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Found 7 matching records:

Displaying record number 59015

HXB2 Location  Gag(147-158)   Gag Epitope Map
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Epitope ISPRTLNAWVKV   Epitope Alignment
Variants
lSPRTLNAWVKV   subtype-specific susceptible form
Epitope Name CE1
Species (MHC/HLA mouse

Variant Details

Showing all: 1 variant(s).


Variant ID.  3207
Epitope Seq.  ISPRTLNAWVKV
Variant Seq.  lSPRTLNAWVKV
Mutations I/L
Epitope Location I1L
HXB2 Location I147L
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype B, C, M group
Variant Subtype A
Method Intracellular cytokine staining
Note lSPRTLNAWVKV is the Clade-A variant of CE1. It was used in the p24CE2 vaccine form in this study, eliciting a strong T-helper response from the vaccinated mouse.

References

Kulkarni2013 Viraj Kulkarni, Margherita Rosati, Antonio Valentin, Brunda Ganneru, Ashish K. Singh, Jian Yan, Morgane Rolland, Candido Alicea, Rachel Kelly Beach, Gen-Mu Zhang, Sylvie Le Gall, Kate E. Broderick, Niranjan Y. Sardesai, David Heckerman, Beatriz Mothe, Christian Brander, David B. Weiner, James I. Mullins, George N. Pavlakis, and Barbara K. Felber. HIV-1 p24(gag) Derived Conserved Element DNA Vaccine Increases the Breadth of Immune Response in Mice. PLoS One, 8(3):e60245, 2013. PubMed ID: 23555935. Show all entries for this paper.


Displaying record number 59019

HXB2 Location  Gag(168-185)   Gag Epitope Map
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Epitope VIPMFSALSEGATPQDLN   Epitope Alignment
Variants
VIPMFtALSEGATPQDLN   subtype-specific susceptible form
Epitope Name CE2
Species (MHC/HLA mouse

Variant Details

Showing all: 1 variant(s).


Variant ID.  3206
Epitope Seq.  VIPMFSALSEGATPQDLN
Variant Seq.  VIPMFtALSEGATPQDLN
Mutations S/T
Epitope Location S6T
HXB2 Location S173T
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype A, B, M group
Variant Subtype C
Method Intracellular cytokine staining
Note VIPMFtALSEGATPQDLN is the Clade-C variant of CE2. It was used in the p24CE2 vaccine form in this study, eliciting a robust CTL response from the vaccinated mouse.

References

Kulkarni2013 Viraj Kulkarni, Margherita Rosati, Antonio Valentin, Brunda Ganneru, Ashish K. Singh, Jian Yan, Morgane Rolland, Candido Alicea, Rachel Kelly Beach, Gen-Mu Zhang, Sylvie Le Gall, Kate E. Broderick, Niranjan Y. Sardesai, David Heckerman, Beatriz Mothe, Christian Brander, David B. Weiner, James I. Mullins, George N. Pavlakis, and Barbara K. Felber. HIV-1 p24(gag) Derived Conserved Element DNA Vaccine Increases the Breadth of Immune Response in Mice. PLoS One, 8(3):e60245, 2013. PubMed ID: 23555935. Show all entries for this paper.


Displaying record number 59020

HXB2 Location  Gag(191-214)   Gag Epitope Map
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Epitope VGGHQAAMQMLKETINEEAAEWDR   Epitope Alignment
Variants
VGGHQAAMQMLKdTINEEAAEWDR   subtype-specific susceptible form
Epitope Name CE3
Species (MHC/HLA mouse

Variant Details

Showing all: 1 variant(s).


Variant ID.  3205
Epitope Seq.  VGGHQAAMQMLKETINEEAAEWDR
Variant Seq.  VGGHQAAMQMLKdTINEEAAEWDR
Mutations E/D
Epitope Location E13D
HXB2 Location E203D
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype B
Variant Subtype A, C, M group
Method Intracellular cytokine staining
Note VGGHQAAMQMLKdTINEEAAEWDR is the Clades-A, -C and -M variant of CE3. It was used in the p24CE1 vaccine form in this study, eliciting a small CTL response.

