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Found 7 matching records:

Displaying record number 55324

HXB2 Location  Gag(197-205)   Gag Epitope Map
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Epitope AMQMLKDTI   Epitope Alignment
Variants
AMQMLKeTI   diminished response
AMQiLKDTI   diminished response
Epitope Name G
Species (MHC/HLA mouse(H-2Kd)

Variant Details

Showing all: 2 variant(s).


Variant ID.  805
Epitope Seq.  AMQMLKDTI
Variant Seq.  AMQMLKeTI
Mutations D/E
Epitope Location D7E
HXB2 Location D203E
Mutation Type DR: diminished response
Epitope Subtype A, C
Variant Subtype B
Method CD8 T-cell Elispot - IFNy
Note After immunization with Clades A or C vaccines, both containing the wt epitope, T cells responded well to the index epitope, but poorly to this variant.


Variant ID.  806
Epitope Seq.  AMQMLKDTI
Variant Seq.  AMQiLKDTI
Mutations M/I
Epitope Location M4I
HXB2 Location M200I
Mutation Type DR: diminished response
Epitope Subtype A, C
Variant Subtype B
Method CD8 T-cell Elispot - IFNy
Note After immunization with Clades A or C vaccines, both containing the wt epitope, T cells responded well to the index epitope, and intermediately to this variant.

References

Larke2007 Natasha Larke, Eung-Jun Im, Ralf Wagner, Carolyn Williamson, Anna-Lise Williamson, Andrew J. McMichael, and Tomáš Hanke. Combined Single-Clade Candidate HIV-1 Vaccines Induce T Cell Responses Limited by Multiple Forms of In Vivo Immune Interference. Eur. J. Immunol., 37(2):566-577, Feb 2007. PubMed ID: 17230443. Show all entries for this paper.


Displaying record number 55330

HXB2 Location  Pol(133-141)   Pol Epitope Map
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Epitope VGPTPVNII   Epitope Alignment
Variants
VGPTPiNII   susceptible form
Epitope Name V
Species (MHC/HLA mouse(H-2Dd)

Variant Details

Showing all: 1 variant(s).


Variant ID.  807
Epitope Seq.  VGPTPVNII
Variant Seq.  VGPTPiNII
Mutations V/I
Epitope Location V6I
HXB2 Location V138I
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note After immunization with clade B vaccine containing the wt epitope, T cells responded well both to the index epitope and to this variant.

References

Larke2007 Natasha Larke, Eung-Jun Im, Ralf Wagner, Carolyn Williamson, Anna-Lise Williamson, Andrew J. McMichael, and Tomáš Hanke. Combined Single-Clade Candidate HIV-1 Vaccines Induce T Cell Responses Limited by Multiple Forms of In Vivo Immune Interference. Eur. J. Immunol., 37(2):566-577, Feb 2007. PubMed ID: 17230443. Show all entries for this paper.


Displaying record number 55328

HXB2 Location  Pol(314-322)   Pol Epitope Map
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Epitope IFQSSMTKI   Epitope Alignment
Variants
IFQaSMTKI   susceptible form
IFQcSMTKI   diminished response
Epitope Name P
Species (MHC/HLA mouse(H-2Kd)

Variant Details

Showing all: 2 variant(s).


Variant ID.  808
Epitope Seq.  IFQSSMTKI
Variant Seq.  IFQaSMTKI
Mutations S/A
Epitope Location S4A
HXB2 Location S317A
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note After immunization with clade A vaccine containing the wt epitope, T cells responded well both to the index epitope and to this variant.


Variant ID.  809
Epitope Seq.  IFQSSMTKI
Variant Seq.  IFQcSMTKI
Mutations S/C
Epitope Location S4C
HXB2 Location S317C
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy
Note After immunization with clade A vaccine containing the wt epitope, T cells responded to the index epitope but responded poorly to this variant.

References

Larke2007 Natasha Larke, Eung-Jun Im, Ralf Wagner, Carolyn Williamson, Anna-Lise Williamson, Andrew J. McMichael, and Tomáš Hanke. Combined Single-Clade Candidate HIV-1 Vaccines Induce T Cell Responses Limited by Multiple Forms of In Vivo Immune Interference. Eur. J. Immunol., 37(2):566-577, Feb 2007. PubMed ID: 17230443. Show all entries for this paper.


