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Found 4 matching records:

Displaying record number 52758

HXB2 Location  Gag(147-155)   Gag Epitope Map
View variants at this location
Epitope ISPRTLNAW   Epitope Alignment
Variants
lSPRTLNAW   observed variant
ISaRTLNAW   observed variant
ISPRTLNAx   observed variant
ISPkTLNAW   observed variant
IaPRTLNAW   observed variant
mSPRTLNAW   observed variant
mSaRTLNAW   observed variant
kSaRTLNAW   observed variant
lSPRTfNAW   observed variant
Species (MHC/HLA human(B*57:01)

Variant Details

Showing all: 9 variant(s).


Variant ID.  1280
Epitope Seq.  ISPRTLNAW
Variant Seq.  lSPRTLNAW
Mutations I/L
Epitope Location I1L
HXB2 Location I147L
Mutation Type OV: observed variant
Method Sequence
Note This variant was seen in 6/10 nonprogressors, 11/12 untreated progressors and 3/5 treated progressors.


Variant ID.  1281
Epitope Seq.  ISPRTLNAW
Variant Seq.  ISaRTLNAW
Mutations P/A
Epitope Location P3A
HXB2 Location P149A
Mutation Type OV: observed variant
Method Sequence
Note This variant was seen in 1/5 treated progressors.


Variant ID.  1282
Epitope Seq.  ISPRTLNAW
Variant Seq.  ISPRTLNAx
Mutations W/X
Epitope Location W9X
HXB2 Location W155X
Mutation Type OV: observed variant
Method Sequence
Note This variant was seen in 1/10 nonprogressors.


Variant ID.  1283
Epitope Seq.  ISPRTLNAW
Variant Seq.  ISPkTLNAW
Mutations R/K
Epitope Location R4K
HXB2 Location R150K
Mutation Type OV: observed variant
Method Sequence
Note This variant was seen in 1/10 nonprogressors.


Variant ID.  1284
Epitope Seq.  ISPRTLNAW
Variant Seq.  IaPRTLNAW
Mutations S/A
Epitope Location S2A
HXB2 Location S148A
Mutation Type OV: observed variant
Method Sequence
Note This variant was seen in 1/12 untreated progressors.


Variant ID.  1285
Epitope Seq.  ISPRTLNAW
Variant Seq.  mSPRTLNAW
Mutations I/M
Epitope Location I1M
HXB2 Location I147M
Mutation Type OV: observed variant
Method Sequence
Note This variant was seen in 1/12 untreated progressors.


Variant ID.  1286
Epitope Seq.  ISPRTLNAW
Variant Seq.  mSaRTLNAW
Mutations I/M P/A
Epitope Location I1M P3A
HXB2 Location I147M P149A
Mutation Type OV: observed variant
Method Sequence
Note This variant was seen in 1/12 untreated progressors.


Variant ID.  1287
Epitope Seq.  ISPRTLNAW
Variant Seq.  kSaRTLNAW
Mutations I/K P/A
Epitope Location I1K P3A
HXB2 Location I147K P149A
Mutation Type OV: observed variant
Method Sequence
Note This variant was seen in 1/12 untreated progressors.


Variant ID.  1288
Epitope Seq.  ISPRTLNAW
Variant Seq.  lSPRTfNAW
Mutations I/L L/F
Epitope Location I1L L6F
HXB2 Location I147L L152F
Mutation Type OV: observed variant
Method Sequence
Note This variant was seen in 1/12 untreated progressors.

References

Migueles2003 Stephen A. Migueles, Alisha C. Laborico, Hiromi Imamichi, W. Lesley Shupert, Cassandra Royce, Mary McLaughlin, Linda Ehler, Julia Metcalf, Shuying Liu, Claire W. Hallahan, and Mark Connors. The Differential Ability of HLA B*5701+ Long-Term Nonprogressors and Progressors to Restrict Human Immunodeficiency Virus Replication Is Not Caused by Loss of Recognition of Autologous Viral gag Sequences. J. Virol., 77(12):6889-6898, Jun 2003. PubMed ID: 12768008. Show all entries for this paper.


Displaying record number 52760

HXB2 Location  Gag(162-172)   Gag Epitope Map
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Epitope KAFSPEVIPMF   Epitope Alignment
Variants
KsFSPEVIPMF   observed variant
KgFnPEVIPMF   observed variant
Epitope Name KAF11
Species (MHC/HLA human(B*57:01)

Variant Details

Showing all: 2 variant(s).


Variant ID.  1289
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KsFSPEVIPMF
Mutations A/S
Epitope Location A2S
HXB2 Location A163S
Mutation Type OV: observed variant
Method Sequence
Note This variant was seen only in one non-progressor and one treated progressor. Index epitope KAF11 is immunodominant in several subjects and highly conserved.


Variant ID.  1290
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KgFnPEVIPMF
Mutations A/G S/N
Epitope Location A2G S4N
HXB2 Location A163G S165N
Mutation Type OV: observed variant
Method Sequence
Note This variant was seen only in one untreated progressor.

References

Migueles2003 Stephen A. Migueles, Alisha C. Laborico, Hiromi Imamichi, W. Lesley Shupert, Cassandra Royce, Mary McLaughlin, Linda Ehler, Julia Metcalf, Shuying Liu, Claire W. Hallahan, and Mark Connors. The Differential Ability of HLA B*5701+ Long-Term Nonprogressors and Progressors to Restrict Human Immunodeficiency Virus Replication Is Not Caused by Loss of Recognition of Autologous Viral gag Sequences. J. Virol., 77(12):6889-6898, Jun 2003. PubMed ID: 12768008. Show all entries for this paper.


