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Epitope |
LKHIVWASREL
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Epitope Alignment | ||||
Variants |
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Epitope Name | Gag LL11 | |||||
Species (MHC/HLA) | human(A*02:06) |
Showing all: 1 variant(s).
Variant ID. | 3930 |
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Epitope Seq. | LKHIVWASREL |
Variant Seq. | mKHlVWASREL |
Mutations | L/M I/L |
Epitope Location | L1M I4L |
HXB2 Location | L31M I34L |
Mutation Type | SSF: subtype-specific susceptible form |
Epitope Subtype | B |
Variant Subtype | CRF01_AE |
Method | Intracellular cytokine staining, Sequence |
Note | A/E clade epitope mKHlVWASREL was found in 14/26 A/E patients of the KI cohort, though it was found in no B virus and 147/315 clade A/E virus sequences in the Los Alamos HIV-1 database. It was not recognized by CTL from clade A/E-infected patient KI-388 which had been elicited by consensus clade B LL11. |
Watanabe2013 Koji Watanabe, Hayato Murakoshi, Yoshiko Tamura, Madoka Koyanagi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Identification of Cross-Clade CTL Epitopes in HIV-1 Clade A/E-Infected Individuals by Using the Clade B Overlapping Peptides. Microbes Infect., 15(13):874-886, Nov 2013. PubMed ID: 23968885. Show all entries for this paper.
HXB2 Location | Gag(31-41) | Gag Epitope Map
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Epitope |
MKHLVWASREL
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Epitope Alignment | ||||
Variants |
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Epitope Name | Gag LL11-1M-4L | |||||
Species (MHC/HLA) | human(A*02:06) |
Showing all: 1 variant(s).
Variant ID. | 3931 |
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Epitope Seq. | MKHLVWASREL |
Variant Seq. | lKHiVWASREL |
Mutations | M/L L/I |
Epitope Location | M1L L4I |
HXB2 Location | M31L L34I |
Mutation Type | SSF: subtype-specific susceptible form |
Epitope Subtype | CRF01_AE |
Variant Subtype | B |
Method | Intracellular cytokine staining, Sequence |
Note | B clade epitope lKHiVWASREL was found in 2/26 A/E patients of the KI cohort, though it was found in 1182/1644 B virus and 18/315 clade A/E virus sequences in the Los Alamos HIV-1 database. It was recognized by CTL from clade A/E-infected patient KI-388 which had been elicited by consensus clade B LL11. |
Watanabe2013 Koji Watanabe, Hayato Murakoshi, Yoshiko Tamura, Madoka Koyanagi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Identification of Cross-Clade CTL Epitopes in HIV-1 Clade A/E-Infected Individuals by Using the Clade B Overlapping Peptides. Microbes Infect., 15(13):874-886, Nov 2013. PubMed ID: 23968885. Show all entries for this paper.
HXB2 Location | Gag(39-46) | Gag Epitope Map
View variants at this location |
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Epitope |
RELERFAL
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Epitope Alignment | ||||
Variants |
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Epitope Name | Gag RV8-8L | |||||
Species (MHC/HLA) | human(B*40:02) |
Showing all: 1 variant(s).
Variant ID. | 3933 |
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Epitope Seq. | RELERFAL |
Variant Seq. | RELERFAv |
Mutations | L/V |
Epitope Location | L8V |
HXB2 Location | L46V |
Mutation Type | SSF: subtype-specific susceptible form |
Epitope Subtype | CRF01_AE |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Sequence |
Note | B clade epitope RELERFAv was found in 4/26 A/E patients of the KI cohort, though it was found in 1299/1644 B virus and 20/315 clade A/E virus sequences in the Los Alamos HIV-1 database. It was recognized by CTL from clade A/E-infected patient KI-388 which had been elicited by consensus clade B RV8. |
Watanabe2013 Koji Watanabe, Hayato Murakoshi, Yoshiko Tamura, Madoka Koyanagi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Identification of Cross-Clade CTL Epitopes in HIV-1 Clade A/E-Infected Individuals by Using the Clade B Overlapping Peptides. Microbes Infect., 15(13):874-886, Nov 2013. PubMed ID: 23968885. Show all entries for this paper.
