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Found 5 matching records:

Displaying record number 61945

HXB2 Location  Gag(124-132)   Gag Epitope Map
View variants at this location
Epitope NSSKVSQNY   Epitope Alignment
Variants
sSSKVSQNY   susceptible form
NSSqVSQNY   susceptible form
NSSqVSrNY   susceptible form
hSnqVSQNY   susceptible form
hSSqVSQNY   susceptible form
sSSqVSQNY   susceptible form
Species (MHC/HLA human(A*01:01)

Variant Details

Showing all: 6 variant(s).


Variant ID.  4148
Epitope Seq.  NSSKVSQNY
Variant Seq.  sSSKVSQNY
Mutations N/S
Epitope Location N1S
HXB2 Location N124S
Mutation Type SF: susceptible form
Epitope Subtype A, D
Variant Subtype A, D
Method CD8 T-cell Elispot - IFNy, Other, Tetramer binding
Note 2/5 female A*0101+ patients responded to this novel variant of NSSKVSQNY, sSSKVSQNY, with a mean of 115 SFU/million cells.


Variant ID.  4149
Epitope Seq.  NSSKVSQNY
Variant Seq.  NSSqVSQNY
Mutations K/Q
Epitope Location K4Q
HXB2 Location K127Q
Mutation Type SF: susceptible form
Epitope Subtype A, D
Variant Subtype A, D
Method CD8 T-cell Elispot - IFNy, Other, Tetramer binding
Note 4/5 female A*0101+ patients responded to this variant of NSSKVSQNY, NSSqVSQNY, with a mean of 96 SFU/million cells.


Variant ID.  4150
Epitope Seq.  NSSKVSQNY
Variant Seq.  NSSqVSrNY
Mutations K/Q Q/R
Epitope Location K4Q Q7R
HXB2 Location K127Q Q130R
Mutation Type SF: susceptible form
Epitope Subtype A, D
Variant Subtype A, D
Method CD8 T-cell Elispot - IFNy, Other, Tetramer binding
Note 3/5 female A*0101+ patients responded to this novel variant of NSSKVSQNY, NSSqVSrNY, with a mean of 127 SFU/million cells.


Variant ID.  4151
Epitope Seq.  NSSKVSQNY
Variant Seq.  hSnqVSQNY
Mutations N/H S/N K/Q
Epitope Location N1H S3N K4Q
HXB2 Location N124H S126N K127Q
Mutation Type SF: susceptible form
Epitope Subtype A, D
Variant Subtype A, D
Method CD8 T-cell Elispot - IFNy, Other, Tetramer binding
Note 4/5 female A*0101+ patients responded to this variant of NSSKVSQNY, hSnqVSQNY, with a mean of 115 SFU/million cells.


Variant ID.  4152
Epitope Seq.  NSSKVSQNY
Variant Seq.  hSSqVSQNY
Mutations N/H K/Q
Epitope Location N1H K4Q
HXB2 Location N124H K127Q
Mutation Type SF: susceptible form
Epitope Subtype A, D
Variant Subtype A, D
Method CD8 T-cell Elispot - IFNy, Other, Tetramer binding
Note 4/5 female A*0101+ patients responded to this novel variant of NSSKVSQNY, hSSqVSQNY, with a mean of 74 SFU/million cells.


Variant ID.  4153
Epitope Seq.  NSSKVSQNY
Variant Seq.  sSSqVSQNY
Mutations N/S K/Q
Epitope Location N1S K4Q
HXB2 Location N124S K127Q
Mutation Type SF: susceptible form
Epitope Subtype A, D
Variant Subtype A, D
Method CD8 T-cell Elispot - IFNy, Other, Tetramer binding
Note 4/5 female A*0101+ patients responded to this novel variant of NSSKVSQNY, sSSqVSQNY, with a mean of 130 SFU/million cells.

References

Luo2012 Ma Luo, Christina A. Daniuk, Tamsir O. Diallo, Rupert E. Capina, Joshua Kimani, Charles Wachihi, Makubo Kimani, Thomas Bielawny, Trevor Peterson, Mark G. R. Mendoza, Sandra Kiazyk, T. Blake Ball, and Francis A. Plummer. For Protection from HIV-1 Infection, More Might Not Be Better: A Systematic Analysis of HIV Gag Epitopes of Two Alleles Associated with Different Outcomes of HIV-1 Infection. J. Virol., 86(2):1166-1180, Jan 2012. PubMed ID: 22072744. Show all entries for this paper.


