HIV molecular immunology database
Found 7 matching records:
| HXB2 Location | Gag(147-158) | Gag Epitope Map
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| Epitope |
ISPRTLNAWVKV
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Epitope Alignment | ||||
| Variants |
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| Epitope Name | CE1 | |||||
| Species (MHC/HLA) | mouse | |||||
Showing all: 1 variant(s).
| Variant ID. | 3207 |
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| Epitope Seq. | ISPRTLNAWVKV |
| Variant Seq. | lSPRTLNAWVKV |
| Mutations | I/L |
| Epitope Location | I1L |
| HXB2 Location | I147L |
| Mutation Type | SSF: subtype-specific susceptible form |
| Epitope Subtype | B, C, M group |
| Variant Subtype | A |
| Method | Intracellular cytokine staining |
| Note | lSPRTLNAWVKV is the Clade-A variant of CE1. It was used in the p24CE2 vaccine form in this study, eliciting a strong T-helper response from the vaccinated mouse. |
Kulkarni2013 Viraj Kulkarni, Margherita Rosati, Antonio Valentin, Brunda Ganneru, Ashish K. Singh, Jian Yan, Morgane Rolland, Candido Alicea, Rachel Kelly Beach, Gen-Mu Zhang, Sylvie Le Gall, Kate E. Broderick, Niranjan Y. Sardesai, David Heckerman, Beatriz Mothe, Christian Brander, David B. Weiner, James I. Mullins, George N. Pavlakis, and Barbara K. Felber. HIV-1 p24(gag) Derived Conserved Element DNA Vaccine Increases the Breadth of Immune Response in Mice. PLoS One, 8(3):e60245, 2013. PubMed ID: 23555935. Show all entries for this paper.
| HXB2 Location | Gag(168-185) | Gag Epitope Map
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| Epitope |
VIPMFSALSEGATPQDLN
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Epitope Alignment | ||||
| Variants |
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| Epitope Name | CE2 | |||||
| Species (MHC/HLA) | mouse | |||||
Showing all: 1 variant(s).
| Variant ID. | 3206 |
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| Epitope Seq. | VIPMFSALSEGATPQDLN |
| Variant Seq. | VIPMFtALSEGATPQDLN |
| Mutations | S/T |
| Epitope Location | S6T |
| HXB2 Location | S173T |
| Mutation Type | SSF: subtype-specific susceptible form |
| Epitope Subtype | A, B, M group |
| Variant Subtype | C |
| Method | Intracellular cytokine staining |
| Note | VIPMFtALSEGATPQDLN is the Clade-C variant of CE2. It was used in the p24CE2 vaccine form in this study, eliciting a robust CTL response from the vaccinated mouse. |
Kulkarni2013 Viraj Kulkarni, Margherita Rosati, Antonio Valentin, Brunda Ganneru, Ashish K. Singh, Jian Yan, Morgane Rolland, Candido Alicea, Rachel Kelly Beach, Gen-Mu Zhang, Sylvie Le Gall, Kate E. Broderick, Niranjan Y. Sardesai, David Heckerman, Beatriz Mothe, Christian Brander, David B. Weiner, James I. Mullins, George N. Pavlakis, and Barbara K. Felber. HIV-1 p24(gag) Derived Conserved Element DNA Vaccine Increases the Breadth of Immune Response in Mice. PLoS One, 8(3):e60245, 2013. PubMed ID: 23555935. Show all entries for this paper.
| HXB2 Location | Gag(191-214) | Gag Epitope Map
View variants at this location |
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| Epitope |
VGGHQAAMQMLKETINEEAAEWDR
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Epitope Alignment | ||||
| Variants |
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| Epitope Name | CE3 | |||||
| Species (MHC/HLA) | mouse | |||||
Showing all: 1 variant(s).
