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Found 2 matching records:

Displaying record number 57649

HXB2 Location  Gag(147-155)   Gag Epitope Map
View variants at this location
Epitope ISPRTLNAW   Epitope Alignment
Variants
lSPRTLNAW   escape documented in this paper
Epitope Name ISW9
Species (MHC/HLA human(B*57)

Variant Details

Showing all: 1 variant(s).


Variant ID.  2567
Epitope Seq.  ISPRTLNAW
Variant Seq.  lSPRTLNAW
Mutations I/L
Epitope Location I1L
HXB2 Location I147L
Mutation Type E: escape documented in this paper
Method Relative replication capacity assay
Note Of 2 HLA-B57-positive early controllers both had, at the earliest time point tested, signature B57 mutations in Gag that impaired viral replication capacity: T242N in TSTLQEQIGW (TSnLQEQIGW) and I147L in ISPRTLNAW (lSPRTLNAW).

References

Miura2010 Toshiyuki Miura, Zabrina L. Brumme, Mark A. Brockman, Pamela Rosato, Jennifer Sela, Chanson J. Brumme, Florencia Pereyra, Daniel E. Kaufmann, Alicja Trocha, Brian L. Block, Eric S. Daar, Elizabeth Connick, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, Martin Markowitz, Kim Schafer, Florin Vaida, Aikichi Iwamoto, Susan Little, and Bruce D. Walker. Impaired Replication Capacity of Acute/Early Viruses in Persons Who Become HIV Controllers. J. Virol., 84(15):7581-7591, Aug 2010. PubMed ID: 20504921. Show all entries for this paper.


Displaying record number 57648

HXB2 Location  Gag(240-249)   Gag Epitope Map
View variants at this location
Epitope TSTLQEQIGW   Epitope Alignment
Variants
TSnLQEQIGW   escape documented in this paper
Epitope Name TW10
Species (MHC/HLA human(B*57)

Variant Details

Showing all: 1 variant(s).


Variant ID.  2566
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSnLQEQIGW
Mutations T/N
Epitope Location T3N
HXB2 Location T242N
Mutation Type E: escape documented in this paper
Method Relative replication capacity assay
Note Of 2 HLA-B57-positive early controllers both had, at the earliest time point tested, signature B57 mutations in Gag that impaired viral replication capacity: T242N in TSTLQEQIGW (TSnLQEQIGW) and I147L in ISPRTLNAW (lSPRTLNAW).

References

Miura2010 Toshiyuki Miura, Zabrina L. Brumme, Mark A. Brockman, Pamela Rosato, Jennifer Sela, Chanson J. Brumme, Florencia Pereyra, Daniel E. Kaufmann, Alicja Trocha, Brian L. Block, Eric S. Daar, Elizabeth Connick, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, Martin Markowitz, Kim Schafer, Florin Vaida, Aikichi Iwamoto, Susan Little, and Bruce D. Walker. Impaired Replication Capacity of Acute/Early Viruses in Persons Who Become HIV Controllers. J. Virol., 84(15):7581-7591, Aug 2010. PubMed ID: 20504921. Show all entries for this paper.


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