HIV molecular immunology database

 

Search the Epitope Variant and Escape Mutation Database

Help


Found 5 matching records:

Displaying record number 61223

HXB2 Location  Gag(140-147)   Gag Epitope Map
View variants at this location
Epitope GQMVHQAI   Epitope Alignment
Variants
GQMVHQsI   HLA association; escape documented in this paper
GQMVHQAl   HLA association; escape documented in this paper
Epitope Name GI8
Species (MHC/HLA human(B*13:02)

Variant Details

Showing all: 2 variant(s).


Variant ID.  3748
Epitope Seq.  GQMVHQAI
Variant Seq.  GQMVHQsI
Mutations A/S
Epitope Location A7S
HXB2 Location A146S
Mutation Type A: HLA association
E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method Relative replication capacity assay
Note Mutation A146S in epitope GQMVHQAI, i.e. GQMVHQsI, is associated with HLA-B*13/1302.


Variant ID.  3749
Epitope Seq.  GQMVHQAI
Variant Seq.  GQMVHQAl
Mutations I/L
Epitope Location I8L
HXB2 Location I147L
Mutation Type A: HLA association
E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method Relative replication capacity assay
Note Mutation I147L in epitope GQMVHQAI, i.e. GQMVHQAl, is associated with HLA-B*13/1302.

References

Shahid2015 Aniqa Shahid, Alex Olvera, Gursev Anmole, Xiaomei T. Kuang, Laura A. Cotton, Montserrat Plana, Christian Brander, Mark A. Brockman, and Zabrina L. Brumme. Consequences of HLA-B*13-Associated Escape Mutations on HIV-1 Replication and Nef Function. J. Virol., 89(22):11557-11571, Nov 2015. PubMed ID: 26355081. Show all entries for this paper.


Displaying record number 61224

HXB2 Location  Gag(429-437)   Gag Epitope Map
View variants at this location
Epitope RQANFLGKI   Epitope Alignment
Variants
RQANFLGKl   HLA association; diminished response; escape documented in this paper
RQANFLGrl   HLA association; compensatory mutation; diminished response; escape documented in this paper
RQANFLGrI   HLA association; diminished response; escape documented in this paper
Epitope Name RI9
Species (MHC/HLA human(B*13:02)

Variant Details

Showing all: 3 variant(s).


Variant ID.  3742
Epitope Seq.  RQANFLGKI
Variant Seq.  RQANFLGKl
Mutations I/L
Epitope Location I9L
HXB2 Location I148L
Mutation Type A: HLA association
DR: diminished response
E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method Relative replication capacity assay
Note Mutant, RQANFLGKl, is experimentally verified to be a B*13-driven escape but decreases replication capacity of the virus. A compensatory mutation for it, K436R exists.


Variant ID.  3743
Epitope Seq.  RQANFLGKI
Variant Seq.  RQANFLGrl
Mutations K/R I/L
Epitope Location K8R I9L
HXB2 Location K147R I148L
Mutation Type A: HLA association
CM: compensatory mutation
DR: diminished response
E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method Relative replication capacity assay
Note Mutant, RQANFLGrl, contains an escape-compensatory pair of substitutions that control for loss of replication capacity.


Variant ID.  3744
Epitope Seq.  RQANFLGKI
Variant Seq.  RQANFLGrI
Mutations K/R
Epitope Location K8R
HXB2 Location K147R
Mutation Type A: HLA association
DR: diminished response
E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method Relative replication capacity assay
Note Mutant, RQANFLGrI, is an experimentally verified B*13-driven escape mutation.

References

Shahid2015 Aniqa Shahid, Alex Olvera, Gursev Anmole, Xiaomei T. Kuang, Laura A. Cotton, Montserrat Plana, Christian Brander, Mark A. Brockman, and Zabrina L. Brumme. Consequences of HLA-B*13-Associated Escape Mutations on HIV-1 Replication and Nef Function. J. Virol., 89(22):11557-11571, Nov 2015. PubMed ID: 26355081. Show all entries for this paper.


Displaying record number 61226

HXB2 Location  Pol(113-122)   Pol Epitope Map
View variants at this location
Epitope RQYDQILIEI   Epitope Alignment
Variants
RQYDQIsIEI   HLA association; escape documented in this paper
Epitope Name RI10
Species (MHC/HLA human(B*13:02)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3746
Epitope Seq.  RQYDQILIEI
Variant Seq.  RQYDQIsIEI
Mutations L/S
Epitope Location L7S
HXB2 Location L119S
Mutation Type A: HLA association
E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method Relative replication capacity assay
Note Mutation L63S in epitope p16 RQYDQILIEI, i.e. RQYDQIsIEI is highly associated with HLA-B*13/1302.

References

Shahid2015 Aniqa Shahid, Alex Olvera, Gursev Anmole, Xiaomei T. Kuang, Laura A. Cotton, Montserrat Plana, Christian Brander, Mark A. Brockman, and Zabrina L. Brumme. Consequences of HLA-B*13-Associated Escape Mutations on HIV-1 Replication and Nef Function. J. Virol., 89(22):11557-11571, Nov 2015. PubMed ID: 26355081. Show all entries for this paper.


Displaying record number 61227

HXB2 Location  Pol(488-496)   Pol Epitope Map
View variants at this location
Epitope GQGQWTYQI   Epitope Alignment
Variants
GnGQWTYQI   HLA association; escape documented in this paper
Epitope Name GI9
Species (MHC/HLA human(B*13:02)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3747
Epitope Seq.  GQGQWTYQI
Variant Seq.  GnGQWTYQI
Mutations Q/N
Epitope Location Q2N
HXB2 Location Q489N
Mutation Type A: HLA association
E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method Relative replication capacity assay
Note Mutation Q334N in epitope p51 GQGQWTYQI, i.e. GnGQWTYQI is associated with HLA-B*13/1302.

References

Shahid2015 Aniqa Shahid, Alex Olvera, Gursev Anmole, Xiaomei T. Kuang, Laura A. Cotton, Montserrat Plana, Christian Brander, Mark A. Brockman, and Zabrina L. Brumme. Consequences of HLA-B*13-Associated Escape Mutations on HIV-1 Replication and Nef Function. J. Virol., 89(22):11557-11571, Nov 2015. PubMed ID: 26355081. Show all entries for this paper.


Displaying record number 61225

HXB2 Location  Nef(106-114)   Nef Epitope Map
View variants at this location
Epitope RQDILDLWI   Epitope Alignment
Variants
RrDILDLWI   HLA association; diminished response; escape documented in this paper
Epitope Name RI9
Species (MHC/HLA human(B*13:02)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3745
Epitope Seq.  RQDILDLWI
Variant Seq.  RrDILDLWI
Mutations Q/R
Epitope Location Q2R
HXB2 Location Q107R
Mutation Type A: HLA association
DR: diminished response
E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method Relative replication capacity assay
Note Nef mutant RrDILDLWI results in replication reduction. Alongwith another substitution, E24Q, however, it loses the ability to downregulate Class I MHC.

References

Shahid2015 Aniqa Shahid, Alex Olvera, Gursev Anmole, Xiaomei T. Kuang, Laura A. Cotton, Montserrat Plana, Christian Brander, Mark A. Brockman, and Zabrina L. Brumme. Consequences of HLA-B*13-Associated Escape Mutations on HIV-1 Replication and Nef Function. J. Virol., 89(22):11557-11571, Nov 2015. PubMed ID: 26355081. Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Managed by Triad National Security, LLC for the U.S. Department of Energy’s National Nuclear Security Administration
Copyright © 2022 Triad National Security, LLC | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health