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Found 6 matching records:

Displaying record number 58010

HXB2 Location  Gag(77-85)   Gag Epitope Map
View variants at this location
Epitope SLYNTVATL   Epitope Alignment
Variants
SLYNTVAvL   HLA association; processing
SLfNTVATL   HLA association; processing
SLYNTiATL   HLA association; processing
SLYNTiAvL   HLA association; processing
SLfNTiATL   HLA association; processing
Epitope Name SL9
Species (MHC/HLA human(A*02)

Variant Details

Showing all: 5 variant(s).


Variant ID.  2705
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNTVAvL
Mutations T/V
Epitope Location T8V
HXB2 Location T84V
Mutation Type A: HLA association
P: processing
Epitope Subtype B
Variant Subtype B
Note A2-SL9 has known HLA-associated mutants (T8V, Y3F, V6I, V6I/T8V, Y3F/V6I). All 5 mutants displayed severely reduced half-lives.


Variant ID.  2706
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfNTVATL
Mutations Y/F
Epitope Location Y3F
HXB2 Location Y79F
Mutation Type A: HLA association
P: processing
Epitope Subtype B
Variant Subtype B
Note A2-SL9 has known HLA-associated mutants (T8V, Y3F, V6I, V6I/T8V, Y3F/V6I). All 5 mutants displayed severely reduced half-lives.


Variant ID.  2707
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNTiATL
Mutations V/I
Epitope Location V6I
HXB2 Location V82I
Mutation Type A: HLA association
P: processing
Epitope Subtype B
Variant Subtype B
Note A2-SL9 has known HLA-associated mutants (T8V, Y3F, V6I, V6I/T8V, Y3F/V6I). All 5 mutants displayed severely reduced half-lives.


Variant ID.  2708
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNTiAvL
Mutations V/I T/V
Epitope Location V6I T8V
HXB2 Location V82I T84V
Mutation Type A: HLA association
P: processing
Epitope Subtype B
Variant Subtype B
Note A2-SL9 has known HLA-associated mutants (T8V, Y3F, V6I, V6I/T8V, Y3F/V6I). All 5 mutants displayed severely reduced half-lives.


Variant ID.  2709
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfNTiATL
Mutations Y/F V/I
Epitope Location Y3F V6I
HXB2 Location Y79F V82I
Mutation Type A: HLA association
P: processing
Epitope Subtype B
Variant Subtype B
Note A2-SL9 has known HLA-associated mutants (T8V, Y3F, V6I, V6I/T8V, Y3F/V6I). All 5 mutants displayed severely reduced half-lives.

References

Lazaro2011 Estibaliz Lazaro, Carl Kadie, Pamela Stamegna, Shao Chong Zhang, Pauline Gourdain, Nicole Y. Lai, Mei Zhang, Sergio A. Martinez, David Heckerman, and Sylvie Le Gall. Variable HIV Peptide Stability in Human Cytosol Is Critical to Epitope Presentation and Immune Escape. J. Clin. Invest., 121(6):2480-2492, Jun 2011. PubMed ID: 21555856. Show all entries for this paper.


Displaying record number 58008

HXB2 Location  Gag(240-249)   Gag Epitope Map
View variants at this location
Epitope TSTLQEQIGW   Epitope Alignment
Variants
TSnLQEQIGW   literature escape; processing
TSnLQEQIaW   literature escape; processing
TSnLQEQIdW   literature escape; processing
TSTLQEQIaW   HLA association; processing
TSTLQEQIdW   HLA association; processing
Epitope Name TW10
Species (MHC/HLA human(B*57)

Variant Details

Showing all: 5 variant(s).


Variant ID.  2696
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSnLQEQIGW
Mutations T/N
Epitope Location T3N
HXB2 Location T242N
Mutation Type LE: literature escape
P: processing
Epitope Subtype B
Variant Subtype B
Note B57-TW10 was selected for analysis based on having known early mutants (T3N and T3N-G9A or T3N-G9D) that were predicted to have reduced intracellular stability. Mutant T3N was stable, while T3N-G9A or T3N-G9D severely reduced half-life. Single mutants G9A and G9D also displayed decreased half-lives.


Variant ID.  2697
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSnLQEQIaW
Mutations T/N G/A
Epitope Location T3N G9A
HXB2 Location T242N G248A
Mutation Type LE: literature escape
P: processing
Epitope Subtype B
Variant Subtype B
Note B57-TW10 was selected for analysis based on having known early mutants (T3N and T3N-G9A or T3N-G9D) that were predicted to have reduced intracellular stability. Mutant T3N was stable, while T3N-G9A or T3N-G9D severely reduced half-life. Single mutants G9A and G9D also displayed decreased half-lives.


