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Found 26 matching records:

Displaying record number 55395

HXB2 Location  Gag(77-85)   Gag Epitope Map
View variants at this location
Epitope SLYNTVATL   Epitope Alignment
Variants
SLfNTVATL   observed variant
SLYNTVAvL   observed variant
SLYNTVATi   observed variant
SLfNTVATi   observed variant
SLnNaiAvL   observed variant
SvYNTVATL   observed variant
Epitope Name Gag 77
Species (MHC/HLA human(A2)

Variant Details

Showing all: 6 variant(s).


Variant ID.  1658
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfNTVATL
Mutations Y/F
Epitope Location Y3F
HXB2 Location Y79F
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subjects Pt15, Pt18 carried this variant epitope, but cross-recognized the challenge HXB2 sequence SLYNTVATL. Subject Pt30 who carried the challenge epitope too did not recognize that HXB2 sequence.


Variant ID.  1660
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNTVAvL
Mutations T/V
Epitope Location T8V
HXB2 Location T84V
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject P43 carried this variant epitope, but cross-recognized the challenge HXB2 sequence SLYNTVATL. Subject Pt21 who also carried the variant epitope did not recognize HXB2 sequence.


Variant ID.  1661
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNTVATi
Mutations L/I
Epitope Location L9I
HXB2 Location L85I
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt23 carried this variant epitope, and recognized the challenge HXB2 sequence SLYNTVATL.


Variant ID.  1662
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfNTVATi
Mutations Y/F L/I
Epitope Location Y3F L9I
HXB2 Location Y79F L85I
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt41 carried this variant epitope, and recognized the challenge HXB2 sequence SLYNTVATL.


Variant ID.  1663
Epitope Seq.  SLYNTVATL
Variant Seq.  SLnNaiAvL
Mutations Y/N T/A V/I T/V
Epitope Location Y3N T5A V6I T8V
HXB2 Location Y79N T81A V82I T84V
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt17 carried this variant epitope, and did not recognize the challenge HXB2 sequence SLYNTVATL.


Variant ID.  2264
Epitope Seq.  SLYNTVATL
Variant Seq.  SvYNTVATL
Mutations L/V
Epitope Location L2V
HXB2 Location L78V
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt33 carried this variant, and did not recognize the challenge HXB2 SLYNTVATL.

References

Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.


Displaying record number 55367

HXB2 Location  Gag(80-88)   Gag Epitope Map
View variants at this location
Epitope NTVATLYCV   Epitope Alignment
Variants
NaiAvLYCV   observed variant
NTVAvLYCV   observed variant
NTVATiYCV   observed variant
NTVATLYCV   observed variant
Epitope Name Gag 80
Species (MHC/HLA human(A2)

Variant Details

Showing all: 4 variant(s).


Variant ID.  1664
Epitope Seq.  NTVATLYCV
Variant Seq.  NaiAvLYCV
Mutations T/A V/I T/V
Epitope Location T2A V3I T5V
HXB2 Location T81A V82I T84V
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subjects Pt15, Pt16, Pt18, Pt30, Pt33 and Pt35 carried this HXB2 epitope. All of the above were unable to recognize it however, except for Pt15 who did recognize the HXB2 sequence. Only Pt17 carried the variant NaiAvLYCV and was unable to cross-recognize the challenge HXB2 sequence.


Variant ID.  1665
Epitope Seq.  NTVATLYCV
Variant Seq.  NTVAvLYCV
Mutations T/V
Epitope Location T5V
HXB2 Location T84V
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subjects Pt21 and Pt43 carried this variant and were unable to recognize the challenge HXB2 form, NTVATLYCV.


Variant ID.  1666
Epitope Seq.  NTVATLYCV
Variant Seq.  NTVATiYCV
Mutations L/I
Epitope Location L6I
HXB2 Location L85I
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subjects Pt23 and Pt41 carried this variant and were unable to recognize the challenge HXB2 form, NTVATLYCV.


Variant ID.  1667
Epitope Seq.  NTVATLYCV
Variant Seq.  NTVATLYCV
Mutations
Epitope Location
HXB2 Location
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt21 carried this variant and was unable to recognize the challenge HXB2 form, NTVATLYCV.

References

Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.


Displaying record number 55368

HXB2 Location  Gag(242-250)   Gag Epitope Map
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Epitope TLQEQIGWM   Epitope Alignment
Variants
TLQEQIaWM   observed variant
nLQEQIGWM   observed variant
Epitope Name Gag 242
Species (MHC/HLA human(A2)

Variant Details

Showing all: 2 variant(s).


Variant ID.  1668
Epitope Seq.  TLQEQIGWM
Variant Seq.  TLQEQIaWM
Mutations G/A
Epitope Location G7A
HXB2 Location G248A
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subjects Pt15 and Pt33 carried this variant and were unable to recognize the challenge HXB2 form. Subjects Pt35 and Pt41 carried the HXB2 sequence and were able to recognize it; all others Pt16, Pt17, Pt18, Pt21, Pt23 and Pt35 did carry the HXB2 epitope, but could not recognize it.


Variant ID.  1669
Epitope Seq.  TLQEQIGWM
Variant Seq.  nLQEQIGWM
Mutations T/N
Epitope Location T1N
HXB2 Location T242N
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt30 carried this variant and was unable to recognize the challenge HXB2 form, NTVATLYCV.

References

Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.


Displaying record number 55371

HXB2 Location  Gag(362-370)   Gag Epitope Map
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Epitope VLAEAMSQV   Epitope Alignment
Variants
VLAEAMSQa   observed variant
VLAEAMSQm   observed variant
Epitope Name Gag 362(9V)
Species (MHC/HLA human(A2)

Variant Details

Showing all: 2 variant(s).


