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Found 26 matching records:

Displaying record number 55395

HXB2 Location Gag(77-85) Gag Epitope Map
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SLYNTVATL

`SLfNTVATL`		observed variant
`SLYNTVAvL`		observed variant
`SLYNTVATi`		observed variant
`SLfNTVATi`		observed variant
`SLnNaiAvL`		observed variant
`SvYNTVATL`		observed variant

Epitope Name Gag 77

Species (MHC/HLA) human(A2)

Variant Details

Showing all: 6 variant(s).

Variant ID.	`1658`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLfNTVATL`
Mutations	Y/F
Epitope Location	Y3F
HXB2 Location	Y79F
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subjects Pt15, Pt18 carried this variant epitope, but cross-recognized the challenge HXB2 sequence SLYNTVATL. Subject Pt30 who carried the challenge epitope too did not recognize that HXB2 sequence.

Variant ID.	`1660`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLYNTVAvL`
Mutations	T/V
Epitope Location	T8V
HXB2 Location	T84V
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject P43 carried this variant epitope, but cross-recognized the challenge HXB2 sequence SLYNTVATL. Subject Pt21 who also carried the variant epitope did not recognize HXB2 sequence.

Variant ID.	`1661`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLYNTVATi`
Mutations	L/I
Epitope Location	L9I
HXB2 Location	L85I
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt23 carried this variant epitope, and recognized the challenge HXB2 sequence SLYNTVATL.

Variant ID.	`1662`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLfNTVATi`
Mutations	Y/F L/I
Epitope Location	Y3F L9I
HXB2 Location	Y79F L85I
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt41 carried this variant epitope, and recognized the challenge HXB2 sequence SLYNTVATL.

Variant ID.	`1663`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLnNaiAvL`
Mutations	Y/N T/A V/I T/V
Epitope Location	Y3N T5A V6I T8V
HXB2 Location	Y79N T81A V82I T84V
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt17 carried this variant epitope, and did not recognize the challenge HXB2 sequence SLYNTVATL.

Variant ID.	`2264`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SvYNTVATL`
Mutations	L/V
Epitope Location	L2V
HXB2 Location	L78V
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt33 carried this variant, and did not recognize the challenge HXB2 SLYNTVATL.

References

Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.

Displaying record number 55367

HXB2 Location Gag(80-88) Gag Epitope Map
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Epitope

NTVATLYCV

Epitope Alignment

Variants

`NaiAvLYCV`		observed variant
`NTVAvLYCV`		observed variant
`NTVATiYCV`		observed variant
`NTVATLYCV`		observed variant

Epitope Name Gag 80

Species (MHC/HLA) human(A2)

Variant Details

Showing all: 4 variant(s).

Variant ID.	`1664`
Epitope Seq.	`NTVATLYCV`
Variant Seq.	`NaiAvLYCV`
Mutations	T/A V/I T/V
Epitope Location	T2A V3I T5V
HXB2 Location	T81A V82I T84V
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subjects Pt15, Pt16, Pt18, Pt30, Pt33 and Pt35 carried this HXB2 epitope. All of the above were unable to recognize it however, except for Pt15 who did recognize the HXB2 sequence. Only Pt17 carried the variant NaiAvLYCV and was unable to cross-recognize the challenge HXB2 sequence.

Variant ID.	`1665`
Epitope Seq.	`NTVATLYCV`
Variant Seq.	`NTVAvLYCV`
Mutations	T/V
Epitope Location	T5V
HXB2 Location	T84V
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subjects Pt21 and Pt43 carried this variant and were unable to recognize the challenge HXB2 form, NTVATLYCV.

Variant ID.	`1666`
Epitope Seq.	`NTVATLYCV`
Variant Seq.	`NTVATiYCV`
Mutations	L/I
Epitope Location	L6I
HXB2 Location	L85I
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subjects Pt23 and Pt41 carried this variant and were unable to recognize the challenge HXB2 form, NTVATLYCV.

Variant ID.	`1667`
Epitope Seq.	`NTVATLYCV`
Variant Seq.	`NTVATLYCV`
Mutations
Epitope Location
HXB2 Location
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt21 carried this variant and was unable to recognize the challenge HXB2 form, NTVATLYCV.

References

Displaying record number 55368

HXB2 Location Gag(242-250) Gag Epitope Map
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Epitope

TLQEQIGWM

Epitope Alignment

Variants

`TLQEQIaWM`		observed variant
`nLQEQIGWM`		observed variant

Epitope Name Gag 242

Species (MHC/HLA) human(A2)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`1668`
Epitope Seq.	`TLQEQIGWM`
Variant Seq.	`TLQEQIaWM`
Mutations	G/A
Epitope Location	G7A
HXB2 Location	G248A
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subjects Pt15 and Pt33 carried this variant and were unable to recognize the challenge HXB2 form. Subjects Pt35 and Pt41 carried the HXB2 sequence and were able to recognize it; all others Pt16, Pt17, Pt18, Pt21, Pt23 and Pt35 did carry the HXB2 epitope, but could not recognize it.

Variant ID.	`1669`
Epitope Seq.	`TLQEQIGWM`
Variant Seq.	`nLQEQIGWM`
Mutations	T/N
Epitope Location	T1N
HXB2 Location	T242N
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt30 carried this variant and was unable to recognize the challenge HXB2 form, NTVATLYCV.

References

Displaying record number 55371

HXB2 Location Gag(362-370) Gag Epitope Map
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Epitope

VLAEAMSQV

Epitope Alignment

Variants

`VLAEAMSQa`		observed variant
`VLAEAMSQm`		observed variant

Epitope Name Gag 362(9V)

Species (MHC/HLA) human(A2)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`1690`
Epitope Seq.	`VLAEAMSQV`
Variant Seq.	`VLAEAMSQa`
Mutations	V/A
Epitope Location	V9A
HXB2 Location	V370A
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt15 carried this variant and was unable to recognize either variant or the challenge HXB2 form, VLAEAMSQV.

