HIV molecular immunology database
Found 9 matching records:
| HXB2 Location | Gag(5-19) | Gag Epitope Map
View variants at this location |
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| Epitope |
ASVLSGGELDRWEKI
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Epitope Alignment | |||||||||||||
| Variants |
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| Epitope Name | AI14 | ||||||||||||||
| Species (MHC/HLA) | human | ||||||||||||||
Showing all: 4 variant(s).
| Variant ID. | 1016 |
|---|---|
| Epitope Seq. | ASVLSGGELDRWEKI |
| Variant Seq. | ASVLSGGkLDaWEKI |
| Mutations | R/A E/K |
| Epitope Location | R11A E8K |
| HXB2 Location | R15A E12K |
| Mutation Type | SNSF: subtype-specific non-susceptible form |
| Epitope Subtype | B |
| Variant Subtype | A, M group |
| Method | CD8 T-cell Elispot - IFNy |
| Note | No cross-recognition of this variant was seen across clades or intra-clade central sequences. |
| Variant ID. | 1017 |
|---|---|
| Epitope Seq. | ASVLSGGELDRWEKI |
| Variant Seq. | ASiLrGGkLDkWEKI |
| Mutations | R/K V/I S/R E/K |
| Epitope Location | R11K V3I S5R E8K |
| HXB2 Location | R15K V7I S9R E12K |
| Mutation Type | SNSF: subtype-specific non-susceptible form |
| Epitope Subtype | B |
| Variant Subtype | C |
| Method | CD8 T-cell Elispot - IFNy |
| Note | No cross-recognition of this variant was seen across clades or intra-clade central sequences. |
| Variant ID. | 1018 |
|---|---|
| Epitope Seq. | ASVLSGGELDRWEKI |
| Variant Seq. | ASVLSGGkLDkWEKI |
| Mutations | R/K E/K |
| Epitope Location | R11K E8K |
| HXB2 Location | R15K E12K |
| Mutation Type | SNSF: subtype-specific non-susceptible form |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | CD8 T-cell Elispot - IFNy |
| Note | No cross-recognition of this variant was seen across clades or intra-clade central sequences. |
| Variant ID. | 1019 |
|---|---|
| Epitope Seq. | ASVLSGGELDRWEKI |
| Variant Seq. | ASVLSGGELDkWEKI |
| Mutations | R/K |
| Epitope Location | R11K |
| HXB2 Location | R15K |
| Mutation Type | SNSF: subtype-specific non-susceptible form |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | CD8 T-cell Elispot - IFNy |
| Note | No cross-recognition of this variant was seen across clades or intra-clade central sequences. |
Malhotra2007 Uma Malhotra, Jessica Nolin, James I. Mullins, and M. Juliana McElrath. Comprehensive Epitope Analysis of Cross-Clade Gag-Specific T-Cell Responses in Individuals with Early HIV-1 Infection in the US Epidemic. Vaccine, 25(2):381-390, 4 Jan 2007. PubMed ID: 17112643. Show all entries for this paper.
| HXB2 Location | Gag(20-28) | Gag Epitope Map
View variants at this location |
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| Epitope |
RLRPGGKKK
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Epitope Alignment | ||||
| Variants |
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| Epitope Name | RK9 | |||||
| Species (MHC/HLA) | human(A3) | |||||
Showing all: 1 variant(s).
| Variant ID. | 1020 |
|---|---|
| Epitope Seq. | RLRPGGKKK |
| Variant Seq. | RLRPGGKKh |
| Mutations | K/H |
| Epitope Location | K9H |
| HXB2 Location | K28H |
| Mutation Type | DR: diminished response |
| Epitope Subtype | B |
| Variant Subtype | C |
| Method | CD8 T-cell Elispot - IFNy |
| Note | Cross-recognition of the variant is seen with both C- and A-clades. The C-clade variant contains a change at position 9 to RLRPGGKKh. Typically, magnitude and avidity of binding for T-cell responses were much lower to the C-clade variant. |
Malhotra2007 Uma Malhotra, Jessica Nolin, James I. Mullins, and M. Juliana McElrath. Comprehensive Epitope Analysis of Cross-Clade Gag-Specific T-Cell Responses in Individuals with Early HIV-1 Infection in the US Epidemic. Vaccine, 25(2):381-390, 4 Jan 2007. PubMed ID: 17112643. Show all entries for this paper.
| HXB2 Location | Gag(147-155) | Gag Epitope Map
View variants at this location |
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| Epitope |
ISPRTLNAW
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Epitope Alignment | ||||
| Variants |
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| Epitope Name | IW9 | |||||
| Species (MHC/HLA) | human(B57) | |||||
Showing all: 1 variant(s).