| Variant ID. | 3205 |
|---|---|
| Epitope Seq. | VGGHQAAMQMLKETINEEAAEWDR |
| Variant Seq. | VGGHQAAMQMLKdTINEEAAEWDR |
| Mutations | E/D |
| Epitope Location | E13D |
| HXB2 Location | E203D |
| Mutation Type | SSF: subtype-specific susceptible form |
| Epitope Subtype | B |
| Variant Subtype | A, C, M group |
| Method | Intracellular cytokine staining |
| Note | VGGHQAAMQMLKdTINEEAAEWDR is the Clades-A, -C and -M variant of CE3. It was used in the p24CE1 vaccine form in this study, eliciting a small CTL response. |
Kulkarni2013 Viraj Kulkarni, Margherita Rosati, Antonio Valentin, Brunda Ganneru, Ashish K. Singh, Jian Yan, Morgane Rolland, Candido Alicea, Rachel Kelly Beach, Gen-Mu Zhang, Sylvie Le Gall, Kate E. Broderick, Niranjan Y. Sardesai, David Heckerman, Beatriz Mothe, Christian Brander, David B. Weiner, James I. Mullins, George N. Pavlakis, and Barbara K. Felber. HIV-1 p24(gag) Derived Conserved Element DNA Vaccine Increases the Breadth of Immune Response in Mice. PLoS One, 8(3):e60245, 2013. PubMed ID: 23555935. Show all entries for this paper.
| HXB2 Location | Gag(231-249) | Gag Epitope Map
View variants at this location |
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| Epitope |
PRGSDIAGTTSTLQEQIGW
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Epitope Alignment | |||||||
| Variants |
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| Epitope Name | CE4 | ||||||||
| Species (MHC/HLA) | mouse | ||||||||
Showing all: 2 variant(s).
| Variant ID. | 3203 |
|---|---|
| Epitope Seq. | PRGSDIAGTTSTLQEQIGW |
| Variant Seq. | PRGSDIAGTTSTpQEQIGW |
| Mutations | L/P |
| Epitope Location | L13P |
| HXB2 Location | L243P |
| Mutation Type | SSF: subtype-specific susceptible form |
| Epitope Subtype | B |
| Variant Subtype | A |
| Method | Intracellular cytokine staining |
| Note | PRGSDIAGTTSTpQEQIGW is the Clade-A variant of CE4. It was not used in any vaccine form in this study. |
| Variant ID. | 3204 |
|---|---|
| Epitope Seq. | PRGSDIAGTTSTLQEQIGW |
| Variant Seq. | PRGSDIAGTTSTLQEQIaW |
| Mutations | G/A |
| Epitope Location | G18A |
| HXB2 Location | G248A |
| Mutation Type | SSF: subtype-specific susceptible form |
| Epitope Subtype | B |
| Variant Subtype | C, M group |
| Method | Intracellular cytokine staining |
| Note | PRGSDIAGTTSTLQEQIaW is the Clades-C and -M variant of CE4. It was used in the p24CE2 vaccine form in this study, eliciting no response. |
Kulkarni2013 Viraj Kulkarni, Margherita Rosati, Antonio Valentin, Brunda Ganneru, Ashish K. Singh, Jian Yan, Morgane Rolland, Candido Alicea, Rachel Kelly Beach, Gen-Mu Zhang, Sylvie Le Gall, Kate E. Broderick, Niranjan Y. Sardesai, David Heckerman, Beatriz Mothe, Christian Brander, David B. Weiner, James I. Mullins, George N. Pavlakis, and Barbara K. Felber. HIV-1 p24(gag) Derived Conserved Element DNA Vaccine Increases the Breadth of Immune Response in Mice. PLoS One, 8(3):e60245, 2013. PubMed ID: 23555935. Show all entries for this paper.
| HXB2 Location | Gag(263-282) | Gag Epitope Map
View variants at this location |
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| Epitope |
KRWIILGLNKIVRMYSPTSI
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Epitope Alignment | ||||
| Variants |
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| Epitope Name | CE5 | |||||
| Species (MHC/HLA) | mouse | |||||
Showing all: 1 variant(s).