Variant ID.	`1691`
Epitope Seq.	`VLAEAMSQV`
Variant Seq.	`VLAEAMSQm`
Mutations	V/M
Epitope Location	V9M
HXB2 Location	V370M
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt17 carried this variant and was unable to recognize either variant or the challenge HXB2 form, VLAEAMSQV.

References

Displaying record number 55372

HXB2 Location Gag(433-440) Gag Epitope Map
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Epitope

FLGKIWPS

Epitope Alignment

Variants

`FLGKIWsS`		observed variant
`FLGrIWPS`		observed variant

Epitope Name Gag 433

Species (MHC/HLA) human(A2)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`1692`
Epitope Seq.	`FLGKIWPS`
Variant Seq.	`FLGKIWsS`
Mutations	P/S
Epitope Location	P7S
HXB2 Location	P439S
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt16 carried this variant and was able to cross-recognize the challenge HXB2 epitope, FLGKIWPS. Of the 9 subjects that did carry the HXB2 epitope sequence, only 3, Pt30, Pt33 and Pt41 were able to recognize it.

Variant ID.	`1693`
Epitope Seq.	`FLGKIWPS`
Variant Seq.	`FLGrIWPS`
Mutations	K/R
Epitope Location	K4R
HXB2 Location	K436R
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt43 carried this variant and was able to cross-recognize the challenge HXB2 epitope, FLGKIWPS.

References

Displaying record number 55374

HXB2 Location Pol(59-67) Pol Epitope Map
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Epitope

ITLWQRPLV

Epitope Alignment

Variants

`ITLWQRPiV`		observed variant
`ITLWQRPfV`		observed variant

Epitope Name Pol 59

Species (MHC/HLA) human(A2)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`1670`
Epitope Seq.	`ITLWQRPLV`
Variant Seq.	`ITLWQRPiV`
Mutations	L/I
Epitope Location	L8I
HXB2 Location	L66I
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt21 carried this variant and was unable to recognize the challenge HXB2 epitope form, ITLWQRPLV.

Variant ID.	`1671`
Epitope Seq.	`ITLWQRPLV`
Variant Seq.	`ITLWQRPfV`
Mutations	L/F
Epitope Location	L8F
HXB2 Location	L66F
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt41 carried this variant and was unable to recognize the challenge HXB2 epitope form, ITLWQRPLV.

References

Displaying record number 55397

HXB2 Location Pol(464-472) Pol Epitope Map
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Epitope

ILKEPVHGV

Epitope Alignment

Variants

`ILKEPVHGa`		observed variant
`IiKEPVHxx`		observed variant

Epitope Name Pol 476

Species (MHC/HLA) human(A2)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`1759`
Epitope Seq.	`ILKEPVHGV`
Variant Seq.	`ILKEPVHGa`
Mutations	V/A
Epitope Location	V9A
HXB2 Location	V472A
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt18 carried this variant epitope, and did not recognize the challenge HXB2 ILKEPVHGV.

Variant ID.	`1760`
Epitope Seq.	`ILKEPVHGV`
Variant Seq.	`IiKEPVHxx`
Mutations	L/I G/X V/X
Epitope Location	L2I G8X V9X
HXB2 Location	L465I G471X V472X
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt41 carried this variant epitope, and did not recognize the challenge HXB2 ILKEPVHGV.

References

Displaying record number 55375

HXB2 Location Pol(571-578) Pol Epitope Map
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Epitope

FVNTPPLV

Epitope Alignment

Variants

FVNTPlLV observed variant

Epitope Name Pol 571

Species (MHC/HLA) human(A2)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`1672`
Epitope Seq.	`FVNTPPLV`
Variant Seq.	`FVNTPlLV`
Mutations	P/L
Epitope Location	P6L
HXB2 Location	P576L
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt18 carried this variant and was unable to recognize the challenge HXB2 epitope form, FVNTPPLV.

References

Displaying record number 55376

HXB2 Location Pol(606-614) Pol Epitope Map
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Epitope

KLGKAGYVT

Epitope Alignment

Variants

`KLGKAGYVv`		observed variant
`KmGKAGYVT`		observed variant
`KtGKAGYVT`		observed variant
`KiGKAGYVT`		observed variant

Epitope Name Pol 606

Species (MHC/HLA) human(A2)

Variant Details

Showing all: 4 variant(s).

Variant ID.	`1694`
Epitope Seq.	`KLGKAGYVT`
Variant Seq.	`KLGKAGYVv`
Mutations	T/V
Epitope Location	T9V
HXB2 Location	T614V
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Though poorly immunogenic in A2 transgenic mice, anchor-optimization of HXB2 Pol 606(9T) to variant Pol606(9V), KLGKAGYVv, induced cross-reaction and higher immunogenicity.

Variant ID.	`1695`
Epitope Seq.	`KLGKAGYVT`
Variant Seq.	`KmGKAGYVT`
Mutations	L/M
Epitope Location	L2M
HXB2 Location	L607M
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subjects Pt15 and Pt35 carried this variant, but while Pt15 was unable to cross-recognize the challenge HXB2 sequence KLGKAGYVT, Pt35 did recognize this challenge HXB2 sequence.

Variant ID.	`1696`
Epitope Seq.	`KLGKAGYVT`
Variant Seq.	`KtGKAGYVT`
Mutations	L/T
Epitope Location	L2T
HXB2 Location	L607T
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt16 carried this variant and was unable to cross-recognize the challenge HXB2 epitope, KLGKAGYVT.

Variant ID.	`1697`
Epitope Seq.	`KLGKAGYVT`
Variant Seq.	`KiGKAGYVT`
Mutations	L/I
Epitope Location	L2I
HXB2 Location	L607I
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt17 carried this variant and was unable to cross-recognize the challenge HXB2 epitope, KLGKAGYVT.

