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Found 10 matching records:

Displaying record number 58160

HXB2 Location Gag(145-155) Gag Epitope Map
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Epitope

QAISPRTLNAW

Epitope Alignment

Variants

QAlSPRTLNAW susceptible form

Epitope Name QW11

Species (MHC/HLA) human(A*25:01)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`2747`
Epitope Seq.	`QAISPRTLNAW`
Variant Seq.	`QAlSPRTLNAW`
Mutations	I/L
Epitope Location	I3L
HXB2 Location	I147L
Mutation Type	SF: susceptible form
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study
Note	Major variant QAlSPRTLNAW replaced the wild type sequence by 800 days post-infection. It did not abrogate EliSpot response to the epitope.

References

Liu2011a Yi Liu, John P. McNevin, Sarah Holte, M. Juliana McElrath, and James I. Mullins. Dynamics of Viral Evolution and CTL Responses in HIV-1 Infection. PLoS One, 6(1):e15639, 2011. PubMed ID: 21283794. Show all entries for this paper.

Displaying record number 58151

HXB2 Location Pol(283-290) Pol Epitope Map
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Epitope

TAFTIPSI

Epitope Alignment

Variants

`TAFTIPSv`		diminished response
`TAFTIPSr`		diminished response
`TAFTIPSt`		diminished response

Epitope Name TI8

Species (MHC/HLA) human(B*51:01)

Variant Details

Showing all: 3 variant(s).

Variant ID.	`2739`
Epitope Seq.	`TAFTIPSI`
Variant Seq.	`TAFTIPSv`
Mutations	I/V
Epitope Location	I8V
HXB2 Location	I290V
Mutation Type	DR: diminished response
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study
Note	Variants TAFTIPSv and TAFTIPSr replaced the wild type sequence by 400 days post-infection, while TAFTIPSt became the dominant variant by 800 days post-infection. Sequence changes were associated with decrease, but not loss of EliSpot response to the epitope.

Variant ID.	`2740`
Epitope Seq.	`TAFTIPSI`
Variant Seq.	`TAFTIPSr`
Mutations	I/R
Epitope Location	I8R
HXB2 Location	I290R
Mutation Type	DR: diminished response
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study
Note	Variants TAFTIPSv and TAFTIPSr replaced the wild type sequence by 400 days post-infection, while TAFTIPSt became the dominant variant by 800 days post-infection. Sequence changes were associated with decrease, but not loss of EliSpot response to the epitope.

Variant ID.	`2741`
Epitope Seq.	`TAFTIPSI`
Variant Seq.	`TAFTIPSt`
Mutations	I/T
Epitope Location	I8T
HXB2 Location	I290T
Mutation Type	DR: diminished response
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study
Note	Variants TAFTIPSv and TAFTIPSr replaced the wild type sequence by 400 days post-infection, while TAFTIPSt became the dominant variant by 800 days post-infection. Sequence changes were associated with decrease, but not loss of EliSpot response to the epitope.

References

Displaying record number 58148

HXB2 Location Pol(291-299) Pol Epitope Map
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Epitope

NNETPGVRY

Epitope Alignment

Variants

`NNEiPGVRY`		diminished response
`NNETPGiRY`		diminished response
`NNgTPGVRY`		escape documented in this paper

Epitope Name NY9

Species (MHC/HLA) human(B*18:01)

Variant Details

Showing all: 3 variant(s).

Variant ID.	`2731`
Epitope Seq.	`NNETPGVRY`
Variant Seq.	`NNEiPGVRY`
Mutations	T/I
Epitope Location	T4I
HXB2 Location	T294I
Mutation Type	DR: diminished response
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study
Note	Variant NNEiPGVRY arose early in infection, and was later replaced by NNETPGiRY and NNgTPGVRY. Sequence changes were associated with loss of EliSpot response to the epitope.

Variant ID.	`2732`
Epitope Seq.	`NNETPGVRY`
Variant Seq.	`NNETPGiRY`
Mutations	V/I
Epitope Location	V7I
HXB2 Location	V297I
Mutation Type	DR: diminished response
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study
Note	Variant NNEiPGVRY arose early in infection, and was later replaced by NNETPGiRY and NNgTPGVRY. Sequence changes were associated with loss of EliSpot response to the epitope.

Variant ID.	`2733`
Epitope Seq.	`NNETPGVRY`
Variant Seq.	`NNgTPGVRY`
Mutations	E/G
Epitope Location	E3G
HXB2 Location	E293G
Mutation Type	E: escape documented in this paper
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study
Note	Variant NNEiPGVRY arose early in infection, and was later replaced by NNETPGiRY and NNgTPGVRY. Sequence changes were associated with loss of EliSpot response to the epitope.