Variant ID.  2698
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSnLQEQIdW
Mutations T/N G/D
Epitope Location T3N G9D
HXB2 Location T242N G248D
Mutation Type LE: literature escape
P: processing
Epitope Subtype B
Variant Subtype B
Note B57-TW10 was selected for analysis based on having known early mutants (T3N and T3N-G9A or T3N-G9D) that were predicted to have reduced intracellular stability. Mutant T3N was stable, while T3N-G9A or T3N-G9D severely reduced half-life. Single mutants G9A and G9D also displayed decreased half-lives.


Variant ID.  2699
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSTLQEQIaW
Mutations G/A
Epitope Location G9A
HXB2 Location G248A
Mutation Type A: HLA association
P: processing
Epitope Subtype B
Variant Subtype B
Note B57-TW10 was selected for analysis based on having known early mutants (T3N and T3N-G9A or T3N-G9D) that were predicted to have reduced intracellular stability. Mutant T3N was stable, while T3N-G9A or T3N-G9D severely reduced half-life. Single mutants G9A and G9D also displayed decreased half-lives.


Variant ID.  2700
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSTLQEQIdW
Mutations G/D
Epitope Location G9D
HXB2 Location G248D
Mutation Type A: HLA association
P: processing
Epitope Subtype B
Variant Subtype B
Note B57-TW10 was selected for analysis based on having known early mutants (T3N and T3N-G9A or T3N-G9D) that were predicted to have reduced intracellular stability. Mutant T3N was stable, while T3N-G9A or T3N-G9D severely reduced half-life. Single mutants G9A and G9D also displayed decreased half-lives.

References

Lazaro2011 Estibaliz Lazaro, Carl Kadie, Pamela Stamegna, Shao Chong Zhang, Pauline Gourdain, Nicole Y. Lai, Mei Zhang, Sergio A. Martinez, David Heckerman, and Sylvie Le Gall. Variable HIV Peptide Stability in Human Cytosol Is Critical to Epitope Presentation and Immune Escape. J. Clin. Invest., 121(6):2480-2492, Jun 2011. PubMed ID: 21555856. Show all entries for this paper.


Displaying record number 58009

HXB2 Location  Gag(263-272)   Gag Epitope Map
View variants at this location
Epitope KRWIILGLNK   Epitope Alignment
Variants
KgWIILGLNK   HLA association; processing
KkWIImGLNK   HLA association; processing
KRWIImGLNK   HLA association; processing
KkWIImGLhK   HLA association; processing
Epitope Name KK10
Species (MHC/HLA human(B*27)

Variant Details

Showing all: 4 variant(s).


Variant ID.  2701
Epitope Seq.  KRWIILGLNK
Variant Seq.  KgWIILGLNK
Mutations R/G
Epitope Location R2G
HXB2 Location R264G
Mutation Type A: HLA association
P: processing
Epitope Subtype B
Variant Subtype B
Note B27-KK10 has known HLA-associated mutants (R2G, R2K/L6M, L6M, R2K/L6M/N8H). All 4 mutants displayed severely reduced half-lives.


Variant ID.  2702
Epitope Seq.  KRWIILGLNK
Variant Seq.  KkWIImGLNK
Mutations R/K L/M
Epitope Location R2K L6M
HXB2 Location R264K L268M
Mutation Type A: HLA association
P: processing
Epitope Subtype B
Variant Subtype B
Note B27-KK10 has known HLA-associated mutants (R2G, R2K/L6M, L6M, R2K/L6M/N8H). All 4 mutants displayed severely reduced half-lives.


Variant ID.  2703
Epitope Seq.  KRWIILGLNK
Variant Seq.  KRWIImGLNK
Mutations L/M
Epitope Location L6M
HXB2 Location L268M
Mutation Type A: HLA association
P: processing
Epitope Subtype B
Variant Subtype B
Note B27-KK10 has known HLA-associated mutants (R2G, R2K/L6M, L6M, R2K/L6M/N8H). All 4 mutants displayed severely reduced half-lives.


Variant ID.  2704
Epitope Seq.  KRWIILGLNK
Variant Seq.  KkWIImGLhK
Mutations R/K L/M N/H
Epitope Location R2K L6M N9H
HXB2 Location R264K L268M N271H
Mutation Type A: HLA association
P: processing
Epitope Subtype B
Variant Subtype B
Note B27-KK10 has known HLA-associated mutants (R2G, R2K/L6M, L6M, R2K/L6M/N8H). All 4 mutants displayed severely reduced half-lives.

References

Lazaro2011 Estibaliz Lazaro, Carl Kadie, Pamela Stamegna, Shao Chong Zhang, Pauline Gourdain, Nicole Y. Lai, Mei Zhang, Sergio A. Martinez, David Heckerman, and Sylvie Le Gall. Variable HIV Peptide Stability in Human Cytosol Is Critical to Epitope Presentation and Immune Escape. J. Clin. Invest., 121(6):2480-2492, Jun 2011. PubMed ID: 21555856. Show all entries for this paper.