HXB2 Location | Gag(39-46) | Gag Epitope Map
View variants at this location |
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Epitope |
RELERFAV
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Epitope Alignment | ||||
Variants |
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Epitope Name | Gag RV8 | |||||
Species (MHC/HLA) | human(B*40:02) |
Showing all: 1 variant(s).
Variant ID. | 3932 |
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Epitope Seq. | RELERFAV |
Variant Seq. | RELERFAl |
Mutations | V/L |
Epitope Location | V8L |
HXB2 Location | V46L |
Mutation Type | SSF: subtype-specific susceptible form |
Epitope Subtype | B |
Variant Subtype | CRF01_AE |
Method | CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Sequence |
Note | A/E clade epitope RELERFAl was found in 17/26 A/E patients of the KI cohort, though it was found in 111/1644 B virus and 217/315 clade A/E virus sequences in the Los Alamos HIV-1 database. It was recognized by CTL from clade A/E-infected patient KI-388 which had been elicited by consensus clade B RV8. |
Watanabe2013 Koji Watanabe, Hayato Murakoshi, Yoshiko Tamura, Madoka Koyanagi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Identification of Cross-Clade CTL Epitopes in HIV-1 Clade A/E-Infected Individuals by Using the Clade B Overlapping Peptides. Microbes Infect., 15(13):874-886, Nov 2013. PubMed ID: 23968885. Show all entries for this paper.
HXB2 Location | Gag(210-217) | Gag Epitope Map
View variants at this location |
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Epitope |
AEWDRVHP
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Epitope Alignment | ||||
Variants |
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Epitope Name | Gag p24 AP8-6V | |||||
Species (MHC/HLA) | human(B*40:02) |
Showing all: 1 variant(s).
Variant ID. | 3935 |
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Epitope Seq. | AEWDRVHP |
Variant Seq. | AEWDRlHP |
Mutations | V/L |
Epitope Location | V6L |
HXB2 Location | V215L |
Mutation Type | SSF: subtype-specific susceptible form |
Epitope Subtype | CRF01_AE |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Sequence |
Note | B clade epitope AEWDRlHP was found in 1/26 A/E patients of the KI cohort, though it was found in 1263/1644 B virus and 53/315 clade A/E virus sequences in the Los Alamos HIV-1 database. It was recognized by CTL from clade A/E-infected patient KI-388 which had been elicited by consensus clade B AP8. |
Watanabe2013 Koji Watanabe, Hayato Murakoshi, Yoshiko Tamura, Madoka Koyanagi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Identification of Cross-Clade CTL Epitopes in HIV-1 Clade A/E-Infected Individuals by Using the Clade B Overlapping Peptides. Microbes Infect., 15(13):874-886, Nov 2013. PubMed ID: 23968885. Show all entries for this paper.
HXB2 Location | Gag(210-217) | Gag Epitope Map
View variants at this location |
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Epitope |
AEWDRLHP
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Epitope Alignment | ||||
Variants |
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Epitope Name | Gag AP8 | |||||
Species (MHC/HLA) | human(B*40:02) |
Showing all: 1 variant(s).
Variant ID. | 3934 |
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Epitope Seq. | AEWDRLHP |
Variant Seq. | AEWDRvHP |
Mutations | L/V |
Epitope Location | L6V |
HXB2 Location | L215V |
Mutation Type | SSF: subtype-specific susceptible form |
Epitope Subtype | B |
Variant Subtype | CRF01_AE |
Method | CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Sequence |
Note | A/E clade epitope AEWDRvHP was found in 10/26 A/E patients of the KI cohort, though it was found in 128/1644 B virus and 185/315 clade A/E virus sequences in the Los Alamos HIV-1 database. It was recognized by CTL from clade A/E-infected patient KI-388 which had been elicited by consensus clade B AP8. |
Watanabe2013 Koji Watanabe, Hayato Murakoshi, Yoshiko Tamura, Madoka Koyanagi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Identification of Cross-Clade CTL Epitopes in HIV-1 Clade A/E-Infected Individuals by Using the Clade B Overlapping Peptides. Microbes Infect., 15(13):874-886, Nov 2013. PubMed ID: 23968885. Show all entries for this paper.