| Variant ID. | 1021 |
|---|---|
| Epitope Seq. | ISPRTLNAW |
| Variant Seq. | lSPRTLNAW |
| Mutations | I/L |
| Epitope Location | I1L |
| HXB2 Location | I147L |
| Mutation Type | SSF: subtype-specific susceptible form |
| Epitope Subtype | B |
| Variant Subtype | A |
| Method | CD8 T-cell Elispot - IFNy |
| Note | Cross-recognition of this variant is seen with both C- and A-clades. Anchor residues are at positions 2 and 9; while the A-clade variant contains a change at position 1 to lSPRTLNAW. |
Malhotra2007 Uma Malhotra, Jessica Nolin, James I. Mullins, and M. Juliana McElrath. Comprehensive Epitope Analysis of Cross-Clade Gag-Specific T-Cell Responses in Individuals with Early HIV-1 Infection in the US Epidemic. Vaccine, 25(2):381-390, 4 Jan 2007. PubMed ID: 17112643. Show all entries for this paper.
| HXB2 Location | Gag(240-249) | Gag Epitope Map
View variants at this location |
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| Epitope |
TSTLQEQIGW
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Epitope Alignment | |||||||
| Variants |
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| Epitope Name | TW10 | ||||||||
| Species (MHC/HLA) | human(B57, B58) | ||||||||
Showing all: 2 variant(s).
| Variant ID. | 1022 |
|---|---|
| Epitope Seq. | TSTLQEQIGW |
| Variant Seq. | TSTpQEQIGW |
| Mutations | L/P |
| Epitope Location | L4P |
| HXB2 Location | L243P |
| Mutation Type | SNSF: subtype-specific non-susceptible form |
| Epitope Subtype | B |
| Variant Subtype | A |
| Method | CD8 T-cell Elispot - IFNy |
| Note | No cross-recognition is seen with this A-clade variant. This A-clade variant contains a non-conservative change at position 4 to TSTpQEQIGW. |
| Variant ID. | 1023 |
|---|---|
| Epitope Seq. | TSTLQEQIGW |
| Variant Seq. | TSTLQEQIaW |
| Mutations | G/A |
| Epitope Location | G9A |
| HXB2 Location | G248A |
| Mutation Type | SSF: subtype-specific susceptible form |
| Epitope Subtype | B |
| Variant Subtype | C |
| Method | CD8 T-cell Elispot - IFNy |
| Note | Cross-recognition is seen only to the C-clade variant. This C-clade variant has a semi-conservative substitution at position 9 to TSTLQEQIaW. Reduced avidity was seen with this variant. |
Malhotra2007 Uma Malhotra, Jessica Nolin, James I. Mullins, and M. Juliana McElrath. Comprehensive Epitope Analysis of Cross-Clade Gag-Specific T-Cell Responses in Individuals with Early HIV-1 Infection in the US Epidemic. Vaccine, 25(2):381-390, 4 Jan 2007. PubMed ID: 17112643. Show all entries for this paper.
| HXB2 Location | Gag(260-267) | Gag Epitope Map
View variants at this location |
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| Epitope |
EIYKRWII
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Epitope Alignment | ||||
| Variants |
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| Epitope Name | EI8 | |||||
| Species (MHC/HLA) | human(B8) | |||||
Showing all: 1 variant(s).
| Variant ID. | 1024 |
|---|---|
| Epitope Seq. | EIYKRWII |
| Variant Seq. | dIYKRWII |
| Mutations | E/D |
| Epitope Location | E1D |
| HXB2 Location | E260D |
| Mutation Type | SSF: subtype-specific susceptible form |
| Epitope Subtype | B |
| Variant Subtype | A, C |
| Method | CD8 T-cell Elispot - IFNy |
| Note | Cross-recognition is seen to both A- and C-clade variants. Both variants contain a change at position 1 to dIYKRWII. |
Malhotra2007 Uma Malhotra, Jessica Nolin, James I. Mullins, and M. Juliana McElrath. Comprehensive Epitope Analysis of Cross-Clade Gag-Specific T-Cell Responses in Individuals with Early HIV-1 Infection in the US Epidemic. Vaccine, 25(2):381-390, 4 Jan 2007. PubMed ID: 17112643. Show all entries for this paper.
| HXB2 Location | Gag(297-310) | Gag Epitope Map
View variants at this location |
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| Epitope |
VDRFYKLTRAEQAS
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Epitope Alignment | ||||
| Variants |
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| Epitope Name | VS14 | |||||
| Species (MHC/HLA) | human | |||||
Showing all: 1 variant(s).