Variant ID.  1690
Epitope Seq.  VLAEAMSQV
Variant Seq.  VLAEAMSQa
Mutations V/A
Epitope Location V9A
HXB2 Location V370A
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt15 carried this variant and was unable to recognize either variant or the challenge HXB2 form, VLAEAMSQV.


Variant ID.  1691
Epitope Seq.  VLAEAMSQV
Variant Seq.  VLAEAMSQm
Mutations V/M
Epitope Location V9M
HXB2 Location V370M
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt17 carried this variant and was unable to recognize either variant or the challenge HXB2 form, VLAEAMSQV.

References

Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.


Displaying record number 55372

HXB2 Location  Gag(433-440)   Gag Epitope Map
View variants at this location
Epitope FLGKIWPS   Epitope Alignment
Variants
FLGKIWsS   observed variant
FLGrIWPS   observed variant
Epitope Name Gag 433
Species (MHC/HLA human(A2)

Variant Details

Showing all: 2 variant(s).


Variant ID.  1692
Epitope Seq.  FLGKIWPS
Variant Seq.  FLGKIWsS
Mutations P/S
Epitope Location P7S
HXB2 Location P439S
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt16 carried this variant and was able to cross-recognize the challenge HXB2 epitope, FLGKIWPS. Of the 9 subjects that did carry the HXB2 epitope sequence, only 3, Pt30, Pt33 and Pt41 were able to recognize it.


Variant ID.  1693
Epitope Seq.  FLGKIWPS
Variant Seq.  FLGrIWPS
Mutations K/R
Epitope Location K4R
HXB2 Location K436R
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt43 carried this variant and was able to cross-recognize the challenge HXB2 epitope, FLGKIWPS.

References

Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.


Displaying record number 55374

HXB2 Location  Pol(59-67)   Pol Epitope Map
View variants at this location
Epitope ITLWQRPLV   Epitope Alignment
Variants
ITLWQRPiV   observed variant
ITLWQRPfV   observed variant
Epitope Name Pol 59
Species (MHC/HLA human(A2)

Variant Details

Showing all: 2 variant(s).


Variant ID.  1670
Epitope Seq.  ITLWQRPLV
Variant Seq.  ITLWQRPiV
Mutations L/I
Epitope Location L8I
HXB2 Location L66I
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt21 carried this variant and was unable to recognize the challenge HXB2 epitope form, ITLWQRPLV.


Variant ID.  1671
Epitope Seq.  ITLWQRPLV
Variant Seq.  ITLWQRPfV
Mutations L/F
Epitope Location L8F
HXB2 Location L66F
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt41 carried this variant and was unable to recognize the challenge HXB2 epitope form, ITLWQRPLV.

References

Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.


Displaying record number 55397

HXB2 Location  Pol(464-472)   Pol Epitope Map
View variants at this location
Epitope ILKEPVHGV   Epitope Alignment
Variants
ILKEPVHGa   observed variant
IiKEPVHxx   observed variant
Epitope Name Pol 476
Species (MHC/HLA human(A2)

Variant Details

Showing all: 2 variant(s).


Variant ID.  1759
Epitope Seq.  ILKEPVHGV
Variant Seq.  ILKEPVHGa
Mutations V/A
Epitope Location V9A
HXB2 Location V472A
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt18 carried this variant epitope, and did not recognize the challenge HXB2 ILKEPVHGV.


Variant ID.  1760
Epitope Seq.  ILKEPVHGV
Variant Seq.  IiKEPVHxx
Mutations L/I G/X V/X
Epitope Location L2I G8X V9X
HXB2 Location L465I G471X V472X
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt41 carried this variant epitope, and did not recognize the challenge HXB2 ILKEPVHGV.

References

Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.


Displaying record number 55375

HXB2 Location  Pol(571-578)   Pol Epitope Map
View variants at this location
Epitope FVNTPPLV   Epitope Alignment
Variants
FVNTPlLV   observed variant
Epitope Name Pol 571
Species (MHC/HLA human(A2)

Variant Details

Showing all: 1 variant(s).


Variant ID.  1672
Epitope Seq.  FVNTPPLV
Variant Seq.  FVNTPlLV
Mutations P/L
Epitope Location P6L
HXB2 Location P576L
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt18 carried this variant and was unable to recognize the challenge HXB2 epitope form, FVNTPPLV.

References

Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.


Displaying record number 55376

HXB2 Location  Pol(606-614)   Pol Epitope Map
View variants at this location
Epitope KLGKAGYVT   Epitope Alignment
Variants
KLGKAGYVv   observed variant
KmGKAGYVT   observed variant
KtGKAGYVT   observed variant
KiGKAGYVT   observed variant
Epitope Name Pol 606
Species (MHC/HLA human(A2)

Variant Details

Showing all: 4 variant(s).


Variant ID.  1694
Epitope Seq.  KLGKAGYVT
Variant Seq.  KLGKAGYVv
Mutations T/V
Epitope Location T9V
HXB2 Location T614V
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Though poorly immunogenic in A2 transgenic mice, anchor-optimization of HXB2 Pol 606(9T) to variant Pol606(9V), KLGKAGYVv, induced cross-reaction and higher immunogenicity.


Variant ID.  1695
Epitope Seq.  KLGKAGYVT
Variant Seq.  KmGKAGYVT
Mutations L/M
Epitope Location L2M
HXB2 Location L607M
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subjects Pt15 and Pt35 carried this variant, but while Pt15 was unable to cross-recognize the challenge HXB2 sequence KLGKAGYVT, Pt35 did recognize this challenge HXB2 sequence.


Variant ID.  1696
Epitope Seq.  KLGKAGYVT
Variant Seq.  KtGKAGYVT
Mutations L/T
Epitope Location L2T
HXB2 Location L607T
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt16 carried this variant and was unable to cross-recognize the challenge HXB2 epitope, KLGKAGYVT.


