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Found 9 matching records:

Displaying record number 54532

HXB2 Location  Gag(5-19)   Gag Epitope Map
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Epitope ASVLSGGELDRWEKI   Epitope Alignment
Variants
ASVLSGGkLDaWEKI   subtype-specific non-susceptible form
ASiLrGGkLDkWEKI   subtype-specific non-susceptible form
ASVLSGGkLDkWEKI   subtype-specific non-susceptible form
ASVLSGGELDkWEKI   subtype-specific non-susceptible form
Epitope Name AI14
Species (MHC/HLA human

Variant Details

Showing all: 4 variant(s).


Variant ID.  1016
Epitope Seq.  ASVLSGGELDRWEKI
Variant Seq.  ASVLSGGkLDaWEKI
Mutations R/A E/K
Epitope Location R11A E8K
HXB2 Location R15A E12K
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype B
Variant Subtype A, M group
Method CD8 T-cell Elispot - IFNy
Note No cross-recognition of this variant was seen across clades or intra-clade central sequences.


Variant ID.  1017
Epitope Seq.  ASVLSGGELDRWEKI
Variant Seq.  ASiLrGGkLDkWEKI
Mutations R/K V/I S/R E/K
Epitope Location R11K V3I S5R E8K
HXB2 Location R15K V7I S9R E12K
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype B
Variant Subtype C
Method CD8 T-cell Elispot - IFNy
Note No cross-recognition of this variant was seen across clades or intra-clade central sequences.


Variant ID.  1018
Epitope Seq.  ASVLSGGELDRWEKI
Variant Seq.  ASVLSGGkLDkWEKI
Mutations R/K E/K
Epitope Location R11K E8K
HXB2 Location R15K E12K
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy
Note No cross-recognition of this variant was seen across clades or intra-clade central sequences.


Variant ID.  1019
Epitope Seq.  ASVLSGGELDRWEKI
Variant Seq.  ASVLSGGELDkWEKI
Mutations R/K
Epitope Location R11K
HXB2 Location R15K
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy
Note No cross-recognition of this variant was seen across clades or intra-clade central sequences.

References

Malhotra2007 Uma Malhotra, Jessica Nolin, James I. Mullins, and M. Juliana McElrath. Comprehensive Epitope Analysis of Cross-Clade Gag-Specific T-Cell Responses in Individuals with Early HIV-1 Infection in the US Epidemic. Vaccine, 25(2):381-390, 4 Jan 2007. PubMed ID: 17112643. Show all entries for this paper.


Displaying record number 54533

HXB2 Location  Gag(20-28)   Gag Epitope Map
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Epitope RLRPGGKKK   Epitope Alignment
Variants
RLRPGGKKh   diminished response
Epitope Name RK9
Species (MHC/HLA human(A3)

Variant Details

Showing all: 1 variant(s).


Variant ID.  1020
Epitope Seq.  RLRPGGKKK
Variant Seq.  RLRPGGKKh
Mutations K/H
Epitope Location K9H
HXB2 Location K28H
Mutation Type DR: diminished response
Epitope Subtype B
Variant Subtype C
Method CD8 T-cell Elispot - IFNy
Note Cross-recognition of the variant is seen with both C- and A-clades. The C-clade variant contains a change at position 9 to RLRPGGKKh. Typically, magnitude and avidity of binding for T-cell responses were much lower to the C-clade variant.

References

Malhotra2007 Uma Malhotra, Jessica Nolin, James I. Mullins, and M. Juliana McElrath. Comprehensive Epitope Analysis of Cross-Clade Gag-Specific T-Cell Responses in Individuals with Early HIV-1 Infection in the US Epidemic. Vaccine, 25(2):381-390, 4 Jan 2007. PubMed ID: 17112643. Show all entries for this paper.


Displaying record number 54534

HXB2 Location  Gag(147-155)   Gag Epitope Map
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Epitope ISPRTLNAW   Epitope Alignment
Variants
lSPRTLNAW   subtype-specific susceptible form
Epitope Name IW9
Species (MHC/HLA human(B57)

Variant Details

Showing all: 1 variant(s).


