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Found 10 matching records:

Displaying record number 58160

HXB2 Location  Gag(145-155)   Gag Epitope Map
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Epitope QAISPRTLNAW   Epitope Alignment
Variants
QAlSPRTLNAW   susceptible form
Epitope Name QW11
Species (MHC/HLA human(A*25:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  2747
Epitope Seq.  QAISPRTLNAW
Variant Seq.  QAlSPRTLNAW
Mutations I/L
Epitope Location I3L
HXB2 Location I147L
Mutation Type SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Longitudinal study
Note Major variant QAlSPRTLNAW replaced the wild type sequence by 800 days post-infection. It did not abrogate EliSpot response to the epitope.

References

Liu2011a Yi Liu, John P. McNevin, Sarah Holte, M. Juliana McElrath, and James I. Mullins. Dynamics of Viral Evolution and CTL Responses in HIV-1 Infection. PLoS One, 6(1):e15639, 2011. PubMed ID: 21283794. Show all entries for this paper.


Displaying record number 58151

HXB2 Location  Pol(283-290)   Pol Epitope Map
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Epitope TAFTIPSI   Epitope Alignment
Variants
TAFTIPSv   diminished response
TAFTIPSr   diminished response
TAFTIPSt   diminished response
Epitope Name TI8
Species (MHC/HLA human(B*51:01)

Variant Details

Showing all: 3 variant(s).


Variant ID.  2739
Epitope Seq.  TAFTIPSI
Variant Seq.  TAFTIPSv
Mutations I/V
Epitope Location I8V
HXB2 Location I290V
Mutation Type DR: diminished response
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Longitudinal study
Note Variants TAFTIPSv and TAFTIPSr replaced the wild type sequence by 400 days post-infection, while TAFTIPSt became the dominant variant by 800 days post-infection. Sequence changes were associated with decrease, but not loss of EliSpot response to the epitope.


Variant ID.  2740
Epitope Seq.  TAFTIPSI
Variant Seq.  TAFTIPSr
Mutations I/R
Epitope Location I8R
HXB2 Location I290R
Mutation Type DR: diminished response
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Longitudinal study
Note Variants TAFTIPSv and TAFTIPSr replaced the wild type sequence by 400 days post-infection, while TAFTIPSt became the dominant variant by 800 days post-infection. Sequence changes were associated with decrease, but not loss of EliSpot response to the epitope.


Variant ID.  2741
Epitope Seq.  TAFTIPSI
Variant Seq.  TAFTIPSt
Mutations I/T
Epitope Location I8T
HXB2 Location I290T
Mutation Type DR: diminished response
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Longitudinal study
Note Variants TAFTIPSv and TAFTIPSr replaced the wild type sequence by 400 days post-infection, while TAFTIPSt became the dominant variant by 800 days post-infection. Sequence changes were associated with decrease, but not loss of EliSpot response to the epitope.

References

Liu2011a Yi Liu, John P. McNevin, Sarah Holte, M. Juliana McElrath, and James I. Mullins. Dynamics of Viral Evolution and CTL Responses in HIV-1 Infection. PLoS One, 6(1):e15639, 2011. PubMed ID: 21283794. Show all entries for this paper.


Displaying record number 58148

HXB2 Location  Pol(291-299)   Pol Epitope Map
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Epitope NNETPGVRY   Epitope Alignment
Variants
NNEiPGVRY   diminished response
NNETPGiRY   diminished response
NNgTPGVRY   escape documented in this paper
Epitope Name NY9
Species (MHC/HLA human(B*18:01)

Variant Details

Showing all: 3 variant(s).


Variant ID.  2731
Epitope Seq.  NNETPGVRY
Variant Seq.  NNEiPGVRY
Mutations T/I
Epitope Location T4I
HXB2 Location T294I
Mutation Type DR: diminished response
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Longitudinal study
Note Variant NNEiPGVRY arose early in infection, and was later replaced by NNETPGiRY and NNgTPGVRY. Sequence changes were associated with loss of EliSpot response to the epitope.