Variant ID.  1697
Epitope Seq.  KLGKAGYVT
Variant Seq.  KiGKAGYVT
Mutations L/I
Epitope Location L2I
HXB2 Location L607I
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt17 carried this variant and was unable to cross-recognize the challenge HXB2 epitope, KLGKAGYVT.

References

Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.


Displaying record number 55377

HXB2 Location  Pol(687-695)   Pol Epitope Map
View variants at this location
Epitope YLAWVPAHK   Epitope Alignment
Variants
YLsWVPAHK   observed variant
Epitope Name Pol 687
Species (MHC/HLA human(A2)

Variant Details

Showing all: 1 variant(s).


Variant ID.  1673
Epitope Seq.  YLAWVPAHK
Variant Seq.  YLsWVPAHK
Mutations A/S
Epitope Location A3S
HXB2 Location A689S
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt15 carried this variant epitope in a structural protein, and did not recognize the challenge HXB2 epitope form, YLAWVPAHK. 10 other subjects were HXB2 epitope carriers, but of them only Pt16 could recognize that epitope.

References

Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.


Displaying record number 55386

HXB2 Location  Vif(23-31)   Vif Epitope Map
View variants at this location
Epitope SLVKHHMYI   Epitope Alignment
Variants
SLVKHHMYv   susceptible form
SvVKHHMYI   susceptible form
Epitope Name VIf 23(9I)
Species (MHC/HLA human(A2)

Variant Details

Showing all: 2 variant(s).


Variant ID.  1698
Epitope Seq.  SLVKHHMYI
Variant Seq.  SLVKHHMYv
Mutations I/V
Epitope Location I9V
HXB2 Location I31V
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note This 9I variant and 9V consensus epitope cross-reacted in A2 transgenic mice. Subjects Pt18 and Pt41 carried the HXB2 epitope SLVKHHMYV and were unable to recognize either the HXB2 or 9I variant form. Subjects Pt17, Pt23 and Pt43 carried the 9I variant form, and while Pt17 and Pt23 were unable to recognize either form, Pt 43 was able to recognize both the consensus and 9I variant.


Variant ID.  1699
Epitope Seq.  SLVKHHMYI
Variant Seq.  SvVKHHMYI
Mutations L/V
Epitope Location L2V
HXB2 Location L24V
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note This 2V variant was the most immunogenic of all epitopes studied and it cross-reacted with the 9I variant, SLVKHHMYi.

References

Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.


Displaying record number 55387

HXB2 Location  Vif(101-109)   Vif Epitope Map
View variants at this location
Epitope GLADQLIHL   Epitope Alignment
Variants
nLADQLIHL   observed variant
dLADhLIHL   observed variant
dLADQLIHL   observed variant
evADQLIHL   observed variant
sLADQLIHL   observed variant
GLADrLIHL   observed variant
hLADQLIHq   observed variant
GLADQLIHm   susceptible form
Epitope Name VIf 101(9L)
Species (MHC/HLA human(A2)

Variant Details

Showing all: 8 variant(s).


Variant ID.  1700
Epitope Seq.  GLADQLIHL
Variant Seq.  nLADQLIHL
Mutations G/N
Epitope Location G1N
HXB2 Location G101N
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subjects Pt16, Pt17 carried this variant and were unable to recognize the 9M variant GLADQLIHL. Pt 17 also did not recognize the challenge 9L HXB2 epitope, but Pt16 did recognize it.


Variant ID.  1701
Epitope Seq.  GLADQLIHL
Variant Seq.  dLADhLIHL
Mutations G/D Q/H
Epitope Location G1D Q5H
HXB2 Location G101D Q105H
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt18 carried this variant and was unable to recognize both the 9L HXB2 epitope GLADQLIHL, as well as the 9M variant GLADQLIHM.


Variant ID.  1702
Epitope Seq.  GLADQLIHL
Variant Seq.  dLADQLIHL
Mutations G/D
Epitope Location G1D
HXB2 Location G101D
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subjects Pt 21, Pt23, Pt33 carried this variant and were unable to recognize the 9M variant GLADQLIHM. Pt21 and Pt33 were also unable to recognize the HXB2 epitope GLADQLIHL, but Pt23 was able to recognize it.


Variant ID.  1703
Epitope Seq.  GLADQLIHL
Variant Seq.  evADQLIHL
Mutations G/E L/V
Epitope Location G1E L2V
HXB2 Location G101E L102V
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt30 carried this variant and did not recognize either the challenge HXB2 epitope GLADQLIHL, or the 9M variant GLADQLIHM.


Variant ID.  1704
Epitope Seq.  GLADQLIHL
Variant Seq.  sLADQLIHL
Mutations G/S
Epitope Location G1S
HXB2 Location G101S
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt35 carried this variant and did not recognize either the challenge HXB2 epitope GLADQLIHL, or the 9M variant GLADQLIHM.


Variant ID.  1705
Epitope Seq.  GLADQLIHL
Variant Seq.  GLADrLIHL
Mutations Q/R
Epitope Location Q5R
HXB2 Location Q105R
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt43 carried this variant and did not recognize either the challenge HXB2 epitope GLADQLIHL, or the 9M variant GLADQLIHM.


Variant ID.  1706
Epitope Seq.  GLADQLIHL
Variant Seq.  hLADQLIHq
Mutations G/H L/Q
Epitope Location G1H L9Q
HXB2 Location G101H L109Q
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt41 carried this variant and did not recognize the challenge HXB2 epitope GLADQLIHL, however it did recognize the 9M variant GLADQLIHM.


Variant ID.  1707
Epitope Seq.  GLADQLIHL
Variant Seq.  GLADQLIHm
Mutations L/M
Epitope Location L9M
HXB2 Location L109M
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt41 carried hLADQLIHq variant and did not recognize the challenge HXB2 epitope GLADQLIHL, however it did recognize the 9M variant GLADQLIHm.