Variant ID.  1021
Epitope Seq.  ISPRTLNAW
Variant Seq.  lSPRTLNAW
Mutations I/L
Epitope Location I1L
HXB2 Location I147L
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype B
Variant Subtype A
Method CD8 T-cell Elispot - IFNy
Note Cross-recognition of this variant is seen with both C- and A-clades. Anchor residues are at positions 2 and 9; while the A-clade variant contains a change at position 1 to lSPRTLNAW.

References

Malhotra2007 Uma Malhotra, Jessica Nolin, James I. Mullins, and M. Juliana McElrath. Comprehensive Epitope Analysis of Cross-Clade Gag-Specific T-Cell Responses in Individuals with Early HIV-1 Infection in the US Epidemic. Vaccine, 25(2):381-390, 4 Jan 2007. PubMed ID: 17112643. Show all entries for this paper.


Displaying record number 54535

HXB2 Location  Gag(240-249)   Gag Epitope Map
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Epitope TSTLQEQIGW   Epitope Alignment
Variants
TSTpQEQIGW   subtype-specific non-susceptible form
TSTLQEQIaW   subtype-specific susceptible form
Epitope Name TW10
Species (MHC/HLA human(B57, B58)

Variant Details

Showing all: 2 variant(s).


Variant ID.  1022
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSTpQEQIGW
Mutations L/P
Epitope Location L4P
HXB2 Location L243P
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype B
Variant Subtype A
Method CD8 T-cell Elispot - IFNy
Note No cross-recognition is seen with this A-clade variant. This A-clade variant contains a non-conservative change at position 4 to TSTpQEQIGW.


Variant ID.  1023
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSTLQEQIaW
Mutations G/A
Epitope Location G9A
HXB2 Location G248A
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype B
Variant Subtype C
Method CD8 T-cell Elispot - IFNy
Note Cross-recognition is seen only to the C-clade variant. This C-clade variant has a semi-conservative substitution at position 9 to TSTLQEQIaW. Reduced avidity was seen with this variant.

References

Malhotra2007 Uma Malhotra, Jessica Nolin, James I. Mullins, and M. Juliana McElrath. Comprehensive Epitope Analysis of Cross-Clade Gag-Specific T-Cell Responses in Individuals with Early HIV-1 Infection in the US Epidemic. Vaccine, 25(2):381-390, 4 Jan 2007. PubMed ID: 17112643. Show all entries for this paper.


Displaying record number 54536

HXB2 Location  Gag(260-267)   Gag Epitope Map
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Epitope EIYKRWII   Epitope Alignment
Variants
dIYKRWII   subtype-specific susceptible form
Epitope Name EI8
Species (MHC/HLA human(B8)

Variant Details

Showing all: 1 variant(s).


Variant ID.  1024
Epitope Seq.  EIYKRWII
Variant Seq.  dIYKRWII
Mutations E/D
Epitope Location E1D
HXB2 Location E260D
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype B
Variant Subtype A, C
Method CD8 T-cell Elispot - IFNy
Note Cross-recognition is seen to both A- and C-clade variants. Both variants contain a change at position 1 to dIYKRWII.

References

Malhotra2007 Uma Malhotra, Jessica Nolin, James I. Mullins, and M. Juliana McElrath. Comprehensive Epitope Analysis of Cross-Clade Gag-Specific T-Cell Responses in Individuals with Early HIV-1 Infection in the US Epidemic. Vaccine, 25(2):381-390, 4 Jan 2007. PubMed ID: 17112643. Show all entries for this paper.


Displaying record number 54538

HXB2 Location  Gag(297-310)   Gag Epitope Map
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Epitope VDRFYKLTRAEQAS   Epitope Alignment
Variants
VDRFYKLTRAEQAt   subtype-specific susceptible form
Epitope Name VS14
Species (MHC/HLA human

Variant Details

Showing all: 1 variant(s).


Variant ID.  1025
Epitope Seq.  VDRFYKLTRAEQAS
Variant Seq.  VDRFYKLTRAEQAt
Mutations S/T
Epitope Location S14T
HXB2 Location S310T
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype B
Variant Subtype A, C
Method CD8 T-cell Elispot - IFNy
Note Cross-recognition is seen to both A- and C-clade variants.