Variant ID.  2732
Epitope Seq.  NNETPGVRY
Variant Seq.  NNETPGiRY
Mutations V/I
Epitope Location V7I
HXB2 Location V297I
Mutation Type DR: diminished response
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Longitudinal study
Note Variant NNEiPGVRY arose early in infection, and was later replaced by NNETPGiRY and NNgTPGVRY. Sequence changes were associated with loss of EliSpot response to the epitope.


Variant ID.  2733
Epitope Seq.  NNETPGVRY
Variant Seq.  NNgTPGVRY
Mutations E/G
Epitope Location E3G
HXB2 Location E293G
Mutation Type E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Longitudinal study
Note Variant NNEiPGVRY arose early in infection, and was later replaced by NNETPGiRY and NNgTPGVRY. Sequence changes were associated with loss of EliSpot response to the epitope.

References

Liu2011a Yi Liu, John P. McNevin, Sarah Holte, M. Juliana McElrath, and James I. Mullins. Dynamics of Viral Evolution and CTL Responses in HIV-1 Infection. PLoS One, 6(1):e15639, 2011. PubMed ID: 21283794. Show all entries for this paper.


Displaying record number 58147

HXB2 Location  Vpr(29-37)   Vpr Epitope Map
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Epitope EAVRHFPRI   Epitope Alignment
Variants
EAVRHFPRt   diminished response
EAVRHFPRl   escape documented in this paper
Epitope Name EI9
Species (MHC/HLA human(B*51:01)

Variant Details

Showing all: 2 variant(s).


Variant ID.  2729
Epitope Seq.  EAVRHFPRI
Variant Seq.  EAVRHFPRt
Mutations I/T
Epitope Location I9T
HXB2 Location I37T
Mutation Type DR: diminished response
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Longitudinal study
Note Variant EAVRHFPRt arose early in infection, then disappeared, while EAVRHFPRl dominated by 200 days post-infection. Sequence changes were associated with loss of EliSpot response to the epitope.


Variant ID.  2730
Epitope Seq.  EAVRHFPRI
Variant Seq.  EAVRHFPRl
Mutations I/L
Epitope Location I9L
HXB2 Location I37L
Mutation Type E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Longitudinal study
Note Variant EAVRHFPRt arose early in infection, then disappeared, while EAVRHFPRl dominated by 200 days post-infection. Sequence changes were associated with loss of EliSpot response to the epitope.

References

Liu2011a Yi Liu, John P. McNevin, Sarah Holte, M. Juliana McElrath, and James I. Mullins. Dynamics of Viral Evolution and CTL Responses in HIV-1 Infection. PLoS One, 6(1):e15639, 2011. PubMed ID: 21283794. Show all entries for this paper.


Displaying record number 58146

HXB2 Location  Tat(30-37)   Tat Epitope Map
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Epitope CCFHCQVC   Epitope Alignment
Variants
CCFHCQsC   escape documented in this paper
CClHCQVC   escape documented in this paper
Epitope Name CC8
Species (MHC/HLA human(C*12:03)

Variant Details

Showing all: 2 variant(s).


Variant ID.  2727
Epitope Seq.  CCFHCQVC
Variant Seq.  CCFHCQsC
Mutations V/S
Epitope Location V7S
HXB2 Location V36S
Mutation Type E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Longitudinal study
Note Variant CCFHCQsC arose early in infection, then disappeared, while CClHCQVC dominated by 200 days post-infection. Both variants were associated with loss of EliSpot response to the epitope.


Variant ID.  2728
Epitope Seq.  CCFHCQVC
Variant Seq.  CClHCQVC
Mutations F/L
Epitope Location F3L
HXB2 Location F32L
Mutation Type E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Longitudinal study
Note Variant CCFHCQsC arose early in infection, then disappeared, while CClHCQVC dominated by 200 days post-infection. Both variants were associated with loss of EliSpot response to the epitope.

References

Liu2011a Yi Liu, John P. McNevin, Sarah Holte, M. Juliana McElrath, and James I. Mullins. Dynamics of Viral Evolution and CTL Responses in HIV-1 Infection. PLoS One, 6(1):e15639, 2011. PubMed ID: 21283794. Show all entries for this paper.


