HIV molecular immunology database
Found 6 matching records:
HXB2 Location | Gag(77-85) | Gag Epitope Map
View variants at this location |
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Epitope |
SLYNTVATL
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Epitope Alignment | ||||||||||||||||
Variants |
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Epitope Name | SL9 | |||||||||||||||||
Species (MHC/HLA) | human(A*02) |
Showing all: 5 variant(s).
Variant ID. | 2705 |
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Epitope Seq. | SLYNTVATL |
Variant Seq. | SLYNTVAvL |
Mutations | T/V |
Epitope Location | T8V |
HXB2 Location | T84V |
Mutation Type | A: HLA association P: processing |
Epitope Subtype | B |
Variant Subtype | B |
Note | A2-SL9 has known HLA-associated mutants (T8V, Y3F, V6I, V6I/T8V, Y3F/V6I). All 5 mutants displayed severely reduced half-lives. |
Variant ID. | 2706 |
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Epitope Seq. | SLYNTVATL |
Variant Seq. | SLfNTVATL |
Mutations | Y/F |
Epitope Location | Y3F |
HXB2 Location | Y79F |
Mutation Type | A: HLA association P: processing |
Epitope Subtype | B |
Variant Subtype | B |
Note | A2-SL9 has known HLA-associated mutants (T8V, Y3F, V6I, V6I/T8V, Y3F/V6I). All 5 mutants displayed severely reduced half-lives. |
Variant ID. | 2707 |
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Epitope Seq. | SLYNTVATL |
Variant Seq. | SLYNTiATL |
Mutations | V/I |
Epitope Location | V6I |
HXB2 Location | V82I |
Mutation Type | A: HLA association P: processing |
Epitope Subtype | B |
Variant Subtype | B |
Note | A2-SL9 has known HLA-associated mutants (T8V, Y3F, V6I, V6I/T8V, Y3F/V6I). All 5 mutants displayed severely reduced half-lives. |
Variant ID. | 2708 |
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Epitope Seq. | SLYNTVATL |
Variant Seq. | SLYNTiAvL |
Mutations | V/I T/V |
Epitope Location | V6I T8V |
HXB2 Location | V82I T84V |
Mutation Type | A: HLA association P: processing |
Epitope Subtype | B |
Variant Subtype | B |
Note | A2-SL9 has known HLA-associated mutants (T8V, Y3F, V6I, V6I/T8V, Y3F/V6I). All 5 mutants displayed severely reduced half-lives. |
Variant ID. | 2709 |
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Epitope Seq. | SLYNTVATL |
Variant Seq. | SLfNTiATL |
Mutations | Y/F V/I |
Epitope Location | Y3F V6I |
HXB2 Location | Y79F V82I |
Mutation Type | A: HLA association P: processing |
Epitope Subtype | B |
Variant Subtype | B |
Note | A2-SL9 has known HLA-associated mutants (T8V, Y3F, V6I, V6I/T8V, Y3F/V6I). All 5 mutants displayed severely reduced half-lives. |
Lazaro2011 Estibaliz Lazaro, Carl Kadie, Pamela Stamegna, Shao Chong Zhang, Pauline Gourdain, Nicole Y. Lai, Mei Zhang, Sergio A. Martinez, David Heckerman, and Sylvie Le Gall. Variable HIV Peptide Stability in Human Cytosol Is Critical to Epitope Presentation and Immune Escape. J. Clin. Invest., 121(6):2480-2492, Jun 2011. PubMed ID: 21555856. Show all entries for this paper.
HXB2 Location | Gag(240-249) | Gag Epitope Map
View variants at this location |
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Epitope |
TSTLQEQIGW
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Epitope Alignment | ||||||||||||||||
Variants |
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Epitope Name | TW10 | |||||||||||||||||
Species (MHC/HLA) | human(B*57) |
Showing all: 5 variant(s).
