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Found 13 matching records:

Displaying record number 53411

HXB2 Location  Gag(77-85)   Gag Epitope Map
View variants at this location
Epitope SLFNTVATL   Epitope Alignment
Variants
SLyNTVATL   escape documented in this paper
SLyNaVATL   escape documented in this paper
Epitope Name SLF
Species (MHC/HLA human(A2)

Variant Details

Showing all: 2 variant(s).


Variant ID.  1349
Epitope Seq.  SLFNTVATL
Variant Seq.  SLyNTVATL
Mutations F/Y
Epitope Location F3Y
HXB2 Location F79Y
Mutation Type E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note Positive selection on this epitope resulted in an escape by phylogenetic analysis. The variant peptide was less potent at inducing production of IFN-gamma than the index peptide.


Variant ID.  1350
Epitope Seq.  SLFNTVATL
Variant Seq.  SLyNaVATL
Mutations F/Y T/A
Epitope Location F3Y T5A
HXB2 Location F79Y T81A
Mutation Type E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note Positive selection on this epitope resulted in an escape by phylogenetic analysis. The variant peptide was less potent at inducing production of IFN-gamma than the index peptide.

References

Oxenius2004 Annette Oxenius, David A. Price, Alexandra Trkola, Charles Edwards, Emma Gostick, Hua-Tang Zhang, Philippa J. Easterbrook, Tin Tun, Andrew Johnson, Anele Waters, Edward C. Holmes, and Rodney E. Phillips. Loss of Viral Control in Early HIV-1 Infection Is Temporally Associated with Sequential Escape from CD8+ T Cell Responses and Decrease in HIV-1-Specific CD4+ and CD8+ T Cell Frequencies. J. Infect. Dis., 190(4):713-721, 15 Aug 2004. PubMed ID: 15272399. Show all entries for this paper.


Displaying record number 53421

HXB2 Location  Gag(210-218)   Gag Epitope Map
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Epitope AEWDRLHPV   Epitope Alignment
Variants
AEWgRLHPV   observed variant
AdWDRvHPV   observed variant
AE*DRLHPV   observed variant
Epitope Name AEW
Species (MHC/HLA human(A2)

Variant Details

Showing all: 3 variant(s).


Variant ID.  1351
Epitope Seq.  AEWDRLHPV
Variant Seq.  AEWgRLHPV
Mutations D/G
Epitope Location D4G
HXB2 Location D213G
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note Only 1/18 viral clones contained this variant sequence at the first time point tested after infection.


Variant ID.  1352
Epitope Seq.  AEWDRLHPV
Variant Seq.  AdWDRvHPV
Mutations E/D L/V
Epitope Location E2D L6V
HXB2 Location E211D L215V
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note Only 1/18 viral clones contained this variant sequence at the first time point tested after infection.


Variant ID.  2302
Epitope Seq.  AEWDRLHPV
Variant Seq.  AE*DRLHPV
Mutations W/*
Epitope Location W3*
HXB2 Location W212*
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note This index epitope sequence had variants at position 3 that were not specified in the paper. Only 2/18 viral clones contained variant sequences at the first time-point tested after infection.

References

Oxenius2004 Annette Oxenius, David A. Price, Alexandra Trkola, Charles Edwards, Emma Gostick, Hua-Tang Zhang, Philippa J. Easterbrook, Tin Tun, Andrew Johnson, Anele Waters, Edward C. Holmes, and Rodney E. Phillips. Loss of Viral Control in Early HIV-1 Infection Is Temporally Associated with Sequential Escape from CD8+ T Cell Responses and Decrease in HIV-1-Specific CD4+ and CD8+ T Cell Frequencies. J. Infect. Dis., 190(4):713-721, 15 Aug 2004. PubMed ID: 15272399. Show all entries for this paper.


Displaying record number 53414

HXB2 Location  Gag(213-232)   Gag Epitope Map
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Epitope DRLHPVHAGPAAPGQMREPR   Epitope Alignment
Variants
DRLHPVHAGPiAPGQMREPR   diminished response
Epitope Name DRL
Species (MHC/HLA human

Variant Details

Showing all: 1 variant(s).


Variant ID.  1353
Epitope Seq.  DRLHPVHAGPAAPGQMREPR
Variant Seq.  DRLHPVHAGPiAPGQMREPR
Mutations A/I
Epitope Location A11I
HXB2 Location A223I
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note Diminished response at higher peptide concentration, similar response at lower peptide concentration.