References

Displaying record number 55377

HXB2 Location Pol(687-695) Pol Epitope Map
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Epitope

YLAWVPAHK

Epitope Alignment

Variants

YLsWVPAHK observed variant

Epitope Name Pol 687

Species (MHC/HLA) human(A2)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`1673`
Epitope Seq.	`YLAWVPAHK`
Variant Seq.	`YLsWVPAHK`
Mutations	A/S
Epitope Location	A3S
HXB2 Location	A689S
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt15 carried this variant epitope in a structural protein, and did not recognize the challenge HXB2 epitope form, YLAWVPAHK. 10 other subjects were HXB2 epitope carriers, but of them only Pt16 could recognize that epitope.

References

Displaying record number 55386

HXB2 Location Vif(23-31) Vif Epitope Map
View variants at this location

Epitope

SLVKHHMYI

Epitope Alignment

Variants

`SLVKHHMYv`		susceptible form
`SvVKHHMYI`		susceptible form

Epitope Name VIf 23(9I)

Species (MHC/HLA) human(A2)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`1698`
Epitope Seq.	`SLVKHHMYI`
Variant Seq.	`SLVKHHMYv`
Mutations	I/V
Epitope Location	I9V
HXB2 Location	I31V
Mutation Type	SF: susceptible form
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	This 9I variant and 9V consensus epitope cross-reacted in A2 transgenic mice. Subjects Pt18 and Pt41 carried the HXB2 epitope SLVKHHMYV and were unable to recognize either the HXB2 or 9I variant form. Subjects Pt17, Pt23 and Pt43 carried the 9I variant form, and while Pt17 and Pt23 were unable to recognize either form, Pt 43 was able to recognize both the consensus and 9I variant.

Variant ID.	`1699`
Epitope Seq.	`SLVKHHMYI`
Variant Seq.	`SvVKHHMYI`
Mutations	L/V
Epitope Location	L2V
HXB2 Location	L24V
Mutation Type	SF: susceptible form
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	This 2V variant was the most immunogenic of all epitopes studied and it cross-reacted with the 9I variant, SLVKHHMYi.

References

Displaying record number 55387

HXB2 Location Vif(101-109) Vif Epitope Map
View variants at this location

Epitope

GLADQLIHL

Epitope Alignment

Variants

`nLADQLIHL`		observed variant
`dLADhLIHL`		observed variant
`dLADQLIHL`		observed variant
`evADQLIHL`		observed variant
`sLADQLIHL`		observed variant
`GLADrLIHL`		observed variant
`hLADQLIHq`		observed variant
`GLADQLIHm`		susceptible form

Epitope Name VIf 101(9L)

Species (MHC/HLA) human(A2)

Variant Details

Showing all: 8 variant(s).

Variant ID.	`1700`
Epitope Seq.	`GLADQLIHL`
Variant Seq.	`nLADQLIHL`
Mutations	G/N
Epitope Location	G1N
HXB2 Location	G101N
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subjects Pt16, Pt17 carried this variant and were unable to recognize the 9M variant GLADQLIHL. Pt 17 also did not recognize the challenge 9L HXB2 epitope, but Pt16 did recognize it.

Variant ID.	`1701`
Epitope Seq.	`GLADQLIHL`
Variant Seq.	`dLADhLIHL`
Mutations	G/D Q/H
Epitope Location	G1D Q5H
HXB2 Location	G101D Q105H
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt18 carried this variant and was unable to recognize both the 9L HXB2 epitope GLADQLIHL, as well as the 9M variant GLADQLIHM.

Variant ID.	`1702`
Epitope Seq.	`GLADQLIHL`
Variant Seq.	`dLADQLIHL`
Mutations	G/D
Epitope Location	G1D
HXB2 Location	G101D
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subjects Pt 21, Pt23, Pt33 carried this variant and were unable to recognize the 9M variant GLADQLIHM. Pt21 and Pt33 were also unable to recognize the HXB2 epitope GLADQLIHL, but Pt23 was able to recognize it.

Variant ID.	`1703`
Epitope Seq.	`GLADQLIHL`
Variant Seq.	`evADQLIHL`
Mutations	G/E L/V
Epitope Location	G1E L2V
HXB2 Location	G101E L102V
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt30 carried this variant and did not recognize either the challenge HXB2 epitope GLADQLIHL, or the 9M variant GLADQLIHM.

Variant ID.	`1704`
Epitope Seq.	`GLADQLIHL`
Variant Seq.	`sLADQLIHL`
Mutations	G/S
Epitope Location	G1S
HXB2 Location	G101S
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt35 carried this variant and did not recognize either the challenge HXB2 epitope GLADQLIHL, or the 9M variant GLADQLIHM.

Variant ID.	`1705`
Epitope Seq.	`GLADQLIHL`
Variant Seq.	`GLADrLIHL`
Mutations	Q/R
Epitope Location	Q5R
HXB2 Location	Q105R
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt43 carried this variant and did not recognize either the challenge HXB2 epitope GLADQLIHL, or the 9M variant GLADQLIHM.

Variant ID.	`1706`
Epitope Seq.	`GLADQLIHL`
Variant Seq.	`hLADQLIHq`
Mutations	G/H L/Q
Epitope Location	G1H L9Q
HXB2 Location	G101H L109Q
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt41 carried this variant and did not recognize the challenge HXB2 epitope GLADQLIHL, however it did recognize the 9M variant GLADQLIHM.

Variant ID.	`1707`
Epitope Seq.	`GLADQLIHL`
Variant Seq.	`GLADQLIHm`
Mutations	L/M
Epitope Location	L9M
HXB2 Location	L109M
Mutation Type	SF: susceptible form
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt41 carried hLADQLIHq variant and did not recognize the challenge HXB2 epitope GLADQLIHL, however it did recognize the 9M variant GLADQLIHm.

References

Displaying record number 55388

HXB2 Location Vif(149-157) Vif Epitope Map
View variants at this location

Epitope

ALAALITPK

Epitope Alignment

Variants

`ALtALITPK`		observed variant
`ALtALIkPK`		observed variant
`ltAALtkPK`		observed variant
`ALtALIatK`		observed variant
`ALAAvITPK`		observed variant
`ALAALvTPK`		observed variant
`ALAALIrPK`		observed variant

Epitope Name VIf 149

Species (MHC/HLA) human(A2)

Variant Details

Showing all: 7 variant(s).