References

Kulkarni2013 Viraj Kulkarni, Margherita Rosati, Antonio Valentin, Brunda Ganneru, Ashish K. Singh, Jian Yan, Morgane Rolland, Candido Alicea, Rachel Kelly Beach, Gen-Mu Zhang, Sylvie Le Gall, Kate E. Broderick, Niranjan Y. Sardesai, David Heckerman, Beatriz Mothe, Christian Brander, David B. Weiner, James I. Mullins, George N. Pavlakis, and Barbara K. Felber. HIV-1 p24(gag) Derived Conserved Element DNA Vaccine Increases the Breadth of Immune Response in Mice. PLoS One, 8(3):e60245, 2013. PubMed ID: 23555935. Show all entries for this paper.


Displaying record number 59021

HXB2 Location  Gag(231-249)   Gag Epitope Map
View variants at this location
Epitope PRGSDIAGTTSTLQEQIGW   Epitope Alignment
Variants
PRGSDIAGTTSTpQEQIGW   subtype-specific susceptible form
PRGSDIAGTTSTLQEQIaW   subtype-specific susceptible form
Epitope Name CE4
Species (MHC/HLA mouse

Variant Details

Showing all: 2 variant(s).


Variant ID.  3203
Epitope Seq.  PRGSDIAGTTSTLQEQIGW
Variant Seq.  PRGSDIAGTTSTpQEQIGW
Mutations L/P
Epitope Location L13P
HXB2 Location L243P
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype B
Variant Subtype A
Method Intracellular cytokine staining
Note PRGSDIAGTTSTpQEQIGW is the Clade-A variant of CE4. It was not used in any vaccine form in this study.


Variant ID.  3204
Epitope Seq.  PRGSDIAGTTSTLQEQIGW
Variant Seq.  PRGSDIAGTTSTLQEQIaW
Mutations G/A
Epitope Location G18A
HXB2 Location G248A
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype B
Variant Subtype C, M group
Method Intracellular cytokine staining
Note PRGSDIAGTTSTLQEQIaW is the Clades-C and -M variant of CE4. It was used in the p24CE2 vaccine form in this study, eliciting no response.

References

Kulkarni2013 Viraj Kulkarni, Margherita Rosati, Antonio Valentin, Brunda Ganneru, Ashish K. Singh, Jian Yan, Morgane Rolland, Candido Alicea, Rachel Kelly Beach, Gen-Mu Zhang, Sylvie Le Gall, Kate E. Broderick, Niranjan Y. Sardesai, David Heckerman, Beatriz Mothe, Christian Brander, David B. Weiner, James I. Mullins, George N. Pavlakis, and Barbara K. Felber. HIV-1 p24(gag) Derived Conserved Element DNA Vaccine Increases the Breadth of Immune Response in Mice. PLoS One, 8(3):e60245, 2013. PubMed ID: 23555935. Show all entries for this paper.


Displaying record number 59023

HXB2 Location  Gag(263-282)   Gag Epitope Map
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Epitope KRWIILGLNKIVRMYSPTSI   Epitope Alignment
Variants
KRWIILGLNKIVRMYSPvSI   subtype-specific susceptible form
Epitope Name CE5
Species (MHC/HLA mouse

Variant Details

Showing all: 1 variant(s).


Variant ID.  3208
Epitope Seq.  KRWIILGLNKIVRMYSPTSI
Variant Seq.  KRWIILGLNKIVRMYSPvSI
Mutations T/V
Epitope Location T18V
HXB2 Location T280V
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype B
Variant Subtype A, C, M group
Method Intracellular cytokine staining
Note KRWIILGLNKIVRMYSPvSI is the Clades-A, -C and -M variant of CE5. It was used in the p24CE2 vaccine form in this study, eliciting no response.