References

Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.


Displaying record number 55388

HXB2 Location  Vif(149-157)   Vif Epitope Map
View variants at this location
Epitope ALAALITPK   Epitope Alignment
Variants
ALtALITPK   observed variant
ALtALIkPK   observed variant
ltAALtkPK   observed variant
ALtALIatK   observed variant
ALAAvITPK   observed variant
ALAALvTPK   observed variant
ALAALIrPK   observed variant
Epitope Name VIf 149
Species (MHC/HLA human(A2)

Variant Details

Showing all: 7 variant(s).


Variant ID.  1679
Epitope Seq.  ALAALITPK
Variant Seq.  ALtALITPK
Mutations A/T
Epitope Location A3T
HXB2 Location A151T
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subjects Pt18, Pt30 carried this variant and were unable to recognize the challenge HXB2 form, ALAALITPK.


Variant ID.  1680
Epitope Seq.  ALAALITPK
Variant Seq.  ALtALIkPK
Mutations A/T T/K
Epitope Location A3T T7K
HXB2 Location A151T T155K
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt15 carried this variant and was unable to recognize the challenge HXB2 form, ALAALITPK.


Variant ID.  1681
Epitope Seq.  ALAALITPK
Variant Seq.  ltAALtkPK
Mutations A/L L/T I/T T/K
Epitope Location A1L L2T I6T T7K
HXB2 Location A149L L150T I154T T155K
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt21 carried this variant and was unable to recognize the challenge HXB2 form, ALAALITPK.


Variant ID.  1682
Epitope Seq.  ALAALITPK
Variant Seq.  ALtALIatK
Mutations A/T T/A P/T
Epitope Location A3T T7A P8T
HXB2 Location A151T T155A P156T
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt23 carried this variant and was unable to recognize the challenge HXB2 form, ALAALITPK.


Variant ID.  1684
Epitope Seq.  ALAALITPK
Variant Seq.  ALAAvITPK
Mutations L/V
Epitope Location L5V
HXB2 Location L153V
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt43 carried this variant and was unable to recognize the challenge HXB2 form, ALAALITPK.


Variant ID.  1685
Epitope Seq.  ALAALITPK
Variant Seq.  ALAALvTPK
Mutations I/V
Epitope Location I6V
HXB2 Location I154V
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt17 carried this variant and was unable to recognize the challenge HXB2 form, ALAALITPK.


Variant ID.  1686
Epitope Seq.  ALAALITPK
Variant Seq.  ALAALIrPK
Mutations T/R
Epitope Location T7R
HXB2 Location T155R
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt33 carried this variant and cross-recognized the challenge HXB2 form, ALAALITPK.

References

Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.


Displaying record number 55389

HXB2 Location  Vif(158-166)   Vif Epitope Map
View variants at this location
Epitope KIKPPLPSV   Epitope Alignment
Variants
KtKPPLPSV   non-susceptible form
KrKPPLPSV   observed variant
KriPPLPSV   observed variant
rttPPLPSi   observed variant
rItPPLPSi   observed variant
Epitope Name VIf 158(2I)
Species (MHC/HLA human(A2)

Variant Details

Showing all: 5 variant(s).


Variant ID.  1708
Epitope Seq.  KIKPPLPSV
Variant Seq.  KtKPPLPSV
Mutations I/T
Epitope Location I2T
HXB2 Location I159T
Mutation Type NSF: non-susceptible form
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subjects Pt35 and Pt41 carried this HXB2 epitope and did not recognize it; Subjects Pt16, Pt18, Pt23, Pt33, Pt43 carried the 2T variant and did not recognize either this 2T variant or the challenge HXB2. Only Subject Pt30 who also carried the 2T variant was able to cross-recognize the HXB2 epitope, KIKPPLPSV.


Variant ID.  1709
Epitope Seq.  KIKPPLPSV
Variant Seq.  KrKPPLPSV
Mutations I/R
Epitope Location I2R
HXB2 Location I159R
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt15 carried this variant and was unable to recognize both the 2T variant, KtKPPLPSV, as well as the HXB2 form. Subject Pt17 who carried this variant did not recognize the 2I challenge HXB2 epitope.


Variant ID.  1710
Epitope Seq.  KIKPPLPSV
Variant Seq.  KriPPLPSV
Mutations I/R K/I
Epitope Location I2R K3I
HXB2 Location I159R K160I
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt17 carried this variant and was not able to recognize the 2T, KtKPPLPSV, variant epitope.


Variant ID.  1711
Epitope Seq.  KIKPPLPSV
Variant Seq.  rttPPLPSi
Mutations K/R I/T K/T V/I
Epitope Location K1R I2T K3T V9I
HXB2 Location K158R I159T K160T V166I
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt21 carried this variant epitope and was not able to recognize the challenge HXB2 form.


Variant ID.  1712
Epitope Seq.  KIKPPLPSV
Variant Seq.  rItPPLPSi
Mutations K/R K/T V/I
Epitope Location K1R K3T V9I
HXB2 Location K158R K160T V166I
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt21 carried this variant was not able to recognize the 2T variant form, KTKPPLPSV.

References

Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.


Displaying record number 55390

HXB2 Location  Vpr(34-42)   Vpr Epitope Map
View variants at this location
Epitope FPRPWLHGL   Epitope Alignment
Variants
FPRmWLHsL   observed variant
FPRiWLHsL   observed variant
FPPtWLHnL   observed variant
FPRvWLHnL   observed variant
FPRvWLHGL   observed variant
FPRiWLHnL   observed variant
FPRtWLHsL   observed variant
FPRmWLHnL   observed variant
Epitope Name Vpr 34
Species (MHC/HLA human(A2)

Variant Details

Showing all: 8 variant(s).


