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Found 2 matching records:

Displaying record number 57258

HXB2 Location  Gag(147-155)   Gag Epitope Map
View variants at this location
Epitope ISPRTLNAW   Epitope Alignment
Variants
lSPRTLNAW   susceptible form
Epitope Name IW9
Species (MHC/HLA human(B*57)

Variant Details

Showing all: 1 variant(s).


Variant ID.  2552
Epitope Seq.  ISPRTLNAW
Variant Seq.  lSPRTLNAW
Mutations I/L
Epitope Location I1L
HXB2 Location I147L
Mutation Type SF: susceptible form
Epitope Subtype A1
Variant Subtype D
Method CD8 T-cell Elispot - IFNy
Note Previously-documented Clade D ISPRTLNAW escape variant I147L was not selected against among B*57+ clade A1 subjects. These subjects responded similarly to 147I and 147L.

References

McKinnon2009 Lyle R. McKinnon, Rupert Capina, Harold Peters, Mark Mendoza, Joshua Kimani, Charles Wachihi, Anthony Kariri, Makobu Kimani, Meika Richmond, Sandy Koesters Kiazyk, Keith R. Fowke, Walter Jaoko, Ma Luo, T Blake Ball, and Francis A. Plummer. Clade-Specific Evolution Mediated by HLA-B*57/5801 in Human Immunodeficiency Virus Type 1 Clade A1 p24. J Virol, 83(23):12636-12642, Dec 2009. PubMed ID: 19759140. Show all entries for this paper.


Displaying record number 57261

HXB2 Location  Gag(240-249)   Gag Epitope Map
View variants at this location
Epitope TSTPQEQIGW   Epitope Alignment
Variants
TSTPtEQIGW   non-susceptible form
TSTPQEQlGW   non-susceptible form
TSTlQEQIGW   diminished response
TSnlQEQIGW   susceptible form
Epitope Name TW10
Species (MHC/HLA human(B*57)

Variant Details

Showing all: 4 variant(s).


Variant ID.  2548
Epitope Seq.  TSTPQEQIGW
Variant Seq.  TSTPtEQIGW
Mutations Q/T
Epitope Location Q5T
HXB2 Location Q244T
Mutation Type NSF: non-susceptible form
Epitope Subtype A1
Variant Subtype A1
Method CD8 T-cell Elispot - IFNy
Note The majority of A1-infected B*57+ subjects who responded to TW10 did not respond to P243T TSTPtEQIGW or I247L TSTPQEQlGW variants, supporting previous findings that these represent escape mutations in clade A1.


Variant ID.  2549
Epitope Seq.  TSTPQEQIGW
Variant Seq.  TSTPQEQlGW
Mutations I/L
Epitope Location I8L
HXB2 Location I247L
Mutation Type NSF: non-susceptible form
Epitope Subtype A1
Variant Subtype A1
Method CD8 T-cell Elispot - IFNy
Note The majority of A1-infected B*57+ subjects who responded to TW10 did not respond to P243T TSTPtEQIGW or I247L TSTPQEQlGW variants, supporting previous findings that these represent escape mutations in clade A1.


Variant ID.  2550
Epitope Seq.  TSTPQEQIGW
Variant Seq.  TSTlQEQIGW
Mutations P/L
Epitope Location P4L
HXB2 Location P243L
Mutation Type DR: diminished response
Epitope Subtype A1
Variant Subtype B, D
Method CD8 T-cell Elispot - IFNy
Note In clade A1-infected patients the recognition of the B/D consensus TSTlQEQIGW was diminished compared to that of clade A1 TSTPQEQIGW. The mutant T242N TSnlQEQIGW was previously documented for clades B and D as escape. However, despite the presumed absence of this variant in these subjects' autologous sequences, the clade B/D escape variant TSnlQEQIGW was recognized at a magnitude similar to that of consensus clade A1 TSTPQEQIGW.


Variant ID.  2551
Epitope Seq.  TSTPQEQIGW
Variant Seq.  TSnlQEQIGW
Mutations T/N P/L
Epitope Location T3N P4L
HXB2 Location T242N P243L
Mutation Type SF: susceptible form
Epitope Subtype A1
Variant Subtype B, D
Method CD8 T-cell Elispot - IFNy
Note In clade A1-infected patients the recognition of the B/D consensus TSTlQEQIGW was diminished compared to that of clade A1 TSTPQEQIGW. The mutant T242N TSnlQEQIGW was previously documented for clades B and D as escape. However, despite the presumed absence of this variant in these subjects' autologous sequences, the clade B/D escape variant TSnlQEQIGW was recognized at a magnitude similar to that of consensus clade A1 TSTPQEQIGW.

References

McKinnon2009 Lyle R. McKinnon, Rupert Capina, Harold Peters, Mark Mendoza, Joshua Kimani, Charles Wachihi, Anthony Kariri, Makobu Kimani, Meika Richmond, Sandy Koesters Kiazyk, Keith R. Fowke, Walter Jaoko, Ma Luo, T Blake Ball, and Francis A. Plummer. Clade-Specific Evolution Mediated by HLA-B*57/5801 in Human Immunodeficiency Virus Type 1 Clade A1 p24. J Virol, 83(23):12636-12642, Dec 2009. PubMed ID: 19759140. Show all entries for this paper.


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