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Found 13 matching records:

Displaying record number 53411

HXB2 Location Gag(77-85) Gag Epitope Map
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SLFNTVATL

`SLyNTVATL`		escape documented in this paper
`SLyNaVATL`		escape documented in this paper

Epitope Name SLF

Species (MHC/HLA) human(A2)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`1349`
Epitope Seq.	`SLFNTVATL`
Variant Seq.	`SLyNTVATL`
Mutations	F/Y
Epitope Location	F3Y
HXB2 Location	F79Y
Mutation Type	E: escape documented in this paper
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	Positive selection on this epitope resulted in an escape by phylogenetic analysis. The variant peptide was less potent at inducing production of IFN-gamma than the index peptide.

Variant ID.	`1350`
Epitope Seq.	`SLFNTVATL`
Variant Seq.	`SLyNaVATL`
Mutations	F/Y T/A
Epitope Location	F3Y T5A
HXB2 Location	F79Y T81A
Mutation Type	E: escape documented in this paper
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	Positive selection on this epitope resulted in an escape by phylogenetic analysis. The variant peptide was less potent at inducing production of IFN-gamma than the index peptide.

References

Oxenius2004 Annette Oxenius, David A. Price, Alexandra Trkola, Charles Edwards, Emma Gostick, Hua-Tang Zhang, Philippa J. Easterbrook, Tin Tun, Andrew Johnson, Anele Waters, Edward C. Holmes, and Rodney E. Phillips. Loss of Viral Control in Early HIV-1 Infection Is Temporally Associated with Sequential Escape from CD8+ T Cell Responses and Decrease in HIV-1-Specific CD4+ and CD8+ T Cell Frequencies. J. Infect. Dis., 190(4):713-721, 15 Aug 2004. PubMed ID: 15272399. Show all entries for this paper.

Displaying record number 53421

HXB2 Location Gag(210-218) Gag Epitope Map
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Epitope

AEWDRLHPV

Epitope Alignment

Variants

`AEWgRLHPV`		observed variant
`AdWDRvHPV`		observed variant
`AE*DRLHPV`		observed variant

Epitope Name AEW

Species (MHC/HLA) human(A2)

Variant Details

Showing all: 3 variant(s).

Variant ID.	`1351`
Epitope Seq.	`AEWDRLHPV`
Variant Seq.	`AEWgRLHPV`
Mutations	D/G
Epitope Location	D4G
HXB2 Location	D213G
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	Only 1/18 viral clones contained this variant sequence at the first time point tested after infection.

Variant ID.	`1352`
Epitope Seq.	`AEWDRLHPV`
Variant Seq.	`AdWDRvHPV`
Mutations	E/D L/V
Epitope Location	E2D L6V
HXB2 Location	E211D L215V
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	Only 1/18 viral clones contained this variant sequence at the first time point tested after infection.

Variant ID.	`2302`
Epitope Seq.	`AEWDRLHPV`
Variant Seq.	`AE*DRLHPV`
Mutations	W/*
Epitope Location	W3*
HXB2 Location	W212*
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	This index epitope sequence had variants at position 3 that were not specified in the paper. Only 2/18 viral clones contained variant sequences at the first time-point tested after infection.

References

Displaying record number 53414

HXB2 Location Gag(213-232) Gag Epitope Map
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Epitope

DRLHPVHAGPAAPGQMREPR

Epitope Alignment

Variants

DRLHPVHAGPiAPGQMREPR diminished response

Epitope Name DRL

Species (MHC/HLA) human

Variant Details

Showing all: 1 variant(s).

Variant ID.	`1353`
Epitope Seq.	`DRLHPVHAGPAAPGQMREPR`
Variant Seq.	`DRLHPVHAGPiAPGQMREPR`
Mutations	A/I
Epitope Location	A11I
HXB2 Location	A223I
Mutation Type	DR: diminished response
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	Diminished response at higher peptide concentration, similar response at lower peptide concentration.