Variant ID.  1713
Epitope Seq.  FPRPWLHGL
Variant Seq.  FPRmWLHsL
Mutations P/M G/S
Epitope Location P4M G8S
HXB2 Location P37M G41S
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt15 carried this variant epitope in a regulatory/accessory protein, and recognized the HXB2 epitope FPRPWLHGL.


Variant ID.  1714
Epitope Seq.  FPRPWLHGL
Variant Seq.  FPRiWLHsL
Mutations P/I G/S
Epitope Location P4I G8S
HXB2 Location P37I G41S
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt23 carried this variant epitope in a regulatory/accessory protein, and recognized the HXB2 epitope FPRPWLHGL.


Variant ID.  1715
Epitope Seq.  FPRPWLHGL
Variant Seq.  FPPtWLHnL
Mutations R/P P/T G/N
Epitope Location R3P P4T G8N
HXB2 Location R36P P37T G41N
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt16 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope FPRPWLHGL.


Variant ID.  1716
Epitope Seq.  FPRPWLHGL
Variant Seq.  FPRvWLHnL
Mutations P/V G/N
Epitope Location P4V G8N
HXB2 Location P37V G41N
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt18 carried this variant epitope in a regulatory/accessory protein, and did not recognize the challenge HXB2 epitope FPRPWLHGL.


Variant ID.  1717
Epitope Seq.  FPRPWLHGL
Variant Seq.  FPRvWLHGL
Mutations P/V
Epitope Location P4V
HXB2 Location P37V
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt21 carried this variant epitope in a regulatory/accessory protein, and did not recognize the challenge HXB2 epitope FPRPWLHGL.


Variant ID.  1718
Epitope Seq.  FPRPWLHGL
Variant Seq.  FPRiWLHnL
Mutations P/I G/N
Epitope Location P4I G8N
HXB2 Location P37I G41N
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subjects Pt30, Pt35 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope FPRPWLHGL.


Variant ID.  1719
Epitope Seq.  FPRPWLHGL
Variant Seq.  FPRtWLHsL
Mutations P/T G/S
Epitope Location P4T G8S
HXB2 Location P37T G41S
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt41 carried this variant epitope in a regulatory/accessory protein, and did not recognize the challenge HXB2 epitope FPRPWLHGL.


Variant ID.  1720
Epitope Seq.  FPRPWLHGL
Variant Seq.  FPRmWLHnL
Mutations P/M G/N
Epitope Location P4M G8N
HXB2 Location P37M G41N
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt43 carried this variant epitope in a regulatory/accessory protein, and did not recognize the challenge HXB2 epitope FPRPWLHGL.

References

Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.


Displaying record number 55391

HXB2 Location  Vpr(41-49)   Vpr Epitope Map
View variants at this location
Epitope SLGQHIYET   Epitope Alignment
Variants
SLGQHIYnT   observed variant
nLGQyIYET   observed variant
nLGQHIYET   observed variant
nLGQfIYET   observed variant
SLGQyIYaT   observed variant
gLGQHIYET   observed variant
Epitope Name Vpr 41
Species (MHC/HLA human(A2)

Variant Details

Showing all: 6 variant(s).


Variant ID.  1721
Epitope Seq.  SLGQHIYET
Variant Seq.  SLGQHIYnT
Mutations E/N
Epitope Location E8N
HXB2 Location E48N
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt15 carried this variant epitope in a regulatory/accessory protein, and did not recognize the challenge HXB2 epitope SLGQHIYET.


Variant ID.  1722
Epitope Seq.  SLGQHIYET
Variant Seq.  nLGQyIYET
Mutations S/N H/Y
Epitope Location S1N H5Y
HXB2 Location S41N H45Y
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt16, Pt30 carried this variant epitope in a regulatory/accessory protein, and did not recognize the index epitope SLGQHIYET.


Variant ID.  1723
Epitope Seq.  SLGQHIYET
Variant Seq.  nLGQHIYET
Mutations S/N
Epitope Location S1N
HXB2 Location S41N
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subjects Pt18, Pt43 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope SLGQHIYET.


Variant ID.  1724
Epitope Seq.  SLGQHIYET
Variant Seq.  nLGQfIYET
Mutations S/N H/F
Epitope Location S1N H5F
HXB2 Location S41N H45F
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt35 carried this variant epitope in a regulatory/accessory protein, and did not recognize the challenge HXB2 epitope SLGQHIYET.


Variant ID.  1725
Epitope Seq.  SLGQHIYET
Variant Seq.  SLGQyIYaT
Mutations H/Y E/A
Epitope Location H5Y E8A
HXB2 Location H45Y E48A
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt41 carried this variant epitope in a regulatory/accessory protein, and did not recognize the challenge HXB2 epitope SLGQHIYET.


Variant ID.  1726
Epitope Seq.  SLGQHIYET
Variant Seq.  gLGQHIYET
Mutations S/G
Epitope Location S1G
HXB2 Location S41G
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subjects Pt17, Pt21, Pt33 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope SLGQHIYET.

References

Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.


Displaying record number 55383

HXB2 Location  Rev(73-81)   Rev Epitope Map
View variants at this location
Epitope LQLPPIERL   Epitope Alignment
Variants
fQLPPIERL   observed variant
LQLPPlERL   observed variant
Epitope Name Rev 73
Species (MHC/HLA human(A2)

Variant Details

Showing all: 2 variant(s).


Variant ID.  1688
Epitope Seq.  LQLPPIERL
Variant Seq.  fQLPPIERL
Mutations L/F
Epitope Location L1F
HXB2 Location L73F
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subjects Pt15 carried this variant but was unable to cross-recognize the challenge HXB2 sequence, LQLPPIERL.


