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Found 4 matching records:

Displaying record number 46

HXB2 Location  Gag(24-32)   Gag Epitope Map
View variants at this location
Epitope GGKKKYKLK   Epitope Alignment
Variants
GGrKKYKLK   escape documented in this paper; susceptible form
Species (MHC/HLA human(B8)

Variant Details

Showing all: 1 variant(s).


Variant ID.  1344
Epitope Seq.  GGKKKYKLK
Variant Seq.  GGrKKYKLK
Mutations K/R
Epitope Location K3R
HXB2 Location K26R
Mutation Type E: escape documented in this paper
SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Chromium-release assay, HLA binding, Longitudinal study
Note Both K and R variants bind HLA-B8. The predominant variant shifts from K to R, back to K. R variant is never recognized; but the K variant is initially recognized, loses recognition and begins to gain recognition by CTL again.

References

Nowak1995 M. A. Nowak, R. M. May, R. E. Phillips, S. Rowland-Jones, D. G. Lalloo, S. McAdam, P. Klenerman, B. Koppe, K. Sigmund, C. R. M. Bangham, and A. J. McMichael. Antigenic Oscillations and Shifting Immunodominance in HIV-1 Infections. Nature, 375:606-611, 1995. This paper presents longitudinal studies of epitope variation and corresponding CTL responses in two patients. A mathematical model was created to provide a framework to explain the observed shifts in epitope and CTLp frequencies. For discussion, see also: J. M. Coffin, Nature 375:534-535 (1995). PubMed ID: 7791879. Show all entries for this paper.


Displaying record number 252

HXB2 Location  Gag(259-267)   Gag Epitope Map
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Epitope GEIYKRWII   Epitope Alignment
Variants
GdIYKRWII   escape documented in this paper
Species (MHC/HLA human(B8)

Variant Details

Showing all: 1 variant(s).


Variant ID.  1345
Epitope Seq.  GEIYKRWII
Variant Seq.  GdIYKRWII
Mutations E/D
Epitope Location E2D
HXB2 Location E260D
Mutation Type E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, Chromium-release assay, HLA binding, Longitudinal study
Note Both E index epitope and D variant bind HLA-B8 similarly. The E index loses recognition by CTL coincident with its emergence as the only detectable form, though later it is recognized again. This appears to be an example of escape from CTL response when the circulating CTL clones fail to recognize the form they are specific for. The latter return of recognition of the E form is thought to be a cross-reactive response.

References

Nowak1995 M. A. Nowak, R. M. May, R. E. Phillips, S. Rowland-Jones, D. G. Lalloo, S. McAdam, P. Klenerman, B. Koppe, K. Sigmund, C. R. M. Bangham, and A. J. McMichael. Antigenic Oscillations and Shifting Immunodominance in HIV-1 Infections. Nature, 375:606-611, 1995. This paper presents longitudinal studies of epitope variation and corresponding CTL responses in two patients. A mathematical model was created to provide a framework to explain the observed shifts in epitope and CTLp frequencies. For discussion, see also: J. M. Coffin, Nature 375:534-535 (1995). PubMed ID: 7791879. Show all entries for this paper.


Displaying record number 281

HXB2 Location  Gag(263-272)   Gag Epitope Map
View variants at this location
Epitope KRWIIMGNK   Epitope Alignment
Variants
KRWIIlGNK   susceptible form
Species (MHC/HLA human(B27)

Variant Details

Showing all: 1 variant(s).


Variant ID.  1346
Epitope Seq.  KRWIIMGNK
Variant Seq.  KRWIIlGNK
Mutations M/L
Epitope Location M6L
HXB2 Location M268L
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Chromium-release assay, HLA binding, Longitudinal study
Note The M variant is the predominant form, but both M and L forms are recognized by patient CTL.

References

Nowak1995 M. A. Nowak, R. M. May, R. E. Phillips, S. Rowland-Jones, D. G. Lalloo, S. McAdam, P. Klenerman, B. Koppe, K. Sigmund, C. R. M. Bangham, and A. J. McMichael. Antigenic Oscillations and Shifting Immunodominance in HIV-1 Infections. Nature, 375:606-611, 1995. This paper presents longitudinal studies of epitope variation and corresponding CTL responses in two patients. A mathematical model was created to provide a framework to explain the observed shifts in epitope and CTLp frequencies. For discussion, see also: J. M. Coffin, Nature 375:534-535 (1995). PubMed ID: 7791879. Show all entries for this paper.


Displaying record number 354

HXB2 Location  Gag(329-337)   Gag Epitope Map
View variants at this location
Epitope DCKTILKAL   Epitope Alignment
Variants
DCrTILKAL   escape documented in this paper
Species (MHC/HLA human(B8)

Variant Details

Showing all: 1 variant(s).


Variant ID.  1347
Epitope Seq.  DCKTILKAL
Variant Seq.  DCrTILKAL
Mutations K/R
Epitope Location K3R
HXB2 Location K331R
Mutation Type E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, Chromium-release assay, HLA binding, Longitudinal study
Note Both K and R variants bind HLA-B8. Initial recognition of the K variant is soon lost. The predominant R variant is never recognized by patient CTL.

References

Nowak1995 M. A. Nowak, R. M. May, R. E. Phillips, S. Rowland-Jones, D. G. Lalloo, S. McAdam, P. Klenerman, B. Koppe, K. Sigmund, C. R. M. Bangham, and A. J. McMichael. Antigenic Oscillations and Shifting Immunodominance in HIV-1 Infections. Nature, 375:606-611, 1995. This paper presents longitudinal studies of epitope variation and corresponding CTL responses in two patients. A mathematical model was created to provide a framework to explain the observed shifts in epitope and CTLp frequencies. For discussion, see also: J. M. Coffin, Nature 375:534-535 (1995). PubMed ID: 7791879. Show all entries for this paper.


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