References

Kulkarni2013 Viraj Kulkarni, Margherita Rosati, Antonio Valentin, Brunda Ganneru, Ashish K. Singh, Jian Yan, Morgane Rolland, Candido Alicea, Rachel Kelly Beach, Gen-Mu Zhang, Sylvie Le Gall, Kate E. Broderick, Niranjan Y. Sardesai, David Heckerman, Beatriz Mothe, Christian Brander, David B. Weiner, James I. Mullins, George N. Pavlakis, and Barbara K. Felber. HIV-1 p24(gag) Derived Conserved Element DNA Vaccine Increases the Breadth of Immune Response in Mice. PLoS One, 8(3):e60245, 2013. PubMed ID: 23555935. Show all entries for this paper.


Displaying record number 59022

HXB2 Location  Gag(296-309)   Gag Epitope Map
View variants at this location
Epitope YVDRFYKTLRAEQA   Epitope Alignment
Variants
YVDRFfKTLRAEQA   subtype-specific susceptible form
Epitope Name CE6
Species (MHC/HLA mouse

Variant Details

Showing all: 1 variant(s).


Variant ID.  3209
Epitope Seq.  YVDRFYKTLRAEQA
Variant Seq.  YVDRFfKTLRAEQA
Mutations Y/F
Epitope Location Y6F
HXB2 Location Y301F
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype B
Variant Subtype A, C, M group
Method Intracellular cytokine staining
Note YVDRFfKTLRAEQA is the Clades-A, -C and -M variant of CE6. It was used in the p24CE2 vaccine form in this study, eliciting a low helper T-cell response.

References

Kulkarni2013 Viraj Kulkarni, Margherita Rosati, Antonio Valentin, Brunda Ganneru, Ashish K. Singh, Jian Yan, Morgane Rolland, Candido Alicea, Rachel Kelly Beach, Gen-Mu Zhang, Sylvie Le Gall, Kate E. Broderick, Niranjan Y. Sardesai, David Heckerman, Beatriz Mothe, Christian Brander, David B. Weiner, James I. Mullins, George N. Pavlakis, and Barbara K. Felber. HIV-1 p24(gag) Derived Conserved Element DNA Vaccine Increases the Breadth of Immune Response in Mice. PLoS One, 8(3):e60245, 2013. PubMed ID: 23555935. Show all entries for this paper.


Displaying record number 59024

HXB2 Location  Gag(343-359)   Gag Epitope Map
View variants at this location
Epitope LEEMMTACQGVGGPGHK   Epitope Alignment
Variants
LEEMMTACQGVGGPsHK   subtype-specific susceptible form
Epitope Name CE7
Species (MHC/HLA mouse

Variant Details

Showing all: 1 variant(s).


Variant ID.  3210
Epitope Seq.  LEEMMTACQGVGGPGHK
Variant Seq.  LEEMMTACQGVGGPsHK
Mutations G/S
Epitope Location G15S
HXB2 Location G357S
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype A, B, M group
Variant Subtype C
Method Intracellular cytokine staining
Note LEEMMTACQGVGGPsHK is the Clade-C variant of CE7. It was used in the p24CE2 vaccine form in this study, eliciting no T-cell response.

References

Kulkarni2013 Viraj Kulkarni, Margherita Rosati, Antonio Valentin, Brunda Ganneru, Ashish K. Singh, Jian Yan, Morgane Rolland, Candido Alicea, Rachel Kelly Beach, Gen-Mu Zhang, Sylvie Le Gall, Kate E. Broderick, Niranjan Y. Sardesai, David Heckerman, Beatriz Mothe, Christian Brander, David B. Weiner, James I. Mullins, George N. Pavlakis, and Barbara K. Felber. HIV-1 p24(gag) Derived Conserved Element DNA Vaccine Increases the Breadth of Immune Response in Mice. PLoS One, 8(3):e60245, 2013. PubMed ID: 23555935. Show all entries for this paper.


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