Variant ID. | 2696 |
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Epitope Seq. | TSTLQEQIGW |
Variant Seq. | TSnLQEQIGW |
Mutations | T/N |
Epitope Location | T3N |
HXB2 Location | T242N |
Mutation Type | LE: literature escape P: processing |
Epitope Subtype | B |
Variant Subtype | B |
Note | B57-TW10 was selected for analysis based on having known early mutants (T3N and T3N-G9A or T3N-G9D) that were predicted to have reduced intracellular stability. Mutant T3N was stable, while T3N-G9A or T3N-G9D severely reduced half-life. Single mutants G9A and G9D also displayed decreased half-lives. |
Variant ID. | 2697 |
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Epitope Seq. | TSTLQEQIGW |
Variant Seq. | TSnLQEQIaW |
Mutations | T/N G/A |
Epitope Location | T3N G9A |
HXB2 Location | T242N G248A |
Mutation Type | LE: literature escape P: processing |
Epitope Subtype | B |
Variant Subtype | B |
Note | B57-TW10 was selected for analysis based on having known early mutants (T3N and T3N-G9A or T3N-G9D) that were predicted to have reduced intracellular stability. Mutant T3N was stable, while T3N-G9A or T3N-G9D severely reduced half-life. Single mutants G9A and G9D also displayed decreased half-lives. |
Variant ID. | 2698 |
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Epitope Seq. | TSTLQEQIGW |
Variant Seq. | TSnLQEQIdW |
Mutations | T/N G/D |
Epitope Location | T3N G9D |
HXB2 Location | T242N G248D |
Mutation Type | LE: literature escape P: processing |
Epitope Subtype | B |
Variant Subtype | B |
Note | B57-TW10 was selected for analysis based on having known early mutants (T3N and T3N-G9A or T3N-G9D) that were predicted to have reduced intracellular stability. Mutant T3N was stable, while T3N-G9A or T3N-G9D severely reduced half-life. Single mutants G9A and G9D also displayed decreased half-lives. |
Variant ID. | 2699 |
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Epitope Seq. | TSTLQEQIGW |
Variant Seq. | TSTLQEQIaW |
Mutations | G/A |
Epitope Location | G9A |
HXB2 Location | G248A |
Mutation Type | A: HLA association P: processing |
Epitope Subtype | B |
Variant Subtype | B |
Note | B57-TW10 was selected for analysis based on having known early mutants (T3N and T3N-G9A or T3N-G9D) that were predicted to have reduced intracellular stability. Mutant T3N was stable, while T3N-G9A or T3N-G9D severely reduced half-life. Single mutants G9A and G9D also displayed decreased half-lives. |
Variant ID. | 2700 |
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Epitope Seq. | TSTLQEQIGW |
Variant Seq. | TSTLQEQIdW |
Mutations | G/D |
Epitope Location | G9D |
HXB2 Location | G248D |
Mutation Type | A: HLA association P: processing |
Epitope Subtype | B |
Variant Subtype | B |
Note | B57-TW10 was selected for analysis based on having known early mutants (T3N and T3N-G9A or T3N-G9D) that were predicted to have reduced intracellular stability. Mutant T3N was stable, while T3N-G9A or T3N-G9D severely reduced half-life. Single mutants G9A and G9D also displayed decreased half-lives. |
Lazaro2011 Estibaliz Lazaro, Carl Kadie, Pamela Stamegna, Shao Chong Zhang, Pauline Gourdain, Nicole Y. Lai, Mei Zhang, Sergio A. Martinez, David Heckerman, and Sylvie Le Gall. Variable HIV Peptide Stability in Human Cytosol Is Critical to Epitope Presentation and Immune Escape. J. Clin. Invest., 121(6):2480-2492, Jun 2011. PubMed ID: 21555856. Show all entries for this paper.
