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Found 4 matching records:

Displaying record number 53776

HXB2 Location  Gag(162-172)   Gag Epitope Map
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Epitope KAFSPEVIPMF   Epitope Alignment
Variants
KgFSPEVIPMF   HLA association; escape documented in this paper; non-susceptible form
KnFSPEVIPMF   HLA association; escape documented in this paper; non-susceptible form
KgFnPEVIPMF   HLA association; escape documented in this paper; non-susceptible form
KgFkPEVIPMF   HLA association; diminished HLA binding or increased off-rate; escape documented in this paper; non-susceptible form
KsFSPEtIPMF   observed variant
KAFSPEiIPMF   observed variant
KAFnPEVIPMF   observed variant
Epitope Name KF11
Species (MHC/HLA human(B*57)

Variant Details

Showing all: 7 variant(s).


Variant ID.  913
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KgFSPEVIPMF
Mutations A/G
Epitope Location A2G
HXB2 Location A163G
Mutation Type A: HLA association
E: escape documented in this paper
NSF: non-susceptible form
Method CD8 T-cell Elispot - IFNy, Sequence
Note Mutation A163G is suggested to be a result of selection pressure from the HLA-B*57 allele, and can be transmitted and stable in the absence of HLA-B*57. Experimental evidence indicated that the mechanism of escape was an increased off-rate; CTL recognition of KgFSPEVIPMF was ablated. 3% of HLA-B*57-positive subjects, 2% of HLA-B*5801-positive subjects carried this variant.


Variant ID.  3067
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KnFSPEVIPMF
Mutations A/N
Epitope Location A2N
HXB2 Location A163N
Mutation Type A: HLA association
E: escape documented in this paper
NSF: non-susceptible form
Method CD8 T-cell Elispot - IFNy, Sequence
Note Variant KnFSPEVIPMF (A163N) did not elicit response in EliSpot assays. 8% of HLA-B*57-positive subjects, 2% of HLA-B*5801-positive subjects, and 1% of HLA-B&57/5801-negative subjects carried this variant.


Variant ID.  3068
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KgFnPEVIPMF
Mutations A/G S/N
Epitope Location A2G S4N
HXB2 Location A163G S165N
Mutation Type A: HLA association
E: escape documented in this paper
NSF: non-susceptible form
Method CD8 T-cell Elispot - IFNy, Sequence
Note For mutation A163G, S165N CTL recognition of KgFnPEVIPMF was ablated. 14% of HLA-B*57-positive subjects, 6% of HLA-B*5801-positive subjects, and 5% of HLA-B*57/5801-negative subjects carried this variant.


Variant ID.  3069
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KgFkPEVIPMF
Mutations A/G S/K
Epitope Location A2G S4K
HXB2 Location A163G S165K
Mutation Type A: HLA association
DHB: diminished HLA binding or increased off-rate
E: escape documented in this paper
NSF: non-susceptible form
Method CD8 T-cell Elispot - IFNy, Sequence
Note For mutation A163G, S165K CTL recognition of KgFkPEVIPMF was ablated. 8% of HLA-B*57-positive subjects carried this variant.


Variant ID.  3070
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KsFSPEtIPMF
Mutations A/S V/T
Epitope Location A2S V7T
HXB2 Location A163S V168T
Mutation Type OV: observed variant
Method Sequence
Note Variant KsFSPEtIPMF (A163S, S168T) was found in 3% of HLA-B*57-positive subjects.


Variant ID.  3071
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KAFSPEiIPMF
Mutations V/I
Epitope Location V7I
HXB2 Location V168I
Mutation Type OV: observed variant
Method Sequence
Note Variant KAFSPEiIPMF (V168I) was found in 4% of HLA-B*57-positive, and 7% of HLA-B*57/5802-negative subjects.


Variant ID.  3072
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KAFnPEVIPMF
Mutations S/N
Epitope Location S4N
HXB2 Location S165N
Mutation Type OV: observed variant
Method Sequence
Note Mutation S165N was found in 7% of HLA-B*57/5801-negative subjects.