| Variant ID. | 3208 |
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| Epitope Seq. | KRWIILGLNKIVRMYSPTSI |
| Variant Seq. | KRWIILGLNKIVRMYSPvSI |
| Mutations | T/V |
| Epitope Location | T18V |
| HXB2 Location | T280V |
| Mutation Type | SSF: subtype-specific susceptible form |
| Epitope Subtype | B |
| Variant Subtype | A, C, M group |
| Method | Intracellular cytokine staining |
| Note | KRWIILGLNKIVRMYSPvSI is the Clades-A, -C and -M variant of CE5. It was used in the p24CE2 vaccine form in this study, eliciting no response. |
Kulkarni2013 Viraj Kulkarni, Margherita Rosati, Antonio Valentin, Brunda Ganneru, Ashish K. Singh, Jian Yan, Morgane Rolland, Candido Alicea, Rachel Kelly Beach, Gen-Mu Zhang, Sylvie Le Gall, Kate E. Broderick, Niranjan Y. Sardesai, David Heckerman, Beatriz Mothe, Christian Brander, David B. Weiner, James I. Mullins, George N. Pavlakis, and Barbara K. Felber. HIV-1 p24(gag) Derived Conserved Element DNA Vaccine Increases the Breadth of Immune Response in Mice. PLoS One, 8(3):e60245, 2013. PubMed ID: 23555935. Show all entries for this paper.
| HXB2 Location | Gag(296-309) | Gag Epitope Map
View variants at this location |
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| Epitope |
YVDRFYKTLRAEQA
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Epitope Alignment | ||||
| Variants |
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| Epitope Name | CE6 | |||||
| Species (MHC/HLA) | mouse | |||||
Showing all: 1 variant(s).
| Variant ID. | 3209 |
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| Epitope Seq. | YVDRFYKTLRAEQA |
| Variant Seq. | YVDRFfKTLRAEQA |
| Mutations | Y/F |
| Epitope Location | Y6F |
| HXB2 Location | Y301F |
| Mutation Type | SSF: subtype-specific susceptible form |
| Epitope Subtype | B |
| Variant Subtype | A, C, M group |
| Method | Intracellular cytokine staining |
| Note | YVDRFfKTLRAEQA is the Clades-A, -C and -M variant of CE6. It was used in the p24CE2 vaccine form in this study, eliciting a low helper T-cell response. |
Kulkarni2013 Viraj Kulkarni, Margherita Rosati, Antonio Valentin, Brunda Ganneru, Ashish K. Singh, Jian Yan, Morgane Rolland, Candido Alicea, Rachel Kelly Beach, Gen-Mu Zhang, Sylvie Le Gall, Kate E. Broderick, Niranjan Y. Sardesai, David Heckerman, Beatriz Mothe, Christian Brander, David B. Weiner, James I. Mullins, George N. Pavlakis, and Barbara K. Felber. HIV-1 p24(gag) Derived Conserved Element DNA Vaccine Increases the Breadth of Immune Response in Mice. PLoS One, 8(3):e60245, 2013. PubMed ID: 23555935. Show all entries for this paper.
| HXB2 Location | Gag(343-359) | Gag Epitope Map
View variants at this location |
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| Epitope |
LEEMMTACQGVGGPGHK
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Epitope Alignment | ||||
| Variants |
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| Epitope Name | CE7 | |||||
| Species (MHC/HLA) | mouse | |||||
Showing all: 1 variant(s).
| Variant ID. | 3210 |
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| Epitope Seq. | LEEMMTACQGVGGPGHK |
| Variant Seq. | LEEMMTACQGVGGPsHK |
| Mutations | G/S |
| Epitope Location | G15S |
| HXB2 Location | G357S |
| Mutation Type | SSF: subtype-specific susceptible form |
| Epitope Subtype | A, B, M group |
| Variant Subtype | C |
| Method | Intracellular cytokine staining |
| Note | LEEMMTACQGVGGPsHK is the Clade-C variant of CE7. It was used in the p24CE2 vaccine form in this study, eliciting no T-cell response. |
Kulkarni2013 Viraj Kulkarni, Margherita Rosati, Antonio Valentin, Brunda Ganneru, Ashish K. Singh, Jian Yan, Morgane Rolland, Candido Alicea, Rachel Kelly Beach, Gen-Mu Zhang, Sylvie Le Gall, Kate E. Broderick, Niranjan Y. Sardesai, David Heckerman, Beatriz Mothe, Christian Brander, David B. Weiner, James I. Mullins, George N. Pavlakis, and Barbara K. Felber. HIV-1 p24(gag) Derived Conserved Element DNA Vaccine Increases the Breadth of Immune Response in Mice. PLoS One, 8(3):e60245, 2013. PubMed ID: 23555935. Show all entries for this paper.