References

Displaying record number 53420

HXB2 Location Gag(326-334) Gag Epitope Map
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Epitope

ANPDCKTIL

Epitope Alignment

Variants

`sNPDCKTIL`		observed variant
`ANPDCKTIs`		observed variant

Epitope Name ANP

Species (MHC/HLA) human(B7)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`1354`
Epitope Seq.	`ANPDCKTIL`
Variant Seq.	`sNPDCKTIL`
Mutations	A/S
Epitope Location	A1S
HXB2 Location	A326S
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	Only 1/18 viral clones contained this variant sequence at the first time point tested after infection.

Variant ID.	`1355`
Epitope Seq.	`ANPDCKTIL`
Variant Seq.	`ANPDCKTIs`
Mutations	L/S
Epitope Location	L9S
HXB2 Location	L334S
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	Only 1/18 viral clones contained this variant sequence at the first time point tested after infection.

References

Displaying record number 53413

HXB2 Location Pol(448-456) Pol Epitope Map
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Epitope

IPLTEEAEL

Epitope Alignment

Variants

`IPLTEaAEL`		diminished response
`IPLTEEAgL`		observed variant
`IPLTEEAgf`		diminished response
`IPLTgEAEL`		diminished response
`IPLTqEAEL`		diminished response
`IPLTvEAEL`		diminished response
`IPLTaEAEL`		diminished response

Epitope Name IPL

Species (MHC/HLA) human(B7)

Variant Details

Showing all: 7 variant(s).

Variant ID.	`1356`
Epitope Seq.	`IPLTEEAEL`
Variant Seq.	`IPLTEaAEL`
Mutations	E/A
Epitope Location	E6A
HXB2 Location	E453A
Mutation Type	DR: diminished response
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	The variant peptide was less potent at inducing production of IFN-gamma than the index peptide.

Variant ID.	`1357`
Epitope Seq.	`IPLTEEAEL`
Variant Seq.	`IPLTEEAgL`
Mutations	E/G
Epitope Location	E8G
HXB2 Location	E455G
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	The variant peptide was less potent at inducing production of IFN-gamma than the index peptide.

Variant ID.	`1358`
Epitope Seq.	`IPLTEEAEL`
Variant Seq.	`IPLTEEAgf`
Mutations	E/G L/F
Epitope Location	E8G L9F
HXB2 Location	E455G L456F
Mutation Type	DR: diminished response
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	The variant peptide was less potent at inducing production of IFN-gamma than the index peptide.

Variant ID.	`1359`
Epitope Seq.	`IPLTEEAEL`
Variant Seq.	`IPLTgEAEL`
Mutations	E/G
Epitope Location	E5G
HXB2 Location	E452G
Mutation Type	DR: diminished response
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	The variant peptide was less potent at inducing production of IFN-gamma than the index peptide.

Variant ID.	`1360`
Epitope Seq.	`IPLTEEAEL`
Variant Seq.	`IPLTqEAEL`
Mutations	E/Q
Epitope Location	E5Q
HXB2 Location	E452Q
Mutation Type	DR: diminished response
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	The variant peptide was less potent at inducing production of IFN-gamma than the index peptide.

Variant ID.	`1361`
Epitope Seq.	`IPLTEEAEL`
Variant Seq.	`IPLTvEAEL`
Mutations	E/V
Epitope Location	E5V
HXB2 Location	E452V
Mutation Type	DR: diminished response
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	The variant peptide was less potent at inducing production of IFN-gamma than the index peptide.

Variant ID.	`1362`
Epitope Seq.	`IPLTEEAEL`
Variant Seq.	`IPLTaEAEL`
Mutations	E/A
Epitope Location	E5A
HXB2 Location	E452A
Mutation Type	DR: diminished response
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	The variant peptide was less potent at inducing production of IFN-gamma than the index peptide.

References

Displaying record number 53424

HXB2 Location Pol(453-467) Pol Epitope Map
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Epitope

EAELELAENREILKE

Epitope Alignment

Variants

`aAELELAENREILKE`		observed variant
`EAgfELAENREILKE`		observed variant
`EAgLELAENREILKE`		observed variant
`EAELELAENREILeE`		observed variant
`EAELELAgNREILKE`		observed variant

Epitope Name EAE

Species (MHC/HLA) human

Variant Details

Showing all: 5 variant(s).

