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Found 4 matching records:

Displaying record number 49

HXB2 Location Gag(24-35) Gag Epitope Map
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GGKKKYKLKHIV

`GGKKKYKLKHIi`		susceptible form
`GrKKKYKLKHIV`		escape documented in this paper
`GrKKKYKfKHIV`		escape documented in this paper
`rGKKrYKLKHIV`		observed variant
`GGKKqYrLKHIV`		observed variant
`GGKKKYqLKHIV`		observed variant
`GGKKKYaLKHli`		observed variant

Species (MHC/HLA) human(B8)

Variant Details

Showing all: 7 variant(s).

Variant ID.	`373`
Epitope Seq.	`GGKKKYKLKHIV`
Variant Seq.	`GGKKKYKLKHIi`
Mutations	V/I
Epitope Location	V12I
HXB2 Location	V35I
Mutation Type	SF: susceptible form
Note	This variant was recognized as efficiently as the wt epitope by patient CTLs.

Variant ID.	`374`
Epitope Seq.	`GGKKKYKLKHIV`
Variant Seq.	`GrKKKYKLKHIV`
Mutations	G/R
Epitope Location	G2R
HXB2 Location	G25R
Mutation Type	E: escape documented in this paper
Note	This variant failed to be recognized by CTLs and failed to induce target specific lysis.

Variant ID.	`375`
Epitope Seq.	`GGKKKYKLKHIV`
Variant Seq.	`GrKKKYKfKHIV`
Mutations	G/R L/F
Epitope Location	G2R L8F
HXB2 Location	G25R L31F
Mutation Type	E: escape documented in this paper
Note	This variant failed to be recognized by CTLs and failed to induce target specific lysis.

Variant ID.	`376`
Epitope Seq.	`GGKKKYKLKHIV`
Variant Seq.	`rGKKrYKLKHIV`
Mutations	G/R K/R
Epitope Location	G1R K5R
HXB2 Location	G24R K28R
Mutation Type	OV: observed variant
Note	Previously published variants of this epitope.

Variant ID.	`377`
Epitope Seq.	`GGKKKYKLKHIV`
Variant Seq.	`GGKKqYrLKHIV`
Mutations	K/Q K/R
Epitope Location	K5Q K7R
HXB2 Location	K28Q K30R
Mutation Type	OV: observed variant
Note	Previously published variants of this epitope.

Variant ID.	`378`
Epitope Seq.	`GGKKKYKLKHIV`
Variant Seq.	`GGKKKYqLKHIV`
Mutations	K/Q
Epitope Location	K7Q
HXB2 Location	K30Q
Mutation Type	OV: observed variant
Note	Previously published variants of this epitope.

Variant ID.	`379`
Epitope Seq.	`GGKKKYKLKHIV`
Variant Seq.	`GGKKKYaLKHli`
Mutations	I/L V/I K/A
Epitope Location	I11L V12I K7A
HXB2 Location	I34L V35I K30A
Mutation Type	OV: observed variant
Note	Previously published variants of this epitope.

References

Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.

Phillips1991 R. E. Phillips, S. Rowland-Jones, D. F. Nixon, F. M. Gotch, J. P. Edwards, A. O. Ogunlesi, J. G. Elvin, J. A. Rothbard, C. R. Bangham, C. R. Rizza, and A. J. McMichael. Human Immunodeficiency Virus Genetic Variation That Can Escape Cytotoxic T Cell Recognition. Nature, 354:453-459, 1991. Fluctuations in the specificity of cytotoxic T-cells for HIV were correlated with variability in proviral gag (DNA) epitope sequences. PubMed ID: 1721107. Show all entries for this paper.

Displaying record number 230

HXB2 Location Gag(253-267) Gag Epitope Map
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Epitope

NPPIPVGEIYKRWII

Epitope Alignment

Variants

NPPIPVGdIYKRWII susceptible form

Species (MHC/HLA) human(B8)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`380`
Epitope Seq.	`NPPIPVGEIYKRWII`
Variant Seq.	`NPPIPVGdIYKRWII`
Mutations	E/D
Epitope Location	E8D
HXB2 Location	E260D
Mutation Type	SF: susceptible form
Note	This variant was recognized by patient CTLs, but the wt epitope was not recognized, indicating that the CTLs tested were of different population than those raised against the wt epitope.

References

Displaying record number 279

HXB2 Location Gag(263-272) Gag Epitope Map
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Epitope

KRWIILGLNK

Epitope Alignment

Variants

KRWIImGLNK susceptible form

Species (MHC/HLA) human(B27)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`381`
Epitope Seq.	`KRWIILGLNK`
Variant Seq.	`KRWIImGLNK`
Mutations	L/M
Epitope Location	L6M
HXB2 Location	L268M
Mutation Type	SF: susceptible form
Note	This variant was recognized more efficiently than the wt epitope by patient CTLs.

References

Displaying record number 345

HXB2 Location Gag(323-337) Gag Epitope Map
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Epitope

VQNANPDCKTILKAL

Epitope Alignment

Variants

VQNANPDCrTILKAL escape documented in this paper

Species (MHC/HLA) human(B8)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`382`
Epitope Seq.	`VQNANPDCKTILKAL`
Variant Seq.	`VQNANPDCrTILKAL`
Mutations	K/R
Epitope Location	K9R
HXB2 Location	K331R
Mutation Type	E: escape documented in this paper
Note	This variant failed to be recognized by CTLs and failed to induce target specific lysis.