Displaying record number 61974

HXB2 Location  Gag(242-250)   Gag Epitope Map
View variants at this location
Epitope TPQEQIGWM   Epitope Alignment
Variants
TPQEQlGWM   non-susceptible form
Species (MHC/HLA human(B*07:02)

Variant Details

Showing all: 1 variant(s).


Variant ID.  4155
Epitope Seq.  TPQEQIGWM
Variant Seq.  TPQEQlGWM
Mutations I/L
Epitope Location I6L
HXB2 Location I247L
Mutation Type NSF: non-susceptible form
Epitope Subtype A, D
Variant Subtype A, D
Method Other, Tetramer binding
Note Variant TPQEQlGWM of epitope TPQEQIGWM was a novel epitope based on binding studies and iTope epitope discovery system. It did not bind any of the tested B*0702 subjects, though not all subjects were tested.

References

Luo2012 Ma Luo, Christina A. Daniuk, Tamsir O. Diallo, Rupert E. Capina, Joshua Kimani, Charles Wachihi, Makubo Kimani, Thomas Bielawny, Trevor Peterson, Mark G. R. Mendoza, Sandra Kiazyk, T. Blake Ball, and Francis A. Plummer. For Protection from HIV-1 Infection, More Might Not Be Better: A Systematic Analysis of HIV Gag Epitopes of Two Alleles Associated with Different Outcomes of HIV-1 Infection. J. Virol., 86(2):1166-1180, Jan 2012. PubMed ID: 22072744. Show all entries for this paper.


Displaying record number 61967

HXB2 Location  Gag(355-363)   Gag Epitope Map
View variants at this location
Epitope GPGHKARVL   Epitope Alignment
Variants
GPsHKARVL   susceptible form
Species (MHC/HLA human(B*07:02)

Variant Details

Showing all: 1 variant(s).


Variant ID.  4154
Epitope Seq.  GPGHKARVL
Variant Seq.  GPsHKARVL
Mutations G/S
Epitope Location G3S
HXB2 Location G357S
Mutation Type SF: susceptible form
Epitope Subtype A, D
Variant Subtype A, D
Method CD8 T-cell Elispot - IFNy, Other, Tetramer binding
Note 9/16 female B*0702+ patients responded to this previously known variant of GPGHKARVL, GPsHKARVL, with a mean of 84 SFU/million cells.

References

Luo2012 Ma Luo, Christina A. Daniuk, Tamsir O. Diallo, Rupert E. Capina, Joshua Kimani, Charles Wachihi, Makubo Kimani, Thomas Bielawny, Trevor Peterson, Mark G. R. Mendoza, Sandra Kiazyk, T. Blake Ball, and Francis A. Plummer. For Protection from HIV-1 Infection, More Might Not Be Better: A Systematic Analysis of HIV Gag Epitopes of Two Alleles Associated with Different Outcomes of HIV-1 Infection. J. Virol., 86(2):1166-1180, Jan 2012. PubMed ID: 22072744. Show all entries for this paper.


Displaying record number 61982

HXB2 Location  Gag(369-377)   Gag Epitope Map
View variants at this location
Epitope QVQHTNIMM   Epitope Alignment
Variants
QaQqpNVMM   susceptible form
QanantaIM   susceptible form
QVngntaiM   susceptible form
Species (MHC/HLA human(B*07:02)

Variant Details

Showing all: 3 variant(s).


Variant ID.  4156
Epitope Seq.  QVQHTNIMM
Variant Seq.  QaQqpNVMM
Mutations V/A H/Q T/P I/V
Epitope Location V2A H4Q T5P I7V
HXB2 Location V370A H372Q T373P I375V
Mutation Type SF: susceptible form
Epitope Subtype A, D
Variant Subtype A, D
Method CD8 T-cell Elispot - IFNy, Other, Tetramer binding
Note 5/8 female B*7202+ patients responded to this novel variant of QVQHTNIMM, QaQqpNVMM, with a mean of 96 SFU/million cells.