References

Oxenius2004 Annette Oxenius, David A. Price, Alexandra Trkola, Charles Edwards, Emma Gostick, Hua-Tang Zhang, Philippa J. Easterbrook, Tin Tun, Andrew Johnson, Anele Waters, Edward C. Holmes, and Rodney E. Phillips. Loss of Viral Control in Early HIV-1 Infection Is Temporally Associated with Sequential Escape from CD8+ T Cell Responses and Decrease in HIV-1-Specific CD4+ and CD8+ T Cell Frequencies. J. Infect. Dis., 190(4):713-721, 15 Aug 2004. PubMed ID: 15272399. Show all entries for this paper.


Displaying record number 53420

HXB2 Location  Gag(326-334)   Gag Epitope Map
View variants at this location
Epitope ANPDCKTIL   Epitope Alignment
Variants
sNPDCKTIL   observed variant
ANPDCKTIs   observed variant
Epitope Name ANP
Species (MHC/HLA human(B7)

Variant Details

Showing all: 2 variant(s).


Variant ID.  1354
Epitope Seq.  ANPDCKTIL
Variant Seq.  sNPDCKTIL
Mutations A/S
Epitope Location A1S
HXB2 Location A326S
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note Only 1/18 viral clones contained this variant sequence at the first time point tested after infection.


Variant ID.  1355
Epitope Seq.  ANPDCKTIL
Variant Seq.  ANPDCKTIs
Mutations L/S
Epitope Location L9S
HXB2 Location L334S
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note Only 1/18 viral clones contained this variant sequence at the first time point tested after infection.

References

Oxenius2004 Annette Oxenius, David A. Price, Alexandra Trkola, Charles Edwards, Emma Gostick, Hua-Tang Zhang, Philippa J. Easterbrook, Tin Tun, Andrew Johnson, Anele Waters, Edward C. Holmes, and Rodney E. Phillips. Loss of Viral Control in Early HIV-1 Infection Is Temporally Associated with Sequential Escape from CD8+ T Cell Responses and Decrease in HIV-1-Specific CD4+ and CD8+ T Cell Frequencies. J. Infect. Dis., 190(4):713-721, 15 Aug 2004. PubMed ID: 15272399. Show all entries for this paper.


Displaying record number 53413

HXB2 Location  Pol(448-456)   Pol Epitope Map
View variants at this location
Epitope IPLTEEAEL   Epitope Alignment
Variants
IPLTEaAEL   diminished response
IPLTEEAgL   observed variant
IPLTEEAgf   diminished response
IPLTgEAEL   diminished response
IPLTqEAEL   diminished response
IPLTvEAEL   diminished response
IPLTaEAEL   diminished response
Epitope Name IPL
Species (MHC/HLA human(B7)

Variant Details

Showing all: 7 variant(s).


Variant ID.  1356
Epitope Seq.  IPLTEEAEL
Variant Seq.  IPLTEaAEL
Mutations E/A
Epitope Location E6A
HXB2 Location E453A
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note The variant peptide was less potent at inducing production of IFN-gamma than the index peptide.


Variant ID.  1357
Epitope Seq.  IPLTEEAEL
Variant Seq.  IPLTEEAgL
Mutations E/G
Epitope Location E8G
HXB2 Location E455G
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note The variant peptide was less potent at inducing production of IFN-gamma than the index peptide.


Variant ID.  1358
Epitope Seq.  IPLTEEAEL
Variant Seq.  IPLTEEAgf
Mutations E/G L/F
Epitope Location E8G L9F
HXB2 Location E455G L456F
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note The variant peptide was less potent at inducing production of IFN-gamma than the index peptide.


Variant ID.  1359
Epitope Seq.  IPLTEEAEL
Variant Seq.  IPLTgEAEL
Mutations E/G
Epitope Location E5G
HXB2 Location E452G
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note The variant peptide was less potent at inducing production of IFN-gamma than the index peptide.


Variant ID.  1360
Epitope Seq.  IPLTEEAEL
Variant Seq.  IPLTqEAEL
Mutations E/Q
Epitope Location E5Q
HXB2 Location E452Q
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note The variant peptide was less potent at inducing production of IFN-gamma than the index peptide.


