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Found 15 matching records:

Displaying record number 53844

HXB2 Location  Gag(11-19)   Gag Epitope Map
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Epitope GELDRWEKI   Epitope Alignment
Variants
GELDRWkKI   diminished response; literature escape
Epitope Name GI9
Species (MHC/HLA human(B*40)

Variant Details

Showing all: 1 variant(s).


Variant ID.  1569
Epitope Seq.  GELDRWEKI
Variant Seq.  GELDRWkKI
Mutations E/K
Epitope Location E7K
HXB2 Location E17K
Mutation Type DR: diminished response
LE: literature escape
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant from the HXB2 sequence was present in the restricting HLA-B40-carrying mother, M-1002, but was never detected in her non-HLA-B40-carrying infant, P-1031. Decreased recognition of the E17K variant relative to the index epitope was seen in the mother.

References

Sanchez-Merino2005 Victor Sanchez-Merino, Siwei Nie, and Katherine Luzuriaga. HIV-1-Specific CD8+ T Cell Responses and Viral Evolution in Women and Infants. J. Immunol., 175(10):6976-6986, 15 Nov 2005. PubMed ID: 16272358. Show all entries for this paper.


Displaying record number 53838

HXB2 Location  Gag(18-26)   Gag Epitope Map
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Epitope KIRLRPGGK   Epitope Alignment
Variants
KIRLRPGGr   literature escape; observed variant
Epitope Name KR9
Species (MHC/HLA human(A*03)

Variant Details

Showing all: 1 variant(s).


Variant ID.  1570
Epitope Seq.  KIRLRPGGK
Variant Seq.  KIRLRPGGr
Mutations K/R
Epitope Location K9R
HXB2 Location K26R
Mutation Type LE: literature escape
OV: observed variant
Method Sequence
Note This variant from the HXB2 sequence was present in the restricting HLA-A3 allele carrying mother, M-1001, as well as her HLA-A*31-carrying infant, P-1024. Infant P-1024 had lost this variant by 15 months of age.

References

Sanchez-Merino2005 Victor Sanchez-Merino, Siwei Nie, and Katherine Luzuriaga. HIV-1-Specific CD8+ T Cell Responses and Viral Evolution in Women and Infants. J. Immunol., 175(10):6976-6986, 15 Nov 2005. PubMed ID: 16272358. Show all entries for this paper.


Displaying record number 53839

HXB2 Location  Gag(20-29)   Gag Epitope Map
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Epitope RLRPGGKKKY   Epitope Alignment
Variants
RLRPGGKKqY   diminished response
RLRPGGKKrY   diminished response
Epitope Name RY10
Species (MHC/HLA human(A*30)

Variant Details

Showing all: 2 variant(s).


Variant ID.  1571
Epitope Seq.  RLRPGGKKKY
Variant Seq.  RLRPGGKKqY
Mutations K/Q
Epitope Location K9Q
HXB2 Location K28Q
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant from the HXB2 sequence was present in the restricting HLA-A30 allele carrying mother, M-1003, as well as her non-HLA-A30-carrying infant, P-1189. Decreased recognition of the variant was seen relative to index epitope. This variant was still detected at 12 months of age in Infant P-1189.


Variant ID.  1572
Epitope Seq.  RLRPGGKKKY
Variant Seq.  RLRPGGKKrY
Mutations K/R
Epitope Location K9R
HXB2 Location K28R
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant from the HXB2 sequence was present in the restricting HLA-A30 allele carrying mother, M-1002, as well as her HLA-A30-carrying infant, P-1031. Decreased recognition of the variant was seen relative to index epitope in the mother. The variant was detected at decreasing frequencies by 11 months of age in infant P-1031, but recognition was equivalent to index epitope recognition in the infant.

References

Sanchez-Merino2005 Victor Sanchez-Merino, Siwei Nie, and Katherine Luzuriaga. HIV-1-Specific CD8+ T Cell Responses and Viral Evolution in Women and Infants. J. Immunol., 175(10):6976-6986, 15 Nov 2005. PubMed ID: 16272358. Show all entries for this paper.