References

Leslie2005a Alasdair Leslie, Daniel Kavanagh, Isobella Honeyborne, Katja Pfafferott, Charles Edwards, Tilly Pillay, Louise Hilton, Christina Thobakgale, Danni Ramduth, Rika Draenert, Sylvie Le Gall, Graz Luzzi, Anne Edwards, Christian Brander, Andrew K. Sewell, Sarah Moore, James Mullins, Corey Moore, Simon Mallal, Nina Bhardwaj, Karina Yusim, Rodney Phillips, Paul Klenerman, Bette Korber, Photini Kiepiela, Bruce Walker, and Philip Goulder. Transmission and Accumulation of CTL Escape Variants Drive Negative Associations between HIV Polymorphisms and HLA. J. Exp. Med., 201(6):891-902, 21 Mar 2005. PubMed ID: 15781581. Show all entries for this paper.


Displaying record number 53777

HXB2 Location  Pol(743-751)   Pol Epitope Map
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Epitope LPPIVAKEI   Epitope Alignment
Variants
LPPvVAKEI   HLA association; observed variant
Epitope Name LI9
Species (MHC/HLA human(B51)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3073
Epitope Seq.  LPPIVAKEI
Variant Seq.  LPPvVAKEI
Mutations I/V
Epitope Location I4V
HXB2 Location I746V
Mutation Type A: HLA association
OV: observed variant
Epitope Subtype B, C
Variant Subtype B, C
Method Sequence
Note Variant LPPvVAKEI (I31V) is found in both clades B and C. For Clade C, the consensus 31I form is present in 68% B*51- subjects, but the variant 31V form is present in all 6/6 B*51+ subjects. The 31V form is stably transmitted from B*51+ donors to B*51- recipients. In B-clade, where HLA-B*51 is not rare (as in C-clade, South Africa), the 31V form has become the consensus.

References

Leslie2005a Alasdair Leslie, Daniel Kavanagh, Isobella Honeyborne, Katja Pfafferott, Charles Edwards, Tilly Pillay, Louise Hilton, Christina Thobakgale, Danni Ramduth, Rika Draenert, Sylvie Le Gall, Graz Luzzi, Anne Edwards, Christian Brander, Andrew K. Sewell, Sarah Moore, James Mullins, Corey Moore, Simon Mallal, Nina Bhardwaj, Karina Yusim, Rodney Phillips, Paul Klenerman, Bette Korber, Photini Kiepiela, Bruce Walker, and Philip Goulder. Transmission and Accumulation of CTL Escape Variants Drive Negative Associations between HIV Polymorphisms and HLA. J. Exp. Med., 201(6):891-902, 21 Mar 2005. PubMed ID: 15781581. Show all entries for this paper.


Displaying record number 53775

HXB2 Location  Nef(82-90)   Nef Epitope Map
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Epitope KAAVDLSHF   Epitope Alignment
Variants
KgAVDLSHF   diminished HLA binding or increased off-rate; escape documented in this paper; susceptible form
Epitope Name KF9
Species (MHC/HLA human(B*57, B*58:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  915
Epitope Seq.  KAAVDLSHF
Variant Seq.  KgAVDLSHF
Mutations A/G
Epitope Location A2G
HXB2 Location A83G
Mutation Type DHB: diminished HLA binding or increased off-rate
E: escape documented in this paper
SF: susceptible form
Variant Subtype B
Note This variant form of the epitope was shown to be an escape variant by virtue of an increased off-rate; however Elispot reactions to both variant and wt are positive. The escape form was shown to be transmitted, and the most common form of the epitope in a B clade infected population in Perth, Australia (52%), though the proportion of HLA-B*57/5801+ population carrying the escape form was 86%.

References

Leslie2005a Alasdair Leslie, Daniel Kavanagh, Isobella Honeyborne, Katja Pfafferott, Charles Edwards, Tilly Pillay, Louise Hilton, Christina Thobakgale, Danni Ramduth, Rika Draenert, Sylvie Le Gall, Graz Luzzi, Anne Edwards, Christian Brander, Andrew K. Sewell, Sarah Moore, James Mullins, Corey Moore, Simon Mallal, Nina Bhardwaj, Karina Yusim, Rodney Phillips, Paul Klenerman, Bette Korber, Photini Kiepiela, Bruce Walker, and Philip Goulder. Transmission and Accumulation of CTL Escape Variants Drive Negative Associations between HIV Polymorphisms and HLA. J. Exp. Med., 201(6):891-902, 21 Mar 2005. PubMed ID: 15781581. Show all entries for this paper.