Variant ID.  4157
Epitope Seq.  QVQHTNIMM
Variant Seq.  QanantaIM
Mutations V/A Q/N H/A T/N N/T I/A M/I
Epitope Location V2A Q3N H4A T5N N6T I7A M8I
HXB2 Location V370A Q371N H372A T373N N374T I375A M376I
Mutation Type SF: susceptible form
Epitope Subtype A, D
Variant Subtype A, D
Method CD8 T-cell Elispot - IFNy, Other, Tetramer binding
Note 6/8 female B*7202+ patients responded to this novel variant of QVQHTNIMM, QanantaIM, with a mean of 109 SFU/million cells.


Variant ID.  4158
Epitope Seq.  QVQHTNIMM
Variant Seq.  QVngntaiM
Mutations Q/N H/G T/N N/T I/A M/I
Epitope Location Q3N H4G T5N N6T I7A M8I
HXB2 Location Q371N H372G T373N N374T I375A M376I
Mutation Type SF: susceptible form
Epitope Subtype A, D
Variant Subtype A, D
Method CD8 T-cell Elispot - IFNy, Other, Tetramer binding
Note 6/8 female B*7202+ patients responded to this novel variant of QVQHTNIMM, QVngntaiM, with a mean of 99 SFU/million cells.

References

Luo2012 Ma Luo, Christina A. Daniuk, Tamsir O. Diallo, Rupert E. Capina, Joshua Kimani, Charles Wachihi, Makubo Kimani, Thomas Bielawny, Trevor Peterson, Mark G. R. Mendoza, Sandra Kiazyk, T. Blake Ball, and Francis A. Plummer. For Protection from HIV-1 Infection, More Might Not Be Better: A Systematic Analysis of HIV Gag Epitopes of Two Alleles Associated with Different Outcomes of HIV-1 Infection. J. Virol., 86(2):1166-1180, Jan 2012. PubMed ID: 22072744. Show all entries for this paper.


Displaying record number 61983

HXB2 Location  Gag(375-383)   Gag Epitope Map
View variants at this location
Epitope NIMMQRGNF   Epitope Alignment
Variants
NIMMQRsNF   susceptible form
NvMMQRsNF   susceptible form
aIMMQRGNF   susceptible form
Species (MHC/HLA human(B*07:02)

Variant Details

Showing all: 3 variant(s).


Variant ID.  4159
Epitope Seq.  NIMMQRGNF
Variant Seq.  NIMMQRsNF
Mutations G/S
Epitope Location G7S
HXB2 Location G381S
Mutation Type SF: susceptible form
Epitope Subtype A, D
Variant Subtype A, D
Method CD8 T-cell Elispot - IFNy, Other, Tetramer binding
Note 6/8 female B*7202+ patients responded to this novel variant of NIMMQRGNF, NIMMQRsNF, with a mean of 121 SFU/million cells.


Variant ID.  4160
Epitope Seq.  NIMMQRGNF
Variant Seq.  NvMMQRsNF
Mutations I/V G/S
Epitope Location I2V G7S
HXB2 Location I376V G381S
Mutation Type SF: susceptible form
Epitope Subtype A, D
Variant Subtype A, D
Method CD8 T-cell Elispot - IFNy, Other, Tetramer binding
Note 6/8 female B*7202+ patients responded to this novel variant of NIMMQRGNF, NvMMQRsNF, with a mean of 117 SFU/million cells.


Variant ID.  4161
Epitope Seq.  NIMMQRGNF
Variant Seq.  aIMMQRGNF
Mutations N/A
Epitope Location N1A
HXB2 Location N375A
Mutation Type SF: susceptible form
Epitope Subtype A, D
Variant Subtype A, D
Method CD8 T-cell Elispot - IFNy, Other, Tetramer binding
Note 4/8 female B*7202+ patients responded to this novel variant of NIMMQRGNF, aIMMQRGNF, with a mean of 113 SFU/million cells.

References

Luo2012 Ma Luo, Christina A. Daniuk, Tamsir O. Diallo, Rupert E. Capina, Joshua Kimani, Charles Wachihi, Makubo Kimani, Thomas Bielawny, Trevor Peterson, Mark G. R. Mendoza, Sandra Kiazyk, T. Blake Ball, and Francis A. Plummer. For Protection from HIV-1 Infection, More Might Not Be Better: A Systematic Analysis of HIV Gag Epitopes of Two Alleles Associated with Different Outcomes of HIV-1 Infection. J. Virol., 86(2):1166-1180, Jan 2012. PubMed ID: 22072744. Show all entries for this paper.


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