HXB2 Location | Gag(263-272) | Gag Epitope Map
View variants at this location |
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Epitope |
KRWIILGLNK
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Epitope Alignment | |||||||||||||
Variants |
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Epitope Name | KK10 | ||||||||||||||
Species (MHC/HLA) | human(B*27) |
Showing all: 4 variant(s).
Variant ID. | 2701 |
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Epitope Seq. | KRWIILGLNK |
Variant Seq. | KgWIILGLNK |
Mutations | R/G |
Epitope Location | R2G |
HXB2 Location | R264G |
Mutation Type | A: HLA association P: processing |
Epitope Subtype | B |
Variant Subtype | B |
Note | B27-KK10 has known HLA-associated mutants (R2G, R2K/L6M, L6M, R2K/L6M/N8H). All 4 mutants displayed severely reduced half-lives. |
Variant ID. | 2702 |
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Epitope Seq. | KRWIILGLNK |
Variant Seq. | KkWIImGLNK |
Mutations | R/K L/M |
Epitope Location | R2K L6M |
HXB2 Location | R264K L268M |
Mutation Type | A: HLA association P: processing |
Epitope Subtype | B |
Variant Subtype | B |
Note | B27-KK10 has known HLA-associated mutants (R2G, R2K/L6M, L6M, R2K/L6M/N8H). All 4 mutants displayed severely reduced half-lives. |
Variant ID. | 2703 |
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Epitope Seq. | KRWIILGLNK |
Variant Seq. | KRWIImGLNK |
Mutations | L/M |
Epitope Location | L6M |
HXB2 Location | L268M |
Mutation Type | A: HLA association P: processing |
Epitope Subtype | B |
Variant Subtype | B |
Note | B27-KK10 has known HLA-associated mutants (R2G, R2K/L6M, L6M, R2K/L6M/N8H). All 4 mutants displayed severely reduced half-lives. |
Variant ID. | 2704 |
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Epitope Seq. | KRWIILGLNK |
Variant Seq. | KkWIImGLhK |
Mutations | R/K L/M N/H |
Epitope Location | R2K L6M N9H |
HXB2 Location | R264K L268M N271H |
Mutation Type | A: HLA association P: processing |
Epitope Subtype | B |
Variant Subtype | B |
Note | B27-KK10 has known HLA-associated mutants (R2G, R2K/L6M, L6M, R2K/L6M/N8H). All 4 mutants displayed severely reduced half-lives. |
Lazaro2011 Estibaliz Lazaro, Carl Kadie, Pamela Stamegna, Shao Chong Zhang, Pauline Gourdain, Nicole Y. Lai, Mei Zhang, Sergio A. Martinez, David Heckerman, and Sylvie Le Gall. Variable HIV Peptide Stability in Human Cytosol Is Critical to Epitope Presentation and Immune Escape. J. Clin. Invest., 121(6):2480-2492, Jun 2011. PubMed ID: 21555856. Show all entries for this paper.
HXB2 Location | Vpr(29-37) | Vpr Epitope Map
View variants at this location |
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Epitope |
EAVRHFPRI
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Epitope Alignment | |||||||
Variants |
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Epitope Name | EI9 | ||||||||
Species (MHC/HLA) | human(B*51) |
Showing all: 2 variant(s).
Variant ID. | 2711 |
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Epitope Seq. | EAVRHFPRI |
Variant Seq. | EAVRHFPRt |
Mutations | I/T |
Epitope Location | I9T |
HXB2 Location | I37T |
Mutation Type | A: HLA association P: processing |
Epitope Subtype | B |
Variant Subtype | B |
Note | B51-EI9 has known HLA-associated mutants (I9T, I9A). Both mutants displayed severely reduced half-lives. |
Variant ID. | 2712 |
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Epitope Seq. | EAVRHFPRI |
Variant Seq. | EAVRHFPRa |
Mutations | I/A |
Epitope Location | I9A |
HXB2 Location | I37A |
Mutation Type | A: HLA association P: processing |
Epitope Subtype | B |
Variant Subtype | B |
Note | B51-EI9 has known HLA-associated mutants (I9T, I9A). Both mutants displayed severely reduced half-lives. |
Lazaro2011 Estibaliz Lazaro, Carl Kadie, Pamela Stamegna, Shao Chong Zhang, Pauline Gourdain, Nicole Y. Lai, Mei Zhang, Sergio A. Martinez, David Heckerman, and Sylvie Le Gall. Variable HIV Peptide Stability in Human Cytosol Is Critical to Epitope Presentation and Immune Escape. J. Clin. Invest., 121(6):2480-2492, Jun 2011. PubMed ID: 21555856. Show all entries for this paper.
