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Search the Epitope Variant and Escape Mutation Database

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Found 7 matching records:

Displaying record number 59383

HXB2 Location  Gag(25-34)   Gag Epitope Map
View variants at this location
Epitope GKKPYMLKHL   Epitope Alignment
Variants
GKKsYMLKHL   diminished response; escape documented in this paper
GKKPYrLKHL   diminished response; escape documented in this paper
Species (MHC/HLA)  human

Variant Details

Showing all: 2 variant(s).

Variant ID.  3463
Epitope Seq.  GKKPYMLKHL
Variant Seq.  GKKsYMLKHL
Mutations P/S
Epitope Location P4S
HXB2 Location P28S
Mutation Type DR: diminished response
E: escape documented in this paper
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Variant GKKsYMLKHL was present in the patient's sequences and had a greatly diminished response as compared to wt epitope.

Variant ID.  3464
Epitope Seq.  GKKPYMLKHL
Variant Seq.  GKKPYrLKHL
Mutations M/R
Epitope Location M6R
HXB2 Location M30R
Mutation Type DR: diminished response
E: escape documented in this paper
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Variant GKKPYrLKHL was present in the patient's sequences and elicits a greatly diminished response as compared to wt epitope.

References

Ritchie2014 Adam John Ritchie, Fangping Cai, Nicola M. G. Smith, Sheri Chen, Hongshuo Song, Simon Brackenridge, Salim S. Abdool Karim, Bette T. Korber, Andrew J. McMichael, Feng Gao, and Nilu Goonetilleke. Recombination-Mediated Escape from Primary CD8+ T Cells in Acute HIV-1 Infection. Retrovirology, 11:69, 2014. PubMed ID: 25212771. Show all entries for this paper.

Displaying record number 59385

HXB2 Location  Pol(426-434)   Pol Epitope Map
View variants at this location
Epitope YPGIKVRQL   Epitope Alignment
Variants
YPGIrVRQL   diminished response; escape documented in this paper
Species (MHC/HLA)  human(B*42, B*81)

Variant Details

Showing all: 1 variant(s).

Variant ID.  3465
Epitope Seq.  YPGIKVRQL
Variant Seq.  YPGIrVRQL
Mutations K/R
Epitope Location K5R
HXB2 Location K430R
Mutation Type DR: diminished response
E: escape documented in this paper
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Variant YPGIrVRQL was present in the patient's sequences and had a diminished response as compared to wt epitope.

References

Ritchie2014 Adam John Ritchie, Fangping Cai, Nicola M. G. Smith, Sheri Chen, Hongshuo Song, Simon Brackenridge, Salim S. Abdool Karim, Bette T. Korber, Andrew J. McMichael, Feng Gao, and Nilu Goonetilleke. Recombination-Mediated Escape from Primary CD8+ T Cells in Acute HIV-1 Infection. Retrovirology, 11:69, 2014. PubMed ID: 25212771. Show all entries for this paper.

Displaying record number 59386

HXB2 Location  Vif(73-81)   Vif Epitope Map
View variants at this location
Epitope QPGERAWHL   Epitope Alignment
Variants
QtGERAWHL   escape documented in this paper
QPGERdWHL   diminished response; escape documented in this paper
Species (MHC/HLA)  human

Variant Details

Showing all: 2 variant(s).

Variant ID.  3466
Epitope Seq.  QPGERAWHL
Variant Seq.  QtGERAWHL
Mutations P/T
Epitope Location P2T
HXB2 Location P74T
Mutation Type E: escape documented in this paper
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Variant QtGERAWHL was present in the patient's sequences and had slightly diminished response as compared to wt epitope.

Variant ID.  3467
Epitope Seq.  QPGERAWHL
Variant Seq.  QPGERdWHL
Mutations A/D
Epitope Location A6D
HXB2 Location A78D
Mutation Type DR: diminished response
E: escape documented in this paper
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Variant QPGERdWHL was present in the patient's sequences and had greatly diminshed response compared to wt epitope.

References

Ritchie2014 Adam John Ritchie, Fangping Cai, Nicola M. G. Smith, Sheri Chen, Hongshuo Song, Simon Brackenridge, Salim S. Abdool Karim, Bette T. Korber, Andrew J. McMichael, Feng Gao, and Nilu Goonetilleke. Recombination-Mediated Escape from Primary CD8+ T Cells in Acute HIV-1 Infection. Retrovirology, 11:69, 2014. PubMed ID: 25212771. Show all entries for this paper.

Displaying record number 59387

HXB2 Location  Rev(12-20)   Rev Epitope Map
View variants at this location
Epitope LLQAVRIIK   Epitope Alignment
Variants
LLQAVkIIK   diminished response; escape documented in this paper
LLQAVRIIr   diminished response; escape documented in this paper
Species (MHC/HLA)  human

Variant Details

Showing all: 2 variant(s).

Variant ID.  3468
Epitope Seq.  LLQAVRIIK
Variant Seq.  LLQAVkIIK
Mutations R/K
Epitope Location R6K
HXB2 Location R17K
Mutation Type DR: diminished response
E: escape documented in this paper
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Variant LLQAVkIIK was present in the patient's sequences and had greatly diminished response compared to wt epitope.

Variant ID.  3469
Epitope Seq.  LLQAVRIIK
Variant Seq.  LLQAVRIIr
Mutations K/R
Epitope Location K9R
HXB2 Location K20R
Mutation Type DR: diminished response
E: escape documented in this paper
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Variant was present in the patient's sequences and had diminished response compared to wt epitope.

