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Displaying record number 54495

HXB2 Location Gag(77-85) Gag Epitope Map
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SLYNTVATL

`SLYNTiATL`		susceptible form
`SLYNTiAvL`		susceptible form
`SLYNTVAvL`		susceptible form
`SLfNTVATL`		susceptible form
`SLfNTiAvL`		susceptible form
`SLfNTVAvL`		susceptible form
`SLfNTiATL`		susceptible form
`SLYNsVATL`		susceptible form
`SLYqTVATL`		susceptible form
`SLYlTVATL`		susceptible form
`aLYNTVATL`		susceptible form
`SLaNTVATL`		non-susceptible form
`SLYaTVATL`		non-susceptible form
`SLYNTaATL`		diminished response
`SLYNTVAaL`		diminished response
`aLYNTaAaL`		non-susceptible form
`SLYNvVATL`		non-susceptible form
`SLYNlVAvL`		escape documented in this paper; TCR related mutation
`SLYNlVAvL`		escape documented in this paper; TCR related mutation
`SLYNaVATL`		escape documented in this paper; TCR related mutation
`SLYNaiATL`		escape documented in this paper; TCR related mutation
`SLYNlVAvL`		escape documented in this paper; TCR related mutation

Epitope Name SL9

Species (MHC/HLA) human(A2)

Variant Details

Showing all: 22 variant(s).

Variant ID.	`1052`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLYNTiATL`
Mutations	V/I
Epitope Location	V6I
HXB2 Location	V82I
Mutation Type	SF: susceptible form
Method	Chromium-release assay, Sequence
Note	This natural variant when tested in the presence of D3 TCR, Gag-specific CTL was susceptible.

Variant ID.	`1053`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLYNTiAvL`
Mutations	V/I T/V
Epitope Location	V6I T8V
HXB2 Location	V82I T84V
Mutation Type	SF: susceptible form
Method	Chromium-release assay, Sequence
Note	This natural variant when tested in the presence of D3 TCR, Gag-specific CTL was susceptible.

Variant ID.	`1054`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLYNTVAvL`
Mutations	T/V
Epitope Location	T8V
HXB2 Location	T84V
Mutation Type	SF: susceptible form
Method	Chromium-release assay, Sequence
Note	This natural variant when tested in the presence of D3 TCR, Gag-specific CTL was susceptible.

Variant ID.	`1055`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLfNTVATL`
Mutations	Y/F
Epitope Location	Y3F
HXB2 Location	Y79F
Mutation Type	SF: susceptible form
Method	Chromium-release assay, Sequence
Note	This natural variant when tested in the presence of D3 TCR, Gag-specific CTL was susceptible and only very slightly less active than wild type SL9.

Variant ID.	`1056`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLfNTiAvL`
Mutations	Y/F V/I T/V
Epitope Location	Y3F V6I T8V
HXB2 Location	Y79F V82I T84V
Mutation Type	SF: susceptible form
Method	Chromium-release assay, Sequence
Note	This natural variant when tested in the presence of D3 TCR, Gag-specific CTL was susceptible.

Variant ID.	`1057`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLfNTVAvL`
Mutations	Y/F T/V
Epitope Location	Y3F T8V
HXB2 Location	Y79F T84V
Mutation Type	SF: susceptible form
Method	Chromium-release assay, Sequence
Note	This natural variant when tested in the presence of D3 TCR, Gag-specific CTL was susceptible.

Variant ID.	`1058`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLfNTiATL`
Mutations	Y/F V/I
Epitope Location	Y3F V6I
HXB2 Location	Y79F V82I
Mutation Type	SF: susceptible form
Method	Chromium-release assay, Sequence
Note	This natural variant when tested in the presence of D3 TCR, Gag-specific CTL was susceptible.

Variant ID.	`1059`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLYNsVATL`
Mutations	T/S
Epitope Location	T5S
HXB2 Location	T81S
Mutation Type	SF: susceptible form
Method	Chromium-release assay, Sequence
Note	This natural variant when tested in the presence of D3 TCR, Gag-specific CTL was susceptible.

Variant ID.	`1060`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLYqTVATL`
Mutations	N/Q
Epitope Location	N4Q
HXB2 Location	N80Q
Mutation Type	SF: susceptible form
Method	Chromium-release assay, Sequence
Note	This synthetic variant when tested in the presence of D3 TCR, Gag-specific CTL was susceptible.

Variant ID.	`1061`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLYlTVATL`
Mutations	N/L
Epitope Location	N4L
HXB2 Location	N80L
Mutation Type	SF: susceptible form
Method	Chromium-release assay, Sequence
Note	This synthetic variant when tested in the presence of D3 TCR, Gag-specific CTL was susceptible.