HXB2 Location | Vpr(59-67) | Vpr Epitope Map
View variants at this location |
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Epitope |
AIIRILQQL
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Epitope Alignment | ||||
Variants |
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Epitope Name | AL9 | |||||
Species (MHC/HLA) | human(A*02) |
Showing all: 1 variant(s).
Variant ID. | 2710 |
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Epitope Seq. | AIIRILQQL |
Variant Seq. | AIIRtLQQL |
Mutations | I/T |
Epitope Location | I5T |
HXB2 Location | I63T |
Mutation Type | A: HLA association P: processing |
Epitope Subtype | B |
Variant Subtype | B |
Note | A2-AL9 has a known HLA-associated mutant (I5T). The wild type epitope displayed a moderate half-life, and the mutant displayed a reduced half-life. |
Lazaro2011 Estibaliz Lazaro, Carl Kadie, Pamela Stamegna, Shao Chong Zhang, Pauline Gourdain, Nicole Y. Lai, Mei Zhang, Sergio A. Martinez, David Heckerman, and Sylvie Le Gall. Variable HIV Peptide Stability in Human Cytosol Is Critical to Epitope Presentation and Immune Escape. J. Clin. Invest., 121(6):2480-2492, Jun 2011. PubMed ID: 21555856. Show all entries for this paper.
HXB2 Location | Nef(90-97) | Nef Epitope Map
View variants at this location |
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Epitope |
FLKEKGGL
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Epitope Alignment | |||||||
Variants |
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Epitope Name | FL8 | ||||||||
Species (MHC/HLA) | human(B*08) |
Showing all: 2 variant(s).
Variant ID. | 2694 |
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Epitope Seq. | FLKEKGGL |
Variant Seq. | FLKEnGGL |
Mutations | K/N |
Epitope Location | K5N |
HXB2 Location | K94N |
Mutation Type | LE: literature escape P: processing |
Epitope Subtype | B |
Variant Subtype | B |
Note | B8-FL8 was selected for analysis based on having known early mutants (K5N and K5M) that were predicted to have reduced intracellular stability. Mutant 5N slightly reduced peptide half-life, while 5M severely reduced half-life. |
Variant ID. | 2695 |
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Epitope Seq. | FLKEKGGL |
Variant Seq. | FLKEmGGL |
Mutations | K/M |
Epitope Location | K5M |
HXB2 Location | K94M |
Mutation Type | LE: literature escape P: processing |
Epitope Subtype | B |
Variant Subtype | B |
Note | B8-FL8 was selected for analysis based on having known early mutants (K5N and K5M) that were predicted to have reduced intracellular stability. Mutant 5N slightly reduced peptide half-life, while 5M severely reduced half-life. |
Lazaro2011 Estibaliz Lazaro, Carl Kadie, Pamela Stamegna, Shao Chong Zhang, Pauline Gourdain, Nicole Y. Lai, Mei Zhang, Sergio A. Martinez, David Heckerman, and Sylvie Le Gall. Variable HIV Peptide Stability in Human Cytosol Is Critical to Epitope Presentation and Immune Escape. J. Clin. Invest., 121(6):2480-2492, Jun 2011. PubMed ID: 21555856. Show all entries for this paper.