Displaying record number 58157

HXB2 Location  gp160(31-39)   gp160 Epitope Map
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Epitope AENLWVTVY   Epitope Alignment
Variants
AdNLWVTVY   susceptible form
AEdsWVTVY   escape documented in this paper
Epitope Name AY9
Species (MHC/HLA human(B*18:01)

Variant Details

Showing all: 2 variant(s).


Variant ID.  2745
Epitope Seq.  AENLWVTVY
Variant Seq.  AdNLWVTVY
Mutations E/D
Epitope Location E2D
HXB2 Location E32D
Mutation Type SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Longitudinal study
Note Variant AdNLWVTVY arose by 400 days post-infection, and was replaced by AEdsWVTVY after 800 days post-infection. The latter variant was associated with loss of EliSpot response to the epitope.


Variant ID.  2746
Epitope Seq.  AENLWVTVY
Variant Seq.  AEdsWVTVY
Mutations N/D L/S
Epitope Location N3D L4S
HXB2 Location N33D L34S
Mutation Type E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Longitudinal study
Note Variant AdNLWVTVY arose by 400 days post-infection, and was replaced by AEdsWVTVY after 800 days post-infection. The latter variant was associated with loss of EliSpot response to the epitope.

References

Liu2011a Yi Liu, John P. McNevin, Sarah Holte, M. Juliana McElrath, and James I. Mullins. Dynamics of Viral Evolution and CTL Responses in HIV-1 Infection. PLoS One, 6(1):e15639, 2011. PubMed ID: 21283794. Show all entries for this paper.


Displaying record number 58149

HXB2 Location  gp160(61-69)   gp160 Epitope Map
View variants at this location
Epitope YETEVHNVW   Epitope Alignment
Variants
YgTEVHNVW   diminished response
YETEaHNVW   diminished response
YdTEVHNVW   diminished response
YdTEaHNVW   escape documented in this paper
Epitope Name YW9
Species (MHC/HLA human(B*18:01)

Variant Details

Showing all: 4 variant(s).


Variant ID.  2734
Epitope Seq.  YETEVHNVW
Variant Seq.  YgTEVHNVW
Mutations E/G
Epitope Location E2G
HXB2 Location E62G
Mutation Type DR: diminished response
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Longitudinal study
Note Variants YgTEVHNVW, YETEaHNVW, and YdTEVHNVW replaced the wild type sequence early in infection, while variant YdTEaHNVW dominated by 800 days post-infection. Sequence changes were associated with loss of EliSpot response to the epitope.


Variant ID.  2735
Epitope Seq.  YETEVHNVW
Variant Seq.  YETEaHNVW
Mutations V/A
Epitope Location V5A
HXB2 Location V65A
Mutation Type DR: diminished response
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Longitudinal study
Note Variants YgTEVHNVW, YETEaHNVW, and YdTEVHNVW replaced the wild type sequence early in infection, while variant YdTEaHNVW dominated by 800 days post-infection. Sequence changes were associated with loss of EliSpot response to the epitope.


Variant ID.  2736
Epitope Seq.  YETEVHNVW
Variant Seq.  YdTEVHNVW
Mutations E/D
Epitope Location E2D
HXB2 Location E62D
Mutation Type DR: diminished response
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Longitudinal study
Note Variants YgTEVHNVW, YETEaHNVW, and YdTEVHNVW replaced the wild type sequence early in infection, while variant YdTEaHNVW dominated by 800 days post-infection. Sequence changes were associated with loss of EliSpot response to the epitope.


Variant ID.  2737
Epitope Seq.  YETEVHNVW
Variant Seq.  YdTEaHNVW
Mutations E/D V/A
Epitope Location E2D V5A
HXB2 Location E62D V65A
Mutation Type E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Longitudinal study
Note Variants YgTEVHNVW, YETEaHNVW, and YdTEVHNVW replaced the wild type sequence early in infection, while variant YdTEaHNVW dominated by 800 days post-infection. Sequence changes were associated with loss of EliSpot response to the epitope.