HXB2 Location | Gag(210-218) | Gag Epitope Map
View variants at this location |
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Epitope |
AEWDRLHPV
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Epitope Alignment | ||||
Variants |
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Epitope Name | Gag AV9 | |||||
Species (MHC/HLA) | human(B*40:02) |
Showing all: 1 variant(s).
Variant ID. | 3937 |
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Epitope Seq. | AEWDRLHPV |
Variant Seq. | AEWDRvHPV |
Mutations | L/V |
Epitope Location | L6V |
HXB2 Location | L215V |
Mutation Type | SSF: subtype-specific susceptible form |
Epitope Subtype | B |
Variant Subtype | CRF01_AE |
Method | CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Sequence |
Note | A/E clade epitope AEWDRvHPV was found in 8/26 A/E patients of the KI cohort, though it was found in 121/1644 B virus and 178/315 clade A/E virus sequences in the Los Alamos HIV-1 database. It was recognized by CTL from clade A/E-infected patient KI-388 which had been elicited by consensus clade B AV9. |
Watanabe2013 Koji Watanabe, Hayato Murakoshi, Yoshiko Tamura, Madoka Koyanagi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Identification of Cross-Clade CTL Epitopes in HIV-1 Clade A/E-Infected Individuals by Using the Clade B Overlapping Peptides. Microbes Infect., 15(13):874-886, Nov 2013. PubMed ID: 23968885. Show all entries for this paper.
HXB2 Location | Gag(210-218) | Gag Epitope Map
View variants at this location |
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Epitope |
AEWDRVHPV
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Epitope Alignment | ||||
Variants |
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Epitope Name | Gag p24 AV9-6V | |||||
Species (MHC/HLA) | human(B*40:02) |
Showing all: 1 variant(s).
Variant ID. | 3936 |
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Epitope Seq. | AEWDRVHPV |
Variant Seq. | AEWDRlHPV |
Mutations | V/L |
Epitope Location | V6L |
HXB2 Location | V215L |
Mutation Type | SSF: subtype-specific susceptible form |
Epitope Subtype | CRF01_AE |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Sequence |
Note | B clade epitope AEWDRlHPV was found in 1/26 A/E patients of the KI cohort, though it was found in 1135/1644 B virus and 47/315 clade A/E virus sequences in the Los Alamos HIV-1 database. It was recognized by CTL from clade A/E-infected patient KI-388 which had been elicited by consensus clade B AV9. |
Watanabe2013 Koji Watanabe, Hayato Murakoshi, Yoshiko Tamura, Madoka Koyanagi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Identification of Cross-Clade CTL Epitopes in HIV-1 Clade A/E-Infected Individuals by Using the Clade B Overlapping Peptides. Microbes Infect., 15(13):874-886, Nov 2013. PubMed ID: 23968885. Show all entries for this paper.
HXB2 Location | Gag(211-221) | Gag Epitope Map
View variants at this location |
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Epitope |
EWDRLHPVHAG
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Epitope Alignment | ||||
Variants |
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Epitope Name | Gag p24 EG11 | |||||
Species (MHC/HLA) | human(B*40:02) |
Showing all: 1 variant(s).