References

Malhotra2007 Uma Malhotra, Jessica Nolin, James I. Mullins, and M. Juliana McElrath. Comprehensive Epitope Analysis of Cross-Clade Gag-Specific T-Cell Responses in Individuals with Early HIV-1 Infection in the US Epidemic. Vaccine, 25(2):381-390, 4 Jan 2007. PubMed ID: 17112643. Show all entries for this paper.


Displaying record number 54537

HXB2 Location  Gag(298-306)   Gag Epitope Map
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Epitope DRFYKLTRA   Epitope Alignment
Variants
DRFfKLTRA   subtype-specific susceptible form
Epitope Name DA9
Species (MHC/HLA human(B14)

Variant Details

Showing all: 1 variant(s).


Variant ID.  1026
Epitope Seq.  DRFYKLTRA
Variant Seq.  DRFfKLTRA
Mutations Y/F
Epitope Location Y4F
HXB2 Location Y301F
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype B
Variant Subtype A, C
Method CD8 T-cell Elispot - IFNy
Note Cross-recognition is seen to both A- and C-clade variants. Both A- and C- variants contain a change at position 4 to DRFfKLTRA.

References

Malhotra2007 Uma Malhotra, Jessica Nolin, James I. Mullins, and M. Juliana McElrath. Comprehensive Epitope Analysis of Cross-Clade Gag-Specific T-Cell Responses in Individuals with Early HIV-1 Infection in the US Epidemic. Vaccine, 25(2):381-390, 4 Jan 2007. PubMed ID: 17112643. Show all entries for this paper.


Displaying record number 54540

HXB2 Location  Gag(313-323)   Gag Epitope Map
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Epitope VKNWMTETLLV   Epitope Alignment
Variants
VKNWMTdTLLV   subtype-specific susceptible form
Epitope Name VV11
Species (MHC/HLA human

Variant Details

Showing all: 1 variant(s).


Variant ID.  1027
Epitope Seq.  VKNWMTETLLV
Variant Seq.  VKNWMTdTLLV
Mutations E/D
Epitope Location E7D
HXB2 Location E319D
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype B
Variant Subtype C
Method CD8 T-cell Elispot - IFNy
Note Cross-recognition is seen only to the A-clade variant. The C-clade variant contains a semi-conservative change at position 7 to VKNWMTdTLLV.

References

Malhotra2007 Uma Malhotra, Jessica Nolin, James I. Mullins, and M. Juliana McElrath. Comprehensive Epitope Analysis of Cross-Clade Gag-Specific T-Cell Responses in Individuals with Early HIV-1 Infection in the US Epidemic. Vaccine, 25(2):381-390, 4 Jan 2007. PubMed ID: 17112643. Show all entries for this paper.


Displaying record number 54539

HXB2 Location  Gag(349-359)   Gag Epitope Map
View variants at this location
Epitope ACQGVGGPGHK   Epitope Alignment
Variants
ACQGVGGPsHK   subtype-specific non-susceptible form; subtype-specific susceptible form
Epitope Name AK11
Species (MHC/HLA human(A11)

Variant Details

Showing all: 1 variant(s).


Variant ID.  1028
Epitope Seq.  ACQGVGGPGHK
Variant Seq.  ACQGVGGPsHK
Mutations G/S
Epitope Location G9S
HXB2 Location G357S
Mutation Type SNSF: subtype-specific non-susceptible form
SSF: subtype-specific susceptible form
Epitope Subtype B
Variant Subtype C
Method CD8 T-cell Elispot - IFNy
Note Cross-recognition is seen only to the A-clade variant. The C-clade variant contains a semi-conservative change at position 9 to ACQGVGGPsHK.

References

Malhotra2007 Uma Malhotra, Jessica Nolin, James I. Mullins, and M. Juliana McElrath. Comprehensive Epitope Analysis of Cross-Clade Gag-Specific T-Cell Responses in Individuals with Early HIV-1 Infection in the US Epidemic. Vaccine, 25(2):381-390, 4 Jan 2007. PubMed ID: 17112643. Show all entries for this paper.


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