Variant ID.	`1062`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`aLYNTVATL`
Mutations	S/A
Epitope Location	S1A
HXB2 Location	S77A
Mutation Type	SF: susceptible form
Method	Chromium-release assay, Sequence
Note	This synthetic variant when tested in the presence of D3 TCR, Gag-specific CTL was susceptible, indistinguishable from the wild type SL9.

Variant ID.	`1063`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLaNTVATL`
Mutations	Y/A
Epitope Location	Y3A
HXB2 Location	Y79A
Mutation Type	NSF: non-susceptible form
Method	Chromium-release assay, Sequence
Note	This synthetic variant when tested in the presence of D3 TCR, Gag-specific CTL elicited no response.

Variant ID.	`1064`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLYaTVATL`
Mutations	N/A
Epitope Location	N4A
HXB2 Location	N80A
Mutation Type	NSF: non-susceptible form
Method	Chromium-release assay, Sequence
Note	This synthetic variant when tested in the presence of D3 TCR, Gag-specific CTL elicited no response.

Variant ID.	`1065`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLYNTaATL`
Mutations	V/A
Epitope Location	V6A
HXB2 Location	V82A
Mutation Type	DR: diminished response
Method	Chromium-release assay, Sequence
Note	This synthetic variant when tested in the presence of D3 TCR, Gag-specific CTL has very low activity.

Variant ID.	`1066`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLYNTVAaL`
Mutations	T/A
Epitope Location	T8A
HXB2 Location	T84A
Mutation Type	DR: diminished response
Method	Chromium-release assay, Sequence
Note	This synthetic variant when tested in the presence of D3 TCR, Gag-specific CTL was less active.

Variant ID.	`1067`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`aLYNTaAaL`
Mutations	S/A V/A T/A
Epitope Location	S1A V6A T8A
HXB2 Location	S77A V82A T84A
Mutation Type	NSF: non-susceptible form
Method	Chromium-release assay, Sequence
Note	This synthetic variant when tested in the presence of D3 TCR, Gag-specific CTL elicited no response.

Variant ID.	`1068`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLYNvVATL`
Mutations	T/V
Epitope Location	T5V
HXB2 Location	T81V
Mutation Type	NSF: non-susceptible form
Method	Chromium-release assay, Sequence
Note	This synthetic variant when tested in the presence of D3 TCR, Gag-specific CTL elicited no response.

Variant ID.	`2224`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLYNlVAvL`
Mutations	T/L T/V
Epitope Location	T5L T8V
HXB2 Location	T81L T84V
Mutation Type	E: escape documented in this paper TCR: TCR related mutation
Method	Chromium-release assay, Sequence
Note	This natural variant when tested in the presence of D3 TCR, Gag-specific CTL abolished CTL recognition, but was still able to bind HLA-A2.

Variant ID.	`2248`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLYNlVAvL`
Mutations	T/L T/V
Epitope Location	T5L T8V
HXB2 Location	T81L T84V
Mutation Type	E: escape documented in this paper TCR: TCR related mutation
Method	Chromium-release assay, Sequence
Note	This natural variant when tested in the presence of D3 TCR, Gag-specific CTL abolished CTL recognition, but was still able to bind HLA-A2.

Variant ID.	`2250`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLYNaVATL`
Mutations	T/A
Epitope Location	T5A
HXB2 Location	T81A
Mutation Type	E: escape documented in this paper TCR: TCR related mutation
Method	Chromium-release assay, Sequence
Note	This natural variant when tested in the presence of D3 TCR, Gag-specific CTL abolished CTL recognition, but was still able to bind HLA-A2.

Variant ID.	`2251`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLYNaiATL`
Mutations	T/A V/I
Epitope Location	T5A V6I
HXB2 Location	T81A V82I
Mutation Type	E: escape documented in this paper TCR: TCR related mutation
Method	Chromium-release assay, Sequence
Note	This natural variant when tested in the presence of D3 TCR, Gag-specific CTL abolished CTL recognition, but was still able to bind HLA-A2.

Variant ID.	`2252`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLYNlVAvL`
Mutations	T/L T/V
Epitope Location	T5L T8V
HXB2 Location	T81L T84V
Mutation Type	E: escape documented in this paper TCR: TCR related mutation
Method	Chromium-release assay, Sequence
Note	This natural variant when tested in the presence of D3 TCR, Gag-specific CTL abolished CTL recognition, but was still able to bind HLA-A2.

References

Martinez-Hackert2006 Erik Martinez-Hackert, Nadia Anikeeva, Spyros A. Kalams, Bruce D. Walker, Wayne A. Hendrickson, and Yuri Sykulev. Structural Basis for Degenerate Recognition of Natural HIV Peptide Variants by Cytotoxic Lymphocytes. J. Biol. Chem., 281(29):20205-20212, 21 Jul 2006. PubMed ID: 16702212. Show all entries for this paper.