HIV molecular immunology database
Found 2 matching records:
| HXB2 Location | Gag(1-20) | Gag Epitope Map
View variants at this location |
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| Epitope |
MGARASVLSGGKLDAWEKIR
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Epitope Alignment | ||||||||||
| Variants |
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| Species (MHC/HLA) | human | |||||||||||
Showing all: 3 variant(s).
| Variant ID. | 3501 |
|---|---|
| Epitope Seq. | MGARASVLSGGKLDAWEKIR |
| Variant Seq. | MGARASVLSGGKLDeWEKIR |
| Mutations | A/E |
| Epitope Location | A15E |
| HXB2 Location | A15E |
| Mutation Type | SSF: subtype-specific susceptible form |
| Epitope Subtype | A1, D, M group |
| Variant Subtype | D |
| Method | CD8 T-cell Elispot - IFNy |
| Note | ConD-specific variant MGARASVLSGGKLDeWEKIR was reactive in 19/20 subjects tested, 232 sfu/106 pbmc. |
| Variant ID. | 4076 |
|---|---|
| Epitope Seq. | MGARASVLSGGKLDAWEKIR |
| Variant Seq. | MGARASVLSGGKLDAWEsIR |
| Mutations | K/S |
| Epitope Location | K18S |
| HXB2 Location | K18S |
| Mutation Type | SSF: subtype-specific susceptible form |
| Epitope Subtype | A1, D, M group |
| Variant Subtype | D |
| Method | CD8 T-cell Elispot - IFNy |
| Note | HIV clone UG042 ConD-specific variant MGARASVLSGGKLDAWEsIR was reactive in 19/20 subjects tested, 102 sfu/106 pbmc. The ConA, ConsM peptide, MGARASVLSGGKLDAWEKIR did not elicit any response in the subjects tested. |
| Variant ID. | 4077 |
|---|---|
| Epitope Seq. | MGARASVLSGGKLDAWEKIR |
| Variant Seq. | MGARASVLSGGKLDA----- |
| Mutations | W/- E/- K/- I/- R/- |
| Epitope Location | W16- E17- K18- I19- R20- |
| HXB2 Location | W16- E17- K18- I19- R20- |
| Mutation Type | NSF: non-susceptible form |
| Epitope Subtype | A1, D, M group |
| Variant Subtype | M group |
| Method | CD8 T-cell Elispot - IFNy |
| Note | ConM-specific truncated peptide MGARASVLSGGKLDA----- was non-reactive in 100% subjects (15/15) tested. The ConA, ConM peptide, MGARASVLSGGKLDAWEKIR did not elicit any response in the subjects tested either. |
Mugaba2014 S. Mugaba, R. Nakiboneka, M. Nanyonjo, D. Bugembe-Lule, I. Kaddu, B. Nanteza, R. Tweyongyere, P. Kaleebu, and J. Serwanga. Group M Consensus Gag and Nef Peptides Are as Efficient at Detecting Clade A1 and D Cross-Subtype T-Cell Functions as Subtype-Specific Consensus Peptides. Vaccine, 32(30):3787-3795, 24 Jun 2014. PubMed ID: 24837770. Show all entries for this paper.
| HXB2 Location | Gag(11-31) | Gag Epitope Map
View variants at this location |
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| Epitope |
GKLDAWEKIRLRPGGKKKYRL
|
Epitope Alignment | |||||||||||||||||||
| Variants |
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| Species (MHC/HLA) | human | ||||||||||||||||||||
Showing all: 6 variant(s).