Displaying record number 53840

HXB2 Location  Gag(24-31)   Gag Epitope Map
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Epitope GGKKKYKL   Epitope Alignment
Variants
GGrKKYKL   reversion
Epitope Name GL8
Species (MHC/HLA human(B*08)

Variant Details

Showing all: 1 variant(s).


Variant ID.  1573
Epitope Seq.  GGKKKYKL
Variant Seq.  GGrKKYKL
Mutations K/R
Epitope Location K3R
HXB2 Location K26R
Mutation Type R: reversion
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant from the HXB2 sequence was present in the restricting HLA-B8 allele carrying mother, M-1001, as well as her non-HLA-B8-carrying infant, P-1024. Infant P-1024 had lost this variant by 15 months of age.

References

Sanchez-Merino2005 Victor Sanchez-Merino, Siwei Nie, and Katherine Luzuriaga. HIV-1-Specific CD8+ T Cell Responses and Viral Evolution in Women and Infants. J. Immunol., 175(10):6976-6986, 15 Nov 2005. PubMed ID: 16272358. Show all entries for this paper.


Displaying record number 53841

HXB2 Location  Gag(28-36)   Gag Epitope Map
View variants at this location
Epitope KYKLKHIVW   Epitope Alignment
Variants
qYKLKHIVW   escape documented in this paper; literature escape
Epitope Name QW9
Species (MHC/HLA human(A*24)

Variant Details

Showing all: 1 variant(s).


Variant ID.  1574
Epitope Seq.  KYKLKHIVW
Variant Seq.  qYKLKHIVW
Mutations K/Q
Epitope Location K1Q
HXB2 Location K28Q
Mutation Type E: escape documented in this paper
LE: literature escape
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant from the HXB2 sequence was present in the restricting HLA-A24 allele carrying mother, M-1003, as well as her HLA-A24-carrying infant, P-1189. Decreased recognition of the variant was seen relative to wild type index epitope. This variant was still detected at 12 months of age in infant P-1189. While the mother could recognize index epitope QW9, but not this variant, infant P-1189 could not recognize either index or variant.

References

Sanchez-Merino2005 Victor Sanchez-Merino, Siwei Nie, and Katherine Luzuriaga. HIV-1-Specific CD8+ T Cell Responses and Viral Evolution in Women and Infants. J. Immunol., 175(10):6976-6986, 15 Nov 2005. PubMed ID: 16272358. Show all entries for this paper.


Displaying record number 53842

HXB2 Location  Gag(250-258)   Gag Epitope Map
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Epitope MTNNPPIPV   Epitope Alignment
Variants
MThNPPIPV   observed variant
Epitope Name MV9
Species (MHC/HLA human(A*02)

Variant Details

Showing all: 1 variant(s).


Variant ID.  1575
Epitope Seq.  MTNNPPIPV
Variant Seq.  MThNPPIPV
Mutations N/H
Epitope Location N3H
HXB2 Location N252H
Mutation Type OV: observed variant
Method Sequence
Note This variant from the HXB2 sequence was present in the non-HLA-A2 allele carrying mother, M-1004, as well as her restricting-HLA-A2-carrying infant, P-1115. This variant was still detected at 12 months of age in infant P-1115.

References

Sanchez-Merino2005 Victor Sanchez-Merino, Siwei Nie, and Katherine Luzuriaga. HIV-1-Specific CD8+ T Cell Responses and Viral Evolution in Women and Infants. J. Immunol., 175(10):6976-6986, 15 Nov 2005. PubMed ID: 16272358. Show all entries for this paper.


Displaying record number 53843

HXB2 Location  Gag(362-370)   Gag Epitope Map
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Epitope VLAEAMSQV   Epitope Alignment
Variants
VLAEAMShV   observed variant
Epitope Name VV9
Species (MHC/HLA human(A*02)

Variant Details

Showing all: 1 variant(s).