References

Displaying record number 58147

HXB2 Location Vpr(29-37) Vpr Epitope Map
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Epitope

EAVRHFPRI

Epitope Alignment

Variants

`EAVRHFPRt`		diminished response
`EAVRHFPRl`		escape documented in this paper

Epitope Name EI9

Species (MHC/HLA) human(B*51:01)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`2729`
Epitope Seq.	`EAVRHFPRI`
Variant Seq.	`EAVRHFPRt`
Mutations	I/T
Epitope Location	I9T
HXB2 Location	I37T
Mutation Type	DR: diminished response
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study
Note	Variant EAVRHFPRt arose early in infection, then disappeared, while EAVRHFPRl dominated by 200 days post-infection. Sequence changes were associated with loss of EliSpot response to the epitope.

Variant ID.	`2730`
Epitope Seq.	`EAVRHFPRI`
Variant Seq.	`EAVRHFPRl`
Mutations	I/L
Epitope Location	I9L
HXB2 Location	I37L
Mutation Type	E: escape documented in this paper
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study
Note	Variant EAVRHFPRt arose early in infection, then disappeared, while EAVRHFPRl dominated by 200 days post-infection. Sequence changes were associated with loss of EliSpot response to the epitope.

References

Displaying record number 58146

HXB2 Location Tat(30-37) Tat Epitope Map
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Epitope

CCFHCQVC

Epitope Alignment

Variants

`CCFHCQsC`		escape documented in this paper
`CClHCQVC`		escape documented in this paper

Epitope Name CC8

Species (MHC/HLA) human(C*12:03)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`2727`
Epitope Seq.	`CCFHCQVC`
Variant Seq.	`CCFHCQsC`
Mutations	V/S
Epitope Location	V7S
HXB2 Location	V36S
Mutation Type	E: escape documented in this paper
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study
Note	Variant CCFHCQsC arose early in infection, then disappeared, while CClHCQVC dominated by 200 days post-infection. Both variants were associated with loss of EliSpot response to the epitope.

Variant ID.	`2728`
Epitope Seq.	`CCFHCQVC`
Variant Seq.	`CClHCQVC`
Mutations	F/L
Epitope Location	F3L
HXB2 Location	F32L
Mutation Type	E: escape documented in this paper
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study
Note	Variant CCFHCQsC arose early in infection, then disappeared, while CClHCQVC dominated by 200 days post-infection. Both variants were associated with loss of EliSpot response to the epitope.

References

Displaying record number 58157

HXB2 Location gp160(31-39) gp160 Epitope Map
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Epitope

AENLWVTVY

Epitope Alignment

Variants

`AdNLWVTVY`		susceptible form
`AEdsWVTVY`		escape documented in this paper

Epitope Name AY9

Species (MHC/HLA) human(B*18:01)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`2745`
Epitope Seq.	`AENLWVTVY`
Variant Seq.	`AdNLWVTVY`
Mutations	E/D
Epitope Location	E2D
HXB2 Location	E32D
Mutation Type	SF: susceptible form
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study
Note	Variant AdNLWVTVY arose by 400 days post-infection, and was replaced by AEdsWVTVY after 800 days post-infection. The latter variant was associated with loss of EliSpot response to the epitope.

Variant ID.	`2746`
Epitope Seq.	`AENLWVTVY`
Variant Seq.	`AEdsWVTVY`
Mutations	N/D L/S
Epitope Location	N3D L4S
HXB2 Location	N33D L34S
Mutation Type	E: escape documented in this paper
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study
Note	Variant AdNLWVTVY arose by 400 days post-infection, and was replaced by AEdsWVTVY after 800 days post-infection. The latter variant was associated with loss of EliSpot response to the epitope.

References

Displaying record number 58149

HXB2 Location gp160(61-69) gp160 Epitope Map
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Epitope

YETEVHNVW

Epitope Alignment

Variants

`YgTEVHNVW`		diminished response
`YETEaHNVW`		diminished response
`YdTEVHNVW`		diminished response
`YdTEaHNVW`		escape documented in this paper

Epitope Name YW9

Species (MHC/HLA) human(B*18:01)

Variant Details

Showing all: 4 variant(s).