Variant ID.  1361
Epitope Seq.  IPLTEEAEL
Variant Seq.  IPLTvEAEL
Mutations E/V
Epitope Location E5V
HXB2 Location E452V
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note The variant peptide was less potent at inducing production of IFN-gamma than the index peptide.


Variant ID.  1362
Epitope Seq.  IPLTEEAEL
Variant Seq.  IPLTaEAEL
Mutations E/A
Epitope Location E5A
HXB2 Location E452A
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note The variant peptide was less potent at inducing production of IFN-gamma than the index peptide.

References

Oxenius2004 Annette Oxenius, David A. Price, Alexandra Trkola, Charles Edwards, Emma Gostick, Hua-Tang Zhang, Philippa J. Easterbrook, Tin Tun, Andrew Johnson, Anele Waters, Edward C. Holmes, and Rodney E. Phillips. Loss of Viral Control in Early HIV-1 Infection Is Temporally Associated with Sequential Escape from CD8+ T Cell Responses and Decrease in HIV-1-Specific CD4+ and CD8+ T Cell Frequencies. J. Infect. Dis., 190(4):713-721, 15 Aug 2004. PubMed ID: 15272399. Show all entries for this paper.


Displaying record number 53424

HXB2 Location  Pol(453-467)   Pol Epitope Map
View variants at this location
Epitope EAELELAENREILKE   Epitope Alignment
Variants
aAELELAENREILKE   observed variant
EAgfELAENREILKE   observed variant
EAgLELAENREILKE   observed variant
EAELELAENREILeE   observed variant
EAELELAgNREILKE   observed variant
Epitope Name EAE
Species (MHC/HLA human

Variant Details

Showing all: 5 variant(s).


Variant ID.  1363
Epitope Seq.  EAELELAENREILKE
Variant Seq.  aAELELAENREILKE
Mutations E/A
Epitope Location E1A
HXB2 Location E453A
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note Only 2/11 viral clones contained this variant sequence at the first time point (Day 60) tested after infection. 1/9 clones contained the variant sequence at the second time point (Day 297).


Variant ID.  1364
Epitope Seq.  EAELELAENREILKE
Variant Seq.  EAgfELAENREILKE
Mutations E/G L/F
Epitope Location E3G L4F
HXB2 Location E455G L456F
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note Only 1/11 viral clones contained this variant sequence at the first time point tested after infection.


Variant ID.  1365
Epitope Seq.  EAELELAENREILKE
Variant Seq.  EAgLELAENREILKE
Mutations E/G
Epitope Location E3G
HXB2 Location E455G
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note Only 1/18 viral clones contained this variant sequence at the first time point tested after infection.


Variant ID.  1366
Epitope Seq.  EAELELAENREILKE
Variant Seq.  EAELELAENREILeE
Mutations K/E
Epitope Location K14E
HXB2 Location K466E
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note Only 1/15 viral clones contained this variant sequence at the third time point (Day 369) tested after infection.


Variant ID.  1367
Epitope Seq.  EAELELAENREILKE
Variant Seq.  EAELELAgNREILKE
Mutations E/G
Epitope Location E8G
HXB2 Location E460G
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note Only 1/14 viral clones contained this variant sequence at the last time point (Day 635) tested after infection.

References

Oxenius2004 Annette Oxenius, David A. Price, Alexandra Trkola, Charles Edwards, Emma Gostick, Hua-Tang Zhang, Philippa J. Easterbrook, Tin Tun, Andrew Johnson, Anele Waters, Edward C. Holmes, and Rodney E. Phillips. Loss of Viral Control in Early HIV-1 Infection Is Temporally Associated with Sequential Escape from CD8+ T Cell Responses and Decrease in HIV-1-Specific CD4+ and CD8+ T Cell Frequencies. J. Infect. Dis., 190(4):713-721, 15 Aug 2004. PubMed ID: 15272399. Show all entries for this paper.


Displaying record number 53418

HXB2 Location  Tat(39-49)   Tat Epitope Map
View variants at this location
Epitope ITKGLGISYGR   Epitope Alignment
Variants
tTKGLGISYGR   observed variant
ITKGsGISYGR   observed variant
Epitope Name ITK
Species (MHC/HLA human(A*68:01)

Variant Details

Showing all: 2 variant(s).


Variant ID.  1368
Epitope Seq.  ITKGLGISYGR
Variant Seq.  tTKGLGISYGR
Mutations I/T
Epitope Location I1T
HXB2 Location I39T
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note 4/13 viral clones contained this variant sequence at the first time point (Day 60) tested after infection. While no variant sequence was detected at the second sampling, 2/13 clones contained it at the third time point (Day 369) and the sequence was lost thereafter.


