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Found 4 matching records:

Displaying record number 52758

HXB2 Location Gag(147-155) Gag Epitope Map
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ISPRTLNAW

`lSPRTLNAW`		observed variant
`ISaRTLNAW`		observed variant
`ISPRTLNAx`		observed variant
`ISPkTLNAW`		observed variant
`IaPRTLNAW`		observed variant
`mSPRTLNAW`		observed variant
`mSaRTLNAW`		observed variant
`kSaRTLNAW`		observed variant
`lSPRTfNAW`		observed variant

Species (MHC/HLA) human(B*57:01)

Variant Details

Showing all: 9 variant(s).

Variant ID.	`1280`
Epitope Seq.	`ISPRTLNAW`
Variant Seq.	`lSPRTLNAW`
Mutations	I/L
Epitope Location	I1L
HXB2 Location	I147L
Mutation Type	OV: observed variant
Method	Sequence
Note	This variant was seen in 6/10 nonprogressors, 11/12 untreated progressors and 3/5 treated progressors.

Variant ID.	`1281`
Epitope Seq.	`ISPRTLNAW`
Variant Seq.	`ISaRTLNAW`
Mutations	P/A
Epitope Location	P3A
HXB2 Location	P149A
Mutation Type	OV: observed variant
Method	Sequence
Note	This variant was seen in 1/5 treated progressors.

Variant ID.	`1282`
Epitope Seq.	`ISPRTLNAW`
Variant Seq.	`ISPRTLNAx`
Mutations	W/X
Epitope Location	W9X
HXB2 Location	W155X
Mutation Type	OV: observed variant
Method	Sequence
Note	This variant was seen in 1/10 nonprogressors.

Variant ID.	`1283`
Epitope Seq.	`ISPRTLNAW`
Variant Seq.	`ISPkTLNAW`
Mutations	R/K
Epitope Location	R4K
HXB2 Location	R150K
Mutation Type	OV: observed variant
Method	Sequence
Note	This variant was seen in 1/10 nonprogressors.

Variant ID.	`1284`
Epitope Seq.	`ISPRTLNAW`
Variant Seq.	`IaPRTLNAW`
Mutations	S/A
Epitope Location	S2A
HXB2 Location	S148A
Mutation Type	OV: observed variant
Method	Sequence
Note	This variant was seen in 1/12 untreated progressors.

Variant ID.	`1285`
Epitope Seq.	`ISPRTLNAW`
Variant Seq.	`mSPRTLNAW`
Mutations	I/M
Epitope Location	I1M
HXB2 Location	I147M
Mutation Type	OV: observed variant
Method	Sequence
Note	This variant was seen in 1/12 untreated progressors.

Variant ID.	`1286`
Epitope Seq.	`ISPRTLNAW`
Variant Seq.	`mSaRTLNAW`
Mutations	I/M P/A
Epitope Location	I1M P3A
HXB2 Location	I147M P149A
Mutation Type	OV: observed variant
Method	Sequence
Note	This variant was seen in 1/12 untreated progressors.

Variant ID.	`1287`
Epitope Seq.	`ISPRTLNAW`
Variant Seq.	`kSaRTLNAW`
Mutations	I/K P/A
Epitope Location	I1K P3A
HXB2 Location	I147K P149A
Mutation Type	OV: observed variant
Method	Sequence
Note	This variant was seen in 1/12 untreated progressors.

Variant ID.	`1288`
Epitope Seq.	`ISPRTLNAW`
Variant Seq.	`lSPRTfNAW`
Mutations	I/L L/F
Epitope Location	I1L L6F
HXB2 Location	I147L L152F
Mutation Type	OV: observed variant
Method	Sequence
Note	This variant was seen in 1/12 untreated progressors.

References

Migueles2003 Stephen A. Migueles, Alisha C. Laborico, Hiromi Imamichi, W. Lesley Shupert, Cassandra Royce, Mary McLaughlin, Linda Ehler, Julia Metcalf, Shuying Liu, Claire W. Hallahan, and Mark Connors. The Differential Ability of HLA B*5701+ Long-Term Nonprogressors and Progressors to Restrict Human Immunodeficiency Virus Replication Is Not Caused by Loss of Recognition of Autologous Viral gag Sequences. J. Virol., 77(12):6889-6898, Jun 2003. PubMed ID: 12768008. Show all entries for this paper.

Displaying record number 52760

HXB2 Location Gag(162-172) Gag Epitope Map
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Epitope

KAFSPEVIPMF

Epitope Alignment

Variants

`KsFSPEVIPMF`		observed variant
`KgFnPEVIPMF`		observed variant

Epitope Name KAF11

Species (MHC/HLA) human(B*57:01)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`1289`
Epitope Seq.	`KAFSPEVIPMF`
Variant Seq.	`KsFSPEVIPMF`
Mutations	A/S
Epitope Location	A2S
HXB2 Location	A163S
Mutation Type	OV: observed variant
Method	Sequence
Note	This variant was seen only in one non-progressor and one treated progressor. Index epitope KAF11 is immunodominant in several subjects and highly conserved.