Variant ID. | 3938 |
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Epitope Seq. | EWDRLHPVHAG |
Variant Seq. | EWDRvHPVHAG |
Mutations | L/V |
Epitope Location | L5V |
HXB2 Location | L215V |
Mutation Type | SSF: subtype-specific susceptible form |
Epitope Subtype | B |
Variant Subtype | CRF01_AE |
Method | CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Sequence |
Note | A/E clade epitope EWDRvHPVHAG was found in 5/26 A/E patients of the KI cohort, though it was found in 107/1644 B virus and 149/315 clade A/E virus sequences in the Los Alamos HIV-1 database. It was recognized by CTL from clade A/E-infected patient KI-388 which had been elicited by consensus clade B EG11. |
Watanabe2013 Koji Watanabe, Hayato Murakoshi, Yoshiko Tamura, Madoka Koyanagi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Identification of Cross-Clade CTL Epitopes in HIV-1 Clade A/E-Infected Individuals by Using the Clade B Overlapping Peptides. Microbes Infect., 15(13):874-886, Nov 2013. PubMed ID: 23968885. Show all entries for this paper.
HXB2 Location | Gag(211-221) | Gag Epitope Map
View variants at this location |
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Epitope |
EWDRVHPVHAG
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Epitope Alignment | ||||
Variants |
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Epitope Name | Gag p24 EG11-5V | |||||
Species (MHC/HLA) | human(B*40:02) |
Showing all: 1 variant(s).
Variant ID. | 3939 |
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Epitope Seq. | EWDRVHPVHAG |
Variant Seq. | EWDRlHPVHAG |
Mutations | V/L |
Epitope Location | V5L |
HXB2 Location | V215L |
Mutation Type | SSF: subtype-specific susceptible form |
Epitope Subtype | CRF01_AE |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Sequence |
Note | B clade epitope EWDRlHPVHAG was found in 1/26 A/E patients of the KI cohort, though it was found in 921/1644 B virus and 48/315 clade A/E virus sequences in the Los Alamos HIV-1 database. It was recognized by CTL from clade A/E-infected patient KI-388 which had been elicited by consensus clade B EG11. |
Watanabe2013 Koji Watanabe, Hayato Murakoshi, Yoshiko Tamura, Madoka Koyanagi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Identification of Cross-Clade CTL Epitopes in HIV-1 Clade A/E-Infected Individuals by Using the Clade B Overlapping Peptides. Microbes Infect., 15(13):874-886, Nov 2013. PubMed ID: 23968885. Show all entries for this paper.
HXB2 Location | Gag(275-282) | Gag Epitope Map
View variants at this location |
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Epitope |
RMYSPVSI
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Epitope Alignment | ||||
Variants |
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Epitope Name | Gag p24 RI8-6V | |||||
Species (MHC/HLA) | human(B*52:01) |
Showing all: 1 variant(s).
Variant ID. | 3941 |
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Epitope Seq. | RMYSPVSI |
Variant Seq. | RMYSPtSI |
Mutations | V/T |
Epitope Location | V6T |
HXB2 Location | V280T |
Mutation Type | SSF: subtype-specific susceptible form |
Epitope Subtype | CRF01_AE |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Sequence |
Note | B clade epitope RMYSPtSI was found in 20/26 A/E patients of the KI cohort, though it was found in 616/1644 B virus and 118/315 clade A/E virus sequences in the Los Alamos HIV-1 database. It was recognized by CTL from clade A/E-infected patient KI-724 which had been elicited by consensus clade B RI8. |
Watanabe2013 Koji Watanabe, Hayato Murakoshi, Yoshiko Tamura, Madoka Koyanagi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Identification of Cross-Clade CTL Epitopes in HIV-1 Clade A/E-Infected Individuals by Using the Clade B Overlapping Peptides. Microbes Infect., 15(13):874-886, Nov 2013. PubMed ID: 23968885. Show all entries for this paper.
HXB2 Location | Gag(275-282) | Gag Epitope Map
View variants at this location |
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Epitope |
RMYSPTSI
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Epitope Alignment | ||||
Variants |
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Epitope Name | Gag RI8 | |||||
Species (MHC/HLA) | human(B*52:01) |
Showing all: 1 variant(s).