Variant ID.  1369
Epitope Seq.  ITKGLGISYGR
Variant Seq.  ITKGsGISYGR
Mutations L/S
Epitope Location L5S
HXB2 Location L43S
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note Only 1/17 viral clones contained this variant sequence at the last time point (Day 635) tested after infection.

References

Oxenius2004 Annette Oxenius, David A. Price, Alexandra Trkola, Charles Edwards, Emma Gostick, Hua-Tang Zhang, Philippa J. Easterbrook, Tin Tun, Andrew Johnson, Anele Waters, Edward C. Holmes, and Rodney E. Phillips. Loss of Viral Control in Early HIV-1 Infection Is Temporally Associated with Sequential Escape from CD8+ T Cell Responses and Decrease in HIV-1-Specific CD4+ and CD8+ T Cell Frequencies. J. Infect. Dis., 190(4):713-721, 15 Aug 2004. PubMed ID: 15272399. Show all entries for this paper.


Displaying record number 53422

HXB2 Location  gp160(30-49)   gp160 Epitope Map
View variants at this location
Epitope ATEKLWVTVYYGVPVWKEAT   Epitope Alignment
Variants
ATEKmWVTVYYGVPVWKEAT   observed variant
ATEKLWVTVYYGaPVWKEAT   observed variant
ATEKLcVTVYYGVPVWKEAT   observed variant
ATEKLWVTVhYGVPVWKEAT   observed variant
ATEKLWVTVYYGVPaWKEAT   observed variant
ATEKLWVTVYhGVPVWKEAT   observed variant
Epitope Name ATE
Species (MHC/HLA human

Variant Details

Showing all: 6 variant(s).


Variant ID.  1370
Epitope Seq.  ATEKLWVTVYYGVPVWKEAT
Variant Seq.  ATEKmWVTVYYGVPVWKEAT
Mutations L/M
Epitope Location L5M
HXB2 Location L34M
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note Only 1/20 viral clones contained this variant sequence at the first time point (Day60) tested after infection.


Variant ID.  1371
Epitope Seq.  ATEKLWVTVYYGVPVWKEAT
Variant Seq.  ATEKLWVTVYYGaPVWKEAT
Mutations V/A
Epitope Location V13A
HXB2 Location V42A
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note Only 1/20 viral clones contained this variant sequence at the first time point (Day60) tested after infection.


Variant ID.  1372
Epitope Seq.  ATEKLWVTVYYGVPVWKEAT
Variant Seq.  ATEKLcVTVYYGVPVWKEAT
Mutations W/C
Epitope Location W6C
HXB2 Location W35C
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note Only 1/19 viral clones contained this variant sequence at the second time point (Day 369) tested after infection.


Variant ID.  1373
Epitope Seq.  ATEKLWVTVYYGVPVWKEAT
Variant Seq.  ATEKLWVTVhYGVPVWKEAT
Mutations Y/H
Epitope Location Y10H
HXB2 Location Y39H
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note Only 1/19 viral clones contained this variant sequence at the second time point (Day 369) tested after infection.


Variant ID.  1374
Epitope Seq.  ATEKLWVTVYYGVPVWKEAT
Variant Seq.  ATEKLWVTVYYGVPaWKEAT
Mutations V/A
Epitope Location V15A
HXB2 Location V44A
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note Only 1/19 viral clones contained this variant sequence at the second time point (Day 369) tested after infection.


Variant ID.  1375
Epitope Seq.  ATEKLWVTVYYGVPVWKEAT
Variant Seq.  ATEKLWVTVYhGVPVWKEAT
Mutations Y/H
Epitope Location Y11H
HXB2 Location Y40H
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note Only 1/12 viral clones contained this variant sequence at the last time point (Day 635) tested after infection.

References

Oxenius2004 Annette Oxenius, David A. Price, Alexandra Trkola, Charles Edwards, Emma Gostick, Hua-Tang Zhang, Philippa J. Easterbrook, Tin Tun, Andrew Johnson, Anele Waters, Edward C. Holmes, and Rodney E. Phillips. Loss of Viral Control in Early HIV-1 Infection Is Temporally Associated with Sequential Escape from CD8+ T Cell Responses and Decrease in HIV-1-Specific CD4+ and CD8+ T Cell Frequencies. J. Infect. Dis., 190(4):713-721, 15 Aug 2004. PubMed ID: 15272399. Show all entries for this paper.