Variant ID.  1689
Epitope Seq.  LQLPPIERL
Variant Seq.  LQLPPlERL
Mutations I/L
Epitope Location I6L
HXB2 Location I78L
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subjects Pt16, Pt17, Pt18, Pt21, Pt23, Pt30, Pt33, Pt35, Pt41 and Pt43 carried the HXB2 epitope LQLPPLERL; and none were able to cross-recognize the variant LQLPPIERL.

References

Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.


Displaying record number 55384

HXB2 Location  Rev(96-104)   Rev Epitope Map
View variants at this location
Epitope GMGSPQILV   Epitope Alignment
Variants
GvGSPQILV   observed variant
GvGSPQIsg   observed variant
GvGSPQIsV   observed variant
GvGSPQILl   observed variant
GvGnPQILV   observed variant
GvGnPQvLV   observed variant
GvGSPQvLV   observed variant
GvGSPeILV   observed variant
Epitope Name Rev 96
Species (MHC/HLA human(A2)

Variant Details

Showing all: 8 variant(s).


Variant ID.  1727
Epitope Seq.  GMGSPQILV
Variant Seq.  GvGSPQILV
Mutations M/V
Epitope Location M2V
HXB2 Location M97V
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subjects Pt16, Pt18, Pt35, Pt41 carried this HXB2 consensus epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope GMGSPQILV.


Variant ID.  1728
Epitope Seq.  GMGSPQILV
Variant Seq.  GvGSPQIsg
Mutations M/V L/S V/G
Epitope Location M2V L8S V9G
HXB2 Location M97V L103S V104G
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt15 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope GMGSPQILV.


Variant ID.  1729
Epitope Seq.  GMGSPQILV
Variant Seq.  GvGSPQIsV
Mutations M/V L/S
Epitope Location M2V L8S
HXB2 Location M97V L103S
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt17 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope GMGSPQILV.


Variant ID.  1730
Epitope Seq.  GMGSPQILV
Variant Seq.  GvGSPQILl
Mutations M/V V/L
Epitope Location M2V V9L
HXB2 Location M97V V104L
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt21 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope GMGSPQILV.


Variant ID.  1731
Epitope Seq.  GMGSPQILV
Variant Seq.  GvGnPQILV
Mutations M/V S/N
Epitope Location M2V S4N
HXB2 Location M97V S99N
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt33 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope GMGSPQILV.


Variant ID.  1732
Epitope Seq.  GMGSPQILV
Variant Seq.  GvGnPQvLV
Mutations M/V S/N I/V
Epitope Location M2V S4N I7V
HXB2 Location M97V S99N I102V
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt23 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope GMGSPQILV.


Variant ID.  1733
Epitope Seq.  GMGSPQILV
Variant Seq.  GvGSPQvLV
Mutations M/V I/V
Epitope Location M2V I7V
HXB2 Location M97V I102V
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt43 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope GMGSPQILV.


Variant ID.  1734
Epitope Seq.  GMGSPQILV
Variant Seq.  GvGSPeILV
Mutations M/V Q/E
Epitope Location M2V Q6E
HXB2 Location M97V Q101E
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt30 carried this variant epitope in a regulatory/accessory protein, and cross-recognized the HXB2 epitope GMGSPQILV.

References

Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.


Displaying record number 55385

HXB2 Location  Rev(102-110)   Rev Epitope Map
View variants at this location
Epitope ILVESPAVL   Epitope Alignment
Variants
IsgkpcAVL   observed variant
ILVEpstVL   observed variant
IsVESPtVL   observed variant
ILVEhPtiL   observed variant
ILlESPtVL   observed variant
ILVESPtVL   observed variant
ILVEpsAVL   observed variant
ILVESPAVi   observed variant
vLVEpPpVL   observed variant
vLVESPAVL   observed variant
Epitope Name Rev 102
Species (MHC/HLA human(A2)

Variant Details

Showing all: 10 variant(s).


Variant ID.  1735
Epitope Seq.  ILVESPAVL
Variant Seq.  IsgkpcAVL
Mutations L/S V/G E/K S/P P/C
Epitope Location L2S V3G E4K S5P P6C
HXB2 Location L103S V104G E105K S106P P107C
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt15 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope ILVESPAVL.


Variant ID.  1736
Epitope Seq.  ILVESPAVL
Variant Seq.  ILVEpstVL
Mutations S/P P/S A/T
Epitope Location S5P P6S A7T
HXB2 Location S106P P107S A108T
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt16 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope ILVESPAVL.


Variant ID.  1737
Epitope Seq.  ILVESPAVL
Variant Seq.  IsVESPtVL
Mutations L/S A/T
Epitope Location L2S A7T
HXB2 Location L103S A108T
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt17 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope ILVESPAVL.


Variant ID.  1738
Epitope Seq.  ILVESPAVL
Variant Seq.  ILVEhPtiL
Mutations S/H A/T V/I
Epitope Location S5H A7T V8I
HXB2 Location S106H A108T V109I
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt18 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope ILVESPAVL.


Variant ID.  1739
Epitope Seq.  ILVESPAVL
Variant Seq.  ILlESPtVL
Mutations V/L A/T
Epitope Location V3L A7T
HXB2 Location V104L A108T
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt21 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope ILVESPAVL.


Variant ID.  1740
Epitope Seq.  ILVESPAVL
Variant Seq.  ILVESPtVL
Mutations A/T
Epitope Location A7T
HXB2 Location A108T
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt33 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope ILVESPAVL.


Variant ID.  1741
Epitope Seq.  ILVESPAVL
Variant Seq.  ILVEpsAVL
Mutations S/P P/S
Epitope Location S5P P6S
HXB2 Location S106P P107S
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt35 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope ILVESPAVL.


Variant ID.  1742
Epitope Seq.  ILVESPAVL
Variant Seq.  ILVESPAVi
Mutations L/I
Epitope Location L9I
HXB2 Location L110I
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt41 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope ILVESPAVL.