Variant ID. | 3940 |
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Epitope Seq. | RMYSPTSI |
Variant Seq. | RMYSPvSI |
Mutations | T/V |
Epitope Location | T6V |
HXB2 Location | T280V |
Mutation Type | SSF: subtype-specific susceptible form |
Epitope Subtype | B |
Variant Subtype | CRF01_AE |
Method | CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Sequence |
Note | A/E clade epitope RMYSPvSI was found in 15/26 A/E patients of the KI cohort, though it was found in 351/1644 B virus and 212/315 clade A/E virus sequences in the Los Alamos HIV-1 database. It was recognized by CTL from clade A/E-infected patient KI-724 which had been elicited by consensus clade B RI8. |
Watanabe2013 Koji Watanabe, Hayato Murakoshi, Yoshiko Tamura, Madoka Koyanagi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Identification of Cross-Clade CTL Epitopes in HIV-1 Clade A/E-Infected Individuals by Using the Clade B Overlapping Peptides. Microbes Infect., 15(13):874-886, Nov 2013. PubMed ID: 23968885. Show all entries for this paper.
HXB2 Location | Gag(277-285) | Gag Epitope Map
View variants at this location |
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Epitope |
YSPTSILDI
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Epitope Alignment | ||||
Variants |
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Epitope Name | Gag YI9 | |||||
Species (MHC/HLA) | human(C*01:02) |
Showing all: 1 variant(s).
Variant ID. | 3942 |
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Epitope Seq. | YSPTSILDI |
Variant Seq. | YSPvSILDI |
Mutations | T/V |
Epitope Location | T4V |
HXB2 Location | T280V |
Mutation Type | SSF: subtype-specific susceptible form |
Epitope Subtype | B |
Variant Subtype | CRF01_AE |
Method | CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Sequence |
Note | A/E clade epitope YSPvSILDI was found in 15/26 A/E patients of the KI cohort, though it was found in 345/1644 B virus and 212/315 clade A/E virus sequences in the Los Alamos HIV-1 database. It was recognized by CTL from clade A/E-infected patient KI-724 which had been elicited by consensus clade B YI9. |
Watanabe2013 Koji Watanabe, Hayato Murakoshi, Yoshiko Tamura, Madoka Koyanagi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Identification of Cross-Clade CTL Epitopes in HIV-1 Clade A/E-Infected Individuals by Using the Clade B Overlapping Peptides. Microbes Infect., 15(13):874-886, Nov 2013. PubMed ID: 23968885. Show all entries for this paper.
HXB2 Location | Gag(277-285) | Gag Epitope Map
View variants at this location |
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Epitope |
YSPVSILDI
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Epitope Alignment | ||||
Variants |
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Epitope Name | Gag YI9-4V | |||||
Species (MHC/HLA) | human(C*01:02) |
Showing all: 1 variant(s).
Variant ID. | 3943 |
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Epitope Seq. | YSPVSILDI |
Variant Seq. | YSPtSILDI |
Mutations | V/T |
Epitope Location | V4T |
HXB2 Location | V280T |
Mutation Type | SSF: subtype-specific susceptible form |
Epitope Subtype | CRF01_AE |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Sequence |
Note | B clade epitope YSPtSILDI was found in 2/26 A/E patients of the KI cohort, though it was found in 1032/1644 B virus and 30/315 clade A/E virus sequences in the Los Alamos HIV-1 database. It was recognized by CTL from clade A/E-infected patient KI-724 which had been elicited by consensus clade B YI9. |
Watanabe2013 Koji Watanabe, Hayato Murakoshi, Yoshiko Tamura, Madoka Koyanagi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Identification of Cross-Clade CTL Epitopes in HIV-1 Clade A/E-Infected Individuals by Using the Clade B Overlapping Peptides. Microbes Infect., 15(13):874-886, Nov 2013. PubMed ID: 23968885. Show all entries for this paper.
HXB2 Location | Pol(595-603) | Pol Epitope Map
View variants at this location |
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Epitope |
FYVDGAANR
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Epitope Alignment | ||||
Variants |
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Epitope Name | Pol RT FR9 | |||||
Species (MHC/HLA) | human(A*33:03) |
Showing all: 1 variant(s).