Variant ID.	`1363`
Epitope Seq.	`EAELELAENREILKE`
Variant Seq.	`aAELELAENREILKE`
Mutations	E/A
Epitope Location	E1A
HXB2 Location	E453A
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	Only 2/11 viral clones contained this variant sequence at the first time point (Day 60) tested after infection. 1/9 clones contained the variant sequence at the second time point (Day 297).

Variant ID.	`1364`
Epitope Seq.	`EAELELAENREILKE`
Variant Seq.	`EAgfELAENREILKE`
Mutations	E/G L/F
Epitope Location	E3G L4F
HXB2 Location	E455G L456F
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	Only 1/11 viral clones contained this variant sequence at the first time point tested after infection.

Variant ID.	`1365`
Epitope Seq.	`EAELELAENREILKE`
Variant Seq.	`EAgLELAENREILKE`
Mutations	E/G
Epitope Location	E3G
HXB2 Location	E455G
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	Only 1/18 viral clones contained this variant sequence at the first time point tested after infection.

Variant ID.	`1366`
Epitope Seq.	`EAELELAENREILKE`
Variant Seq.	`EAELELAENREILeE`
Mutations	K/E
Epitope Location	K14E
HXB2 Location	K466E
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	Only 1/15 viral clones contained this variant sequence at the third time point (Day 369) tested after infection.

Variant ID.	`1367`
Epitope Seq.	`EAELELAENREILKE`
Variant Seq.	`EAELELAgNREILKE`
Mutations	E/G
Epitope Location	E8G
HXB2 Location	E460G
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	Only 1/14 viral clones contained this variant sequence at the last time point (Day 635) tested after infection.

References

Displaying record number 53418

HXB2 Location Tat(39-49) Tat Epitope Map
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Epitope

ITKGLGISYGR

Epitope Alignment

Variants

`tTKGLGISYGR`		observed variant
`ITKGsGISYGR`		observed variant

Epitope Name ITK

Species (MHC/HLA) human(A*68:01)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`1368`
Epitope Seq.	`ITKGLGISYGR`
Variant Seq.	`tTKGLGISYGR`
Mutations	I/T
Epitope Location	I1T
HXB2 Location	I39T
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	4/13 viral clones contained this variant sequence at the first time point (Day 60) tested after infection. While no variant sequence was detected at the second sampling, 2/13 clones contained it at the third time point (Day 369) and the sequence was lost thereafter.

Variant ID.	`1369`
Epitope Seq.	`ITKGLGISYGR`
Variant Seq.	`ITKGsGISYGR`
Mutations	L/S
Epitope Location	L5S
HXB2 Location	L43S
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	Only 1/17 viral clones contained this variant sequence at the last time point (Day 635) tested after infection.

References

Displaying record number 53422

HXB2 Location gp160(30-49) gp160 Epitope Map
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Epitope

ATEKLWVTVYYGVPVWKEAT

Epitope Alignment

Variants

`ATEKmWVTVYYGVPVWKEAT`		observed variant
`ATEKLWVTVYYGaPVWKEAT`		observed variant
`ATEKLcVTVYYGVPVWKEAT`		observed variant
`ATEKLWVTVhYGVPVWKEAT`		observed variant
`ATEKLWVTVYYGVPaWKEAT`		observed variant
`ATEKLWVTVYhGVPVWKEAT`		observed variant

Epitope Name ATE

Species (MHC/HLA) human

Variant Details

Showing all: 6 variant(s).

Variant ID.	`1370`
Epitope Seq.	`ATEKLWVTVYYGVPVWKEAT`
Variant Seq.	`ATEKmWVTVYYGVPVWKEAT`
Mutations	L/M
Epitope Location	L5M
HXB2 Location	L34M
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	Only 1/20 viral clones contained this variant sequence at the first time point (Day60) tested after infection.