| Variant ID. | 1025 |
|---|---|
| Epitope Seq. | VDRFYKLTRAEQAS |
| Variant Seq. | VDRFYKLTRAEQAt |
| Mutations | S/T |
| Epitope Location | S14T |
| HXB2 Location | S310T |
| Mutation Type | SSF: subtype-specific susceptible form |
| Epitope Subtype | B |
| Variant Subtype | A, C |
| Method | CD8 T-cell Elispot - IFNy |
| Note | Cross-recognition is seen to both A- and C-clade variants. |
Malhotra2007 Uma Malhotra, Jessica Nolin, James I. Mullins, and M. Juliana McElrath. Comprehensive Epitope Analysis of Cross-Clade Gag-Specific T-Cell Responses in Individuals with Early HIV-1 Infection in the US Epidemic. Vaccine, 25(2):381-390, 4 Jan 2007. PubMed ID: 17112643. Show all entries for this paper.
| HXB2 Location | Gag(298-306) | Gag Epitope Map
View variants at this location |
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|---|---|---|---|---|---|---|
| Epitope |
DRFYKLTRA
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Epitope Alignment | ||||
| Variants |
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| Epitope Name | DA9 | |||||
| Species (MHC/HLA) | human(B14) | |||||
Showing all: 1 variant(s).
| Variant ID. | 1026 |
|---|---|
| Epitope Seq. | DRFYKLTRA |
| Variant Seq. | DRFfKLTRA |
| Mutations | Y/F |
| Epitope Location | Y4F |
| HXB2 Location | Y301F |
| Mutation Type | SSF: subtype-specific susceptible form |
| Epitope Subtype | B |
| Variant Subtype | A, C |
| Method | CD8 T-cell Elispot - IFNy |
| Note | Cross-recognition is seen to both A- and C-clade variants. Both A- and C- variants contain a change at position 4 to DRFfKLTRA. |
Malhotra2007 Uma Malhotra, Jessica Nolin, James I. Mullins, and M. Juliana McElrath. Comprehensive Epitope Analysis of Cross-Clade Gag-Specific T-Cell Responses in Individuals with Early HIV-1 Infection in the US Epidemic. Vaccine, 25(2):381-390, 4 Jan 2007. PubMed ID: 17112643. Show all entries for this paper.
| HXB2 Location | Gag(313-323) | Gag Epitope Map
View variants at this location |
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| Epitope |
VKNWMTETLLV
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Epitope Alignment | ||||
| Variants |
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| Epitope Name | VV11 | |||||
| Species (MHC/HLA) | human | |||||
Showing all: 1 variant(s).
| Variant ID. | 1027 |
|---|---|
| Epitope Seq. | VKNWMTETLLV |
| Variant Seq. | VKNWMTdTLLV |
| Mutations | E/D |
| Epitope Location | E7D |
| HXB2 Location | E319D |
| Mutation Type | SSF: subtype-specific susceptible form |
| Epitope Subtype | B |
| Variant Subtype | C |
| Method | CD8 T-cell Elispot - IFNy |
| Note | Cross-recognition is seen only to the A-clade variant. The C-clade variant contains a semi-conservative change at position 7 to VKNWMTdTLLV. |
Malhotra2007 Uma Malhotra, Jessica Nolin, James I. Mullins, and M. Juliana McElrath. Comprehensive Epitope Analysis of Cross-Clade Gag-Specific T-Cell Responses in Individuals with Early HIV-1 Infection in the US Epidemic. Vaccine, 25(2):381-390, 4 Jan 2007. PubMed ID: 17112643. Show all entries for this paper.
| HXB2 Location | Gag(349-359) | Gag Epitope Map
View variants at this location |
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| Epitope |
ACQGVGGPGHK
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Epitope Alignment | ||||
| Variants |
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| Epitope Name | AK11 | |||||
| Species (MHC/HLA) | human(A11) | |||||
Showing all: 1 variant(s).
| Variant ID. | 1028 |
|---|---|
| Epitope Seq. | ACQGVGGPGHK |
| Variant Seq. | ACQGVGGPsHK |
| Mutations | G/S |
| Epitope Location | G9S |
| HXB2 Location | G357S |
| Mutation Type | SNSF: subtype-specific non-susceptible form SSF: subtype-specific susceptible form |
| Epitope Subtype | B |
| Variant Subtype | C |
| Method | CD8 T-cell Elispot - IFNy |
| Note | Cross-recognition is seen only to the A-clade variant. The C-clade variant contains a semi-conservative change at position 9 to ACQGVGGPsHK. |
Malhotra2007 Uma Malhotra, Jessica Nolin, James I. Mullins, and M. Juliana McElrath. Comprehensive Epitope Analysis of Cross-Clade Gag-Specific T-Cell Responses in Individuals with Early HIV-1 Infection in the US Epidemic. Vaccine, 25(2):381-390, 4 Jan 2007. PubMed ID: 17112643. Show all entries for this paper.