Variant ID. | 3944 |
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Epitope Seq. | FYVDGAANR |
Variant Seq. | FYVDGAAsR |
Mutations | N/S |
Epitope Location | N8S |
HXB2 Location | N602S |
Mutation Type | SSF: subtype-specific susceptible form |
Epitope Subtype | B |
Variant Subtype | CRF01_AE |
Method | CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Sequence |
Note | A/E clade epitope FYVDGAAsR was found in 15/26 A/E patients of the KI cohort, though it was found in 47/1003 B virus and 45/59 clade A/E virus sequences in the Los Alamos HIV-1 database. It was recognized by CTL from clade A/E-infected patient KI-632 which had been elicited by consensus clade B FR9. |
Watanabe2013 Koji Watanabe, Hayato Murakoshi, Yoshiko Tamura, Madoka Koyanagi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Identification of Cross-Clade CTL Epitopes in HIV-1 Clade A/E-Infected Individuals by Using the Clade B Overlapping Peptides. Microbes Infect., 15(13):874-886, Nov 2013. PubMed ID: 23968885. Show all entries for this paper.
HXB2 Location | Pol(595-603) | Pol Epitope Map
View variants at this location |
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Epitope |
FYVDGAASR
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Epitope Alignment | ||||
Variants |
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Epitope Name | Pol RT FR9-8S | |||||
Species (MHC/HLA) | human(A*33:03) |
Showing all: 1 variant(s).
Variant ID. | 3945 |
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Epitope Seq. | FYVDGAASR |
Variant Seq. | FYVDGAAnR |
Mutations | S/N |
Epitope Location | S8N |
HXB2 Location | S602N |
Mutation Type | SSF: subtype-specific susceptible form |
Epitope Subtype | CRF01_AE |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Sequence |
Note | B clade epitope FYVDGAAnR was found in 9/26 A/E patients of the KI cohort, though it was found in 838/1003 B virus and 9/59 clade A/E virus sequences in the Los Alamos HIV-1 database. It was recognized by CTL from clade A/E-infected patient KI-632 which had been elicited by consensus clade B FR9. |
Watanabe2013 Koji Watanabe, Hayato Murakoshi, Yoshiko Tamura, Madoka Koyanagi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Identification of Cross-Clade CTL Epitopes in HIV-1 Clade A/E-Infected Individuals by Using the Clade B Overlapping Peptides. Microbes Infect., 15(13):874-886, Nov 2013. PubMed ID: 23968885. Show all entries for this paper.
HXB2 Location | Pol(912-919) | Pol Epitope Map
View variants at this location |
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Epitope |
GERIIDII
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Epitope Alignment | ||||
Variants |
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Epitope Name | Pol GI8-5I | |||||
Species (MHC/HLA) | human(B*40:02) |
Showing all: 1 variant(s).
Variant ID. | 3946 |
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Epitope Seq. | GERIIDII |
Variant Seq. | GERIvDII |
Mutations | I/V |
Epitope Location | I5V |
HXB2 Location | I916V |
Mutation Type | SSF: subtype-specific susceptible form |
Epitope Subtype | CRF01_AE |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Sequence |
Note | B clade epitope GERIvDII was found in 0/26 A/E patients of the KI cohort, though it was found in 535/1003 clade B virus and 0/57 clade A/E virus sequences in the Los Alamos HIV-1 database. It was less strongly recognized than a consensus clade A/E peptide by CTL from clade A/E-infected patient KI-837 which had been elicited by consensus clade B GI8. |
Watanabe2013 Koji Watanabe, Hayato Murakoshi, Yoshiko Tamura, Madoka Koyanagi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Identification of Cross-Clade CTL Epitopes in HIV-1 Clade A/E-Infected Individuals by Using the Clade B Overlapping Peptides. Microbes Infect., 15(13):874-886, Nov 2013. PubMed ID: 23968885. Show all entries for this paper.