Displaying record number 53423

HXB2 Location  gp160(42-61)   gp160 Epitope Map
View variants at this location
Epitope VPVWKEATTTLFCASDAKAY   Epitope Alignment
Variants
VPVWKEATTTLsrASDAKAY   observed variant
aPVWKEATTTLFCASDAKAY   observed variant
VPVWKEATTTLFrASDAKAY   observed variant
VPVWKEATTTLFCvSDAKAY   observed variant
VPVWKEATTTLFCAtDAKAY   observed variant
VPVWKEATTTLFyASDAKAY   observed variant
VPVWKEATTTpFCASDAKAY   observed variant
VPaWKEATTTLFCASDAKsY   observed variant
Epitope Name VPV
Species (MHC/HLA human

Variant Details

Showing all: 8 variant(s).


Variant ID.  1376
Epitope Seq.  VPVWKEATTTLFCASDAKAY
Variant Seq.  VPVWKEATTTLsrASDAKAY
Mutations F/S C/R
Epitope Location F12S C13R
HXB2 Location F53S C54R
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note Only 3/20 viral clones contained this variant sequence at the first time point (Day 60) tested after infection.


Variant ID.  1377
Epitope Seq.  VPVWKEATTTLFCASDAKAY
Variant Seq.  aPVWKEATTTLFCASDAKAY
Mutations V/A
Epitope Location V1A
HXB2 Location V42A
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note Only 1/20 viral clones contained this variant sequence at the first time point (Day60) tested after infection.


Variant ID.  1378
Epitope Seq.  VPVWKEATTTLFCASDAKAY
Variant Seq.  VPVWKEATTTLFrASDAKAY
Mutations C/R
Epitope Location C13R
HXB2 Location C54R
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note Only 1/20 viral clones contained this variant sequence at the first time point (Day60) tested after infection.


Variant ID.  1379
Epitope Seq.  VPVWKEATTTLFCASDAKAY
Variant Seq.  VPVWKEATTTLFCvSDAKAY
Mutations A/V
Epitope Location A14V
HXB2 Location A55V
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note Only 1/20 viral clones contained this variant sequence at the first time point (Day60) tested after infection.


Variant ID.  1380
Epitope Seq.  VPVWKEATTTLFCASDAKAY
Variant Seq.  VPVWKEATTTLFCAtDAKAY
Mutations S/T
Epitope Location S15T
HXB2 Location S56T
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note Only 1/19 viral clones contained this variant sequence at the second time point (Day 369) tested after infection.


Variant ID.  1381
Epitope Seq.  VPVWKEATTTLFCASDAKAY
Variant Seq.  VPVWKEATTTLFyASDAKAY
Mutations C/Y
Epitope Location C13Y
HXB2 Location C54Y
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note Only 1/19 viral clones contained this variant sequence at the second time point (Day 369) tested after infection.


Variant ID.  1382
Epitope Seq.  VPVWKEATTTLFCASDAKAY
Variant Seq.  VPVWKEATTTpFCASDAKAY
Mutations L/P
Epitope Location L11P
HXB2 Location L52P
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note Only 1/19 viral clones contained this variant sequence at the second time point (Day 369) tested after infection.


Variant ID.  1383
Epitope Seq.  VPVWKEATTTLFCASDAKAY
Variant Seq.  VPaWKEATTTLFCASDAKsY
Mutations A/S V/A
Epitope Location A19S V3A
HXB2 Location A60S V44A
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note Only 1/19 viral clones contained this variant sequence at the second time point (Day 369) tested after infection.

References

Oxenius2004 Annette Oxenius, David A. Price, Alexandra Trkola, Charles Edwards, Emma Gostick, Hua-Tang Zhang, Philippa J. Easterbrook, Tin Tun, Andrew Johnson, Anele Waters, Edward C. Holmes, and Rodney E. Phillips. Loss of Viral Control in Early HIV-1 Infection Is Temporally Associated with Sequential Escape from CD8+ T Cell Responses and Decrease in HIV-1-Specific CD4+ and CD8+ T Cell Frequencies. J. Infect. Dis., 190(4):713-721, 15 Aug 2004. PubMed ID: 15272399. Show all entries for this paper.