Displaying record number 58635

HXB2 Location  Nef(82-90)   Nef Epitope Map
View variants at this location
Epitope KAAFDLSFF   Epitope Alignment
Variants
KgAFDLSFF   HLA association; diminished HLA binding or increased off-rate; diminished response; escape documented in this paper
KgAFgLSFF   HLA association; observed variant
KAAFgLSFF   observed variant
KgAvDLSFF   observed variant; susceptible form
Epitope Name KF9
Species (MHC/HLA human(B*57, B*58:01)

Variant Details

Showing all: 4 variant(s).


Variant ID.  3062
Epitope Seq.  KAAFDLSFF
Variant Seq.  KgAFDLSFF
Mutations A/G
Epitope Location A2G
HXB2 Location A83G
Mutation Type A: HLA association
DHB: diminished HLA binding or increased off-rate
DR: diminished response
E: escape documented in this paper
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, HLA binding, Sequence
Note The KgAFDLSFF (A83G) form of the epitope was shown to be an escape mutation by virtue of increased off-rate; and diminished CTL recognition in 3 patients, but ablated recognition by ex-vivo EliSpot. Consensus KF9 in a B*57/5801 negative mother quickly mutates to the variant A83G form when transmitted to B*57/5801 positive infants. This variant form was transmitted and persisted from mother to infant in B*57/5801 positive and B*57/5801 negative pairs.


Variant ID.  3064
Epitope Seq.  KAAFDLSFF
Variant Seq.  KgAFgLSFF
Mutations A/G D/G
Epitope Location A2G D5G
HXB2 Location A83G D86G
Mutation Type A: HLA association
OV: observed variant
Epitope Subtype C
Variant Subtype C
Method Sequence
Note The KgAFgLSFF (A83G, D86G) form of the epitope was a variant found in an HLA-B*57/5801 positive child, S30. This variant was found at 9 months postpartum and was transmitted initially from its HLA-B*57/5801 negative KAAFgLSFF (D86G)-carrying mother, S30.


Variant ID.  3065
Epitope Seq.  KAAFDLSFF
Variant Seq.  KAAFgLSFF
Mutations D/G
Epitope Location D5G
HXB2 Location D86G
Mutation Type OV: observed variant
Epitope Subtype C
Variant Subtype C
Method Sequence
Note The KAAFgLSFF (D86G) form of the epitope was a variant found in an HLA-B*57/5801 negative mother, S30 from 6-weeks up to 9 months postpartum.


Variant ID.  3066
Epitope Seq.  KAAFDLSFF
Variant Seq.  KgAvDLSFF
Mutations A/G F/V
Epitope Location A2G F4V
HXB2 Location A83G F85V
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype C
Variant Subtype C
Method Sequence
Note Variant KgAvDLSFF was found in a mother child pair, both of whom were HLA-B*57/5801 negative. It persisted in the child up to 2 years postpartum.

References

Leslie2005a Alasdair Leslie, Daniel Kavanagh, Isobella Honeyborne, Katja Pfafferott, Charles Edwards, Tilly Pillay, Louise Hilton, Christina Thobakgale, Danni Ramduth, Rika Draenert, Sylvie Le Gall, Graz Luzzi, Anne Edwards, Christian Brander, Andrew K. Sewell, Sarah Moore, James Mullins, Corey Moore, Simon Mallal, Nina Bhardwaj, Karina Yusim, Rodney Phillips, Paul Klenerman, Bette Korber, Photini Kiepiela, Bruce Walker, and Philip Goulder. Transmission and Accumulation of CTL Escape Variants Drive Negative Associations between HIV Polymorphisms and HLA. J. Exp. Med., 201(6):891-902, 21 Mar 2005. PubMed ID: 15781581. Show all entries for this paper.


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