Variant ID.	`1679`
Epitope Seq.	`ALAALITPK`
Variant Seq.	`ALtALITPK`
Mutations	A/T
Epitope Location	A3T
HXB2 Location	A151T
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subjects Pt18, Pt30 carried this variant and were unable to recognize the challenge HXB2 form, ALAALITPK.

Variant ID.	`1680`
Epitope Seq.	`ALAALITPK`
Variant Seq.	`ALtALIkPK`
Mutations	A/T T/K
Epitope Location	A3T T7K
HXB2 Location	A151T T155K
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt15 carried this variant and was unable to recognize the challenge HXB2 form, ALAALITPK.

Variant ID.	`1681`
Epitope Seq.	`ALAALITPK`
Variant Seq.	`ltAALtkPK`
Mutations	A/L L/T I/T T/K
Epitope Location	A1L L2T I6T T7K
HXB2 Location	A149L L150T I154T T155K
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt21 carried this variant and was unable to recognize the challenge HXB2 form, ALAALITPK.

Variant ID.	`1682`
Epitope Seq.	`ALAALITPK`
Variant Seq.	`ALtALIatK`
Mutations	A/T T/A P/T
Epitope Location	A3T T7A P8T
HXB2 Location	A151T T155A P156T
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt23 carried this variant and was unable to recognize the challenge HXB2 form, ALAALITPK.

Variant ID.	`1684`
Epitope Seq.	`ALAALITPK`
Variant Seq.	`ALAAvITPK`
Mutations	L/V
Epitope Location	L5V
HXB2 Location	L153V
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt43 carried this variant and was unable to recognize the challenge HXB2 form, ALAALITPK.

Variant ID.	`1685`
Epitope Seq.	`ALAALITPK`
Variant Seq.	`ALAALvTPK`
Mutations	I/V
Epitope Location	I6V
HXB2 Location	I154V
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt17 carried this variant and was unable to recognize the challenge HXB2 form, ALAALITPK.

Variant ID.	`1686`
Epitope Seq.	`ALAALITPK`
Variant Seq.	`ALAALIrPK`
Mutations	T/R
Epitope Location	T7R
HXB2 Location	T155R
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt33 carried this variant and cross-recognized the challenge HXB2 form, ALAALITPK.

References

Displaying record number 55389

HXB2 Location Vif(158-166) Vif Epitope Map
View variants at this location

Epitope

KIKPPLPSV

Epitope Alignment

Variants

`KtKPPLPSV`		non-susceptible form
`KrKPPLPSV`		observed variant
`KriPPLPSV`		observed variant
`rttPPLPSi`		observed variant
`rItPPLPSi`		observed variant

Epitope Name VIf 158(2I)

Species (MHC/HLA) human(A2)

Variant Details

Showing all: 5 variant(s).

Variant ID.	`1708`
Epitope Seq.	`KIKPPLPSV`
Variant Seq.	`KtKPPLPSV`
Mutations	I/T
Epitope Location	I2T
HXB2 Location	I159T
Mutation Type	NSF: non-susceptible form
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subjects Pt35 and Pt41 carried this HXB2 epitope and did not recognize it; Subjects Pt16, Pt18, Pt23, Pt33, Pt43 carried the 2T variant and did not recognize either this 2T variant or the challenge HXB2. Only Subject Pt30 who also carried the 2T variant was able to cross-recognize the HXB2 epitope, KIKPPLPSV.

Variant ID.	`1709`
Epitope Seq.	`KIKPPLPSV`
Variant Seq.	`KrKPPLPSV`
Mutations	I/R
Epitope Location	I2R
HXB2 Location	I159R
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt15 carried this variant and was unable to recognize both the 2T variant, KtKPPLPSV, as well as the HXB2 form. Subject Pt17 who carried this variant did not recognize the 2I challenge HXB2 epitope.

Variant ID.	`1710`
Epitope Seq.	`KIKPPLPSV`
Variant Seq.	`KriPPLPSV`
Mutations	I/R K/I
Epitope Location	I2R K3I
HXB2 Location	I159R K160I
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt17 carried this variant and was not able to recognize the 2T, KtKPPLPSV, variant epitope.

Variant ID.	`1711`
Epitope Seq.	`KIKPPLPSV`
Variant Seq.	`rttPPLPSi`
Mutations	K/R I/T K/T V/I
Epitope Location	K1R I2T K3T V9I
HXB2 Location	K158R I159T K160T V166I
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt21 carried this variant epitope and was not able to recognize the challenge HXB2 form.

Variant ID.	`1712`
Epitope Seq.	`KIKPPLPSV`
Variant Seq.	`rItPPLPSi`
Mutations	K/R K/T V/I
Epitope Location	K1R K3T V9I
HXB2 Location	K158R K160T V166I
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt21 carried this variant was not able to recognize the 2T variant form, KTKPPLPSV.

References

Displaying record number 55390

HXB2 Location Vpr(34-42) Vpr Epitope Map
View variants at this location

Epitope

FPRPWLHGL

Epitope Alignment

Variants

`FPRmWLHsL`		observed variant
`FPRiWLHsL`		observed variant
`FPPtWLHnL`		observed variant
`FPRvWLHnL`		observed variant
`FPRvWLHGL`		observed variant
`FPRiWLHnL`		observed variant
`FPRtWLHsL`		observed variant
`FPRmWLHnL`		observed variant

Epitope Name Vpr 34

Species (MHC/HLA) human(A2)

Variant Details

Showing all: 8 variant(s).

Variant ID.	`1713`
Epitope Seq.	`FPRPWLHGL`
Variant Seq.	`FPRmWLHsL`
Mutations	P/M G/S
Epitope Location	P4M G8S
HXB2 Location	P37M G41S
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt15 carried this variant epitope in a regulatory/accessory protein, and recognized the HXB2 epitope FPRPWLHGL.