Variant ID.  1743
Epitope Seq.  ILVESPAVL
Variant Seq.  vLVEpPpVL
Mutations I/V S/P A/P
Epitope Location I1V S5P A7P
HXB2 Location I102V S106P A108P
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt43 carried this variant epitope in a regulatory/accessory protein, and recognized the HXB2 epitope ILVESPAVL.


Variant ID.  1744
Epitope Seq.  ILVESPAVL
Variant Seq.  vLVESPAVL
Mutations I/V
Epitope Location I1V
HXB2 Location I102V
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt23 carried this variant epitope in a regulatory/accessory protein, and recognized the HXB2 epitope ILVESPAVL.

References

Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.


Displaying record number 55393

HXB2 Location  Vpu(66-74)   Vpu Epitope Map
View variants at this location
Epitope ALVEMGHHA   Epitope Alignment
Variants
ALVEMGHHv   observed variant
tmVdMGnlr   observed variant
iLVEMGHdA   observed variant
gLVEMGHpA   observed variant
ALVErGylA   observed variant
iLmEMGHdA   observed variant
ALmgMGHHA   observed variant
Epitope Name Vpu 66
Species (MHC/HLA human

Variant Details

Showing all: 7 variant(s).


Variant ID.  1745
Epitope Seq.  ALVEMGHHA
Variant Seq.  ALVEMGHHv
Mutations A/V
Epitope Location A9V
HXB2 Location A75V
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note This modified variant, designed to optimize the anchor residue was cross-recognized strongly by index epitope ALVEMGHHA-recognizing CTL.


Variant ID.  1746
Epitope Seq.  ALVEMGHHA
Variant Seq.  tmVdMGnlr
Mutations A/T L/M E/D H/N H/L A/R
Epitope Location A1T L2M E4D H7N H8L A9R
HXB2 Location A67T L68M E70D H73N H74L A75R
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt15 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope ALVEMGHHA.


Variant ID.  1747
Epitope Seq.  ALVEMGHHA
Variant Seq.  iLVEMGHdA
Mutations A/I H/D
Epitope Location A1I H8D
HXB2 Location A67I H74D
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt16 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope ALVEMGHHA.


Variant ID.  1748
Epitope Seq.  ALVEMGHHA
Variant Seq.  gLVEMGHpA
Mutations A/G H/P
Epitope Location A1G H8P
HXB2 Location A67G H74P
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt17 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope ALVEMGHHA.


Variant ID.  1749
Epitope Seq.  ALVEMGHHA
Variant Seq.  ALVErGylA
Mutations M/R H/Y H/L
Epitope Location M5R H7Y H8L
HXB2 Location M71R H73Y H74L
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt23 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope ALVEMGHHA.


Variant ID.  1750
Epitope Seq.  ALVEMGHHA
Variant Seq.  iLmEMGHdA
Mutations A/I V/M H/D
Epitope Location A1I V3M H8D
HXB2 Location A67I V69M H74D
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt35 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope ALVEMGHHA.


Variant ID.  1751
Epitope Seq.  ALVEMGHHA
Variant Seq.  ALmgMGHHA
Mutations V/M E/G
Epitope Location V3M E4G
HXB2 Location V69M E70G
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt41 carried this variant epitope in a regulatory/accessory protein, and did not recognize the HXB2 epitope ALVEMGHHA.

References

Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.


Displaying record number 55379

HXB2 Location  gp160(67-75)   gp160 Epitope Map
View variants at this location
Epitope NVWATHACV   Epitope Alignment
Variants
NiWATHACV   susceptible form
NVWATrACV   observed variant
NiWATrACV   observed variant
Epitope Name Env 67(2V)
Species (MHC/HLA human(A2)

Variant Details

Showing all: 3 variant(s).


Variant ID.  10
Epitope Seq.  NVWATHACV
Variant Seq.  NiWATHACV
Mutations V/I
Epitope Location V2I
HXB2 Location V68I
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt23 carried the challenge HXB2 epitope, and recognized the 2I variant epitope NIWATRACV, while all other Subjects Pt15, Pt16, Pt17, Pt18, Pt21, Pt33, Pt35, Pt41 and Pt43 did not recognize the 2I variant. All of the above subjects, however, also did not recognize the consensus HXB2 epitope that they carried.


Variant ID.  1752
Epitope Seq.  NVWATHACV
Variant Seq.  NVWATrACV
Mutations H/R
Epitope Location H6R
HXB2 Location H72R
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt30 carried this variant epitope, and did not recognize the challenge HXB2 epitope NIWATRACV.


Variant ID.  1753
Epitope Seq.  NVWATHACV
Variant Seq.  NiWATrACV
Mutations V/I H/R
Epitope Location V2I H6R
HXB2 Location V68I H72R
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt30 carried this variant epitope, and did not recognize the HXB2 epitope NVWATRACV.

References

Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.


Displaying record number 55398

HXB2 Location  gp160(121-129)   gp160 Epitope Map
View variants at this location
Epitope KLTPLCVTL   Epitope Alignment
Variants
KLTPfCVvL   observed variant
KLTPLCVsL   observed variant
KiTPLCVTL   observed variant
Epitope Name Env 121
Species (MHC/HLA human(A2)

Variant Details

Showing all: 3 variant(s).


Variant ID.  1761
Epitope Seq.  KLTPLCVTL
Variant Seq.  KLTPfCVvL
Mutations L/F T/V
Epitope Location L5F T8V
HXB2 Location L125F T128V
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt30 carried this variant epitope, and did not recognize the challenge HXB2 epitope KLTPLCVTL.


Variant ID.  1762
Epitope Seq.  KLTPLCVTL
Variant Seq.  KLTPLCVsL
Mutations T/S
Epitope Location T8S
HXB2 Location T128S
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt41 carried the HXB2 epitope KLTPLCVsL, and did not recognize the index epitope KLTPLCVTL.