Variant ID.  1576
Epitope Seq.  VLAEAMSQV
Variant Seq.  VLAEAMShV
Mutations Q/H
Epitope Location Q8H
HXB2 Location Q369H
Mutation Type OV: observed variant
Method Sequence
Note This variant from the HXB2 sequence was present in the restricting HLA-A2 allele carrying mother, M-1005, as well as her non-HLA-A2-carrying infant, P-1026. This variant was still detected at 15 months of age in infant P-1026.

References

Sanchez-Merino2005 Victor Sanchez-Merino, Siwei Nie, and Katherine Luzuriaga. HIV-1-Specific CD8+ T Cell Responses and Viral Evolution in Women and Infants. J. Immunol., 175(10):6976-6986, 15 Nov 2005. PubMed ID: 16272358. Show all entries for this paper.


Displaying record number 53845

HXB2 Location  Gag(481-489)   Gag Epitope Map
View variants at this location
Epitope KELYPLTSL   Epitope Alignment
Variants
KEmYPLaSL   observed variant
Epitope Name KL9
Species (MHC/HLA human(B*40)

Variant Details

Showing all: 1 variant(s).


Variant ID.  1577
Epitope Seq.  KELYPLTSL
Variant Seq.  KEmYPLaSL
Mutations L/M T/A
Epitope Location L3M T7A
HXB2 Location L483M T487A
Mutation Type OV: observed variant
Method Sequence
Note This variant from the HXB2 sequence was present in the restricting HLA-B40 allele carrying mother, M-1005, as well as her non-HLA-B40-carrying infant, P-1026. This variant was still detected at 15 months of age in infant P-1026.

References

Sanchez-Merino2005 Victor Sanchez-Merino, Siwei Nie, and Katherine Luzuriaga. HIV-1-Specific CD8+ T Cell Responses and Viral Evolution in Women and Infants. J. Immunol., 175(10):6976-6986, 15 Nov 2005. PubMed ID: 16272358. Show all entries for this paper.


Displaying record number 53846

HXB2 Location  Nef(13-20)   Nef Epitope Map
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Epitope WPTVRERM   Epitope Alignment
Variants
WnTVRERM   observed variant
Epitope Name WM8
Species (MHC/HLA human(B*08)

Variant Details

Showing all: 1 variant(s).


Variant ID.  1578
Epitope Seq.  WPTVRERM
Variant Seq.  WnTVRERM
Mutations P/N
Epitope Location P2N
HXB2 Location P14N
Mutation Type OV: observed variant
Method Sequence
Note This variant from the HXB2 sequence was present in the restricting HLA-B8 allele carrying mother, M-1001, as well as her non-HLA-B8-carrying infant, P-1024. The variant was still detected at 15 months of age in infant P-1024.

References

Sanchez-Merino2005 Victor Sanchez-Merino, Siwei Nie, and Katherine Luzuriaga. HIV-1-Specific CD8+ T Cell Responses and Viral Evolution in Women and Infants. J. Immunol., 175(10):6976-6986, 15 Nov 2005. PubMed ID: 16272358. Show all entries for this paper.


Displaying record number 53847

HXB2 Location  Nef(77-85)   Nef Epitope Map
View variants at this location
Epitope RPMTYKAAL   Epitope Alignment
Variants
RPMThqAAw   diminished response; susceptible form
Epitope Name RW9
Species (MHC/HLA human(B*07)

Variant Details

Showing all: 1 variant(s).


Variant ID.  1579
Epitope Seq.  RPMTYKAAL
Variant Seq.  RPMThqAAw
Mutations Y/H K/Q L/W
Epitope Location Y5H K6Q L9W
HXB2 Location Y81H K82Q L85W
Mutation Type DR: diminished response
SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant from the HXB2 sequence was present in the non-HLA-B7 allele carrying mother, M-1003, as well as her restricting-HLA-B7-carrying infant, P-1189. The variant was still detected at 12 months of age in infant P-1189. Decreased recognition of the variant was seen relative to index epitope in the mother, but recognition was equivalent to index epitope recognition in the infant.