Variant ID.	`1714`
Epitope Seq.	`FPRPWLHGL`
Variant Seq.	`FPRiWLHsL`
Mutations	P/I G/S
Epitope Location	P4I G8S
HXB2 Location	P37I G41S
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt23 carried this variant epitope in a regulatory/accessory protein, and recognized the HXB2 epitope FPRPWLHGL.

Variant ID.	`1715`
Epitope Seq.	`FPRPWLHGL`
Variant Seq.	`FPPtWLHnL`
Mutations	R/P P/T G/N
Epitope Location	R3P P4T G8N
HXB2 Location	R36P P37T G41N
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt16 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope FPRPWLHGL.

Variant ID.	`1716`
Epitope Seq.	`FPRPWLHGL`
Variant Seq.	`FPRvWLHnL`
Mutations	P/V G/N
Epitope Location	P4V G8N
HXB2 Location	P37V G41N
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt18 carried this variant epitope in a regulatory/accessory protein, and did not recognize the challenge HXB2 epitope FPRPWLHGL.

Variant ID.	`1717`
Epitope Seq.	`FPRPWLHGL`
Variant Seq.	`FPRvWLHGL`
Mutations	P/V
Epitope Location	P4V
HXB2 Location	P37V
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt21 carried this variant epitope in a regulatory/accessory protein, and did not recognize the challenge HXB2 epitope FPRPWLHGL.

Variant ID.	`1718`
Epitope Seq.	`FPRPWLHGL`
Variant Seq.	`FPRiWLHnL`
Mutations	P/I G/N
Epitope Location	P4I G8N
HXB2 Location	P37I G41N
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subjects Pt30, Pt35 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope FPRPWLHGL.

Variant ID.	`1719`
Epitope Seq.	`FPRPWLHGL`
Variant Seq.	`FPRtWLHsL`
Mutations	P/T G/S
Epitope Location	P4T G8S
HXB2 Location	P37T G41S
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt41 carried this variant epitope in a regulatory/accessory protein, and did not recognize the challenge HXB2 epitope FPRPWLHGL.

Variant ID.	`1720`
Epitope Seq.	`FPRPWLHGL`
Variant Seq.	`FPRmWLHnL`
Mutations	P/M G/N
Epitope Location	P4M G8N
HXB2 Location	P37M G41N
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt43 carried this variant epitope in a regulatory/accessory protein, and did not recognize the challenge HXB2 epitope FPRPWLHGL.

References

Displaying record number 55391

HXB2 Location Vpr(41-49) Vpr Epitope Map
View variants at this location

Epitope

SLGQHIYET

Epitope Alignment

Variants

`SLGQHIYnT`		observed variant
`nLGQyIYET`		observed variant
`nLGQHIYET`		observed variant
`nLGQfIYET`		observed variant
`SLGQyIYaT`		observed variant
`gLGQHIYET`		observed variant

Epitope Name Vpr 41

Species (MHC/HLA) human(A2)

Variant Details

Showing all: 6 variant(s).

Variant ID.	`1721`
Epitope Seq.	`SLGQHIYET`
Variant Seq.	`SLGQHIYnT`
Mutations	E/N
Epitope Location	E8N
HXB2 Location	E48N
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt15 carried this variant epitope in a regulatory/accessory protein, and did not recognize the challenge HXB2 epitope SLGQHIYET.

Variant ID.	`1722`
Epitope Seq.	`SLGQHIYET`
Variant Seq.	`nLGQyIYET`
Mutations	S/N H/Y
Epitope Location	S1N H5Y
HXB2 Location	S41N H45Y
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt16, Pt30 carried this variant epitope in a regulatory/accessory protein, and did not recognize the index epitope SLGQHIYET.

Variant ID.	`1723`
Epitope Seq.	`SLGQHIYET`
Variant Seq.	`nLGQHIYET`
Mutations	S/N
Epitope Location	S1N
HXB2 Location	S41N
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subjects Pt18, Pt43 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope SLGQHIYET.

Variant ID.	`1724`
Epitope Seq.	`SLGQHIYET`
Variant Seq.	`nLGQfIYET`
Mutations	S/N H/F
Epitope Location	S1N H5F
HXB2 Location	S41N H45F
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt35 carried this variant epitope in a regulatory/accessory protein, and did not recognize the challenge HXB2 epitope SLGQHIYET.

Variant ID.	`1725`
Epitope Seq.	`SLGQHIYET`
Variant Seq.	`SLGQyIYaT`
Mutations	H/Y E/A
Epitope Location	H5Y E8A
HXB2 Location	H45Y E48A
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt41 carried this variant epitope in a regulatory/accessory protein, and did not recognize the challenge HXB2 epitope SLGQHIYET.

Variant ID.	`1726`
Epitope Seq.	`SLGQHIYET`
Variant Seq.	`gLGQHIYET`
Mutations	S/G
Epitope Location	S1G
HXB2 Location	S41G
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subjects Pt17, Pt21, Pt33 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope SLGQHIYET.

References

Displaying record number 55383

HXB2 Location Rev(73-81) Rev Epitope Map
View variants at this location

Epitope

LQLPPIERL

Epitope Alignment

Variants

`fQLPPIERL`		observed variant
`LQLPPlERL`		observed variant

Epitope Name Rev 73

Species (MHC/HLA) human(A2)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`1688`
Epitope Seq.	`LQLPPIERL`
Variant Seq.	`fQLPPIERL`
Mutations	L/F
Epitope Location	L1F
HXB2 Location	L73F
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subjects Pt15 carried this variant but was unable to cross-recognize the challenge HXB2 sequence, LQLPPIERL.

Variant ID.	`1689`
Epitope Seq.	`LQLPPIERL`
Variant Seq.	`LQLPPlERL`
Mutations	I/L
Epitope Location	I6L
HXB2 Location	I78L
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subjects Pt16, Pt17, Pt18, Pt21, Pt23, Pt30, Pt33, Pt35, Pt41 and Pt43 carried the HXB2 epitope LQLPPLERL; and none were able to cross-recognize the variant LQLPPIERL.

