HIV molecular immunology database
Found 2 matching records:
| HXB2 Location | Gag(147-155) | Gag Epitope Map
View variants at this location |
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|---|---|---|---|---|---|---|
| Epitope |
ISPRTLNAW
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Epitope Alignment | ||||
| Variants |
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| Epitope Name | ISW9 | |||||
| Species (MHC/HLA) | human(B*57) | |||||
Showing all: 1 variant(s).
| Variant ID. | 2567 |
|---|---|
| Epitope Seq. | ISPRTLNAW |
| Variant Seq. | lSPRTLNAW |
| Mutations | I/L |
| Epitope Location | I1L |
| HXB2 Location | I147L |
| Mutation Type | E: escape documented in this paper |
| Method | Relative replication capacity assay |
| Note | Of 2 HLA-B57-positive early controllers both had, at the earliest time point tested, signature B57 mutations in Gag that impaired viral replication capacity: T242N in TSTLQEQIGW (TSnLQEQIGW) and I147L in ISPRTLNAW (lSPRTLNAW). |
Miura2010 Toshiyuki Miura, Zabrina L. Brumme, Mark A. Brockman, Pamela Rosato, Jennifer Sela, Chanson J. Brumme, Florencia Pereyra, Daniel E. Kaufmann, Alicja Trocha, Brian L. Block, Eric S. Daar, Elizabeth Connick, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, Martin Markowitz, Kim Schafer, Florin Vaida, Aikichi Iwamoto, Susan Little, and Bruce D. Walker. Impaired Replication Capacity of Acute/Early Viruses in Persons Who Become HIV Controllers. J. Virol., 84(15):7581-7591, Aug 2010. PubMed ID: 20504921. Show all entries for this paper.
| HXB2 Location | Gag(240-249) | Gag Epitope Map
View variants at this location |
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|---|---|---|---|---|---|---|
| Epitope |
TSTLQEQIGW
|
Epitope Alignment | ||||
| Variants |
|
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| Epitope Name | TW10 | |||||
| Species (MHC/HLA) | human(B*57) | |||||
Showing all: 1 variant(s).
| Variant ID. | 2566 |
|---|---|
| Epitope Seq. | TSTLQEQIGW |
| Variant Seq. | TSnLQEQIGW |
| Mutations | T/N |
| Epitope Location | T3N |
| HXB2 Location | T242N |
| Mutation Type | E: escape documented in this paper |
| Method | Relative replication capacity assay |
| Note | Of 2 HLA-B57-positive early controllers both had, at the earliest time point tested, signature B57 mutations in Gag that impaired viral replication capacity: T242N in TSTLQEQIGW (TSnLQEQIGW) and I147L in ISPRTLNAW (lSPRTLNAW). |
Miura2010 Toshiyuki Miura, Zabrina L. Brumme, Mark A. Brockman, Pamela Rosato, Jennifer Sela, Chanson J. Brumme, Florencia Pereyra, Daniel E. Kaufmann, Alicja Trocha, Brian L. Block, Eric S. Daar, Elizabeth Connick, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, Martin Markowitz, Kim Schafer, Florin Vaida, Aikichi Iwamoto, Susan Little, and Bruce D. Walker. Impaired Replication Capacity of Acute/Early Viruses in Persons Who Become HIV Controllers. J. Virol., 84(15):7581-7591, Aug 2010. PubMed ID: 20504921. Show all entries for this paper.