Displaying record number 55326

HXB2 Location  Pol(361-369)   Pol Epitope Map
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Epitope RAHLLSWGF   Epitope Alignment
Variants
RqHLLrWGl   susceptible form
RkHLLkWGF   susceptible form
RAHLLrWGF   escape documented in this paper; susceptible form
RqHLLrWGF   escape documented in this paper; susceptible form
ReHLLkWGF   diminished response; escape documented in this paper
ReHLLrWGF   escape documented in this paper; susceptible form
RgHLLkWGF   diminished response; escape documented in this paper
RkHLLSWGF   susceptible form
Epitope Name RT1
Species (MHC/HLA mouse(H-2Kd)

Variant Details

Showing all: 8 variant(s).


Variant ID.  810
Epitope Seq.  RAHLLSWGF
Variant Seq.  RqHLLrWGl
Mutations A/Q S/R F/L
Epitope Location A2Q S6R F9L
HXB2 Location A362Q S366R F369L
Mutation Type SF: susceptible form
Epitope Subtype A
Variant Subtype B
Method CD8 T-cell Elispot - IFNy
Note This variant was recognized by CTLs from both clade B vaccine containing the variant, and clade C vaccine containing the RkHLLkWGF variant.


Variant ID.  811
Epitope Seq.  RAHLLSWGF
Variant Seq.  RkHLLkWGF
Mutations A/K S/K
Epitope Location A2K S6K
HXB2 Location A362K S366K
Mutation Type SF: susceptible form
Epitope Subtype A
Variant Subtype C
Method CD8 T-cell Elispot - IFNy
Note This variant was recognized by CTLs from both clade B vaccine containing the RqHLLrWGl variant, and clade C vaccine containing this variant.


Variant ID.  812
Epitope Seq.  RAHLLSWGF
Variant Seq.  RAHLLrWGF
Mutations S/R
Epitope Location S6R
HXB2 Location S366R
Mutation Type E: escape documented in this paper
SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note This variant was recognized by CTLs from clade B vaccine containing the RqHLLrWGl variant, but not by CTLs from clade C vaccine containing the RkHLLkWGF variant.


Variant ID.  813
Epitope Seq.  RAHLLSWGF
Variant Seq.  RqHLLrWGF
Mutations A/Q S/R
Epitope Location A2Q S6R
HXB2 Location A362Q S366R
Mutation Type E: escape documented in this paper
SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note This variant was recognized by CTLs from clade B vaccine containing the RqHLLrWGl variant, but not by CTLs from clade C vaccine containing the RkHLLkWGF variant.


Variant ID.  814
Epitope Seq.  RAHLLSWGF
Variant Seq.  ReHLLkWGF
Mutations A/E S/K
Epitope Location A2E S6K
HXB2 Location A362E S366K
Mutation Type DR: diminished response
E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy
Note This variant was poorly recognized by CTLs from clade B vaccine containing the RqHLLrWGl variant, and not recognized by CTLs from clade C vaccine containing the RkHLLkWGF variant.


Variant ID.  815
Epitope Seq.  RAHLLSWGF
Variant Seq.  ReHLLrWGF
Mutations A/E S/R
Epitope Location A2E S6R
HXB2 Location A362E S366R
Mutation Type E: escape documented in this paper
SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note This variant was recognized by CTLs from clade B vaccine containing the RqHLLrWGl variant, but not by CTLs from clade C vaccine containing the RkHLLkWGF variant.


Variant ID.  816
Epitope Seq.  RAHLLSWGF
Variant Seq.  RgHLLkWGF
Mutations A/G S/K
Epitope Location A2G S6K
HXB2 Location A362G S366K
Mutation Type DR: diminished response
E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy
Note This variant was poorly recognized by CTLs from clade B vaccine containing the RqHLLrWGl variant, and not recognized by CTLs from clade C vaccine containing the RkHLLkWGF variant.


Variant ID.  817
Epitope Seq.  RAHLLSWGF
Variant Seq.  RkHLLSWGF
Mutations A/K
Epitope Location A2K
HXB2 Location A362K
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note This variant was recognized by CTLs from both clade B vaccine containing the variant, and clade C vaccine containing the RkHLLkWGF variant.