Variant ID.	`1371`
Epitope Seq.	`ATEKLWVTVYYGVPVWKEAT`
Variant Seq.	`ATEKLWVTVYYGaPVWKEAT`
Mutations	V/A
Epitope Location	V13A
HXB2 Location	V42A
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	Only 1/20 viral clones contained this variant sequence at the first time point (Day60) tested after infection.

Variant ID.	`1372`
Epitope Seq.	`ATEKLWVTVYYGVPVWKEAT`
Variant Seq.	`ATEKLcVTVYYGVPVWKEAT`
Mutations	W/C
Epitope Location	W6C
HXB2 Location	W35C
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	Only 1/19 viral clones contained this variant sequence at the second time point (Day 369) tested after infection.

Variant ID.	`1373`
Epitope Seq.	`ATEKLWVTVYYGVPVWKEAT`
Variant Seq.	`ATEKLWVTVhYGVPVWKEAT`
Mutations	Y/H
Epitope Location	Y10H
HXB2 Location	Y39H
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	Only 1/19 viral clones contained this variant sequence at the second time point (Day 369) tested after infection.

Variant ID.	`1374`
Epitope Seq.	`ATEKLWVTVYYGVPVWKEAT`
Variant Seq.	`ATEKLWVTVYYGVPaWKEAT`
Mutations	V/A
Epitope Location	V15A
HXB2 Location	V44A
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	Only 1/19 viral clones contained this variant sequence at the second time point (Day 369) tested after infection.

Variant ID.	`1375`
Epitope Seq.	`ATEKLWVTVYYGVPVWKEAT`
Variant Seq.	`ATEKLWVTVYhGVPVWKEAT`
Mutations	Y/H
Epitope Location	Y11H
HXB2 Location	Y40H
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	Only 1/12 viral clones contained this variant sequence at the last time point (Day 635) tested after infection.

References

Displaying record number 53423

HXB2 Location gp160(42-61) gp160 Epitope Map
View variants at this location

Epitope

VPVWKEATTTLFCASDAKAY

Epitope Alignment

Variants

`VPVWKEATTTLsrASDAKAY`		observed variant
`aPVWKEATTTLFCASDAKAY`		observed variant
`VPVWKEATTTLFrASDAKAY`		observed variant
`VPVWKEATTTLFCvSDAKAY`		observed variant
`VPVWKEATTTLFCAtDAKAY`		observed variant
`VPVWKEATTTLFyASDAKAY`		observed variant
`VPVWKEATTTpFCASDAKAY`		observed variant
`VPaWKEATTTLFCASDAKsY`		observed variant

Epitope Name VPV

Species (MHC/HLA) human

Variant Details

Showing all: 8 variant(s).

Variant ID.	`1376`
Epitope Seq.	`VPVWKEATTTLFCASDAKAY`
Variant Seq.	`VPVWKEATTTLsrASDAKAY`
Mutations	F/S C/R
Epitope Location	F12S C13R
HXB2 Location	F53S C54R
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	Only 3/20 viral clones contained this variant sequence at the first time point (Day 60) tested after infection.

Variant ID.	`1377`
Epitope Seq.	`VPVWKEATTTLFCASDAKAY`
Variant Seq.	`aPVWKEATTTLFCASDAKAY`
Mutations	V/A
Epitope Location	V1A
HXB2 Location	V42A
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	Only 1/20 viral clones contained this variant sequence at the first time point (Day60) tested after infection.

Variant ID.	`1378`
Epitope Seq.	`VPVWKEATTTLFCASDAKAY`
Variant Seq.	`VPVWKEATTTLFrASDAKAY`
Mutations	C/R
Epitope Location	C13R
HXB2 Location	C54R
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	Only 1/20 viral clones contained this variant sequence at the first time point (Day60) tested after infection.

Variant ID.	`1379`
Epitope Seq.	`VPVWKEATTTLFCASDAKAY`
Variant Seq.	`VPVWKEATTTLFCvSDAKAY`
Mutations	A/V
Epitope Location	A14V
HXB2 Location	A55V
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	Only 1/20 viral clones contained this variant sequence at the first time point (Day60) tested after infection.