References

Displaying record number 55384

HXB2 Location Rev(96-104) Rev Epitope Map
View variants at this location

Epitope

GMGSPQILV

Epitope Alignment

Variants

`GvGSPQILV`		observed variant
`GvGSPQIsg`		observed variant
`GvGSPQIsV`		observed variant
`GvGSPQILl`		observed variant
`GvGnPQILV`		observed variant
`GvGnPQvLV`		observed variant
`GvGSPQvLV`		observed variant
`GvGSPeILV`		observed variant

Epitope Name Rev 96

Species (MHC/HLA) human(A2)

Variant Details

Showing all: 8 variant(s).

Variant ID.	`1727`
Epitope Seq.	`GMGSPQILV`
Variant Seq.	`GvGSPQILV`
Mutations	M/V
Epitope Location	M2V
HXB2 Location	M97V
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subjects Pt16, Pt18, Pt35, Pt41 carried this HXB2 consensus epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope GMGSPQILV.

Variant ID.	`1728`
Epitope Seq.	`GMGSPQILV`
Variant Seq.	`GvGSPQIsg`
Mutations	M/V L/S V/G
Epitope Location	M2V L8S V9G
HXB2 Location	M97V L103S V104G
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt15 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope GMGSPQILV.

Variant ID.	`1729`
Epitope Seq.	`GMGSPQILV`
Variant Seq.	`GvGSPQIsV`
Mutations	M/V L/S
Epitope Location	M2V L8S
HXB2 Location	M97V L103S
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt17 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope GMGSPQILV.

Variant ID.	`1730`
Epitope Seq.	`GMGSPQILV`
Variant Seq.	`GvGSPQILl`
Mutations	M/V V/L
Epitope Location	M2V V9L
HXB2 Location	M97V V104L
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt21 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope GMGSPQILV.

Variant ID.	`1731`
Epitope Seq.	`GMGSPQILV`
Variant Seq.	`GvGnPQILV`
Mutations	M/V S/N
Epitope Location	M2V S4N
HXB2 Location	M97V S99N
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt33 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope GMGSPQILV.

Variant ID.	`1732`
Epitope Seq.	`GMGSPQILV`
Variant Seq.	`GvGnPQvLV`
Mutations	M/V S/N I/V
Epitope Location	M2V S4N I7V
HXB2 Location	M97V S99N I102V
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt23 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope GMGSPQILV.

Variant ID.	`1733`
Epitope Seq.	`GMGSPQILV`
Variant Seq.	`GvGSPQvLV`
Mutations	M/V I/V
Epitope Location	M2V I7V
HXB2 Location	M97V I102V
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt43 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope GMGSPQILV.

Variant ID.	`1734`
Epitope Seq.	`GMGSPQILV`
Variant Seq.	`GvGSPeILV`
Mutations	M/V Q/E
Epitope Location	M2V Q6E
HXB2 Location	M97V Q101E
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt30 carried this variant epitope in a regulatory/accessory protein, and cross-recognized the HXB2 epitope GMGSPQILV.

References

Displaying record number 55385

HXB2 Location Rev(102-110) Rev Epitope Map
View variants at this location

Epitope

ILVESPAVL

Epitope Alignment

Variants

`IsgkpcAVL`		observed variant
`ILVEpstVL`		observed variant
`IsVESPtVL`		observed variant
`ILVEhPtiL`		observed variant
`ILlESPtVL`		observed variant
`ILVESPtVL`		observed variant
`ILVEpsAVL`		observed variant
`ILVESPAVi`		observed variant
`vLVEpPpVL`		observed variant
`vLVESPAVL`		observed variant

Epitope Name Rev 102

Species (MHC/HLA) human(A2)

Variant Details

Showing all: 10 variant(s).

Variant ID.	`1735`
Epitope Seq.	`ILVESPAVL`
Variant Seq.	`IsgkpcAVL`
Mutations	L/S V/G E/K S/P P/C
Epitope Location	L2S V3G E4K S5P P6C
HXB2 Location	L103S V104G E105K S106P P107C
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt15 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope ILVESPAVL.

Variant ID.	`1736`
Epitope Seq.	`ILVESPAVL`
Variant Seq.	`ILVEpstVL`
Mutations	S/P P/S A/T
Epitope Location	S5P P6S A7T
HXB2 Location	S106P P107S A108T
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt16 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope ILVESPAVL.

Variant ID.	`1737`
Epitope Seq.	`ILVESPAVL`
Variant Seq.	`IsVESPtVL`
Mutations	L/S A/T
Epitope Location	L2S A7T
HXB2 Location	L103S A108T
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt17 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope ILVESPAVL.

Variant ID.	`1738`
Epitope Seq.	`ILVESPAVL`
Variant Seq.	`ILVEhPtiL`
Mutations	S/H A/T V/I
Epitope Location	S5H A7T V8I
HXB2 Location	S106H A108T V109I
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt18 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope ILVESPAVL.

Variant ID.	`1739`
Epitope Seq.	`ILVESPAVL`
Variant Seq.	`ILlESPtVL`
Mutations	V/L A/T
Epitope Location	V3L A7T
HXB2 Location	V104L A108T
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt21 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope ILVESPAVL.

Variant ID.	`1740`
Epitope Seq.	`ILVESPAVL`
Variant Seq.	`ILVESPtVL`
Mutations	A/T
Epitope Location	A7T
HXB2 Location	A108T
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt33 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope ILVESPAVL.

Variant ID.	`1741`
Epitope Seq.	`ILVESPAVL`
Variant Seq.	`ILVEpsAVL`
Mutations	S/P P/S
Epitope Location	S5P P6S
HXB2 Location	S106P P107S
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt35 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope ILVESPAVL.

Variant ID.	`1742`
Epitope Seq.	`ILVESPAVL`
Variant Seq.	`ILVESPAVi`
Mutations	L/I
Epitope Location	L9I
HXB2 Location	L110I
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt41 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope ILVESPAVL.