Variant ID.  1763
Epitope Seq.  KLTPLCVTL
Variant Seq.  KiTPLCVTL
Mutations L/I
Epitope Location L2I
HXB2 Location L122I
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt43 carried this variant epitope, and did not recognize the challenge HXB2 epitope KLTPLCVTL.

References

Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.


Displaying record number 55380

HXB2 Location  gp160(529-537)   gp160 Epitope Map
View variants at this location
Epitope TMGAASITL   Epitope Alignment
Variants
TMGAASmTL   observed variant
TMGAASlTL   observed variant
TMGAASvTL   observed variant
TMGAASmaL   observed variant
TMGAASvaL   observed variant
Epitope Name Env 529
Species (MHC/HLA human(A2)

Variant Details

Showing all: 5 variant(s).


Variant ID.  1754
Epitope Seq.  TMGAASITL
Variant Seq.  TMGAASmTL
Mutations I/M
Epitope Location I7M
HXB2 Location I535M
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subjects Pt16, Pt21 carried the HXB2 epitope TMGAASmTL, but cross-recognized the variant TMGAASITL; Pt18, Pt43 also carried the consensus HXB2 sequence but failed to recognize the index TMGAASITL.


Variant ID.  1755
Epitope Seq.  TMGAASITL
Variant Seq.  TMGAASlTL
Mutations I/L
Epitope Location I7L
HXB2 Location I535L
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt35 carried this variant epitope in a structural protein, and did not recognize the challenge HXB2 epitope TMGAASITL.


Variant ID.  1756
Epitope Seq.  TMGAASITL
Variant Seq.  TMGAASvTL
Mutations I/V
Epitope Location I7V
HXB2 Location I535V
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt41 carried this variant epitope in a structural protein, and recognized the challenge HXB2 epitope TMGAASITL.


Variant ID.  1757
Epitope Seq.  TMGAASITL
Variant Seq.  TMGAASmaL
Mutations I/M T/A
Epitope Location I7M T8A
HXB2 Location I535M T536A
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt23 carried this variant epitope in a structural protein, and did not recognize the challenge HXB2 epitope TMGAASITL.


Variant ID.  1758
Epitope Seq.  TMGAASITL
Variant Seq.  TMGAASvaL
Mutations I/V T/A
Epitope Location I7V T8A
HXB2 Location I535V T536A
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt17 carried this variant epitope in a structural protein, and did not recognize the challenge HXB2 epitope TMGAASITL.

References

Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.


Displaying record number 55381

HXB2 Location  gp160(565-573)   gp160 Epitope Map
View variants at this location
Epitope LLQLTVWGI   Epitope Alignment
Variants
mLQLTVWGI   observed variant
LLkLTVWGI   observed variant
Epitope Name Env 565
Species (MHC/HLA human(A2)

Variant Details

Showing all: 2 variant(s).


Variant ID.  1674
Epitope Seq.  LLQLTVWGI
Variant Seq.  mLQLTVWGI
Mutations L/M
Epitope Location L1M
HXB2 Location L565M
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subjects Pt15, Pt18, Pt23 and Pt30 were carriers of this variant and were all unable to recognize the challenge HXB2 epitope, LLQLTVWGI.


Variant ID.  1675
Epitope Seq.  LLQLTVWGI
Variant Seq.  LLkLTVWGI
Mutations Q/K
Epitope Location Q3K
HXB2 Location Q567K
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt41 was a carrier of this variant and was unable to recognize the challenge HXB2 epitope, LLQLTVWGI.

References

Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.


Displaying record number 55382

HXB2 Location  gp160(681-689)   gp160 Epitope Map
View variants at this location
Epitope YIKIFIMIV   Epitope Alignment
Variants
YIKIFIMIi   observed variant
YIrlFIMIV   observed variant
YIrIFIMIV   observed variant
Epitope Name Env 681
Species (MHC/HLA human(A2)

Variant Details

Showing all: 3 variant(s).


Variant ID.  1676
Epitope Seq.  YIKIFIMIV
Variant Seq.  YIKIFIMIi
Mutations V/I
Epitope Location V9I
HXB2 Location V689I
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subjects Pt23 and Pt35 were carriers of this variant. Pt23 was able to cross-recognize the consensus HXB2 epitope tested, YIKIFIMIV, but Pt35 was not. Of the 7 subjects who carried the challenge HXB2, YIKIFIMIV, only Pt16 could recognize it.


Variant ID.  1677
Epitope Seq.  YIKIFIMIV
Variant Seq.  YIrlFIMIV
Mutations K/R I/L
Epitope Location K3R I4L
HXB2 Location K683R I684L
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt17 was a carrier of this variant and was unable to recognize the challenge HXB2 epitope, YIKIFIMIV.


Variant ID.  1678
Epitope Seq.  YIKIFIMIV
Variant Seq.  YIrIFIMIV
Mutations K/R
Epitope Location K3R
HXB2 Location K683R
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt41 was a carrier of this variant and was unable to recognize the challenge HXB2 epitope, YIKIFIMIV.

References

Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.


Displaying record number 55394

HXB2 Location  Nef(141-148)   Nef Epitope Map
View variants at this location
Epitope WCFKLVPV   Epitope Alignment
Variants
WCyKLVPV   observed variant
Epitope Name Nef 141
Species (MHC/HLA human(A2)

Variant Details

Showing all: 1 variant(s).


Variant ID.  1687
Epitope Seq.  WCFKLVPV
Variant Seq.  WCyKLVPV
Mutations F/Y
Epitope Location F3Y
HXB2 Location F143Y
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subjects Pt15 and Pt16 carried the HXB2 epitope WCYKLVPV; but while Pt15 was able to cross-recognize the challenge variant sequence WCFKLVPV, Pt 16 was not.

References

Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.


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