References

Ritchie2014 Adam John Ritchie, Fangping Cai, Nicola M. G. Smith, Sheri Chen, Hongshuo Song, Simon Brackenridge, Salim S. Abdool Karim, Bette T. Korber, Andrew J. McMichael, Feng Gao, and Nilu Goonetilleke. Recombination-Mediated Escape from Primary CD8+ T Cells in Acute HIV-1 Infection. Retrovirology, 11:69, 2014. PubMed ID: 25212771. Show all entries for this paper.

Displaying record number 59389

HXB2 Location  Nef(19-27)   Nef Epitope Map
View variants at this location
Epitope RIRRTAPTA   Epitope Alignment
Variants
kIkRTAPTA   escape documented in this paper
RIRRTAPkA   escape documented in this paper
Species (MHC/HLA)  human

Variant Details

Showing all: 2 variant(s).

Variant ID.  3472
Epitope Seq.  RIRRTAPTA
Variant Seq.  kIkRTAPTA
Mutations R/K R/K
Epitope Location R1K R3K
HXB2 Location R19K R21K
Mutation Type E: escape documented in this paper
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note By 441 days post-screening, the patient's sequences were dominated by two escape variants, kIkRTAPTA and RIRRTAPkA.

Variant ID.  3473
Epitope Seq.  RIRRTAPTA
Variant Seq.  RIRRTAPkA
Mutations T/K
Epitope Location T8K
HXB2 Location T26K
Mutation Type E: escape documented in this paper
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note By 441 days post-screening, the patient's sequences were dominated by two escape variants, KIKRTAPTA and RIRRTAPKA.

References

Ritchie2014 Adam John Ritchie, Fangping Cai, Nicola M. G. Smith, Sheri Chen, Hongshuo Song, Simon Brackenridge, Salim S. Abdool Karim, Bette T. Korber, Andrew J. McMichael, Feng Gao, and Nilu Goonetilleke. Recombination-Mediated Escape from Primary CD8+ T Cells in Acute HIV-1 Infection. Retrovirology, 11:69, 2014. PubMed ID: 25212771. Show all entries for this paper.

Displaying record number 61631

HXB2 Location  Nef(19-27)   Nef Epitope Map
View variants at this location
Epitope RIRRTAQAA   Epitope Alignment
Variants
kIkRTAPTA   escape documented in this paper
RIRRTAPkA   escape documented in this paper
Species (MHC/HLA)  human

Variant Details

Showing all: 2 variant(s).

Variant ID.  4034
Epitope Seq.  RIRRTAQAA
Variant Seq.  kIkRTAPTA
Mutations R/K R/K Q/P A/T
Epitope Location R1K R3K Q7P A8T
HXB2 Location R19K R21K Q25P A26T
Mutation Type E: escape documented in this paper
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note By 441 days post-screening, the patient's sequences were dominated by two escape variants, kIkRTAPTA and RIRRTAPkA.

Variant ID.  4035
Epitope Seq.  RIRRTAQAA
Variant Seq.  RIRRTAPkA
Mutations Q/P A/K
Epitope Location Q7P A8K
HXB2 Location Q25P A26K
Mutation Type E: escape documented in this paper
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note By 441 days post-screening, the patient's sequences were dominated by two escape variants, kIkRTAPTA and RIRRTAPkA.

References

Ritchie2014 Adam John Ritchie, Fangping Cai, Nicola M. G. Smith, Sheri Chen, Hongshuo Song, Simon Brackenridge, Salim S. Abdool Karim, Bette T. Korber, Andrew J. McMichael, Feng Gao, and Nilu Goonetilleke. Recombination-Mediated Escape from Primary CD8+ T Cells in Acute HIV-1 Infection. Retrovirology, 11:69, 2014. PubMed ID: 25212771. Show all entries for this paper.

Displaying record number 59390

HXB2 Location  Nef(68-76)   Nef Epitope Map
View variants at this location
Epitope FPVRPQVPL   Epitope Alignment
Variants
FPVtPQVPL   escape documented in this paper
FPVkPQVPL   diminished response
Species (MHC/HLA)  human

Variant Details

Showing all: 2 variant(s).

Variant ID.  3470
Epitope Seq.  FPVRPQVPL
Variant Seq.  FPVtPQVPL
Mutations R/T
Epitope Location R4T
HXB2 Location R71T
Mutation Type E: escape documented in this paper
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Variant FPVtPQVPL increased in the patient's sequences from 134-441 days post-screening, and became the sole variant by 441 days with loss of EliSpot response.

Variant ID.  3471
Epitope Seq.  FPVRPQVPL
Variant Seq.  FPVkPQVPL
Mutations R/K
Epitope Location R4K
HXB2 Location R71K
Mutation Type DR: diminished response
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note FPVkPQVPL was present at 35 and 49 days post-screening and showed diminished EliS+pot response.

References

Ritchie2014 Adam John Ritchie, Fangping Cai, Nicola M. G. Smith, Sheri Chen, Hongshuo Song, Simon Brackenridge, Salim S. Abdool Karim, Bette T. Korber, Andrew J. McMichael, Feng Gao, and Nilu Goonetilleke. Recombination-Mediated Escape from Primary CD8+ T Cells in Acute HIV-1 Infection. Retrovirology, 11:69, 2014. PubMed ID: 25212771. Show all entries for this paper.

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