| Variant ID. | 4078 |
|---|---|
| Epitope Seq. | GKLDAWEKIRLRPGGKKKYRL |
| Variant Seq. | -----WEKIRLRPGG------ |
| Mutations | G/- K/- K/- K/- Y/- K/- R/- L/- L/- D/- A/- |
| Epitope Location | G1- K16- K17- K18- Y19- K2- R20- L21- L3- D4- A5- |
| HXB2 Location | G11- K26- K27- K28- Y29- K12- R30- L31- L13- D14- A15- |
| Mutation Type | NSF: non-susceptible form SF: susceptible form |
| Epitope Subtype | A1, D, M group |
| Variant Subtype | A |
| Method | CD8 T-cell Elispot - IFNy |
| Note | HIV clone UG003 ConA- or ConD-specific truncated OLP variant -----WEKIRLRPGG------ was reactive in 9/10 subjects tested each, 1540 or 2225 sfu/106 pbmc. |
| Variant ID. | 4079 |
|---|---|
| Epitope Seq. | GKLDAWEKIRLRPGGKKKYRL |
| Variant Seq. | GKLDAWEKIyLRPGGKKKYRL |
| Mutations | R/Y |
| Epitope Location | R10Y |
| HXB2 Location | R20Y |
| Mutation Type | NSF: non-susceptible form SF: susceptible form |
| Epitope Subtype | A1, D, M group |
| Variant Subtype | A |
| Method | CD8 T-cell Elispot - IFNy |
| Note | HIV clone UG012 ConA-specific OLP variant GKLDAWEKIyLRPGGKKKYRL was reactive in 19/20 subjects tested, 132 sfu/106 pbmc. |
| Variant ID. | 4080 |
|---|---|
| Epitope Seq. | GKLDAWEKIRLRPGGKKKYRL |
| Variant Seq. | GKLDkWEKIRLRPGGKKKYRL |
| Mutations | A/K |
| Epitope Location | A5K |
| HXB2 Location | A15K |
| Mutation Type | NSF: non-susceptible form SF: susceptible form |
| Epitope Subtype | A1, D, M group |
| Variant Subtype | A |
| Method | CD8 T-cell Elispot - IFNy |
| Note | HIV clone UG060 ConA-specific OLP variant GKLDkWEKIRLRPGGKKKYRL was reactive in 19/20 subjects tested, 388 sfu/106 pbmc. |
| Variant ID. | 4081 |
|---|---|
| Epitope Seq. | GKLDAWEKIRLRPGGKKKYRL |
| Variant Seq. | ---DrWEKIRLRPGGKKKYRL |
| Mutations | G/- K/- L/- A/R |
| Epitope Location | G1- K2- L3- A5R |
| HXB2 Location | G11- K12- L13- A15R |
| Mutation Type | NSF: non-susceptible form SF: susceptible form |
| Epitope Subtype | A1, D, M group |
| Variant Subtype | A |
| Method | CD8 T-cell Elispot - IFNy |
| Note | HIV clone UG026 ConA-specific truncated OLP variant ---DrWEKIRLRPGGKKKYRL was reactive in 16/17 subjects tested, 190 sfu/106 pbmc. |
| Variant ID. | 4082 |
|---|---|
| Epitope Seq. | GKLDAWEKIRLRPGGKKKYRL |
| Variant Seq. | GKLDeWEKIRLRPGGKKKYRL |
| Mutations | A/E |
| Epitope Location | A5E |
| HXB2 Location | A15E |
| Mutation Type | NSF: non-susceptible form SF: susceptible form SSF: subtype-specific susceptible form |
| Epitope Subtype | A1, D, M group |
| Variant Subtype | D |
| Method | CD8 T-cell Elispot - IFNy |
| Note | HIV ConD-specific OLP GKLDeWEKIRLRPGGKKKYRL was reactive in 19/20 subjects tested, 2377 sfu/106 pbmc. |
| Variant ID. | 4083 |
|---|---|
| Epitope Seq. | GKLDAWEKIRLRPGGKKKYRL |
| Variant Seq. | GKLDeWEKIRLRPGGKKKYRL |
| Mutations | A/E |
| Epitope Location | A5E |
| HXB2 Location | A15E |
| Mutation Type | NSF: non-susceptible form SF: susceptible form SSF: subtype-specific susceptible form |
| Epitope Subtype | A1, D, M group |
| Variant Subtype | D |
| Method | CD8 T-cell Elispot - IFNy |
| Note | HIV ConD-specific OLP GKLDeWEKIRLRPGGKKKYRL was reactive in 19/20 subjects tested, 2377 sfu/106 pbmc. |
Mugaba2014 S. Mugaba, R. Nakiboneka, M. Nanyonjo, D. Bugembe-Lule, I. Kaddu, B. Nanteza, R. Tweyongyere, P. Kaleebu, and J. Serwanga. Group M Consensus Gag and Nef Peptides Are as Efficient at Detecting Clade A1 and D Cross-Subtype T-Cell Functions as Subtype-Specific Consensus Peptides. Vaccine, 32(30):3787-3795, 24 Jun 2014. PubMed ID: 24837770. Show all entries for this paper.