Variant ID.	`1380`
Epitope Seq.	`VPVWKEATTTLFCASDAKAY`
Variant Seq.	`VPVWKEATTTLFCAtDAKAY`
Mutations	S/T
Epitope Location	S15T
HXB2 Location	S56T
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	Only 1/19 viral clones contained this variant sequence at the second time point (Day 369) tested after infection.

Variant ID.	`1381`
Epitope Seq.	`VPVWKEATTTLFCASDAKAY`
Variant Seq.	`VPVWKEATTTLFyASDAKAY`
Mutations	C/Y
Epitope Location	C13Y
HXB2 Location	C54Y
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	Only 1/19 viral clones contained this variant sequence at the second time point (Day 369) tested after infection.

Variant ID.	`1382`
Epitope Seq.	`VPVWKEATTTLFCASDAKAY`
Variant Seq.	`VPVWKEATTTpFCASDAKAY`
Mutations	L/P
Epitope Location	L11P
HXB2 Location	L52P
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	Only 1/19 viral clones contained this variant sequence at the second time point (Day 369) tested after infection.

Variant ID.	`1383`
Epitope Seq.	`VPVWKEATTTLFCASDAKAY`
Variant Seq.	`VPaWKEATTTLFCASDAKsY`
Mutations	A/S V/A
Epitope Location	A19S V3A
HXB2 Location	A60S V44A
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	Only 1/19 viral clones contained this variant sequence at the second time point (Day 369) tested after infection.

References

Displaying record number 53415

HXB2 Location gp160(78-86) gp160 Epitope Map
View variants at this location

Epitope

DPNPQEVAL

Epitope Alignment

Variants

`DPNPQEaAL`		escape documented in this paper
`DPNPQEtAL`		escape documented in this paper
`DlNPQEVAL`		escape documented in this paper
`DPNPQEVpL`		escape documented in this paper

Epitope Name DPN

Species (MHC/HLA) human(B35)

Variant Details

Showing all: 4 variant(s).

Variant ID.	`1384`
Epitope Seq.	`DPNPQEVAL`
Variant Seq.	`DPNPQEaAL`
Mutations	V/A
Epitope Location	V7A
HXB2 Location	V84A
Mutation Type	E: escape documented in this paper
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	Positive selection on this epitope resulted in an escape by phylogenetic analysis. The variant peptide was less potent at inducing production of IFN-gamma than the index peptide.

Variant ID.	`1385`
Epitope Seq.	`DPNPQEVAL`
Variant Seq.	`DPNPQEtAL`
Mutations	V/T
Epitope Location	V7T
HXB2 Location	V84T
Mutation Type	E: escape documented in this paper
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	Positive selection on this epitope resulted in an escape by phylogenetic analysis. The variant peptide was less potent at inducing production of IFN-gamma than the index peptide.

Variant ID.	`1386`
Epitope Seq.	`DPNPQEVAL`
Variant Seq.	`DlNPQEVAL`
Mutations	P/L
Epitope Location	P2L
HXB2 Location	P79L
Mutation Type	E: escape documented in this paper
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	Positive selection on this epitope resulted in an escape by phylogenetic analysis. The variant peptide was less potent at inducing production of IFN-gamma than the index peptide.

Variant ID.	`1387`
Epitope Seq.	`DPNPQEVAL`
Variant Seq.	`DPNPQEVpL`
Mutations	A/P
Epitope Location	A8P
HXB2 Location	A85P
Mutation Type	E: escape documented in this paper
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	Positive selection on this epitope resulted in an escape by phylogenetic analysis. The variant peptide was less potent at inducing production of IFN-gamma than the index peptide.

References

Displaying record number 53417

HXB2 Location gp160(843-851) gp160 Epitope Map
View variants at this location

Epitope

IPRRIRQGL

Epitope Alignment

Variants

`vPRRIRQGL`		observed variant
`IPgRIRQGL`		observed variant
`IPRRkRQGL`		observed variant
`IPRRIRQGf`		observed variant

Epitope Name IPR

Species (MHC/HLA) human(B7)

Variant Details

Showing all: 4 variant(s).