References

Larke2007 Natasha Larke, Eung-Jun Im, Ralf Wagner, Carolyn Williamson, Anna-Lise Williamson, Andrew J. McMichael, and Tomáš Hanke. Combined Single-Clade Candidate HIV-1 Vaccines Induce T Cell Responses Limited by Multiple Forms of In Vivo Immune Interference. Eur. J. Immunol., 37(2):566-577, Feb 2007. PubMed ID: 17230443. Show all entries for this paper.


Displaying record number 55327

HXB2 Location  Pol(472-481)   Pol Epitope Map
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Epitope VYYDPSKDLI   Epitope Alignment
Variants
VYYDPSKDLv   susceptible form
VYYDPtKDLI   susceptible form
VYYDPSKeLI   diminished response; non-susceptible form
aYYDPSKeLI   diminished response; non-susceptible form
VYYePSKeLI   diminished response; non-susceptible form
Epitope Name RT2
Species (MHC/HLA mouse(H-2Kd)

Variant Details

Showing all: 5 variant(s).


Variant ID.  818
Epitope Seq.  VYYDPSKDLI
Variant Seq.  VYYDPSKDLv
Mutations I/V
Epitope Location I10V
HXB2 Location I481V
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note After immunization with any clade vaccine, index epitope was recognized, as well as this variant.


Variant ID.  819
Epitope Seq.  VYYDPSKDLI
Variant Seq.  VYYDPtKDLI
Mutations S/T
Epitope Location S6T
HXB2 Location S477T
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note After immunization with any clade vaccine, index epitope was recognized, as well as this variant.


Variant ID.  820
Epitope Seq.  VYYDPSKDLI
Variant Seq.  VYYDPSKeLI
Mutations D/E
Epitope Location D8E
HXB2 Location D479E
Mutation Type DR: diminished response
NSF: non-susceptible form
Method CD8 T-cell Elispot - IFNy
Note After immunization with any clade vaccine, index epitope was recognized, but the variant was not, or was poorly recognized.


Variant ID.  821
Epitope Seq.  VYYDPSKDLI
Variant Seq.  aYYDPSKeLI
Mutations V/A D/E
Epitope Location V1A D8E
HXB2 Location V472A D479E
Mutation Type DR: diminished response
NSF: non-susceptible form
Method CD8 T-cell Elispot - IFNy
Note After immunization with any clade vaccine, index epitope was recognized, but the variant was not, or was poorly recognized.


Variant ID.  822
Epitope Seq.  VYYDPSKDLI
Variant Seq.  VYYePSKeLI
Mutations D/E D/E
Epitope Location D4E D8E
HXB2 Location D475E D479E
Mutation Type DR: diminished response
NSF: non-susceptible form
Method CD8 T-cell Elispot - IFNy
Note After immunization with any clade vaccine, index epitope was recognized, but the variant was not, or was poorly recognized.

References

Larke2007 Natasha Larke, Eung-Jun Im, Ralf Wagner, Carolyn Williamson, Anna-Lise Williamson, Andrew J. McMichael, and Tomáš Hanke. Combined Single-Clade Candidate HIV-1 Vaccines Induce T Cell Responses Limited by Multiple Forms of In Vivo Immune Interference. Eur. J. Immunol., 37(2):566-577, Feb 2007. PubMed ID: 17230443. Show all entries for this paper.


Displaying record number 55322

HXB2 Location  gp160(311-320)   gp160 Epitope Map
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Epitope RGPGRAFVTI   Epitope Alignment
Variants
iGPGqAFyat   non-susceptible form
fGPGqAFyTn   non-susceptible form
iGPGRAFyTt   non-susceptible form
iGPGqtFyat   non-susceptible form
iGlGqAlyTt   non-susceptible form
lGPGqAFyat   non-susceptible form
iGPGRAFyat   non-susceptible form
iGPGqvFyrt   non-susceptible form
mGPGRvFyTt   non-susceptible form
Epitope Name H
Species (MHC/HLA mouse(H-2Dd)

Variant Details

Showing all: 9 variant(s).