Variant ID.	`1743`
Epitope Seq.	`ILVESPAVL`
Variant Seq.	`vLVEpPpVL`
Mutations	I/V S/P A/P
Epitope Location	I1V S5P A7P
HXB2 Location	I102V S106P A108P
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt43 carried this variant epitope in a regulatory/accessory protein, and recognized the HXB2 epitope ILVESPAVL.

Variant ID.	`1744`
Epitope Seq.	`ILVESPAVL`
Variant Seq.	`vLVESPAVL`
Mutations	I/V
Epitope Location	I1V
HXB2 Location	I102V
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt23 carried this variant epitope in a regulatory/accessory protein, and recognized the HXB2 epitope ILVESPAVL.

References

Displaying record number 55393

HXB2 Location Vpu(66-74) Vpu Epitope Map
View variants at this location

Epitope

ALVEMGHHA

Epitope Alignment

Variants

`ALVEMGHHv`		observed variant
`tmVdMGnlr`		observed variant
`iLVEMGHdA`		observed variant
`gLVEMGHpA`		observed variant
`ALVErGylA`		observed variant
`iLmEMGHdA`		observed variant
`ALmgMGHHA`		observed variant

Epitope Name Vpu 66

Species (MHC/HLA) human

Variant Details

Showing all: 7 variant(s).

Variant ID.	`1745`
Epitope Seq.	`ALVEMGHHA`
Variant Seq.	`ALVEMGHHv`
Mutations	A/V
Epitope Location	A9V
HXB2 Location	A75V
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	This modified variant, designed to optimize the anchor residue was cross-recognized strongly by index epitope ALVEMGHHA-recognizing CTL.

Variant ID.	`1746`
Epitope Seq.	`ALVEMGHHA`
Variant Seq.	`tmVdMGnlr`
Mutations	A/T L/M E/D H/N H/L A/R
Epitope Location	A1T L2M E4D H7N H8L A9R
HXB2 Location	A67T L68M E70D H73N H74L A75R
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt15 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope ALVEMGHHA.

Variant ID.	`1747`
Epitope Seq.	`ALVEMGHHA`
Variant Seq.	`iLVEMGHdA`
Mutations	A/I H/D
Epitope Location	A1I H8D
HXB2 Location	A67I H74D
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt16 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope ALVEMGHHA.

Variant ID.	`1748`
Epitope Seq.	`ALVEMGHHA`
Variant Seq.	`gLVEMGHpA`
Mutations	A/G H/P
Epitope Location	A1G H8P
HXB2 Location	A67G H74P
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt17 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope ALVEMGHHA.

Variant ID.	`1749`
Epitope Seq.	`ALVEMGHHA`
Variant Seq.	`ALVErGylA`
Mutations	M/R H/Y H/L
Epitope Location	M5R H7Y H8L
HXB2 Location	M71R H73Y H74L
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt23 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope ALVEMGHHA.

Variant ID.	`1750`
Epitope Seq.	`ALVEMGHHA`
Variant Seq.	`iLmEMGHdA`
Mutations	A/I V/M H/D
Epitope Location	A1I V3M H8D
HXB2 Location	A67I V69M H74D
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt35 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope ALVEMGHHA.

Variant ID.	`1751`
Epitope Seq.	`ALVEMGHHA`
Variant Seq.	`ALmgMGHHA`
Mutations	V/M E/G
Epitope Location	V3M E4G
HXB2 Location	V69M E70G
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt41 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope ALVEMGHHA.

References

Displaying record number 55379

HXB2 Location gp160(67-75) gp160 Epitope Map
View variants at this location

Epitope

NVWATHACV

Epitope Alignment

Variants

`NiWATHACV`		susceptible form
`NVWATrACV`		observed variant
`NiWATrACV`		observed variant

Epitope Name Env 67(2V)

Species (MHC/HLA) human(A2)

Variant Details

Showing all: 3 variant(s).

Variant ID.	`10`
Epitope Seq.	`NVWATHACV`
Variant Seq.	`NiWATHACV`
Mutations	V/I
Epitope Location	V2I
HXB2 Location	V68I
Mutation Type	SF: susceptible form
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt23 carried the challenge HXB2 epitope, and recognized the 2I variant epitope NIWATRACV, while all other Subjects Pt15, Pt16, Pt17, Pt18, Pt21, Pt33, Pt35, Pt41 and Pt43 did not recognize the 2I variant. All of the above subjects, however, also did not recognize the consensus HXB2 epitope that they carried.

Variant ID.	`1752`
Epitope Seq.	`NVWATHACV`
Variant Seq.	`NVWATrACV`
Mutations	H/R
Epitope Location	H6R
HXB2 Location	H72R
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt30 carried this variant epitope, and did not recognize the challenge HXB2 epitope NIWATRACV.

Variant ID.	`1753`
Epitope Seq.	`NVWATHACV`
Variant Seq.	`NiWATrACV`
Mutations	V/I H/R
Epitope Location	V2I H6R
HXB2 Location	V68I H72R
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt30 carried this variant epitope, and did not recognize the HXB2 epitope NVWATRACV.

References

Displaying record number 55398

HXB2 Location gp160(121-129) gp160 Epitope Map
View variants at this location

Epitope

KLTPLCVTL

Epitope Alignment

Variants

`KLTPfCVvL`		observed variant
`KLTPLCVsL`		observed variant
`KiTPLCVTL`		observed variant

Epitope Name Env 121

Species (MHC/HLA) human(A2)

Variant Details

Showing all: 3 variant(s).

Variant ID.	`1761`
Epitope Seq.	`KLTPLCVTL`
Variant Seq.	`KLTPfCVvL`
Mutations	L/F T/V
Epitope Location	L5F T8V
HXB2 Location	L125F T128V
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt30 carried this variant epitope, and did not recognize the challenge HXB2 epitope KLTPLCVTL.

Variant ID.	`1762`
Epitope Seq.	`KLTPLCVTL`
Variant Seq.	`KLTPLCVsL`
Mutations	T/S
Epitope Location	T8S
HXB2 Location	T128S
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt41 carried the HXB2 epitope KLTPLCVsL, and did not recognize the index epitope KLTPLCVTL.