References

Sanchez-Merino2005 Victor Sanchez-Merino, Siwei Nie, and Katherine Luzuriaga. HIV-1-Specific CD8+ T Cell Responses and Viral Evolution in Women and Infants. J. Immunol., 175(10):6976-6986, 15 Nov 2005. PubMed ID: 16272358. Show all entries for this paper.


Displaying record number 53848

HXB2 Location  Nef(83-91)   Nef Epitope Map
View variants at this location
Epitope AAVDLSHFL   Epitope Alignment
Variants
AAVDmSHFL   diminished response; literature escape
gAlDLSHFL   observed variant
Epitope Name AL9
Species (MHC/HLA human(A*02)

Variant Details

Showing all: 2 variant(s).


Variant ID.  1580
Epitope Seq.  AAVDLSHFL
Variant Seq.  AAVDmSHFL
Mutations L/M
Epitope Location L5M
HXB2 Location L87M
Mutation Type DR: diminished response
LE: literature escape
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant from the HXB2 sequence was present in the non-HLA-A2 allele carrying mother, M-1002, as well as her restricting-HLA-A2-carrying infant, P-1031. The variant was still detected at 12 months of age in infant P-1031. Decreased recognition of the variant was seen relative to index epitope, in time.


Variant ID.  1581
Epitope Seq.  AAVDLSHFL
Variant Seq.  gAlDLSHFL
Mutations A/G V/L
Epitope Location A1G V3L
HXB2 Location A83G V85L
Mutation Type OV: observed variant
Method Sequence
Note This variant from the HXB2 sequence was present in the restricting HLA-A2 allele carrying mother, M-1005, as well as her non-HLA-A2-carrying infant, P-1026. The variant was still detected at 15 months of age in infant P-1026.

References

Sanchez-Merino2005 Victor Sanchez-Merino, Siwei Nie, and Katherine Luzuriaga. HIV-1-Specific CD8+ T Cell Responses and Viral Evolution in Women and Infants. J. Immunol., 175(10):6976-6986, 15 Nov 2005. PubMed ID: 16272358. Show all entries for this paper.


Displaying record number 53849

HXB2 Location  Nef(84-92)   Nef Epitope Map
View variants at this location
Epitope AVDLSHFLK   Epitope Alignment
Variants
AmDLSHFLK   observed variant
Epitope Name AK9
Species (MHC/HLA human(A*03)

Variant Details

Showing all: 1 variant(s).


Variant ID.  1582
Epitope Seq.  AVDLSHFLK
Variant Seq.  AmDLSHFLK
Mutations V/M
Epitope Location V2M
HXB2 Location V85M
Mutation Type OV: observed variant
Method Sequence
Note This variant from the HXB2 sequence was present in the restricting HLA-A3 allele carrying mother, M-1001, as well as her HLA-A*31-carrying infant, P-1024. Infant P-1024 had lost this variant by 15 months of age.

References

Sanchez-Merino2005 Victor Sanchez-Merino, Siwei Nie, and Katherine Luzuriaga. HIV-1-Specific CD8+ T Cell Responses and Viral Evolution in Women and Infants. J. Immunol., 175(10):6976-6986, 15 Nov 2005. PubMed ID: 16272358. Show all entries for this paper.


Displaying record number 53852

HXB2 Location  Nef(134-143)   Nef Epitope Map
View variants at this location
Epitope RYPLTFGWCF   Epitope Alignment
Variants
RfPLTFGWCF   literature escape; observed variant
kfPLTFGWCF   observed variant
RYPLTlGWCF   inferred escape
Species (MHC/HLA human(A*24)

Variant Details

Showing all: 3 variant(s).


Variant ID.  1583
Epitope Seq.  RYPLTFGWCF
Variant Seq.  RfPLTFGWCF
Mutations Y/F
Epitope Location Y2F
HXB2 Location Y135F
Mutation Type LE: literature escape
OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant from the HXB2 sequence was absent in the non-HLA-A24 carrying mother; but was present early in infant P-1026, becoming the predominant form by 13 months. This Y135F mutation is a previously described escape in hemophiliacs.


