HIV molecular immunology database
Found 5 matching records:
HXB2 Location | Gag(140-147) | Gag Epitope Map
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Epitope |
GQMVHQAI
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Epitope Name | GI8 | ||||||||
Species (MHC/HLA) | human(B*13:02) |
Showing all: 2 variant(s).
Variant ID. | 3748 |
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Epitope Seq. | GQMVHQAI |
Variant Seq. | GQMVHQsI |
Mutations | A/S |
Epitope Location | A7S |
HXB2 Location | A146S |
Mutation Type | A: HLA association E: escape documented in this paper |
Epitope Subtype | B |
Variant Subtype | B |
Method | Relative replication capacity assay |
Note | Mutation A146S in epitope GQMVHQAI, i.e. GQMVHQsI, is associated with HLA-B*13/1302. |
Variant ID. | 3749 |
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Epitope Seq. | GQMVHQAI |
Variant Seq. | GQMVHQAl |
Mutations | I/L |
Epitope Location | I8L |
HXB2 Location | I147L |
Mutation Type | A: HLA association E: escape documented in this paper |
Epitope Subtype | B |
Variant Subtype | B |
Method | Relative replication capacity assay |
Note | Mutation I147L in epitope GQMVHQAI, i.e. GQMVHQAl, is associated with HLA-B*13/1302. |
Shahid2015 Aniqa Shahid, Alex Olvera, Gursev Anmole, Xiaomei T. Kuang, Laura A. Cotton, Montserrat Plana, Christian Brander, Mark A. Brockman, and Zabrina L. Brumme. Consequences of HLA-B*13-Associated Escape Mutations on HIV-1 Replication and Nef Function. J. Virol., 89(22):11557-11571, Nov 2015. PubMed ID: 26355081. Show all entries for this paper.
HXB2 Location | Gag(429-437) | Gag Epitope Map
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Epitope |
RQANFLGKI
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Epitope Name | RI9 | |||||||||||
Species (MHC/HLA) | human(B*13:02) |
Showing all: 3 variant(s).
Variant ID. | 3742 |
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Epitope Seq. | RQANFLGKI |
Variant Seq. | RQANFLGKl |
Mutations | I/L |
Epitope Location | I9L |
HXB2 Location | I148L |
Mutation Type | A: HLA association DR: diminished response E: escape documented in this paper |
Epitope Subtype | B |
Variant Subtype | B |
Method | Relative replication capacity assay |
Note | Mutant, RQANFLGKl, is experimentally verified to be a B*13-driven escape but decreases replication capacity of the virus. A compensatory mutation for it, K436R exists. |
Variant ID. | 3743 |
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Epitope Seq. | RQANFLGKI |
Variant Seq. | RQANFLGrl |
Mutations | K/R I/L |
Epitope Location | K8R I9L |
HXB2 Location | K147R I148L |
Mutation Type | A: HLA association CM: compensatory mutation DR: diminished response E: escape documented in this paper |
Epitope Subtype | B |
Variant Subtype | B |
Method | Relative replication capacity assay |
Note | Mutant, RQANFLGrl, contains an escape-compensatory pair of substitutions that control for loss of replication capacity. |
Variant ID. | 3744 |
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Epitope Seq. | RQANFLGKI |
Variant Seq. | RQANFLGrI |
Mutations | K/R |
Epitope Location | K8R |
HXB2 Location | K147R |
Mutation Type | A: HLA association DR: diminished response E: escape documented in this paper |
Epitope Subtype | B |
Variant Subtype | B |
Method | Relative replication capacity assay |
Note | Mutant, RQANFLGrI, is an experimentally verified B*13-driven escape mutation. |
Shahid2015 Aniqa Shahid, Alex Olvera, Gursev Anmole, Xiaomei T. Kuang, Laura A. Cotton, Montserrat Plana, Christian Brander, Mark A. Brockman, and Zabrina L. Brumme. Consequences of HLA-B*13-Associated Escape Mutations on HIV-1 Replication and Nef Function. J. Virol., 89(22):11557-11571, Nov 2015. PubMed ID: 26355081. Show all entries for this paper.