HXB2 Location | Pol(912-919) | Pol Epitope Map
View variants at this location |
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Epitope |
GERIVDII
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Epitope Alignment | ||||
Variants |
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Epitope Name | Pol GI8 | |||||
Species (MHC/HLA) | human(B*40:02) |
Showing all: 1 variant(s).
Variant ID. | 3947 |
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Epitope Seq. | GERIVDII |
Variant Seq. | GERIiDII |
Mutations | V/I |
Epitope Location | V5I |
HXB2 Location | V916I |
Mutation Type | SSF: subtype-specific susceptible form |
Epitope Subtype | B |
Variant Subtype | CRF01_AE |
Method | CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Sequence |
Note | A/E clade epitope GERIiDII was found in 23/26 A/E patients of the KI cohort, though it was found in 378/1003 clade B virus and 56/59 clade A/E virus sequences in the Los Alamos HIV-1 database. It was much more strongly recognized than a consensus clade B peptide by CTL from clade A/E-infected patient KI-837 which had been elicited by consensus clade B GI8. |
Watanabe2013 Koji Watanabe, Hayato Murakoshi, Yoshiko Tamura, Madoka Koyanagi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Identification of Cross-Clade CTL Epitopes in HIV-1 Clade A/E-Infected Individuals by Using the Clade B Overlapping Peptides. Microbes Infect., 15(13):874-886, Nov 2013. PubMed ID: 23968885. Show all entries for this paper.
HXB2 Location | Nef(83-91) | Nef Epitope Map
View variants at this location |
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Epitope |
GAFDLSFFL
|
Epitope Alignment | ||||
Variants |
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Epitope Name | Nef GL9-3F-7F | |||||
Species (MHC/HLA) | human(A*02:06) |
Showing all: 1 variant(s).
Variant ID. | 3927 |
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Epitope Seq. | GAFDLSFFL |
Variant Seq. | GalDLShFL |
Mutations | F/L F/H |
Epitope Location | F3L F7H |
HXB2 Location | F85L F89H |
Mutation Type | SSF: subtype-specific susceptible form |
Epitope Subtype | CRF01_AE |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Sequence |
Note | B clade epitope GalDLShFL was found in 1/26 A/E patients of the KI cohort, though it was found in 529/1594 clade B virus and no clade A/E virus sequences in the Los Alamos HIV-1 database. It was less strongly recognized than a consensus clade A/E peptide by CTL from clade A/E-infected patient KI-648 which had been elicited by consensus clade B GL9 . |
Watanabe2013 Koji Watanabe, Hayato Murakoshi, Yoshiko Tamura, Madoka Koyanagi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Identification of Cross-Clade CTL Epitopes in HIV-1 Clade A/E-Infected Individuals by Using the Clade B Overlapping Peptides. Microbes Infect., 15(13):874-886, Nov 2013. PubMed ID: 23968885. Show all entries for this paper.
HXB2 Location | Nef(83-91) | Nef Epitope Map
View variants at this location |
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Epitope |
GALDLSHFL
|
Epitope Alignment | |||||||
Variants |
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Epitope Name | Nef GL9 | ||||||||
Species (MHC/HLA) | human(A*02:06) |
Showing all: 2 variant(s).