Variant ID.  1584
Epitope Seq.  RYPLTFGWCF
Variant Seq.  kfPLTFGWCF
Mutations R/K Y/F
Epitope Location R1K Y2F
HXB2 Location R134K Y135F
Mutation Type OV: observed variant
Method Sequence
Note This variant from the HXB2 sequence was absent in the non-HLA-A24 carrying mother; but was present early in infant P-1026 at a very low copy number.


Variant ID.  1585
Epitope Seq.  RYPLTFGWCF
Variant Seq.  RYPLTlGWCF
Mutations F/L
Epitope Location F6L
HXB2 Location F139L
Mutation Type IE: inferred escape
Method Sequence
Note This variant from the HXB2 sequence was absent in the non-HLA-A24 carrying mother; but was present early in infant P-1026.

References

Sanchez-Merino2005 Victor Sanchez-Merino, Siwei Nie, and Katherine Luzuriaga. HIV-1-Specific CD8+ T Cell Responses and Viral Evolution in Women and Infants. J. Immunol., 175(10):6976-6986, 15 Nov 2005. PubMed ID: 16272358. Show all entries for this paper.


Displaying record number 53850

HXB2 Location  Nef(186-194)   Nef Epitope Map
View variants at this location
Epitope DSRLAFHHM   Epitope Alignment
Variants
DSRLAFqHM   diminished response; literature escape
DStLAFqHk   diminished response; literature escape
Epitope Name DM9
Species (MHC/HLA human(A*24)

Variant Details

Showing all: 2 variant(s).


Variant ID.  1586
Epitope Seq.  DSRLAFHHM
Variant Seq.  DSRLAFqHM
Mutations H/Q
Epitope Location H7Q
HXB2 Location H192Q
Mutation Type DR: diminished response
LE: literature escape
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant from the HXB2 sequence was present in the non-HLA-A24 allele carrying mother, M-1001, as well as her restricting HLA-A24-carrying infant, P-1024. Infant P-1024 had lost this variant by 15 months of age. Decreased recognition of the variant was seen relative to the index epitope.


Variant ID.  1587
Epitope Seq.  DSRLAFHHM
Variant Seq.  DStLAFqHk
Mutations R/T H/Q M/K
Epitope Location R3T H7Q M9K
HXB2 Location R188T H192Q M194K
Mutation Type DR: diminished response
LE: literature escape
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant from the HXB2 sequence was present in the restricting HLA-A24 allele carrying mother, M-1003, as well as her restricting HLA-A24-carrying infant, P-1089. This variant was still detected at 15 months of age. Decreased recognition of the variant was seen relative to the index epitope.

References

Sanchez-Merino2005 Victor Sanchez-Merino, Siwei Nie, and Katherine Luzuriaga. HIV-1-Specific CD8+ T Cell Responses and Viral Evolution in Women and Infants. J. Immunol., 175(10):6976-6986, 15 Nov 2005. PubMed ID: 16272358. Show all entries for this paper.


Displaying record number 53851

HXB2 Location  Nef(190-198)   Nef Epitope Map
View variants at this location
Epitope AFHHVAREK   Epitope Alignment
Variants
AFqHmAREl   observed variant
Epitope Name AL9
Species (MHC/HLA human(A*03)

Variant Details

Showing all: 1 variant(s).


Variant ID.  1588
Epitope Seq.  AFHHVAREK
Variant Seq.  AFqHmAREl
Mutations H/Q V/M K/L
Epitope Location H3Q V5M K9L
HXB2 Location H192Q V194M K198L
Mutation Type OV: observed variant
Method Sequence
Note This variant from the HXB2 sequence was present in the restricting HLA-A3 allele carrying mother, M-1001, as well as her HLA-A*31-carrying infant, P-1024. Infant P-1024 had lost this variant by 15 months of age.

References

Sanchez-Merino2005 Victor Sanchez-Merino, Siwei Nie, and Katherine Luzuriaga. HIV-1-Specific CD8+ T Cell Responses and Viral Evolution in Women and Infants. J. Immunol., 175(10):6976-6986, 15 Nov 2005. PubMed ID: 16272358. Show all entries for this paper.


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