Variant ID.	`2734`
Epitope Seq.	`YETEVHNVW`
Variant Seq.	`YgTEVHNVW`
Mutations	E/G
Epitope Location	E2G
HXB2 Location	E62G
Mutation Type	DR: diminished response
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study
Note	Variants YgTEVHNVW, YETEaHNVW, and YdTEVHNVW replaced the wild type sequence early in infection, while variant YdTEaHNVW dominated by 800 days post-infection. Sequence changes were associated with loss of EliSpot response to the epitope.

Variant ID.	`2735`
Epitope Seq.	`YETEVHNVW`
Variant Seq.	`YETEaHNVW`
Mutations	V/A
Epitope Location	V5A
HXB2 Location	V65A
Mutation Type	DR: diminished response
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study
Note	Variants YgTEVHNVW, YETEaHNVW, and YdTEVHNVW replaced the wild type sequence early in infection, while variant YdTEaHNVW dominated by 800 days post-infection. Sequence changes were associated with loss of EliSpot response to the epitope.

Variant ID.	`2736`
Epitope Seq.	`YETEVHNVW`
Variant Seq.	`YdTEVHNVW`
Mutations	E/D
Epitope Location	E2D
HXB2 Location	E62D
Mutation Type	DR: diminished response
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study
Note	Variants YgTEVHNVW, YETEaHNVW, and YdTEVHNVW replaced the wild type sequence early in infection, while variant YdTEaHNVW dominated by 800 days post-infection. Sequence changes were associated with loss of EliSpot response to the epitope.

Variant ID.	`2737`
Epitope Seq.	`YETEVHNVW`
Variant Seq.	`YdTEaHNVW`
Mutations	E/D V/A
Epitope Location	E2D V5A
HXB2 Location	E62D V65A
Mutation Type	E: escape documented in this paper
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study
Note	Variants YgTEVHNVW, YETEaHNVW, and YdTEVHNVW replaced the wild type sequence early in infection, while variant YdTEaHNVW dominated by 800 days post-infection. Sequence changes were associated with loss of EliSpot response to the epitope.

References

Displaying record number 58153

HXB2 Location gp160(88-96) gp160 Epitope Map
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Epitope

NVTENFNMW

Epitope Alignment

Variants

`NVTEdFdMW`		diminished response
`NVTEeFdMW`		diminished response

Epitope Name NW9

Species (MHC/HLA) human(A*25:01)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`2743`
Epitope Seq.	`NVTENFNMW`
Variant Seq.	`NVTEdFdMW`
Mutations	N/D N/D
Epitope Location	N5D N7D
HXB2 Location	N92D N94D
Mutation Type	DR: diminished response
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study
Note	Variants NVTEdFdMW and NVTEeFdMW replaced the wild type sequence by 400 days post-infection. Sequence changes were associated with decrease in EliSpot response to the epitope.

Variant ID.	`2744`
Epitope Seq.	`NVTENFNMW`
Variant Seq.	`NVTEeFdMW`
Mutations	N/E N/D
Epitope Location	N5E N7D
HXB2 Location	N92E N94D
Mutation Type	DR: diminished response
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study
Note	Variants NVTEdFdMW and NVTEeFdMW replaced the wild type sequence by 400 days post-infection. Sequence changes were associated with decrease in EliSpot response to the epitope.

References

Displaying record number 58152

HXB2 Location gp160(217-226) gp160 Epitope Map
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Epitope

YCAPAGFAIL

Epitope Alignment

Variants

YCAPAGFAIi escape documented in this paper

Epitope Name YL10

Species (MHC/HLA) human(C*01:02)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`2742`
Epitope Seq.	`YCAPAGFAIL`
Variant Seq.	`YCAPAGFAIi`
Mutations	L/I
Epitope Location	L10I
HXB2 Location	L226I
Mutation Type	E: escape documented in this paper
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study
Note	Variant YCAPAGFAIi had replaced the wild type sequence by 400 days post-infection. Sequence change was associated with loss of EliSpot response to the epitope.

References

Displaying record number 58150

HXB2 Location gp160(712-720) gp160 Epitope Map
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Epitope

YSPLSLQTL

Epitope Alignment

Variants

YSPLSLQTr escape documented in this paper

Epitope Name YL9

Species (MHC/HLA) human(C*01:02)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`2738`
Epitope Seq.	`YSPLSLQTL`
Variant Seq.	`YSPLSLQTr`
Mutations	L/R
Epitope Location	L9R
HXB2 Location	L720R
Mutation Type	E: escape documented in this paper
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study
Note	Variant YSPLSLQTr replaced the wild type sequence by 400 days post-infection. Sequence changes were associated with loss of EliSpot response to the epitope.