Displaying record number 53415

HXB2 Location  gp160(78-86)   gp160 Epitope Map
View variants at this location
Epitope DPNPQEVAL   Epitope Alignment
Variants
DPNPQEaAL   escape documented in this paper
DPNPQEtAL   escape documented in this paper
DlNPQEVAL   escape documented in this paper
DPNPQEVpL   escape documented in this paper
Epitope Name DPN
Species (MHC/HLA human(B35)

Variant Details

Showing all: 4 variant(s).


Variant ID.  1384
Epitope Seq.  DPNPQEVAL
Variant Seq.  DPNPQEaAL
Mutations V/A
Epitope Location V7A
HXB2 Location V84A
Mutation Type E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note Positive selection on this epitope resulted in an escape by phylogenetic analysis. The variant peptide was less potent at inducing production of IFN-gamma than the index peptide.


Variant ID.  1385
Epitope Seq.  DPNPQEVAL
Variant Seq.  DPNPQEtAL
Mutations V/T
Epitope Location V7T
HXB2 Location V84T
Mutation Type E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note Positive selection on this epitope resulted in an escape by phylogenetic analysis. The variant peptide was less potent at inducing production of IFN-gamma than the index peptide.


Variant ID.  1386
Epitope Seq.  DPNPQEVAL
Variant Seq.  DlNPQEVAL
Mutations P/L
Epitope Location P2L
HXB2 Location P79L
Mutation Type E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note Positive selection on this epitope resulted in an escape by phylogenetic analysis. The variant peptide was less potent at inducing production of IFN-gamma than the index peptide.


Variant ID.  1387
Epitope Seq.  DPNPQEVAL
Variant Seq.  DPNPQEVpL
Mutations A/P
Epitope Location A8P
HXB2 Location A85P
Mutation Type E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note Positive selection on this epitope resulted in an escape by phylogenetic analysis. The variant peptide was less potent at inducing production of IFN-gamma than the index peptide.

References

Oxenius2004 Annette Oxenius, David A. Price, Alexandra Trkola, Charles Edwards, Emma Gostick, Hua-Tang Zhang, Philippa J. Easterbrook, Tin Tun, Andrew Johnson, Anele Waters, Edward C. Holmes, and Rodney E. Phillips. Loss of Viral Control in Early HIV-1 Infection Is Temporally Associated with Sequential Escape from CD8+ T Cell Responses and Decrease in HIV-1-Specific CD4+ and CD8+ T Cell Frequencies. J. Infect. Dis., 190(4):713-721, 15 Aug 2004. PubMed ID: 15272399. Show all entries for this paper.


Displaying record number 53417

HXB2 Location  gp160(843-851)   gp160 Epitope Map
View variants at this location
Epitope IPRRIRQGL   Epitope Alignment
Variants
vPRRIRQGL   observed variant
IPgRIRQGL   observed variant
IPRRkRQGL   observed variant
IPRRIRQGf   observed variant
Epitope Name IPR
Species (MHC/HLA human(B7)

Variant Details

Showing all: 4 variant(s).


Variant ID.  1388
Epitope Seq.  IPRRIRQGL
Variant Seq.  vPRRIRQGL
Mutations I/V
Epitope Location I1V
HXB2 Location I843V
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note Only 1/11 viral clones contained this variant sequence at the last time point (Day 635) tested after infection.


Variant ID.  1389
Epitope Seq.  IPRRIRQGL
Variant Seq.  IPgRIRQGL
Mutations R/G
Epitope Location R3G
HXB2 Location R845G
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note Only 1/11 viral clones contained this variant sequence at the last time point (Day 635) tested after infection.


Variant ID.  1390
Epitope Seq.  IPRRIRQGL
Variant Seq.  IPRRkRQGL
Mutations I/K
Epitope Location I5K
HXB2 Location I847K
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note Only 1/10 viral clones contained this variant sequence at the second time point (Day 369) tested after infection.


Variant ID.  1391
Epitope Seq.  IPRRIRQGL
Variant Seq.  IPRRIRQGf
Mutations L/F
Epitope Location L9F
HXB2 Location L851F
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note Only 1/11 viral clones contained this variant sequence at the last time point (Day 635) tested after infection.