Displaying record number 52759

HXB2 Location  Gag(240-249)   Gag Epitope Map
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Epitope TSTLQEQIGN   Epitope Alignment
Variants
TSnLQEQIGN   observed variant
TtnLQEQIaN   observed variant
TSnLQEQIaN   observed variant
TSnLQEQvaN   observed variant
TSnLQEQIqN   observed variant
Species (MHC/HLA human(B*57:01)

Variant Details

Showing all: 5 variant(s).


Variant ID.  1291
Epitope Seq.  TSTLQEQIGN
Variant Seq.  TSnLQEQIGN
Mutations T/N
Epitope Location T3N
HXB2 Location T242N
Mutation Type OV: observed variant
Method Sequence
Note This variant is seen in 4/10 nonprogressors, 4/12 untreated progressors and 3/5 treated progressors.


Variant ID.  1292
Epitope Seq.  TSTLQEQIGN
Variant Seq.  TtnLQEQIaN
Mutations S/T T/N G/A
Epitope Location S2T T3N G9A
HXB2 Location S241T T242N G248A
Mutation Type OV: observed variant
Method Sequence
Note This variant is seen in 1/12 untreated progressors.


Variant ID.  1293
Epitope Seq.  TSTLQEQIGN
Variant Seq.  TSnLQEQIaN
Mutations T/N G/A
Epitope Location T3N G9A
HXB2 Location T242N G248A
Mutation Type OV: observed variant
Method Sequence
Note This variant is seen in 2/10 nonprogressors, 5/12 untreated progressors and 2/5 treated progressors.


Variant ID.  1294
Epitope Seq.  TSTLQEQIGN
Variant Seq.  TSnLQEQvaN
Mutations T/N I/V G/A
Epitope Location T3N I8V G9A
HXB2 Location T242N I247V G248A
Mutation Type OV: observed variant
Method Sequence
Note This variant is seen in 1/12 untreated progressor.


Variant ID.  1295
Epitope Seq.  TSTLQEQIGN
Variant Seq.  TSnLQEQIqN
Mutations T/N G/Q
Epitope Location T3N G9Q
HXB2 Location T242N G248Q
Mutation Type OV: observed variant
Method Sequence
Note This variant is seen in 1/12 untreated progressor.

References

Migueles2003 Stephen A. Migueles, Alisha C. Laborico, Hiromi Imamichi, W. Lesley Shupert, Cassandra Royce, Mary McLaughlin, Linda Ehler, Julia Metcalf, Shuying Liu, Claire W. Hallahan, and Mark Connors. The Differential Ability of HLA B*5701+ Long-Term Nonprogressors and Progressors to Restrict Human Immunodeficiency Virus Replication Is Not Caused by Loss of Recognition of Autologous Viral gag Sequences. J. Virol., 77(12):6889-6898, Jun 2003. PubMed ID: 12768008. Show all entries for this paper.


Displaying record number 52761

HXB2 Location  Gag(308-316)   Gag Epitope Map
View variants at this location
Epitope QASQEVKNW   Epitope Alignment
Variants
QASQdVKNW   non-susceptible form; susceptible form
QAtQEVKNW   observed variant
QAtQdVKNW   observed variant
QASQdVKNx   observed variant
Epitope Name QW9
Species (MHC/HLA human(B*57:01)

Variant Details

Showing all: 4 variant(s).


Variant ID.  1296
Epitope Seq.  QASQEVKNW
Variant Seq.  QASQdVKNW
Mutations E/D
Epitope Location E5D
HXB2 Location E312D
Mutation Type NSF: non-susceptible form
SF: susceptible form
Method HLA binding, Intracellular cytokine staining, Sequence
Note The E312D variant is more common in progressors (8/17) than controllers (1/10) of infection. This variant does not reliably confer loss of binding to HLA. 2/4 carriers of this variant and not the consensus, recognized it, but 2/4 did not.


Variant ID.  1297
Epitope Seq.  QASQEVKNW
Variant Seq.  QAtQEVKNW
Mutations S/T
Epitope Location S3T
HXB2 Location S310T
Mutation Type OV: observed variant
Method Sequence
Note This variant is found in 1/10 nonprogressors and 1/12 untreated progressors.


Variant ID.  1298
Epitope Seq.  QASQEVKNW
Variant Seq.  QAtQdVKNW
Mutations S/T E/D
Epitope Location S3T E5D
HXB2 Location S310T E312D
Mutation Type OV: observed variant
Method Sequence
Note This variant is found in 1/10 nonprogressors.


Variant ID.  1299
Epitope Seq.  QASQEVKNW
Variant Seq.  QASQdVKNx
Mutations E/D W/X
Epitope Location E5D W9X
HXB2 Location E312D W316X
Mutation Type OV: observed variant
Method Sequence
Note This variant is found in 1/10 nonprogressors.

References

Migueles2003 Stephen A. Migueles, Alisha C. Laborico, Hiromi Imamichi, W. Lesley Shupert, Cassandra Royce, Mary McLaughlin, Linda Ehler, Julia Metcalf, Shuying Liu, Claire W. Hallahan, and Mark Connors. The Differential Ability of HLA B*5701+ Long-Term Nonprogressors and Progressors to Restrict Human Immunodeficiency Virus Replication Is Not Caused by Loss of Recognition of Autologous Viral gag Sequences. J. Virol., 77(12):6889-6898, Jun 2003. PubMed ID: 12768008. Show all entries for this paper.


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