Variant ID.	`1763`
Epitope Seq.	`KLTPLCVTL`
Variant Seq.	`KiTPLCVTL`
Mutations	L/I
Epitope Location	L2I
HXB2 Location	L122I
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt43 carried this variant epitope, and did not recognize the challenge HXB2 epitope KLTPLCVTL.

References

Displaying record number 55380

HXB2 Location gp160(529-537) gp160 Epitope Map
View variants at this location

Epitope

TMGAASITL

Epitope Alignment

Variants

`TMGAASmTL`		observed variant
`TMGAASlTL`		observed variant
`TMGAASvTL`		observed variant
`TMGAASmaL`		observed variant
`TMGAASvaL`		observed variant

Epitope Name Env 529

Species (MHC/HLA) human(A2)

Variant Details

Showing all: 5 variant(s).

Variant ID.	`1754`
Epitope Seq.	`TMGAASITL`
Variant Seq.	`TMGAASmTL`
Mutations	I/M
Epitope Location	I7M
HXB2 Location	I535M
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subjects Pt16, Pt21 carried the HXB2 epitope TMGAASmTL, but cross-recognized the variant TMGAASITL; Pt18, Pt43 also carried the consensus HXB2 sequence but failed to recognize the index TMGAASITL.

Variant ID.	`1755`
Epitope Seq.	`TMGAASITL`
Variant Seq.	`TMGAASlTL`
Mutations	I/L
Epitope Location	I7L
HXB2 Location	I535L
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt35 carried this variant epitope in a structural protein, and did not recognize the challenge HXB2 epitope TMGAASITL.

Variant ID.	`1756`
Epitope Seq.	`TMGAASITL`
Variant Seq.	`TMGAASvTL`
Mutations	I/V
Epitope Location	I7V
HXB2 Location	I535V
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt41 carried this variant epitope in a structural protein, and recognized the challenge HXB2 epitope TMGAASITL.

Variant ID.	`1757`
Epitope Seq.	`TMGAASITL`
Variant Seq.	`TMGAASmaL`
Mutations	I/M T/A
Epitope Location	I7M T8A
HXB2 Location	I535M T536A
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt23 carried this variant epitope in a structural protein, and did not recognize the challenge HXB2 epitope TMGAASITL.

Variant ID.	`1758`
Epitope Seq.	`TMGAASITL`
Variant Seq.	`TMGAASvaL`
Mutations	I/V T/A
Epitope Location	I7V T8A
HXB2 Location	I535V T536A
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt17 carried this variant epitope in a structural protein, and did not recognize the challenge HXB2 epitope TMGAASITL.

References

Displaying record number 55381

HXB2 Location gp160(565-573) gp160 Epitope Map
View variants at this location

Epitope

LLQLTVWGI

Epitope Alignment

Variants

`mLQLTVWGI`		observed variant
`LLkLTVWGI`		observed variant

Epitope Name Env 565

Species (MHC/HLA) human(A2)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`1674`
Epitope Seq.	`LLQLTVWGI`
Variant Seq.	`mLQLTVWGI`
Mutations	L/M
Epitope Location	L1M
HXB2 Location	L565M
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subjects Pt15, Pt18, Pt23 and Pt30 were carriers of this variant and were all unable to recognize the challenge HXB2 epitope, LLQLTVWGI.

Variant ID.	`1675`
Epitope Seq.	`LLQLTVWGI`
Variant Seq.	`LLkLTVWGI`
Mutations	Q/K
Epitope Location	Q3K
HXB2 Location	Q567K
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt41 was a carrier of this variant and was unable to recognize the challenge HXB2 epitope, LLQLTVWGI.

References

Displaying record number 55382

HXB2 Location gp160(681-689) gp160 Epitope Map
View variants at this location

Epitope

YIKIFIMIV

Epitope Alignment

Variants

`YIKIFIMIi`		observed variant
`YIrlFIMIV`		observed variant
`YIrIFIMIV`		observed variant

Epitope Name Env 681

Species (MHC/HLA) human(A2)

Variant Details

Showing all: 3 variant(s).

Variant ID.	`1676`
Epitope Seq.	`YIKIFIMIV`
Variant Seq.	`YIKIFIMIi`
Mutations	V/I
Epitope Location	V9I
HXB2 Location	V689I
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subjects Pt23 and Pt35 were carriers of this variant. Pt23 was able to cross-recognize the consensus HXB2 epitope tested, YIKIFIMIV, but Pt35 was not. Of the 7 subjects who carried the challenge HXB2, YIKIFIMIV, only Pt16 could recognize it.

Variant ID.	`1677`
Epitope Seq.	`YIKIFIMIV`
Variant Seq.	`YIrlFIMIV`
Mutations	K/R I/L
Epitope Location	K3R I4L
HXB2 Location	K683R I684L
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt17 was a carrier of this variant and was unable to recognize the challenge HXB2 epitope, YIKIFIMIV.

Variant ID.	`1678`
Epitope Seq.	`YIKIFIMIV`
Variant Seq.	`YIrIFIMIV`
Mutations	K/R
Epitope Location	K3R
HXB2 Location	K683R
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subject Pt41 was a carrier of this variant and was unable to recognize the challenge HXB2 epitope, YIKIFIMIV.

References

Displaying record number 55394

HXB2 Location Nef(141-148) Nef Epitope Map
View variants at this location

Epitope

WCFKLVPV

Epitope Alignment

Variants

WCyKLVPV observed variant

Epitope Name Nef 141

Species (MHC/HLA) human(A2)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`1687`
Epitope Seq.	`WCFKLVPV`
Variant Seq.	`WCyKLVPV`
Mutations	F/Y
Epitope Location	F3Y
HXB2 Location	F143Y
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Subjects Pt15 and Pt16 carried the HXB2 epitope WCYKLVPV; but while Pt15 was able to cross-recognize the challenge variant sequence WCFKLVPV, Pt 16 was not.