Variant ID.  823
Epitope Seq.  RGPGRAFVTI
Variant Seq.  iGPGqAFyat
Mutations R/I I/T R/Q V/Y T/A
Epitope Location R1I I10T R5Q V8Y T9A
HXB2 Location R311I I320T R315Q V318Y T319A
Mutation Type NSF: non-susceptible form
Method CD8 T-cell Elispot - IFNy
Note There was no cross-reactivity seen with this epitope variant after immunization with Clade A containing index epitope


Variant ID.  824
Epitope Seq.  RGPGRAFVTI
Variant Seq.  fGPGqAFyTn
Mutations R/F I/N R/Q V/Y
Epitope Location R1F I10N R5Q V8Y
HXB2 Location R311F I320N R315Q V318Y
Mutation Type NSF: non-susceptible form
Method CD8 T-cell Elispot - IFNy
Note There was no cross-reactivity seen with this epitope variant after immunization with Clade A containing index epitope


Variant ID.  825
Epitope Seq.  RGPGRAFVTI
Variant Seq.  iGPGRAFyTt
Mutations R/I I/T V/Y
Epitope Location R1I I10T V8Y
HXB2 Location R311I I320T V318Y
Mutation Type NSF: non-susceptible form
Method CD8 T-cell Elispot - IFNy
Note There was no cross-reactivity seen with this epitope variant after immunization with Clade A containing index epitope


Variant ID.  826
Epitope Seq.  RGPGRAFVTI
Variant Seq.  iGPGqtFyat
Mutations R/I I/T R/Q A/T V/Y T/A
Epitope Location R1I I10T R5Q A6T V8Y T9A
HXB2 Location R311I I320T R315Q A316T V318Y T319A
Mutation Type NSF: non-susceptible form
Method CD8 T-cell Elispot - IFNy
Note There was no cross-reactivity seen with this epitope variant after immunization with Clade A containing index epitope


Variant ID.  827
Epitope Seq.  RGPGRAFVTI
Variant Seq.  iGlGqAlyTt
Mutations R/I I/T P/L R/Q F/L V/Y
Epitope Location R1I I10T P3L R5Q F7L V8Y
HXB2 Location R311I I320T P313L R315Q F317L V318Y
Mutation Type NSF: non-susceptible form
Method CD8 T-cell Elispot - IFNy
Note There was no cross-reactivity seen with this epitope variant after immunization with Clade A containing index epitope


Variant ID.  828
Epitope Seq.  RGPGRAFVTI
Variant Seq.  lGPGqAFyat
Mutations R/L I/T R/Q V/Y T/A
Epitope Location R1L I10T R5Q V8Y T9A
HXB2 Location R311L I320T R315Q V318Y T319A
Mutation Type NSF: non-susceptible form
Method CD8 T-cell Elispot - IFNy
Note There was no cross-reactivity seen with this epitope variant after immunization with Clade A containing index epitope


Variant ID.  829
Epitope Seq.  RGPGRAFVTI
Variant Seq.  iGPGRAFyat
Mutations R/I I/T V/Y T/A
Epitope Location R1I I10T V8Y T9A
HXB2 Location R311I I320T V318Y T319A
Mutation Type NSF: non-susceptible form
Method CD8 T-cell Elispot - IFNy
Note There was no cross-reactivity seen with this epitope variant after immunization with Clade A containing index epitope


Variant ID.  830
Epitope Seq.  RGPGRAFVTI
Variant Seq.  iGPGqvFyrt
Mutations R/I I/T R/Q A/V V/Y T/R
Epitope Location R1I I10T R5Q A6V V8Y T9R
HXB2 Location R311I I320T R315Q A316V V318Y T319R
Mutation Type NSF: non-susceptible form
Method CD8 T-cell Elispot - IFNy
Note There was no cross-reactivity seen with this epitope variant after immunization with Clade A containing index epitope


Variant ID.  831
Epitope Seq.  RGPGRAFVTI
Variant Seq.  mGPGRvFyTt
Mutations R/M I/T A/V V/Y
Epitope Location R1M I10T A6V V8Y
HXB2 Location R311M I320T A316V V318Y
Mutation Type NSF: non-susceptible form
Method CD8 T-cell Elispot - IFNy
Note There was no cross-reactivity seen with this epitope variant after immunization with Clade A containing index epitope

References

Larke2007 Natasha Larke, Eung-Jun Im, Ralf Wagner, Carolyn Williamson, Anna-Lise Williamson, Andrew J. McMichael, and Tomáš Hanke. Combined Single-Clade Candidate HIV-1 Vaccines Induce T Cell Responses Limited by Multiple Forms of In Vivo Immune Interference. Eur. J. Immunol., 37(2):566-577, Feb 2007. PubMed ID: 17230443. Show all entries for this paper.