HXB2 Location | Pol(113-122) | Pol Epitope Map
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Epitope |
RQYDQILIEI
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Epitope Alignment | ||||
Variants |
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Epitope Name | RI10 | |||||
Species (MHC/HLA) | human(B*13:02) |
Showing all: 1 variant(s).
Variant ID. | 3746 |
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Epitope Seq. | RQYDQILIEI |
Variant Seq. | RQYDQIsIEI |
Mutations | L/S |
Epitope Location | L7S |
HXB2 Location | L119S |
Mutation Type | A: HLA association E: escape documented in this paper |
Epitope Subtype | B |
Variant Subtype | B |
Method | Relative replication capacity assay |
Note | Mutation L63S in epitope p16 RQYDQILIEI, i.e. RQYDQIsIEI is highly associated with HLA-B*13/1302. |
Shahid2015 Aniqa Shahid, Alex Olvera, Gursev Anmole, Xiaomei T. Kuang, Laura A. Cotton, Montserrat Plana, Christian Brander, Mark A. Brockman, and Zabrina L. Brumme. Consequences of HLA-B*13-Associated Escape Mutations on HIV-1 Replication and Nef Function. J. Virol., 89(22):11557-11571, Nov 2015. PubMed ID: 26355081. Show all entries for this paper.
HXB2 Location | Pol(488-496) | Pol Epitope Map
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Epitope |
GQGQWTYQI
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Epitope Alignment | ||||
Variants |
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Epitope Name | GI9 | |||||
Species (MHC/HLA) | human(B*13:02) |
Showing all: 1 variant(s).
Variant ID. | 3747 |
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Epitope Seq. | GQGQWTYQI |
Variant Seq. | GnGQWTYQI |
Mutations | Q/N |
Epitope Location | Q2N |
HXB2 Location | Q489N |
Mutation Type | A: HLA association E: escape documented in this paper |
Epitope Subtype | B |
Variant Subtype | B |
Method | Relative replication capacity assay |
Note | Mutation Q334N in epitope p51 GQGQWTYQI, i.e. GnGQWTYQI is associated with HLA-B*13/1302. |
Shahid2015 Aniqa Shahid, Alex Olvera, Gursev Anmole, Xiaomei T. Kuang, Laura A. Cotton, Montserrat Plana, Christian Brander, Mark A. Brockman, and Zabrina L. Brumme. Consequences of HLA-B*13-Associated Escape Mutations on HIV-1 Replication and Nef Function. J. Virol., 89(22):11557-11571, Nov 2015. PubMed ID: 26355081. Show all entries for this paper.
HXB2 Location | Nef(106-114) | Nef Epitope Map
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Epitope |
RQDILDLWI
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Epitope Alignment | ||||
Variants |
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Epitope Name | RI9 | |||||
Species (MHC/HLA) | human(B*13:02) |
Showing all: 1 variant(s).
Variant ID. | 3745 |
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Epitope Seq. | RQDILDLWI |
Variant Seq. | RrDILDLWI |
Mutations | Q/R |
Epitope Location | Q2R |
HXB2 Location | Q107R |
Mutation Type | A: HLA association DR: diminished response E: escape documented in this paper |
Epitope Subtype | B |
Variant Subtype | B |
Method | Relative replication capacity assay |
Note | Nef mutant RrDILDLWI results in replication reduction. Alongwith another substitution, E24Q, however, it loses the ability to downregulate Class I MHC. |
Shahid2015 Aniqa Shahid, Alex Olvera, Gursev Anmole, Xiaomei T. Kuang, Laura A. Cotton, Montserrat Plana, Christian Brander, Mark A. Brockman, and Zabrina L. Brumme. Consequences of HLA-B*13-Associated Escape Mutations on HIV-1 Replication and Nef Function. J. Virol., 89(22):11557-11571, Nov 2015. PubMed ID: 26355081. Show all entries for this paper.