Displaying record number 58012

HXB2 Location  Vpr(29-37)   Vpr Epitope Map
View variants at this location
Epitope EAVRHFPRI   Epitope Alignment
Variants
EAVRHFPRt   HLA association; processing
EAVRHFPRa   HLA association; processing
Epitope Name EI9
Species (MHC/HLA human(B*51)

Variant Details

Showing all: 2 variant(s).


Variant ID.  2711
Epitope Seq.  EAVRHFPRI
Variant Seq.  EAVRHFPRt
Mutations I/T
Epitope Location I9T
HXB2 Location I37T
Mutation Type A: HLA association
P: processing
Epitope Subtype B
Variant Subtype B
Note B51-EI9 has known HLA-associated mutants (I9T, I9A). Both mutants displayed severely reduced half-lives.


Variant ID.  2712
Epitope Seq.  EAVRHFPRI
Variant Seq.  EAVRHFPRa
Mutations I/A
Epitope Location I9A
HXB2 Location I37A
Mutation Type A: HLA association
P: processing
Epitope Subtype B
Variant Subtype B
Note B51-EI9 has known HLA-associated mutants (I9T, I9A). Both mutants displayed severely reduced half-lives.

References

Lazaro2011 Estibaliz Lazaro, Carl Kadie, Pamela Stamegna, Shao Chong Zhang, Pauline Gourdain, Nicole Y. Lai, Mei Zhang, Sergio A. Martinez, David Heckerman, and Sylvie Le Gall. Variable HIV Peptide Stability in Human Cytosol Is Critical to Epitope Presentation and Immune Escape. J. Clin. Invest., 121(6):2480-2492, Jun 2011. PubMed ID: 21555856. Show all entries for this paper.


Displaying record number 58011

HXB2 Location  Vpr(59-67)   Vpr Epitope Map
View variants at this location
Epitope AIIRILQQL   Epitope Alignment
Variants
AIIRtLQQL   HLA association; processing
Epitope Name AL9
Species (MHC/HLA human(A*02)

Variant Details

Showing all: 1 variant(s).


Variant ID.  2710
Epitope Seq.  AIIRILQQL
Variant Seq.  AIIRtLQQL
Mutations I/T
Epitope Location I5T
HXB2 Location I63T
Mutation Type A: HLA association
P: processing
Epitope Subtype B
Variant Subtype B
Note A2-AL9 has a known HLA-associated mutant (I5T). The wild type epitope displayed a moderate half-life, and the mutant displayed a reduced half-life.

References

Lazaro2011 Estibaliz Lazaro, Carl Kadie, Pamela Stamegna, Shao Chong Zhang, Pauline Gourdain, Nicole Y. Lai, Mei Zhang, Sergio A. Martinez, David Heckerman, and Sylvie Le Gall. Variable HIV Peptide Stability in Human Cytosol Is Critical to Epitope Presentation and Immune Escape. J. Clin. Invest., 121(6):2480-2492, Jun 2011. PubMed ID: 21555856. Show all entries for this paper.


Displaying record number 58007

HXB2 Location  Nef(90-97)   Nef Epitope Map
View variants at this location
Epitope FLKEKGGL   Epitope Alignment
Variants
FLKEnGGL   literature escape; processing
FLKEmGGL   literature escape; processing
Epitope Name FL8
Species (MHC/HLA human(B*08)

Variant Details

Showing all: 2 variant(s).


Variant ID.  2694
Epitope Seq.  FLKEKGGL
Variant Seq.  FLKEnGGL
Mutations K/N
Epitope Location K5N
HXB2 Location K94N
Mutation Type LE: literature escape
P: processing
Epitope Subtype B
Variant Subtype B
Note B8-FL8 was selected for analysis based on having known early mutants (K5N and K5M) that were predicted to have reduced intracellular stability. Mutant 5N slightly reduced peptide half-life, while 5M severely reduced half-life.


Variant ID.  2695
Epitope Seq.  FLKEKGGL
Variant Seq.  FLKEmGGL
Mutations K/M
Epitope Location K5M
HXB2 Location K94M
Mutation Type LE: literature escape
P: processing
Epitope Subtype B
Variant Subtype B
Note B8-FL8 was selected for analysis based on having known early mutants (K5N and K5M) that were predicted to have reduced intracellular stability. Mutant 5N slightly reduced peptide half-life, while 5M severely reduced half-life.

References

Lazaro2011 Estibaliz Lazaro, Carl Kadie, Pamela Stamegna, Shao Chong Zhang, Pauline Gourdain, Nicole Y. Lai, Mei Zhang, Sergio A. Martinez, David Heckerman, and Sylvie Le Gall. Variable HIV Peptide Stability in Human Cytosol Is Critical to Epitope Presentation and Immune Escape. J. Clin. Invest., 121(6):2480-2492, Jun 2011. PubMed ID: 21555856. Show all entries for this paper.


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