Variant ID.	`1388`
Epitope Seq.	`IPRRIRQGL`
Variant Seq.	`vPRRIRQGL`
Mutations	I/V
Epitope Location	I1V
HXB2 Location	I843V
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	Only 1/11 viral clones contained this variant sequence at the last time point (Day 635) tested after infection.

Variant ID.	`1389`
Epitope Seq.	`IPRRIRQGL`
Variant Seq.	`IPgRIRQGL`
Mutations	R/G
Epitope Location	R3G
HXB2 Location	R845G
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	Only 1/11 viral clones contained this variant sequence at the last time point (Day 635) tested after infection.

Variant ID.	`1390`
Epitope Seq.	`IPRRIRQGL`
Variant Seq.	`IPRRkRQGL`
Mutations	I/K
Epitope Location	I5K
HXB2 Location	I847K
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	Only 1/10 viral clones contained this variant sequence at the second time point (Day 369) tested after infection.

Variant ID.	`1391`
Epitope Seq.	`IPRRIRQGL`
Variant Seq.	`IPRRIRQGf`
Mutations	L/F
Epitope Location	L9F
HXB2 Location	L851F
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	Only 1/11 viral clones contained this variant sequence at the last time point (Day 635) tested after infection.

References

Displaying record number 53416

HXB2 Location Nef(74-81) Nef Epitope Map
View variants at this location

Epitope

VPLRPMTY

Epitope Alignment

Variants

`VPLRPMsY`		escape documented in this paper
`VPLRPMTf`		escape documented in this paper

Epitope Name VPL

Species (MHC/HLA) human(B35)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`1392`
Epitope Seq.	`VPLRPMTY`
Variant Seq.	`VPLRPMsY`
Mutations	T/S
Epitope Location	T7S
HXB2 Location	T80S
Mutation Type	E: escape documented in this paper
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	This variant was an escape. Response greatly diminished.

Variant ID.	`1393`
Epitope Seq.	`VPLRPMTY`
Variant Seq.	`VPLRPMTf`
Mutations	Y/F
Epitope Location	Y8F
HXB2 Location	Y81F
Mutation Type	E: escape documented in this paper
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	This variant was an escape. Response diminished.

References

Displaying record number 53412

HXB2 Location Nef(77-85) Nef Epitope Map
View variants at this location

Epitope

RPMTYKGAL

Epitope Alignment

Variants

`RPMTYrGAL`		observed variant
`RPMTYKaAL`		observed variant
`RPMTYKGAv`		observed variant
`RPMsYKaAL`		observed variant
`RPMTfKGAL`		observed variant

Epitope Name RPM

Species (MHC/HLA) human(B7)

Variant Details

Showing all: 5 variant(s).

Variant ID.	`1394`
Epitope Seq.	`RPMTYKGAL`
Variant Seq.	`RPMTYrGAL`
Mutations	K/R
Epitope Location	K6R
HXB2 Location	K82R
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	This variant was seen earlier and was proposed to be an escape.

Variant ID.	`1395`
Epitope Seq.	`RPMTYKGAL`
Variant Seq.	`RPMTYKaAL`
Mutations	G/A
Epitope Location	G7A
HXB2 Location	G83A
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	This variant was seen earlier and was proposed to be an escape.

Variant ID.	`1396`
Epitope Seq.	`RPMTYKGAL`
Variant Seq.	`RPMTYKGAv`
Mutations	L/V
Epitope Location	L9V
HXB2 Location	L85V
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	This variant was seen earlier and was proposed to be an escape.

Variant ID.	`1397`
Epitope Seq.	`RPMTYKGAL`
Variant Seq.	`RPMsYKaAL`
Mutations	T/S G/A
Epitope Location	T4S G7A
HXB2 Location	T80S G83A
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	This was one of two most common forms of variants.

Variant ID.	`1398`
Epitope Seq.	`RPMTYKGAL`
Variant Seq.	`RPMTfKGAL`
Mutations	Y/F
Epitope Location	Y5F
HXB2 Location	Y81F
Mutation Type	OV: observed variant
Method	CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note	This was one of two most common forms of variants.