References

Oxenius2004 Annette Oxenius, David A. Price, Alexandra Trkola, Charles Edwards, Emma Gostick, Hua-Tang Zhang, Philippa J. Easterbrook, Tin Tun, Andrew Johnson, Anele Waters, Edward C. Holmes, and Rodney E. Phillips. Loss of Viral Control in Early HIV-1 Infection Is Temporally Associated with Sequential Escape from CD8+ T Cell Responses and Decrease in HIV-1-Specific CD4+ and CD8+ T Cell Frequencies. J. Infect. Dis., 190(4):713-721, 15 Aug 2004. PubMed ID: 15272399. Show all entries for this paper.


Displaying record number 53416

HXB2 Location  Nef(74-81)   Nef Epitope Map
View variants at this location
Epitope VPLRPMTY   Epitope Alignment
Variants
VPLRPMsY   escape documented in this paper
VPLRPMTf   escape documented in this paper
Epitope Name VPL
Species (MHC/HLA human(B35)

Variant Details

Showing all: 2 variant(s).


Variant ID.  1392
Epitope Seq.  VPLRPMTY
Variant Seq.  VPLRPMsY
Mutations T/S
Epitope Location T7S
HXB2 Location T80S
Mutation Type E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note This variant was an escape. Response greatly diminished.


Variant ID.  1393
Epitope Seq.  VPLRPMTY
Variant Seq.  VPLRPMTf
Mutations Y/F
Epitope Location Y8F
HXB2 Location Y81F
Mutation Type E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note This variant was an escape. Response diminished.

References

Oxenius2004 Annette Oxenius, David A. Price, Alexandra Trkola, Charles Edwards, Emma Gostick, Hua-Tang Zhang, Philippa J. Easterbrook, Tin Tun, Andrew Johnson, Anele Waters, Edward C. Holmes, and Rodney E. Phillips. Loss of Viral Control in Early HIV-1 Infection Is Temporally Associated with Sequential Escape from CD8+ T Cell Responses and Decrease in HIV-1-Specific CD4+ and CD8+ T Cell Frequencies. J. Infect. Dis., 190(4):713-721, 15 Aug 2004. PubMed ID: 15272399. Show all entries for this paper.


Displaying record number 53412

HXB2 Location  Nef(77-85)   Nef Epitope Map
View variants at this location
Epitope RPMTYKGAL   Epitope Alignment
Variants
RPMTYrGAL   observed variant
RPMTYKaAL   observed variant
RPMTYKGAv   observed variant
RPMsYKaAL   observed variant
RPMTfKGAL   observed variant
Epitope Name RPM
Species (MHC/HLA human(B7)

Variant Details

Showing all: 5 variant(s).


Variant ID.  1394
Epitope Seq.  RPMTYKGAL
Variant Seq.  RPMTYrGAL
Mutations K/R
Epitope Location K6R
HXB2 Location K82R
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note This variant was seen earlier and was proposed to be an escape.


Variant ID.  1395
Epitope Seq.  RPMTYKGAL
Variant Seq.  RPMTYKaAL
Mutations G/A
Epitope Location G7A
HXB2 Location G83A
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note This variant was seen earlier and was proposed to be an escape.


Variant ID.  1396
Epitope Seq.  RPMTYKGAL
Variant Seq.  RPMTYKGAv
Mutations L/V
Epitope Location L9V
HXB2 Location L85V
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note This variant was seen earlier and was proposed to be an escape.


Variant ID.  1397
Epitope Seq.  RPMTYKGAL
Variant Seq.  RPMsYKaAL
Mutations T/S G/A
Epitope Location T4S G7A
HXB2 Location T80S G83A
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note This was one of two most common forms of variants.


Variant ID.  1398
Epitope Seq.  RPMTYKGAL
Variant Seq.  RPMTfKGAL
Mutations Y/F
Epitope Location Y5F
HXB2 Location Y81F
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note This was one of two most common forms of variants.

References

Oxenius2004 Annette Oxenius, David A. Price, Alexandra Trkola, Charles Edwards, Emma Gostick, Hua-Tang Zhang, Philippa J. Easterbrook, Tin Tun, Andrew Johnson, Anele Waters, Edward C. Holmes, and Rodney E. Phillips. Loss of Viral Control in Early HIV-1 Infection Is Temporally Associated with Sequential Escape from CD8+ T Cell Responses and Decrease in HIV-1-Specific CD4+ and CD8+ T Cell Frequencies. J. Infect. Dis., 190(4):713-721, 15 Aug 2004. PubMed ID: 15272399. Show all entries for this paper.


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