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Found 3 matching records:

Displaying record number 60669

HXB2 Location  Gag(28-36)   Gag Epitope Map
View variants at this location
Epitope KYRLKHIVW   Epitope Alignment
Variants
qYkLKHIVW   observed variant; susceptible form
rYrLKHlVW   observed variant; susceptible form
Species (MHC/HLA human(A*24:02)

Variant Details

Showing all: 2 variant(s).


Variant ID.  3551
Epitope Seq.  KYRLKHIVW
Variant Seq.  qYkLKHIVW
Mutations K/Q R/K
Epitope Location K1Q R3K
HXB2 Location K28Q R30K
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Other
Note Autologous variant Gag qYkLKHIVW of subject S3 also elicits a greater CTL response from DC-primed naive T cells than DC-stimulated memory T cells.


Variant ID.  3552
Epitope Seq.  KYRLKHIVW
Variant Seq.  rYrLKHlVW
Mutations K/R I/L
Epitope Location K1R I7L
HXB2 Location K28R I34L
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Other
Note Contrary to most cases, autologous variant Gag rYRLKHlVW of subject S4 elicits a smaller CTL response from DC-primed naive T cells than DC-stimulated memory T cells.

References

Smith2016 Kellie N. Smith, Robbie B. Mailliard, Paolo A. Piazza, Will Fischer, Bette T. Korber, Ronald J. Fecek, Deena Ratner, Phalguni Gupta, James I. Mullins, and Charles R. Rinaldo. Effective Cytotoxic T Lymphocyte Targeting of Persistent HIV-1 during Antiretroviral Therapy Requires Priming of Naive CD8+ T Cells. MBio, 7(3), 31 May 2016. PubMed ID: 27247230. Show all entries for this paper.


Displaying record number 60671

HXB2 Location  Gag(28-36)   Gag Epitope Map
View variants at this location
Epitope QYKLKHIVW   Epitope Alignment
Variants
kYrLKHIVW   observed variant; susceptible form
rYrLKHlVW   observed variant; susceptible form
Species (MHC/HLA human(A*24:02)

Variant Details

Showing all: 2 variant(s).


Variant ID.  3553
Epitope Seq.  QYKLKHIVW
Variant Seq.  kYrLKHIVW
Mutations Q/K K/R
Epitope Location Q1K K3R
HXB2 Location Q28K K30R
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Other
Note Autologous variant Gag kYrLKHIVW of subject S2 also elicits a greater CTL response from DC-primed naive T cells than DC-stimulated memory T cells.


Variant ID.  3554
Epitope Seq.  QYKLKHIVW
Variant Seq.  rYrLKHlVW
Mutations Q/R K/R I/L
Epitope Location Q1R K3R I7L
HXB2 Location Q28R K30R I34L
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Other
Note Contrary to most cases, autologous variant Gag rYrLKHlVW of subject S4 elicits a smaller CTL response from DC-primed naive T cells than DC-stimulated memory T cells.

References

Smith2016 Kellie N. Smith, Robbie B. Mailliard, Paolo A. Piazza, Will Fischer, Bette T. Korber, Ronald J. Fecek, Deena Ratner, Phalguni Gupta, James I. Mullins, and Charles R. Rinaldo. Effective Cytotoxic T Lymphocyte Targeting of Persistent HIV-1 during Antiretroviral Therapy Requires Priming of Naive CD8+ T Cells. MBio, 7(3), 31 May 2016. PubMed ID: 27247230. Show all entries for this paper.


Displaying record number 60672

HXB2 Location  Gag(28-36)   Gag Epitope Map
View variants at this location
Epitope RYRLKHLVW   Epitope Alignment
Variants
kYRLKHiVW   observed variant; susceptible form
qYkLKHiVW   observed variant; susceptible form
Species (MHC/HLA human(A*24:02)

Variant Details

Showing all: 2 variant(s).


Variant ID.  3555
Epitope Seq.  RYRLKHLVW
Variant Seq.  kYRLKHiVW
Mutations R/K L/I
Epitope Location R1K L7I
HXB2 Location R28K L34I
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Other
Note Autologous variant Gag kYRLKHiVW of subject S2 also elicits a greater CTL response from DC-primed naive T cells than DC-stimulated memory T cells.


Variant ID.  3556
Epitope Seq.  RYRLKHLVW
Variant Seq.  qYkLKHiVW
Mutations R/Q R/K L/I
Epitope Location R1Q R3K L7I
HXB2 Location R28Q R30K L34I
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Other
Note Autologous variant Gag qYkLKHiVW of subject S3 also elicits a greater CTL response from DC-primed naive T cells than DC-stimulated memory T cells.

References

Smith2016 Kellie N. Smith, Robbie B. Mailliard, Paolo A. Piazza, Will Fischer, Bette T. Korber, Ronald J. Fecek, Deena Ratner, Phalguni Gupta, James I. Mullins, and Charles R. Rinaldo. Effective Cytotoxic T Lymphocyte Targeting of Persistent HIV-1 during Antiretroviral Therapy Requires Priming of Naive CD8+ T Cells. MBio, 7(3), 31 May 2016. PubMed ID: 27247230. Show all entries for this paper.


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