Variant ID.	`1290`
Epitope Seq.	`KAFSPEVIPMF`
Variant Seq.	`KgFnPEVIPMF`
Mutations	A/G S/N
Epitope Location	A2G S4N
HXB2 Location	A163G S165N
Mutation Type	OV: observed variant
Method	Sequence
Note	This variant was seen only in one untreated progressor.

References

Displaying record number 52759

HXB2 Location Gag(240-249) Gag Epitope Map
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Epitope

TSTLQEQIGN

Epitope Alignment

Variants

`TSnLQEQIGN`		observed variant
`TtnLQEQIaN`		observed variant
`TSnLQEQIaN`		observed variant
`TSnLQEQvaN`		observed variant
`TSnLQEQIqN`		observed variant

Species (MHC/HLA) human(B*57:01)

Variant Details

Showing all: 5 variant(s).

Variant ID.	`1291`
Epitope Seq.	`TSTLQEQIGN`
Variant Seq.	`TSnLQEQIGN`
Mutations	T/N
Epitope Location	T3N
HXB2 Location	T242N
Mutation Type	OV: observed variant
Method	Sequence
Note	This variant is seen in 4/10 nonprogressors, 4/12 untreated progressors and 3/5 treated progressors.

Variant ID.	`1292`
Epitope Seq.	`TSTLQEQIGN`
Variant Seq.	`TtnLQEQIaN`
Mutations	S/T T/N G/A
Epitope Location	S2T T3N G9A
HXB2 Location	S241T T242N G248A
Mutation Type	OV: observed variant
Method	Sequence
Note	This variant is seen in 1/12 untreated progressors.

Variant ID.	`1293`
Epitope Seq.	`TSTLQEQIGN`
Variant Seq.	`TSnLQEQIaN`
Mutations	T/N G/A
Epitope Location	T3N G9A
HXB2 Location	T242N G248A
Mutation Type	OV: observed variant
Method	Sequence
Note	This variant is seen in 2/10 nonprogressors, 5/12 untreated progressors and 2/5 treated progressors.

Variant ID.	`1294`
Epitope Seq.	`TSTLQEQIGN`
Variant Seq.	`TSnLQEQvaN`
Mutations	T/N I/V G/A
Epitope Location	T3N I8V G9A
HXB2 Location	T242N I247V G248A
Mutation Type	OV: observed variant
Method	Sequence
Note	This variant is seen in 1/12 untreated progressor.

Variant ID.	`1295`
Epitope Seq.	`TSTLQEQIGN`
Variant Seq.	`TSnLQEQIqN`
Mutations	T/N G/Q
Epitope Location	T3N G9Q
HXB2 Location	T242N G248Q
Mutation Type	OV: observed variant
Method	Sequence
Note	This variant is seen in 1/12 untreated progressor.

References

Displaying record number 52761

HXB2 Location Gag(308-316) Gag Epitope Map
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Epitope

QASQEVKNW

Epitope Alignment

Variants

`QASQdVKNW`		non-susceptible form; susceptible form
`QAtQEVKNW`		observed variant
`QAtQdVKNW`		observed variant
`QASQdVKNx`		observed variant

Epitope Name QW9

Species (MHC/HLA) human(B*57:01)

Variant Details

Showing all: 4 variant(s).

Variant ID.	`1296`
Epitope Seq.	`QASQEVKNW`
Variant Seq.	`QASQdVKNW`
Mutations	E/D
Epitope Location	E5D
HXB2 Location	E312D
Mutation Type	NSF: non-susceptible form SF: susceptible form
Method	HLA binding, Intracellular cytokine staining, Sequence
Note	The E312D variant is more common in progressors (8/17) than controllers (1/10) of infection. This variant does not reliably confer loss of binding to HLA. 2/4 carriers of this variant and not the consensus, recognized it, but 2/4 did not.

Variant ID.	`1297`
Epitope Seq.	`QASQEVKNW`
Variant Seq.	`QAtQEVKNW`
Mutations	S/T
Epitope Location	S3T
HXB2 Location	S310T
Mutation Type	OV: observed variant
Method	Sequence
Note	This variant is found in 1/10 nonprogressors and 1/12 untreated progressors.

Variant ID.	`1298`
Epitope Seq.	`QASQEVKNW`
Variant Seq.	`QAtQdVKNW`
Mutations	S/T E/D
Epitope Location	S3T E5D
HXB2 Location	S310T E312D
Mutation Type	OV: observed variant
Method	Sequence
Note	This variant is found in 1/10 nonprogressors.

Variant ID.	`1299`
Epitope Seq.	`QASQEVKNW`
Variant Seq.	`QASQdVKNx`
Mutations	E/D W/X
Epitope Location	E5D W9X
HXB2 Location	E312D W316X
Mutation Type	OV: observed variant
Method	Sequence
Note	This variant is found in 1/10 nonprogressors.