Variant ID. | 3925 |
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Epitope Seq. | GALDLSHFL |
Variant Seq. | GAfDLSfFL |
Mutations | L/F H/F |
Epitope Location | L3F H7F |
HXB2 Location | L85F H89F |
Mutation Type | SSF: subtype-specific susceptible form |
Epitope Subtype | B |
Variant Subtype | CRF01_AE |
Method | CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Sequence |
Note | A/E epitope GAfDLSfFL was found in 16/26 A/E patients of the KI cohort, though it was found in only 12/1594 clade B virus and 47/76 clade A/E virus sequences in the Los Alamos HIV-1 database. It was more strongly recognized than a consensus clade B peptide by CTL from clade A/E-infected patient KI-648 which had been elicited by a consensus clade B GL9 . |
Variant ID. | 3926 |
---|---|
Epitope Seq. | GALDLSHFL |
Variant Seq. | aAvDLSHFL |
Mutations | G/A L/V |
Epitope Location | G1A L3V |
HXB2 Location | G83A L85V |
Mutation Type | OV: observed variant SSF: subtype-specific susceptible form |
Epitope Subtype | B |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Sequence |
Note | This GL9 epitope variant aAvDLSHFL is found in clade B strain NL4-3 and is different from the clade B consensus GL9 epitope reported in this paper as well as in Watanabe2011 and Murakoshi2009. Cells infected by NL4-3 are not recognized by CTL that are elicited upon recognition of the consensus B GL9 peptide used in these studies. |
Watanabe2013 Koji Watanabe, Hayato Murakoshi, Yoshiko Tamura, Madoka Koyanagi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Identification of Cross-Clade CTL Epitopes in HIV-1 Clade A/E-Infected Individuals by Using the Clade B Overlapping Peptides. Microbes Infect., 15(13):874-886, Nov 2013. PubMed ID: 23968885. Show all entries for this paper.
HXB2 Location | Nef(134-143) | Nef Epitope Map
View variants at this location |
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Epitope |
RYPLTFGWCF
|
Epitope Alignment | ||||
Variants |
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Epitope Name | Nef RF10 | |||||
Species (MHC/HLA) | human(A*24:02) |
Showing all: 1 variant(s).
Variant ID. | 3928 |
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Epitope Seq. | RYPLTFGWCF |
Variant Seq. | RYPLcFGWCF |
Mutations | T/C |
Epitope Location | T5C |
HXB2 Location | T138C |
Mutation Type | SSF: subtype-specific susceptible form |
Epitope Subtype | B |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Sequence |
Note | A/E clade epitope RYPLcFGWCF was found in 10/25 A/E patients of the KI cohort, though it was found in 94/1494 clade B virus and 56/76 clade A/E virus sequences in the Los Alamos HIV-1 database. It was equally recognized as a consensus clade B peptide by CTL from clade A/E-infected patient KI-632 which had been elicited by consensus clade B RF10. |
Watanabe2013 Koji Watanabe, Hayato Murakoshi, Yoshiko Tamura, Madoka Koyanagi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Identification of Cross-Clade CTL Epitopes in HIV-1 Clade A/E-Infected Individuals by Using the Clade B Overlapping Peptides. Microbes Infect., 15(13):874-886, Nov 2013. PubMed ID: 23968885. Show all entries for this paper.
HXB2 Location | Nef(134-143) | Nef Epitope Map
View variants at this location |
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Epitope |
RYPLCFGWCF
|
Epitope Alignment | ||||
Variants |
|
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Epitope Name | Nef RF10-5C | |||||
Species (MHC/HLA) | human(A*24:02) |
Showing all: 1 variant(s).
Variant ID. | 3929 |
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Epitope Seq. | RYPLCFGWCF |
Variant Seq. | RYPLtFGWCF |
Mutations | C/T |
Epitope Location | C5T |
HXB2 Location | C138T |
Mutation Type | SSF: subtype-specific susceptible form |
Epitope Subtype | B |
Variant Subtype | CRF01_AE |
Method | CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Sequence |
Note | B clade epitope RYPLcFGWCF was found in 2/25 A/E patients of the KI cohort, though it was found in 800/1494 clade B virus and no clade A/E virus sequences in the Los Alamos HIV-1 database. It was equally recognized as a consensus clade A/E peptide by CTL from clade A/E-infected patient KI-632 which had been elicited by consensus clade B RF10. |
Watanabe2013 Koji Watanabe, Hayato Murakoshi, Yoshiko Tamura, Madoka Koyanagi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Identification of Cross-Clade CTL Epitopes in HIV-1 Clade A/E-Infected Individuals by Using the Clade B Overlapping Peptides. Microbes Infect., 15(13):874-886, Nov 2013. PubMed ID: 23968885. Show all entries for this paper.