References

Liu2011a Yi Liu, John P. McNevin, Sarah Holte, M. Juliana McElrath, and James I. Mullins. Dynamics of Viral Evolution and CTL Responses in HIV-1 Infection. PLoS One, 6(1):e15639, 2011. PubMed ID: 21283794. Show all entries for this paper.


Displaying record number 58153

HXB2 Location  gp160(88-96)   gp160 Epitope Map
View variants at this location
Epitope NVTENFNMW   Epitope Alignment
Variants
NVTEdFdMW   diminished response
NVTEeFdMW   diminished response
Epitope Name NW9
Species (MHC/HLA human(A*25:01)

Variant Details

Showing all: 2 variant(s).


Variant ID.  2743
Epitope Seq.  NVTENFNMW
Variant Seq.  NVTEdFdMW
Mutations N/D N/D
Epitope Location N5D N7D
HXB2 Location N92D N94D
Mutation Type DR: diminished response
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Longitudinal study
Note Variants NVTEdFdMW and NVTEeFdMW replaced the wild type sequence by 400 days post-infection. Sequence changes were associated with decrease in EliSpot response to the epitope.


Variant ID.  2744
Epitope Seq.  NVTENFNMW
Variant Seq.  NVTEeFdMW
Mutations N/E N/D
Epitope Location N5E N7D
HXB2 Location N92E N94D
Mutation Type DR: diminished response
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Longitudinal study
Note Variants NVTEdFdMW and NVTEeFdMW replaced the wild type sequence by 400 days post-infection. Sequence changes were associated with decrease in EliSpot response to the epitope.

References

Liu2011a Yi Liu, John P. McNevin, Sarah Holte, M. Juliana McElrath, and James I. Mullins. Dynamics of Viral Evolution and CTL Responses in HIV-1 Infection. PLoS One, 6(1):e15639, 2011. PubMed ID: 21283794. Show all entries for this paper.


Displaying record number 58152

HXB2 Location  gp160(217-226)   gp160 Epitope Map
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Epitope YCAPAGFAIL   Epitope Alignment
Variants
YCAPAGFAIi   escape documented in this paper
Epitope Name YL10
Species (MHC/HLA human(C*01:02)

Variant Details

Showing all: 1 variant(s).


Variant ID.  2742
Epitope Seq.  YCAPAGFAIL
Variant Seq.  YCAPAGFAIi
Mutations L/I
Epitope Location L10I
HXB2 Location L226I
Mutation Type E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Longitudinal study
Note Variant YCAPAGFAIi had replaced the wild type sequence by 400 days post-infection. Sequence change was associated with loss of EliSpot response to the epitope.

References

Liu2011a Yi Liu, John P. McNevin, Sarah Holte, M. Juliana McElrath, and James I. Mullins. Dynamics of Viral Evolution and CTL Responses in HIV-1 Infection. PLoS One, 6(1):e15639, 2011. PubMed ID: 21283794. Show all entries for this paper.


Displaying record number 58150

HXB2 Location  gp160(712-720)   gp160 Epitope Map
View variants at this location
Epitope YSPLSLQTL   Epitope Alignment
Variants
YSPLSLQTr   escape documented in this paper
Epitope Name YL9
Species (MHC/HLA human(C*01:02)

Variant Details

Showing all: 1 variant(s).


Variant ID.  2738
Epitope Seq.  YSPLSLQTL
Variant Seq.  YSPLSLQTr
Mutations L/R
Epitope Location L9R
HXB2 Location L720R
Mutation Type E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Longitudinal study
Note Variant YSPLSLQTr replaced the wild type sequence by 400 days post-infection. Sequence changes were associated with loss of EliSpot response to the epitope.

References

Liu2011a Yi Liu, John P. McNevin, Sarah Holte, M. Juliana McElrath, and James I. Mullins. Dynamics of Viral Evolution and CTL Responses in HIV-1 Infection. PLoS One, 6(1):e15639, 2011. PubMed ID: 21283794. Show all entries for this paper.


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