Displaying record number 55323

HXB2 Location  gp160(767-775)   gp160 Epitope Map
View variants at this location
Epitope SYHRLRDFI   Epitope Alignment
Variants
SYHRLRDFv   susceptible form
SYHRLRDcI   diminished response
SYHRLRDll   diminished response
SYHRLRDlI   diminished response
SYrhLRDFI   non-susceptible form
iYHhLRDll   non-susceptible form
SYrlLRDll   non-susceptible form
Epitope Name E
Species (MHC/HLA mouse(H-2Kd)

Variant Details

Showing all: 7 variant(s).


Variant ID.  832
Epitope Seq.  SYHRLRDFI
Variant Seq.  SYHRLRDFv
Mutations I/V
Epitope Location I9V
HXB2 Location I775V
Mutation Type SF: susceptible form
Epitope Subtype A
Method CD8 T-cell Elispot - IFNy
Note After immunization with Clade A vaccine containing the wt epitope, T cells were able to respond to this epitope variant.


Variant ID.  833
Epitope Seq.  SYHRLRDFI
Variant Seq.  SYHRLRDcI
Mutations F/C
Epitope Location F8C
HXB2 Location F774C
Mutation Type DR: diminished response
Epitope Subtype A
Method CD8 T-cell Elispot - IFNy
Note After immunization with Clade A vaccine containing the wt epitope, T cells were able to respond to this epitope variant at <50% magnitude.


Variant ID.  834
Epitope Seq.  SYHRLRDFI
Variant Seq.  SYHRLRDll
Mutations F/L I/L
Epitope Location F8L I9L
HXB2 Location F774L I775L
Mutation Type DR: diminished response
Epitope Subtype A
Method CD8 T-cell Elispot - IFNy
Note After immunization with Clade A vaccine containing the wt epitope, T cells were able to respond to this epitope variant at <50% magnitude.


Variant ID.  835
Epitope Seq.  SYHRLRDFI
Variant Seq.  SYHRLRDlI
Mutations F/L
Epitope Location F8L
HXB2 Location F774L
Mutation Type DR: diminished response
Epitope Subtype A
Method CD8 T-cell Elispot - IFNy
Note After immunization with Clade A vaccine containing the wt epitope, T cells were able to respond to this epitope variant at <50% magnitude.


Variant ID.  836
Epitope Seq.  SYHRLRDFI
Variant Seq.  SYrhLRDFI
Mutations H/R R/H
Epitope Location H3R R4H
HXB2 Location H769R R770H
Mutation Type NSF: non-susceptible form
Epitope Subtype A
Method CD8 T-cell Elispot - IFNy
Note After immunization with Clade A vaccine containing the wt epitope, T cells did not recognize this epitope variant.


Variant ID.  837
Epitope Seq.  SYHRLRDFI
Variant Seq.  iYHhLRDll
Mutations S/I R/H F/L I/L
Epitope Location S1I R4H F8L I9L
HXB2 Location S767I R770H F774L I775L
Mutation Type NSF: non-susceptible form
Epitope Subtype A
Method CD8 T-cell Elispot - IFNy
Note After immunization with Clade A vaccine containing the wt epitope, T cells did not recognize this epitope variant.


Variant ID.  838
Epitope Seq.  SYHRLRDFI
Variant Seq.  SYrlLRDll
Mutations H/R R/L F/L I/L
Epitope Location H3R R4L F8L I9L
HXB2 Location H769R R770L F774L I775L
Mutation Type NSF: non-susceptible form
Epitope Subtype A
Method CD8 T-cell Elispot - IFNy
Note After immunization with Clade A vaccine containing the wt epitope, T cells did not recognize this epitope variant.

References

Larke2007 Natasha Larke, Eung-Jun Im, Ralf Wagner, Carolyn Williamson, Anna-Lise Williamson, Andrew J. McMichael, and Tomáš Hanke. Combined Single-Clade Candidate HIV-1 Vaccines Induce T Cell Responses Limited by Multiple Forms of In Vivo Immune Interference. Eur. J. Immunol., 37(2):566-577, Feb 2007. PubMed ID: 17230443. Show all entries for this paper.


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